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Protein

CCAAT/enhancer-binding protein delta

Gene

Cebpd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:1714459). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein delta
Short name:
C/EBP delta
Alternative name(s):
Transcription factor CELF
Gene namesi
Name:Cebpd
Synonyms:Celf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi2328 Cebpd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000766232 – 268CCAAT/enhancer-binding protein deltaAdd BLAST267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Cross-linki120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ03484
PRIDEiQ03484

PTM databases

iPTMnetiQ03484
PhosphoSitePlusiQ03484

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSRNOG00000050869 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ03484 RN

Interactioni

Subunit structurei

Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPE. Interacts with SPI1/PU.1. Interacts with PRDM16.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064025

Structurei

3D structure databases

ProteinModelPortaliQ03484
SMRiQ03484
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 254bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni195 – 222Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni226 – 254Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated

Phylogenomic databases

eggNOGiENOG410ISXQ Eukaryota
ENOG4111HWR LUCA
GeneTreeiENSGT00530000063192
HOVERGENiHBG050879
InParanoidiQ03484
KOiK10050
OMAiVPNLELC
OrthoDBiEOG091G11FC
PhylomeDBiQ03484

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR016468 C/EBP_chordates
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
PIRSFiPIRSF005879 CCAAT/enhancer-binding, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03484-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAALFSLDS PARGAPWPTE PAAFYEPGRV GKPGRGPEPG DLGEPGSTTP
60 70 80 90 100
AMYDDESAID FSAYIDSMAA VPTLELCHDE IFADLFNSNH KAAGAGSLEL
110 120 130 140 150
LQGGPTRPPG VGSIARGPLK REPDWGDGDA PGSLLPAQVA VCAQTVVSLA
160 170 180 190 200
AAAQPTPPTS PEPPRGSPGP SLAPGPVREK GAGKRGPDRG SPEYRQRRER
210 220 230 240 250
NNIAVRKSRD KAKRRNQEMQ QKLVELSAEN EKLHQRVEQL TRDLASLRQF
260
FKELPSPPFL PPTGTDCR
Length:268
Mass (Da):28,600
Last modified:October 1, 1996 - v1
Checksum:iEF12ABA104C7B9F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65149 mRNA Translation: AAA40913.1
PIRiB39429
RefSeqiNP_037286.1, NM_013154.2
UniGeneiRn.202620
Rn.6975

Genome annotation databases

EnsembliENSRNOT00000074586; ENSRNOP00000064025; ENSRNOG00000050869
GeneIDi25695
KEGGirno:25695

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65149 mRNA Translation: AAA40913.1
PIRiB39429
RefSeqiNP_037286.1, NM_013154.2
UniGeneiRn.202620
Rn.6975

3D structure databases

ProteinModelPortaliQ03484
SMRiQ03484
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064025

PTM databases

iPTMnetiQ03484
PhosphoSitePlusiQ03484

Proteomic databases

PaxDbiQ03484
PRIDEiQ03484

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074586; ENSRNOP00000064025; ENSRNOG00000050869
GeneIDi25695
KEGGirno:25695

Organism-specific databases

CTDi1052
RGDi2328 Cebpd

Phylogenomic databases

eggNOGiENOG410ISXQ Eukaryota
ENOG4111HWR LUCA
GeneTreeiENSGT00530000063192
HOVERGENiHBG050879
InParanoidiQ03484
KOiK10050
OMAiVPNLELC
OrthoDBiEOG091G11FC
PhylomeDBiQ03484

Miscellaneous databases

PROiPR:Q03484

Gene expression databases

BgeeiENSRNOG00000050869 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ03484 RN

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR016468 C/EBP_chordates
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
PIRSFiPIRSF005879 CCAAT/enhancer-binding, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCEBPD_RAT
AccessioniPrimary (citable) accession number: Q03484
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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