UniProtKB - Q03484 (CEBPD_RAT)
CCAAT/enhancer-binding protein delta
Cebpd
Functioni
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:1714459).
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (By similarity).
By similarity1 PublicationGO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- identical protein binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
- transcription cis-regulatory region binding Source: RGD
GO - Biological processi
- fat cell differentiation Source: RGD
- hematopoietic progenitor cell differentiation Source: RGD
- inner ear development Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- positive regulation of osteoblast differentiation Source: RGD
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of cell differentiation Source: GO_Central
- regulation of transcription by RNA polymerase II Source: RGD
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: CCAAT/enhancer-binding protein deltaShort name: C/EBP delta Alternative name(s): Transcription factor CELF |
Gene namesi | Name:Cebpd Synonyms:Celf |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2328, Cebpd |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: RGD
- RNA polymerase II transcription regulator complex Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000076623 | 2 – 268 | CCAAT/enhancer-binding protein deltaAdd BLAST | 267 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Cross-linki | 120 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity |
Keywords - PTMi
Acetylation, Isopeptide bond, Ubl conjugationProteomic databases
PaxDbi | Q03484 |
PTM databases
iPTMneti | Q03484 |
PhosphoSitePlusi | Q03484 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000050869, Expressed in brain and 22 other tissues |
Genevisiblei | Q03484, RN |
Interactioni
Subunit structurei
Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPE.
Interacts with SPI1/PU.1.
Interacts with PRDM16.
By similarityGO - Molecular functioni
- identical protein binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000064025 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 191 – 254 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 50 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 98 – 132 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 152 – 223 | DisorderedSequence analysisAdd BLAST | 72 | |
Regioni | 195 – 222 | Basic motifPROSITE-ProRule annotationAdd BLAST | 28 | |
Regioni | 226 – 254 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 156 – 171 | Pro residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 181 – 223 | Basic and acidic residuesSequence analysisAdd BLAST | 43 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000163032 |
HOGENOMi | CLU_043327_2_1_1 |
InParanoidi | Q03484 |
OMAi | QIATCAQ |
OrthoDBi | 1284308at2759 |
PhylomeDBi | Q03484 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf IPR016468, C/EBP_chordates |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
PIRSFi | PIRSF005879, CCAAT/enhancer-binding, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MSAALFSLDS PARGAPWPTE PAAFYEPGRV GKPGRGPEPG DLGEPGSTTP
60 70 80 90 100
AMYDDESAID FSAYIDSMAA VPTLELCHDE IFADLFNSNH KAAGAGSLEL
110 120 130 140 150
LQGGPTRPPG VGSIARGPLK REPDWGDGDA PGSLLPAQVA VCAQTVVSLA
160 170 180 190 200
AAAQPTPPTS PEPPRGSPGP SLAPGPVREK GAGKRGPDRG SPEYRQRRER
210 220 230 240 250
NNIAVRKSRD KAKRRNQEMQ QKLVELSAEN EKLHQRVEQL TRDLASLRQF
260
FKELPSPPFL PPTGTDCR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M65149 mRNA Translation: AAA40913.1 |
PIRi | B39429 |
RefSeqi | NP_037286.1, NM_013154.2 |
Genome annotation databases
Ensembli | ENSRNOT00000074586; ENSRNOP00000064025; ENSRNOG00000050869 |
GeneIDi | 25695 |
KEGGi | rno:25695 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M65149 mRNA Translation: AAA40913.1 |
PIRi | B39429 |
RefSeqi | NP_037286.1, NM_013154.2 |
3D structure databases
AlphaFoldDBi | Q03484 |
SMRi | Q03484 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000064025 |
PTM databases
iPTMneti | Q03484 |
PhosphoSitePlusi | Q03484 |
Proteomic databases
PaxDbi | Q03484 |
Genome annotation databases
Ensembli | ENSRNOT00000074586; ENSRNOP00000064025; ENSRNOG00000050869 |
GeneIDi | 25695 |
KEGGi | rno:25695 |
Organism-specific databases
CTDi | 1052 |
RGDi | 2328, Cebpd |
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000163032 |
HOGENOMi | CLU_043327_2_1_1 |
InParanoidi | Q03484 |
OMAi | QIATCAQ |
OrthoDBi | 1284308at2759 |
PhylomeDBi | Q03484 |
Miscellaneous databases
PROi | PR:Q03484 |
Gene expression databases
Bgeei | ENSRNOG00000050869, Expressed in brain and 22 other tissues |
Genevisiblei | Q03484, RN |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf IPR016468, C/EBP_chordates |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
PIRSFi | PIRSF005879, CCAAT/enhancer-binding, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CEBPD_RAT | |
Accessioni | Q03484Primary (citable) accession number: Q03484 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families