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UniProtKB - Q03431 (PTH1R_HUMAN)

Entry version 213 (10 Feb 2021)
Sequence version 1 (01 Oct 1993)
Previous versions | rss
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Protein

Parathyroid hormone/parathyroid hormone-related peptide receptor

Gene

PTH1R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.3 Publications

Caution

PubMed:11850620 suggests PTH1R involvement in multiple enchondromatosis. However, PubMed:15523647 shows evidence that this diseae is not caused by PTH1R.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q03431

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-373080, Class B/2 (Secretin family receptors)
R-HSA-418555, G alpha (s) signalling events
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q03431

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q03431

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.14.4.11, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Alternative name(s):
PTH/PTHrP type I receptor
Short name:
PTH/PTHr receptor
Parathyroid hormone 1 receptor
Short name:
PTH1 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTH1R
Synonyms:PTHR, PTHR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9608, PTH1R

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		168468, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q03431

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000160801.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 188ExtracellularSequence analysisAdd BLAST162
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei189 – 212Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini213 – 219CytoplasmicSequence analysis7
Transmembranei220 – 239Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini240 – 282ExtracellularSequence analysisAdd BLAST43
Transmembranei283 – 306Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini307 – 320CytoplasmicSequence analysisAdd BLAST14
Transmembranei321 – 342Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini343 – 361ExtracellularSequence analysisAdd BLAST19
Transmembranei362 – 382Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini383 – 409CytoplasmicSequence analysisAdd BLAST27
Transmembranei410 – 428Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini429 – 440ExtracellularSequence analysisAdd BLAST12
Transmembranei441 – 463Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini464 – 593CytoplasmicSequence analysisAdd BLAST130

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Metaphyseal chondrodysplasia, Jansen type (MCDJ)6 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare autosomal dominant disorder characterized by a short-limbed dwarfism associated with hypercalcemia and normal or low serum concentrations of the two parathyroid hormones.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_003582223H → R in MCDJ; constitutively activated; constitutively increases adenylate cyclase-activating G-protein coupled receptor signaling pathway; decreases the degree of N-glycosylation; does not affect homodimerization. 4 PublicationsCorresponds to variant dbSNP:rs121434597EnsemblClinVar.1
Natural variantiVAR_003583410T → P in MCDJ; constitutively activated. 2 PublicationsCorresponds to variant dbSNP:rs121434598EnsemblClinVar.1
Natural variantiVAR_038811410T → R in MCDJ; leads to agonist-independent cAMP formation which is less pronounced than that observed with the Pro-410 mutant. 1 PublicationCorresponds to variant dbSNP:rs121434602EnsemblClinVar.1
Natural variantiVAR_016064458I → R in MCDJ. 1 PublicationCorresponds to variant dbSNP:rs121434600EnsemblClinVar.1
Chondrodysplasia Blomstrand type (BOCD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionSevere skeletal dysplasia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016062132P → L in BOCD. 1 PublicationCorresponds to variant dbSNP:rs121434599EnsemblClinVar.1
Eiken skeletal dysplasia (EISD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare skeletal dysplasia characterized by severely retarded ossification, principally of the epiphyses, pelvis, hands and feet, as well as by abnormal modeling of the bones in hands and feet, abnormal persistence of cartilage in the pelvis and mild growth retardation.
Related information in OMIM
Primary failure of tooth eruption (PFE)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionRare condition that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi135I → K: Abolishes hormone binding and homodimerization. 1 Publication1
Mutagenesisi137D → A: Abolishes hormone binding. No effect on homodimerization. 1 Publication1

Keywords - Diseasei

Disease variant, Dwarfism

Organism-specific databases

DisGeNET

More...DisGeNETi		5745

MalaCards human disease database

More...MalaCardsi		PTH1R
MIMi125350, phenotype
156400, phenotype
215045, phenotype
600002, phenotype

Open Targets

More...OpenTargetsi		ENSG00000160801

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		50945, Blomstrand lethal chondrodysplasia
79106, Eiken syndrome
33067, Metaphyseal chondrodysplasia, Jansen type
296, Ollier disease
412206, Primary failure of tooth eruption

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33953

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q03431, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1793

Drug and drug target database

More...DrugBanki		DB05084, Abaloparatide
DB05829, Parathyroid hormone
DB06285, Teriparatide

DrugCentral

More...DrugCentrali		Q03431

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		331

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PTH1R

Domain mapping of disease mutations (DMDM)

More...DMDMi		417555

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001284527 – 593Parathyroid hormone/parathyroid hormone-related peptide receptorAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi48 ↔ 117Combined sources3 Publications
Disulfide bondi108 ↔ 148Combined sources3 Publications
Disulfide bondi131 ↔ 170Combined sources3 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei551PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q03431

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q03431

PeptideAtlas

More...PeptideAtlasi		Q03431

PRoteomics IDEntifications database

More...PRIDEi		Q03431

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58212

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q03431

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		Q03431

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q03431, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q03431

