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UniProtKB - Q03456 (FUR_PSEAE)
Protein
Ferric uptake regulation protein
Gene
fur
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Functioni
Fur acts as a repressor, employing Fe2+ as a cofactor to bind the operator of the iron transport operon. Involved in exotoxin A regulation, siderophore regulation and manganese susceptibility.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 32 | Zinc | 1 | |
Metal bindingi | 80 | Zinc | 1 | |
Metal bindingi | 86 | IronCurated | 1 | |
Metal bindingi | 88 | IronCurated | 1 | |
Metal bindingi | 89 | Zinc | 1 | |
Metal bindingi | 100 | Zinc | 1 | |
Metal bindingi | 107 | IronCurated | 1 | |
Metal bindingi | 124 | IronCurated | 1 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription repressor activity Source: CollecTF
- ferrous iron binding Source: PseudoCAP
- transcription cis-regulatory region binding Source: CollecTF
- zinc ion binding Source: GO_Central
GO - Biological processi
- negative regulation of lyase activity Source: PseudoCAP
- negative regulation of siderophore biosynthetic process Source: PseudoCAP
- negative regulation of transcription, DNA-templated Source: CollecTF
- positive regulation of peroxidase activity Source: PseudoCAP
- regulation of secondary metabolite biosynthetic process Source: GO_Central
- regulation of superoxide dismutase activity Source: PseudoCAP
- siderophore biosynthetic process Source: CACAO
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Iron, Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Ferric uptake regulation proteinShort name: Ferric uptake regulator |
Gene namesi | Name:fur Ordered Locus Names:PA4764 |
Organismi | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Taxonomic identifieri | 208964 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Organism-specific databases
PseudoCAPi | PA4764 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: GO_Central
Other locations
- protein-DNA complex Source: CollecTF
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000095567 | 1 – 134 | Ferric uptake regulation proteinAdd BLAST | 134 |
Proteomic databases
PaxDbi | Q03456 |
2D gel databases
World-2DPAGEi | 0008:Q03456 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
STRINGi | 287.DR97_2108 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q03456 |
SMRi | Q03456 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q03456 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 83 | DNA-bindingAdd BLAST | 83 | |
Regioni | 84 – 134 | DimerizationAdd BLAST | 51 |
Sequence similaritiesi
Belongs to the Fur family.Curated
Phylogenomic databases
HOGENOMi | CLU_096072_3_3_6 |
InParanoidi | Q03456 |
OMAi | YLYGVCT |
PhylomeDBi | Q03456 |
Family and domain databases
CDDi | cd07153, Fur_like, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 3.30.1490.190, 1 hit |
InterProi | View protein in InterPro IPR002481, FUR IPR043135, Fur_C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR33202, PTHR33202, 1 hit |
Pfami | View protein in Pfam PF01475, FUR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
i Sequence
Sequence statusi: Complete.
Q03456-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVENSELRKA GLKVTLPRVK ILQMLDSAEQ RHMSAEDVYK ALMEAGEDVG
60 70 80 90 100
LATVYRVLTQ FEAAGLVVRH NFDGGHAVFE LADSGHHDHM VCVDTGEVIE
110 120 130
FMDAEIEKRQ KEIVRERGFE LVDHNLVLYV RKKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L00604 Genomic DNA Translation: AAA25820.1 AF050676 Genomic DNA Translation: AAC05679.1 AE004091 Genomic DNA Translation: AAG08150.1 |
PIRi | A40622 |
RefSeqi | NP_253452.1, NC_002516.2 WP_003095216.1, NZ_QZGE01000018.1 |
Genome annotation databases
EnsemblBacteriai | AAG08150; AAG08150; PA4764 |
GeneIDi | 881780 |
KEGGi | pae:PA4764 |
PATRICi | fig|208964.12.peg.4991 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L00604 Genomic DNA Translation: AAA25820.1 AF050676 Genomic DNA Translation: AAC05679.1 AE004091 Genomic DNA Translation: AAG08150.1 |
PIRi | A40622 |
RefSeqi | NP_253452.1, NC_002516.2 WP_003095216.1, NZ_QZGE01000018.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MZB | X-ray | 1.80 | A | 1-134 | [»] | |
6H1C | X-ray | 2.34 | A/B | 1-134 | [»] | |
AlphaFoldDBi | Q03456 | |||||
SMRi | Q03456 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 287.DR97_2108 |
2D gel databases
World-2DPAGEi | 0008:Q03456 |
Proteomic databases
PaxDbi | Q03456 |
Protocols and materials databases
DNASUi | 881780 |
Genome annotation databases
EnsemblBacteriai | AAG08150; AAG08150; PA4764 |
GeneIDi | 881780 |
KEGGi | pae:PA4764 |
PATRICi | fig|208964.12.peg.4991 |
Organism-specific databases
PseudoCAPi | PA4764 |
Phylogenomic databases
HOGENOMi | CLU_096072_3_3_6 |
InParanoidi | Q03456 |
OMAi | YLYGVCT |
PhylomeDBi | Q03456 |
Miscellaneous databases
EvolutionaryTracei | Q03456 |
Gene expression databases
CollecTFi | EXPREG_00000c80 |
Family and domain databases
CDDi | cd07153, Fur_like, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 3.30.1490.190, 1 hit |
InterProi | View protein in InterPro IPR002481, FUR IPR043135, Fur_C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR33202, PTHR33202, 1 hit |
Pfami | View protein in Pfam PF01475, FUR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FUR_PSEAE | |
Accessioni | Q03456Primary (citable) accession number: Q03456 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | May 25, 2022 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families