Cebpd

Functionⁱ

Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:1714459). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 8572170
sequence-specific DNA binding
Source: RGD
Inferred from direct assayⁱ
- 11792653
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 8572170

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fat cell differentiation Source: Ensembl
hematopoietic progenitor cell differentiation Source: Ensembl
inner ear development Source: Ensembl
negative regulation of transcription, DNA-templated Source: Ensembl
positive regulation of osteoblast differentiation Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 8572170

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CCAAT/enhancer-binding protein delta Short name: C/EBP delta Alternative name(s): Transcription factor CELF
Gene namesⁱ	Name:Cebpd Synonyms:Celf
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 11

Organism-specific databases

Rat genome database More...RGDⁱ	2328 Cebpd

RGDⁱ

2328 Cebpd

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000076623	2 – 268	CCAAT/enhancer-binding protein deltaAdd BLAST		267

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylserineBy similarity		1
Cross-linkⁱ	120	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q03484
PRIDEⁱ	Q03484

PTM databases

iPTMnetⁱ	Q03484
PhosphoSitePlusⁱ	Q03484

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSRNOG00000050869 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
Genevisibleⁱ	Q03484 RN

Interactionⁱ

Subunit structureⁱ

Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPE. Interacts with SPI1/PU.1. Interacts with PRDM16.By similarity

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000064025

STRINGⁱ

10116.ENSRNOP00000064025

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q03484
SMRⁱ	Q03484
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	191 – 254	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	195 – 222	Basic motifPROSITE-ProRule annotationAdd BLAST		28
Regionⁱ	226 – 254	Leucine-zipperPROSITE-ProRule annotationAdd BLAST		29

Sequence similaritiesⁱ

Belongs to the bZIP family. C/EBP subfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410ISXQ Eukaryota ENOG4111HWR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063192
HOVERGENⁱ	HBG050879
InParanoidⁱ	Q03484
KEGG Orthology (KO) More...KOⁱ	K10050
OMAⁱ	VPNLELC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11FC
PhylomeDBⁱ	Q03484

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR016468 C/EBP_chordates
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07716 bZIP_2, 1 hit
PIRSFⁱ	PIRSF005879 CCAAT/enhancer-binding, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q03484-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSAALFSLDS PARGAPWPTE PAAFYEPGRV GKPGRGPEPG DLGEPGSTTP 
        60         70         80         90        100
AMYDDESAID FSAYIDSMAA VPTLELCHDE IFADLFNSNH KAAGAGSLEL 
       110        120        130        140        150
LQGGPTRPPG VGSIARGPLK REPDWGDGDA PGSLLPAQVA VCAQTVVSLA 
       160        170        180        190        200
AAAQPTPPTS PEPPRGSPGP SLAPGPVREK GAGKRGPDRG SPEYRQRRER 
       210        220        230        240        250
NNIAVRKSRD KAKRRNQEMQ QKLVELSAEN EKLHQRVEQL TRDLASLRQF 
       260 
FKELPSPPFL PPTGTDCR

Length:268

Mass (Da):28,600

Last modified:October 1, 1996 - v1

Checksum:ⁱEF12ABA104C7B9F8

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M65149 mRNA Translation: AAA40913.1
PIRⁱ	B39429
NCBI Reference Sequences More...RefSeqⁱ	NP_037286.1, NM_013154.2
UniGeneⁱ	Rn.202620 Rn.6975

Genome annotation databases

Ensemblⁱ	ENSRNOT00000074586; ENSRNOP00000064025; ENSRNOG00000050869
GeneIDⁱ	25695
KEGGⁱ	rno:25695

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q03484	CCAAT/enhancer-binding protein delta		MOUSE		268	UniRef90_Q00322
CCAAT/enhancer-binding protein delta		MESAU		268
Uncharacterized protein		NEOLE		268
CCAAT/enhancer-binding protein delta		CRIGR		268
UPI000B4FD286		MERUN		279
+6

Protein	Similar proteins		Species	Score	Length	Source
Q03484	CCAAT/enhancer-binding protein delta		MOUSE		268	UniRef50_Q00322
CCAAT/enhancer-binding protein delta		SHEEP		255
CCAAT/enhancer-binding protein delta		BOVIN		256
Uncharacterized protein		NEOLE		268
CCAAT/enhancer-binding protein delta		CRIGR		268
+56

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M65149 mRNA Translation: AAA40913.1
PIRⁱ	B39429
RefSeqⁱ	NP_037286.1, NM_013154.2
UniGeneⁱ	Rn.202620 Rn.6975

3D structure databases

ProteinModelPortalⁱ	Q03484
SMRⁱ	Q03484
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000064025

STRINGⁱ

10116.ENSRNOP00000064025

PTM databases

iPTMnetⁱ	Q03484
PhosphoSitePlusⁱ	Q03484

Proteomic databases

PaxDbⁱ	Q03484
PRIDEⁱ	Q03484

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000074586; ENSRNOP00000064025; ENSRNOG00000050869
GeneIDⁱ	25695
KEGGⁱ	rno:25695

Organism-specific databases

CTDⁱ	1052
RGDⁱ	2328 Cebpd

Phylogenomic databases

eggNOGⁱ	ENOG410ISXQ Eukaryota ENOG4111HWR LUCA
GeneTreeⁱ	ENSGT00530000063192
HOVERGENⁱ	HBG050879
InParanoidⁱ	Q03484
KOⁱ	K10050
OMAⁱ	VPNLELC
OrthoDBⁱ	EOG091G11FC
PhylomeDBⁱ	Q03484

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q03484

PROⁱ

PR:Q03484

Gene expression databases

Bgeeⁱ	ENSRNOG00000050869 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
Genevisibleⁱ	Q03484 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR016468 C/EBP_chordates
Pfamⁱ	View protein in Pfam PF07716 bZIP_2, 1 hit
PIRSFⁱ	PIRSF005879 CCAAT/enhancer-binding, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CEBPD_RAT
Accessionⁱ	Q03484Primary (citable) accession number: Q03484
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	September 12, 2018
	This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - Q03484 (CEBPD_RAT)

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CCAAT/enhancer-binding protein delta

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