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Entry version 197 (13 Feb 2019)
Sequence version 1 (01 Oct 1993)
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Protein

Parathyroid hormone/parathyroid hormone-related peptide receptor

Gene

PTH1R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled peptide receptor activity Source: GO_Central
  • parathyroid hormone receptor activity Source: UniProtKB
  • peptide hormone binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein self-association Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-418555 G alpha (s) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q03431

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q03431

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.4.11 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Alternative name(s):
PTH/PTHrP type I receptor
Short name:
PTH/PTHr receptor
Parathyroid hormone 1 receptor
Short name:
PTH1 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTH1R
Synonyms:PTHR, PTHR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160801.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9608 PTH1R

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
168468 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q03431

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 188ExtracellularSequence analysisAdd BLAST162
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei189 – 212Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini213 – 219CytoplasmicSequence analysis7
Transmembranei220 – 239Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini240 – 282ExtracellularSequence analysisAdd BLAST43
Transmembranei283 – 306Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini307 – 320CytoplasmicSequence analysisAdd BLAST14
Transmembranei321 – 342Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini343 – 361ExtracellularSequence analysisAdd BLAST19
Transmembranei362 – 382Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini383 – 409CytoplasmicSequence analysisAdd BLAST27
Transmembranei410 – 428Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini429 – 440ExtracellularSequence analysisAdd BLAST12
Transmembranei441 – 463Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini464 – 593CytoplasmicSequence analysisAdd BLAST130

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Jansen metaphyseal chondrodysplasia (JMC)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare autosomal dominant disorder characterized by a short-limbed dwarfism associated with hypercalcemia and normal or low serum concentrations of the two parathyroid hormones.
See also OMIM:156400
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_003582223H → R in JMC; constitutively activated; constitutively increases adenylate cyclase-activating G-protein coupled receptor signaling pathway; decreases the degree of N-glycosylation; does not affect homodimerization. 4 PublicationsCorresponds to variant dbSNP:rs121434597EnsemblClinVar.1
Natural variantiVAR_003583410T → P in JMC; constitutively activated. 2 PublicationsCorresponds to variant dbSNP:rs121434598EnsemblClinVar.1
Natural variantiVAR_038811410T → R in JMC; leads to agonist-independent cAMP formation which is less pronounced than that observed with the Pro-410 mutant. 1 PublicationCorresponds to variant dbSNP:rs121434602EnsemblClinVar.1
Natural variantiVAR_016064458I → R in JMC. 1 PublicationCorresponds to variant dbSNP:rs121434600EnsemblClinVar.1
Chondrodysplasia Blomstrand type (BOCD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSevere skeletal dysplasia.
See also OMIM:215045
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016062132P → L in BOCD. 1 PublicationCorresponds to variant dbSNP:rs121434599EnsemblClinVar.1
Enchondromatosis multiple (ENCHOM)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by multiple formation of enchondromas, benign neoplasms derived from mesodermal cells that form cartilage. Enchondromas remain within the substance of a cartilage or bone. Clinical problems caused by enchondromas include skeletal deformity and the potential for malignant change to osteosarcoma.
See also OMIM:166000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016063150R → C in ENCHOM; Ollier type; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121434601EnsemblClinVar.1
Eiken skeletal dysplasia (EISD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare skeletal dysplasia characterized by severely retarded ossification, principally of the epiphyses, pelvis, hands and feet, as well as by abnormal modeling of the bones in hands and feet, abnormal persistence of cartilage in the pelvis and mild growth retardation.
See also OMIM:600002
Primary failure of tooth eruption (PFE)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare condition that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption.
See also OMIM:125350

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi135I → K: Abolishes hormone binding and homodimerization. 1 Publication1
Mutagenesisi137D → A: Abolishes hormone binding. No effect on homodimerization. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...
DisGeNETi
5745

MalaCards human disease database

More...
MalaCardsi
PTH1R
MIMi125350 phenotype
156400 phenotype
166000 phenotype
215045 phenotype
600002 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000160801

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
50945 Blomstrand lethal chondrodysplasia
79106 Eiken syndrome
296 Enchondromatosis
33067 Metaphyseal chondrodysplasia, Jansen type
412206 Primary failure of tooth eruption

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33953

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1793

Drug and drug target database

More...
DrugBanki
DB05829 Parathyroid hormone
DB06285 Teriparatide

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
331

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTH1R

Domain mapping of disease mutations (DMDM)

More...
DMDMi
417555

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001284527 – 593Parathyroid hormone/parathyroid hormone-related peptide receptorAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi48 ↔ 117Combined sources3 Publications
Disulfide bondi108 ↔ 148Combined sources3 Publications
Disulfide bondi131 ↔ 170Combined sources3 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei551PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q03431

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q03431

PeptideAtlas

More...
PeptideAtlasi
Q03431

PRoteomics IDEntifications database

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PRIDEi
Q03431

ProteomicsDB human proteome resource

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ProteomicsDBi
58212

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q03431

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
Q03431

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q03431

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q03431

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q03431

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in most tissues. Most abundant in kidney, bone and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160801 Expressed in 174 organ(s), highest expression level in adult mammalian kidney

