Ferric uptake regulation protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity Source: CollecTF <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis."
    Wilderman P.J., Sowa N.A., FitzGerald D.J., FitzGerald P.C., Gottesman S., Ochsner U.A., Vasil M.L.
    Proc. Natl. Acad. Sci. U.S.A. 101:9792-9797(2004) [PubMed] [Europe PMC] [Abstract]
  • "Gene repression by the ferric uptake regulator in Pseudomonas aeruginosa: cycle selection of iron-regulated genes."
    Ochsner U.A., Vasil M.L.
    Proc. Natl. Acad. Sci. U.S.A. 93:4409-4414(1996) [PubMed] [Europe PMC] [Abstract]
  • "An operon containing fumC and sodA encoding fumarase C and manganese superoxide dismutase is controlled by the ferric uptake regulator in Pseudomonas aeruginosa: fur mutants produce elevated alginate levels."
    Hassett D.J., Howell M.L., Ochsner U.A., Vasil M.L., Johnson Z., Dean G.E.
    J. Bacteriol. 179:1452-1459(1997) [PubMed] [Europe PMC] [Abstract]
• ferrous iron binding Source: PseudoCAP <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Role of the ferric uptake regulator of Pseudomonas aeruginosa in the regulation of siderophores and exotoxin A expression: purification and activity on iron-regulated promoters."
    Ochsner U.A., Vasil A.I., Vasil M.L.
    J. Bacteriol. 177:7194-7201(1995) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region DNA binding Source: PseudoCAPInferred from direct assayⁱ
  • "Role of the ferric uptake regulator of Pseudomonas aeruginosa in the regulation of siderophores and exotoxin A expression: purification and activity on iron-regulated promoters."
    Ochsner U.A., Vasil A.I., Vasil M.L.
    J. Bacteriol. 177:7194-7201(1995) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region sequence-specific DNA binding Source: CollecTFInferred from direct assayⁱ
  • "Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis."
    Wilderman P.J., Sowa N.A., FitzGerald D.J., FitzGerald P.C., Gottesman S., Ochsner U.A., Vasil M.L.
    Proc. Natl. Acad. Sci. U.S.A. 101:9792-9797(2004) [PubMed] [Europe PMC] [Abstract]
  • "Gene repression by the ferric uptake regulator in Pseudomonas aeruginosa: cycle selection of iron-regulated genes."
    Ochsner U.A., Vasil M.L.
    Proc. Natl. Acad. Sci. U.S.A. 93:4409-4414(1996) [PubMed] [Europe PMC] [Abstract]
  • "An operon containing fumC and sodA encoding fumarase C and manganese superoxide dismutase is controlled by the ferric uptake regulator in Pseudomonas aeruginosa: fur mutants produce elevated alginate levels."
    Hassett D.J., Howell M.L., Ochsner U.A., Vasil M.L., Johnson Z., Dean G.E.
    J. Bacteriol. 179:1452-1459(1997) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• negative regulation of lyase activity Source: PseudoCAP <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "An operon containing fumC and sodA encoding fumarase C and manganese superoxide dismutase is controlled by the ferric uptake regulator in Pseudomonas aeruginosa: fur mutants produce elevated alginate levels."
    Hassett D.J., Howell M.L., Ochsner U.A., Vasil M.L., Johnson Z., Dean G.E.
    J. Bacteriol. 179:1452-1459(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of siderophore biosynthetic process Source: PseudoCAPInferred from mutant phenotypeⁱ
  • "Ferric uptake regulator mutants of Pseudomonas aeruginosa with distinct alterations in the iron-dependent repression of exotoxin A and siderophores in aerobic and microaerobic environments."
    Barton H.A., Johnson Z., Cox C.D., Vasil A.I., Vasil M.L.
    Mol. Microbiol. 21:1001-1017(1996) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: CollecTF <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis."
    Wilderman P.J., Sowa N.A., FitzGerald D.J., FitzGerald P.C., Gottesman S., Ochsner U.A., Vasil M.L.
    Proc. Natl. Acad. Sci. U.S.A. 101:9792-9797(2004) [PubMed] [Europe PMC] [Abstract]
  • "An operon containing fumC and sodA encoding fumarase C and manganese superoxide dismutase is controlled by the ferric uptake regulator in Pseudomonas aeruginosa: fur mutants produce elevated alginate levels."
    Hassett D.J., Howell M.L., Ochsner U.A., Vasil M.L., Johnson Z., Dean G.E.
    J. Bacteriol. 179:1452-1459(1997) [PubMed] [Europe PMC] [Abstract]
• positive regulation of peroxidase activity Source: PseudoCAPInferred from mutant phenotypeⁱ
  • "Ferric uptake regulator (Fur) mutants of Pseudomonas aeruginosa demonstrate defective siderophore-mediated iron uptake, altered aerobic growth, and decreased superoxide dismutase and catalase activities."
    Hassett D.J., Sokol P.A., Howell M.L., Ma J.F., Schweizer H.T., Ochsner U., Vasil M.L.
    J. Bacteriol. 178:3996-4003(1996) [PubMed] [Europe PMC] [Abstract]
• regulation of secondary metabolite biosynthetic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of superoxide dismutase activity Source: PseudoCAPInferred from mutant phenotypeⁱ
  • "Ferric uptake regulator (Fur) mutants of Pseudomonas aeruginosa demonstrate defective siderophore-mediated iron uptake, altered aerobic growth, and decreased superoxide dismutase and catalase activities."
    Hassett D.J., Sokol P.A., Howell M.L., Ma J.F., Schweizer H.T., Ochsner U., Vasil M.L.
    J. Bacteriol. 178:3996-4003(1996) [PubMed] [Europe PMC] [Abstract]
• siderophore biosynthetic process Source: CACAOInferred from mutant phenotypeⁱ
  • Ref.1

    "Coordinate regulation of siderophore and exotoxin A production: molecular cloning and sequencing of the Pseudomonas aeruginosa fur gene."
    Prince R.W., Cox C.D., Vasil M.L.
    J. Bacteriol. 175:2589-2598(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

GO - Cellular componentⁱ

• cytosol Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein-DNA complex Source: CollecTFInferred from direct assayⁱ
  • "Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis."
    Wilderman P.J., Sowa N.A., FitzGerald D.J., FitzGerald P.C., Gottesman S., Ochsner U.A., Vasil M.L.
    Proc. Natl. Acad. Sci. U.S.A. 101:9792-9797(2004) [PubMed] [Europe PMC] [Abstract]
  • "Gene repression by the ferric uptake regulator in Pseudomonas aeruginosa: cycle selection of iron-regulated genes."
    Ochsner U.A., Vasil M.L.
    Proc. Natl. Acad. Sci. U.S.A. 93:4409-4414(1996) [PubMed] [Europe PMC] [Abstract]
  • "An operon containing fumC and sodA encoding fumarase C and manganese superoxide dismutase is controlled by the ferric uptake regulator in Pseudomonas aeruginosa: fur mutants produce elevated alginate levels."
    Hassett D.J., Howell M.L., Ochsner U.A., Vasil M.L., Johnson Z., Dean G.E.
    J. Bacteriol. 179:1452-1459(1997) [PubMed] [Europe PMC] [Abstract]

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

2D gel databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MVENSELRKA GLKVTLPRVK ILQMLDSAEQ RHMSAEDVYK ALMEAGEDVG 
        60         70         80         90        100
LATVYRVLTQ FEAAGLVVRH NFDGGHAVFE LADSGHHDHM VCVDTGEVIE 
       110        120        130 
FMDAEIEKRQ KEIVRERGFE LVDHNLVLYV RKKK                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families