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q03431

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in most tissues. Most abundant in kidney, bone and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160801, Expressed in adult mammalian kidney and 185 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q03431, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q03431, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160801, Tissue enriched (kidney)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminal extracellular domain) with PTHLH and PTH (PubMed:8397094, PubMed:10913300, PubMed:18375760, PubMed:19674967). Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer (PubMed:19674967, PubMed:20172855).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111717, 60 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q03431

Protein interaction database and analysis system

More...IntActi		Q03431, 37 interactors

Molecular INTeraction database

More...MINTi		Q03431

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000321999

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q03431

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q03431, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q03431

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q03431

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi474 – 477Important for interaction with G proteins4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4564, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158574

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q03431

Identification of Orthologs from Complete Genome Data

More...OMAi		SGTLWQI

Database of Orthologous Groups

More...OrthoDBi		651627at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q03431

TreeFam database of animal gene trees

More...TreeFami		TF315710

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR002170, GPCR_2_parathyroid_rcpt
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS

The PANTHER Classification System

More...PANTHERi		PTHR45620:SF27, PTHR45620:SF27, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002, 7tm_2, 1 hit
PF02793, HRM, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00249, GPCRSECRETIN
PR00393, PTRHORMONER

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00008, HormR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111418, SSF111418, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00649, G_PROTEIN_RECEP_F2_1, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q03431-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTARIAPGL ALLLCCPVLS SAYALVDADD VMTKEEQIFL LHRAQAQCEK 
        60         70         80         90        100
RLKEVLQRPA SIMESDKGWT SASTSGKPRK DKASGKLYPE SEEDKEAPTG 
       110        120        130        140        150
SRYRGRPCLP EWDHILCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR 
       160        170        180        190        200
NGSWELVPGH NRTWANYSEC VKFLTNETRE REVFDRLGMI YTVGYSVSLA 
       210        220        230        240        250
SLTVAVLILA YFRRLHCTRN YIHMHLFLSF MLRAVSIFVK DAVLYSGATL 
       260        270        280        290        300
DEAERLTEEE LRAIAQAPPP PATAAAGYAG CRVAVTFFLY FLATNYYWIL 
       310        320        330        340        350
VEGLYLHSLI FMAFFSEKKY LWGFTVFGWG LPAVFVAVWV SVRATLANTG 
       360        370        380        390        400
CWDLSSGNKK WIIQVPILAS IVLNFILFIN IVRVLATKLR ETNAGRCDTR 
       410        420        430        440        450
QQYRKLLKST LVLMPLFGVH YIVFMATPYT EVSGTLWQVQ MHYEMLFNSF 
       460        470        480        490        500
QGFFVAIIYC FCNGEVQAEI KKSWSRWTLA LDFKRKARSG SSSYSYGPMV 
       510        520        530        540        550
SHTSVTNVGP RVGLGLPLSP RLLPTATTNG HPQLPGHAKP GTPALETLET 
       560        570        580        590 
TPPAMAAPKD DGFLNGSCSG LDEEASGPER PPALLQEEWE TVM
Length:593
Mass (Da):66,361
Last modified:October 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA1400640A6C7F2B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EWE7E7EWE7_HUMAN
PTH/PTHrP type I receptor
PTH1R
527Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z314F2Z314_HUMAN
PTH/PTHrP type I receptor
PTH1R
333Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0Q3H7C0Q3_HUMAN
Parathyroid hormone/parathyroid hor...
PTH1R
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti471K → N (PubMed:8397094).Curated1
Sequence conflicti473S → C (PubMed:8397094).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016062132P → L in BOCD. 1 PublicationCorresponds to variant dbSNP:rs121434599EnsemblClinVar.1
Natural variantiVAR_016063150R → C1 PublicationCorresponds to variant dbSNP:rs121434601EnsemblClinVar.1
Natural variantiVAR_003582223H → R in MCDJ; constitutively activated; constitutively increases adenylate cyclase-activating G-protein coupled receptor signaling pathway; decreases the degree of N-glycosylation; does not affect homodimerization. 4 PublicationsCorresponds to variant dbSNP:rs121434597EnsemblClinVar.1
Natural variantiVAR_003583410T → P in MCDJ; constitutively activated. 2 PublicationsCorresponds to variant dbSNP:rs121434598EnsemblClinVar.1
Natural variantiVAR_038811410T → R in MCDJ; leads to agonist-independent cAMP formation which is less pronounced than that observed with the Pro-410 mutant. 1 PublicationCorresponds to variant dbSNP:rs121434602EnsemblClinVar.1
Natural variantiVAR_016064458I → R in MCDJ. 1 PublicationCorresponds to variant dbSNP:rs121434600EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L04308 mRNA Translation: AAA36525.1
X68596 mRNA Translation: CAA48589.1
U22409 U22408 Genomic DNA Translation: AAB60657.1
U17418 mRNA Translation: AAA56774.1
AY449732 mRNA Translation: AAR18076.1
BC112221 mRNA Translation: AAI12222.1
BC112247 mRNA Translation: AAI12248.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2747.1