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q03431 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q03431 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007978

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminal extracellular domain) with PTHLH and PTH (PubMed:8397094, PubMed:10913300, PubMed:18375760, PubMed:19674967). Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer (PubMed:19674967, PubMed:20172855).6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P352224EBI-2860297,EBI-491549

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111717, 52 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q03431

Protein interaction database and analysis system

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IntActi
Q03431, 9 interactors

Molecular INTeraction database

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MINTi
Q03431

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000321999

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q03431

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BL1NMR-A168-197[»]
1ET2model-S168-469[»]
1ET3model-S168-469[»]
3C4MX-ray1.95A/B29-187[»]
3H3GX-ray1.94A29-187[»]
3L2JX-ray3.24A/B29-187[»]
4Z8JX-ray0.95B586-593[»]
5EMBX-ray0.85B586-593[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q03431

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q03431

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q03431

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi474 – 477Important for interaction with G proteins4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4564 Eukaryota
ENOG410XRS2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158574

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008248

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG008318

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q03431

KEGG Orthology (KO)

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KOi
K04585

Identification of Orthologs from Complete Genome Data

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OMAi
KKWIIQV

Database of Orthologous Groups

More...
OrthoDBi
828211at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q03431

TreeFam database of animal gene trees

More...
TreeFami
TF315710

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR002170 GPCR_2_parathyroid_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS

The PANTHER Classification System

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PANTHERi
PTHR12011:SF24 PTHR12011:SF24, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00249 GPCRSECRETIN
PR00393 PTRHORMONER

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00008 HormR, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF111418 SSF111418, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q03431-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTARIAPGL ALLLCCPVLS SAYALVDADD VMTKEEQIFL LHRAQAQCEK
60 70 80 90 100
RLKEVLQRPA SIMESDKGWT SASTSGKPRK DKASGKLYPE SEEDKEAPTG
110 120 130 140 150
SRYRGRPCLP EWDHILCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR
160 170 180 190 200
NGSWELVPGH NRTWANYSEC VKFLTNETRE REVFDRLGMI YTVGYSVSLA
210 220 230 240 250
SLTVAVLILA YFRRLHCTRN YIHMHLFLSF MLRAVSIFVK DAVLYSGATL
260 270 280 290 300
DEAERLTEEE LRAIAQAPPP PATAAAGYAG CRVAVTFFLY FLATNYYWIL
310 320 330 340 350
VEGLYLHSLI FMAFFSEKKY LWGFTVFGWG LPAVFVAVWV SVRATLANTG
360 370 380 390 400
CWDLSSGNKK WIIQVPILAS IVLNFILFIN IVRVLATKLR ETNAGRCDTR
410 420 430 440 450
QQYRKLLKST LVLMPLFGVH YIVFMATPYT EVSGTLWQVQ MHYEMLFNSF
460 470 480 490 500
QGFFVAIIYC FCNGEVQAEI KKSWSRWTLA LDFKRKARSG SSSYSYGPMV
510 520 530 540 550
SHTSVTNVGP RVGLGLPLSP RLLPTATTNG HPQLPGHAKP GTPALETLET
560 570 580 590
TPPAMAAPKD DGFLNGSCSG LDEEASGPER PPALLQEEWE TVM
Length:593
Mass (Da):66,361
Last modified:October 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA1400640A6C7F2B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z314F2Z314_HUMAN
Parathyroid hormone/parathyroid hor...
PTH1R
333Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWE7E7EWE7_HUMAN
Parathyroid hormone/parathyroid hor...
PTH1R
527Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0Q3H7C0Q3_HUMAN
Parathyroid hormone/parathyroid hor...
PTH1R
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti471K → N (PubMed:8397094).Curated1
Sequence conflicti473S → C (PubMed:8397094).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016062132P → L in BOCD. 1 PublicationCorresponds to variant dbSNP:rs121434599EnsemblClinVar.1
Natural variantiVAR_016063150R → C in ENCHOM; Ollier type; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121434601EnsemblClinVar.1
Natural variantiVAR_003582223H → R in JMC; constitutively activated; constitutively increases adenylate cyclase-activating G-protein coupled receptor signaling pathway; decreases the degree of N-glycosylation; does not affect homodimerization. 4 PublicationsCorresponds to variant dbSNP:rs121434597EnsemblClinVar.1
Natural variantiVAR_003583410T → P in JMC; constitutively activated. 2 PublicationsCorresponds to variant dbSNP:rs121434598EnsemblClinVar.1
Natural variantiVAR_038811410T → R in JMC; leads to agonist-independent cAMP formation which is less pronounced than that observed with the Pro-410 mutant. 1 PublicationCorresponds to variant dbSNP:rs121434602EnsemblClinVar.1
Natural variantiVAR_016064458I → R in JMC. 1 PublicationCorresponds to variant dbSNP:rs121434600EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L04308 mRNA Translation: AAA36525.1
X68596 mRNA Translation: CAA48589.1
U22409
, U22401, U22402, U22403, U22404, U22405, U22406, U22407, U22408 Genomic DNA Translation: AAB60657.1
U17418 mRNA Translation: AAA56774.1
AY449732 mRNA Translation: AAR18076.1
BC112221 mRNA Translation: AAI12222.1
BC112247 mRNA Translation: AAI12248.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2747.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I38139 A49191