Protein sequence database of the Protein Information Resource

More...PIRi		I38139, A49191

NCBI Reference Sequences

More...RefSeqi		NP_000307.1, NM_000316.2
NP_001171673.1, NM_001184744.1
XP_016862422.1, XM_017006933.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000313049; ENSP00000321999; ENSG00000160801
ENST00000418619; ENSP00000411424; ENSG00000160801
ENST00000430002; ENSP00000413774; ENSG00000160801
ENST00000449590; ENSP00000402723; ENSG00000160801

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5745

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5745

UCSC genome browser

More...UCSCi		uc003cqm.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04308 mRNA Translation: AAA36525.1
X68596 mRNA Translation: CAA48589.1
U22409 U22408 Genomic DNA Translation: AAB60657.1
U17418 mRNA Translation: AAA56774.1
AY449732 mRNA Translation: AAR18076.1
BC112221 mRNA Translation: AAI12222.1
BC112247 mRNA Translation: AAI12248.1
CCDSiCCDS2747.1
PIRiI38139, A49191
RefSeqiNP_000307.1, NM_000316.2
NP_001171673.1, NM_001184744.1
XP_016862422.1, XM_017006933.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BL1NMR-A168-197[»]
1ET2model-S168-469[»]
1ET3model-S168-469[»]
3C4MX-ray1.95A/B29-187[»]
3H3GX-ray1.94A29-187[»]
3L2JX-ray3.24A/B29-187[»]
4Z8JX-ray0.95B586-593[»]
5EMBX-ray0.85B586-593[»]
6NBFelectron microscopy3.00R27-502[»]
6NBHelectron microscopy3.50R27-502[»]
6NBIelectron microscopy4.00R27-502[»]
SMRiQ03431
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111717, 60 interactors
CORUMiQ03431
IntActiQ03431, 37 interactors
MINTiQ03431
STRINGi9606.ENSP00000321999

Chemistry databases

BindingDBiQ03431
ChEMBLiCHEMBL1793
DrugBankiDB05084, Abaloparatide
DB05829, Parathyroid hormone
DB06285, Teriparatide
DrugCentraliQ03431
GuidetoPHARMACOLOGYi331

Protein family/group databases

TCDBi9.A.14.4.11, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ03431, 4 sites
iPTMnetiQ03431
PhosphoSitePlusiQ03431

Genetic variation databases

BioMutaiPTH1R
DMDMi417555

2D gel databases

REPRODUCTION-2DPAGEiQ03431

Proteomic databases

MassIVEiQ03431
PaxDbiQ03431
PeptideAtlasiQ03431
PRIDEiQ03431
ProteomicsDBi58212
TopDownProteomicsiQ03431

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q03431, 23 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1960, 402 antibodies

The DNASU plasmid repository

More...DNASUi		5745

Genome annotation databases

EnsembliENST00000313049; ENSP00000321999; ENSG00000160801
ENST00000418619; ENSP00000411424; ENSG00000160801
ENST00000430002; ENSP00000413774; ENSG00000160801
ENST00000449590; ENSP00000402723; ENSG00000160801
GeneIDi5745
KEGGihsa:5745
UCSCiuc003cqm.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5745
DisGeNETi5745

GeneCards: human genes, protein and diseases

More...GeneCardsi		PTH1R
HGNCiHGNC:9608, PTH1R
HPAiENSG00000160801, Tissue enriched (kidney)
MalaCardsiPTH1R
MIMi125350, phenotype
156400, phenotype
168468, gene
215045, phenotype
600002, phenotype
neXtProtiNX_Q03431
OpenTargetsiENSG00000160801
Orphaneti50945, Blomstrand lethal chondrodysplasia
79106, Eiken syndrome
33067, Metaphyseal chondrodysplasia, Jansen type
296, Ollier disease
412206, Primary failure of tooth eruption
PharmGKBiPA33953
VEuPathDBiHostDB:ENSG00000160801.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4564, Eukaryota
GeneTreeiENSGT00940000158574
InParanoidiQ03431
OMAiSGTLWQI
OrthoDBi651627at2759
PhylomeDBiQ03431
TreeFamiTF315710

Enzyme and pathway databases

PathwayCommonsiQ03431
ReactomeiR-HSA-373080, Class B/2 (Secretin family receptors)
R-HSA-418555, G alpha (s) signalling events
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
SignaLinkiQ03431
SIGNORiQ03431

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5745, 8 hits in 883 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PTH1R, human
EvolutionaryTraceiQ03431

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Parathyroid_hormone_1_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5745
PharosiQ03431, Tclin

Protein Ontology

More...PROi		PR:Q03431
RNActiQ03431, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160801, Expressed in adult mammalian kidney and 185 other tissues
ExpressionAtlasiQ03431, baseline and differential
GenevisibleiQ03431, HS

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR002170, GPCR_2_parathyroid_rcpt
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
PANTHERiPTHR45620:SF27, PTHR45620:SF27, 1 hit
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF02793, HRM, 1 hit
PRINTSiPR00249, GPCRSECRETIN
PR00393, PTRHORMONER
SMARTiView protein in SMART
SM00008, HormR, 1 hit
SUPFAMiSSF111418, SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649, G_PROTEIN_RECEP_F2_1, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTH1R_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03431
Secondary accession number(s): Q2M1U3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: February 10, 2021
This is version 213 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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