NCBI Reference Sequences

More...
RefSeqi
NP_000307.1, NM_000316.2
NP_001171673.1, NM_001184744.1
XP_016862422.1, XM_017006933.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.1019

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000313049; ENSP00000321999; ENSG00000160801
ENST00000418619; ENSP00000411424; ENSG00000160801
ENST00000430002; ENSP00000413774; ENSG00000160801
ENST00000449590; ENSP00000402723; ENSG00000160801

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5745

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5745

UCSC genome browser

More...
UCSCi
uc003cqm.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04308 mRNA Translation: AAA36525.1
X68596 mRNA Translation: CAA48589.1
U22409
, U22401, U22402, U22403, U22404, U22405, U22406, U22407, U22408 Genomic DNA Translation: AAB60657.1
U17418 mRNA Translation: AAA56774.1
AY449732 mRNA Translation: AAR18076.1
BC112221 mRNA Translation: AAI12222.1
BC112247 mRNA Translation: AAI12248.1
CCDSiCCDS2747.1
PIRiI38139 A49191
RefSeqiNP_000307.1, NM_000316.2
NP_001171673.1, NM_001184744.1
XP_016862422.1, XM_017006933.1
UniGeneiHs.1019

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BL1NMR-A168-197[»]
1ET2model-S168-469[»]
1ET3model-S168-469[»]
3C4MX-ray1.95A/B29-187[»]
3H3GX-ray1.94A29-187[»]
3L2JX-ray3.24A/B29-187[»]
4Z8JX-ray0.95B586-593[»]
5EMBX-ray0.85B586-593[»]
ProteinModelPortaliQ03431
SMRiQ03431
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111717, 52 interactors
CORUMiQ03431
IntActiQ03431, 9 interactors
MINTiQ03431
STRINGi9606.ENSP00000321999

Chemistry databases

BindingDBiQ03431
ChEMBLiCHEMBL1793
DrugBankiDB05829 Parathyroid hormone
DB06285 Teriparatide
GuidetoPHARMACOLOGYi331

Protein family/group databases

TCDBi9.A.14.4.11 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ03431
PhosphoSitePlusiQ03431

Polymorphism and mutation databases

BioMutaiPTH1R
DMDMi417555

2D gel databases

REPRODUCTION-2DPAGEiQ03431

Proteomic databases

jPOSTiQ03431
PaxDbiQ03431
PeptideAtlasiQ03431
PRIDEiQ03431
ProteomicsDBi58212
TopDownProteomicsiQ03431

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5745
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313049; ENSP00000321999; ENSG00000160801
ENST00000418619; ENSP00000411424; ENSG00000160801
ENST00000430002; ENSP00000413774; ENSG00000160801
ENST00000449590; ENSP00000402723; ENSG00000160801
GeneIDi5745
KEGGihsa:5745
UCSCiuc003cqm.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5745
DisGeNETi5745
EuPathDBiHostDB:ENSG00000160801.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTH1R
HGNCiHGNC:9608 PTH1R
HPAiHPA007978
MalaCardsiPTH1R
MIMi125350 phenotype
156400 phenotype
166000 phenotype
168468 gene
215045 phenotype
600002 phenotype
neXtProtiNX_Q03431
OpenTargetsiENSG00000160801
Orphaneti50945 Blomstrand lethal chondrodysplasia
79106 Eiken syndrome
296 Enchondromatosis
33067 Metaphyseal chondrodysplasia, Jansen type
412206 Primary failure of tooth eruption
PharmGKBiPA33953

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00940000158574
HOGENOMiHOG000008248
HOVERGENiHBG008318
InParanoidiQ03431
KOiK04585
OMAiKKWIIQV
OrthoDBi828211at2759
PhylomeDBiQ03431
TreeFamiTF315710

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-418555 G alpha (s) signalling events
SignaLinkiQ03431
SIGNORiQ03431

Miscellaneous databases

EvolutionaryTraceiQ03431

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Parathyroid_hormone_1_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5745
PMAP-CutDBiQ03431

Protein Ontology

More...
PROi
PR:Q03431

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160801 Expressed in 174 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ03431 baseline and differential
GenevisibleiQ03431 HS

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR002170 GPCR_2_parathyroid_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF24 PTHR12011:SF24, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR00393 PTRHORMONER
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTH1R_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03431
Secondary accession number(s): Q2M1U3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: February 13, 2019
This is version 197 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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