PTH1R

Functionⁱ

Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.3 Publications

GO - Molecular functionⁱ

G protein-coupled peptide receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
parathyroid hormone receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19674967
- 8397094
peptide hormone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19674967
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 27160269
protein self-association
Source: UniProtKB
Inferred from direct assayⁱ
- 19674967

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating G protein-coupled receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 27160269
- 8397094
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 19674967
aging Source: Ensembl
bone mineralization Source: Ensembl
bone resorption Source: Ensembl
cell maturation Source: Ensembl
cell surface receptor signaling pathway Source: InterPro
cellular calcium ion homeostasis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chondrocyte differentiation Source: Ensembl
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: ProtInc
Traceable author statementⁱ
- 9927325
negative regulation of cell proliferation Source: Ensembl
osteoblast development Source: Ensembl
phospholipase C-activating G protein-coupled receptor signaling pathway
Source: BHF-UCL
Inferred by curatorⁱ
- 19608645
positive regulation of cell proliferation Source: Ensembl
positive regulation of cytosolic calcium ion concentration Source: Ensembl
positive regulation of inositol phosphate biosynthetic process Source: BHF-UCL
skeletal system development
Source: ProtInc
Traceable author statementⁱ
- 9745456

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-418555 G alpha (s) signalling events
SignaLinkⁱ	Q03431
SIGNORⁱ	Q03431

Protein family/group databases

TCDBⁱ

9.A.14.4.11 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Parathyroid hormone/parathyroid hormone-related peptide receptor Alternative name(s): PTH/PTHrP type I receptor Short name: PTH/PTHr receptor Parathyroid hormone 1 receptor Short name: PTH1 receptor
Gene namesⁱ	Name:PTH1R Synonyms:PTHR, PTHR1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160801.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9608 PTH1R
MIMⁱ	168468 gene
neXtProtⁱ	NX_Q03431

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	27 – 188	ExtracellularSequence analysisAdd BLAST	162
Transmembraneⁱ	189 – 212	Helical; Name=1Sequence analysisAdd BLAST	24
Topological domainⁱ	213 – 219	CytoplasmicSequence analysis	7
Transmembraneⁱ	220 – 239	Helical; Name=2Sequence analysisAdd BLAST	20
Topological domainⁱ	240 – 282	ExtracellularSequence analysisAdd BLAST	43
Transmembraneⁱ	283 – 306	Helical; Name=3Sequence analysisAdd BLAST	24
Topological domainⁱ	307 – 320	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	321 – 342	Helical; Name=4Sequence analysisAdd BLAST	22
Topological domainⁱ	343 – 361	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	362 – 382	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	383 – 409	CytoplasmicSequence analysisAdd BLAST	27
Transmembraneⁱ	410 – 428	Helical; Name=6Sequence analysisAdd BLAST	19
Topological domainⁱ	429 – 440	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	441 – 463	Helical; Name=7Sequence analysisAdd BLAST	23
Topological domainⁱ	464 – 593	CytoplasmicSequence analysisAdd BLAST	130

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Jansen metaphyseal chondrodysplasia (JMC)6 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionRare autosomal dominant disorder characterized by a short-limbed dwarfism associated with hypercalcemia and normal or low serum concentrations of the two parathyroid hormones.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_003582	223	H → R in JMC; constitutively activated; constitutively increases adenylate cyclase-activating G-protein coupled receptor signaling pathway; decreases the degree of N-glycosylation; does not affect homodimerization. 4 PublicationsCorresponds to variant dbSNP:rs121434597EnsemblClinVar.	1
Natural variantⁱVAR_003583	410	T → P in JMC; constitutively activated. 2 PublicationsCorresponds to variant dbSNP:rs121434598EnsemblClinVar.	1
Natural variantⁱVAR_038811	410	T → R in JMC; leads to agonist-independent cAMP formation which is less pronounced than that observed with the Pro-410 mutant. 1 PublicationCorresponds to variant dbSNP:rs121434602EnsemblClinVar.	1
Natural variantⁱVAR_016064	458	I → R in JMC. 1 PublicationCorresponds to variant dbSNP:rs121434600EnsemblClinVar.	1

Chondrodysplasia Blomstrand type (BOCD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionSevere skeletal dysplasia.

Enchondromatosis multiple (ENCHOM)1 Publication

The disease may be caused by mutations affecting the gene represented in this entry.

Disease descriptionA condition characterized by multiple formation of enchondromas, benign neoplasms derived from mesodermal cells that form cartilage. Enchondromas remain within the substance of a cartilage or bone. Clinical problems caused by enchondromas include skeletal deformity and the potential for malignant change to osteosarcoma.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_016063	150	R → C in ENCHOM; Ollier type; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121434601EnsemblClinVar.		1

Eiken skeletal dysplasia (EISD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare skeletal dysplasia characterized by severely retarded ossification, principally of the epiphyses, pelvis, hands and feet, as well as by abnormal modeling of the bones in hands and feet, abnormal persistence of cartilage in the pelvis and mild growth retardation.

Primary failure of tooth eruption (PFE)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionRare condition that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	135	I → K: Abolishes hormone binding and homodimerization. 1 Publication		1
Mutagenesisⁱ	137	D → A: Abolishes hormone binding. No effect on homodimerization. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5745
MalaCards human disease database More...MalaCardsⁱ	PTH1R
MIMⁱ	125350 phenotype 156400 phenotype 166000 phenotype 215045 phenotype 600002 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000160801
Orphanetⁱ	50945 Blomstrand lethal chondrodysplasia 79106 Eiken syndrome 296 Enchondromatosis 33067 Metaphyseal chondrodysplasia, Jansen type 412206 Primary failure of tooth eruption
PharmGKBⁱ	PA33953

Chemistry databases

ChEMBLⁱ	CHEMBL1793
Drug and drug target database More...DrugBankⁱ	DB05829 Parathyroid hormone DB06285 Teriparatide
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	331

Polymorphism and mutation databases

BioMutaⁱ	PTH1R
DMDMⁱ	417555

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST		26
ChainⁱPRO_0000012845	27 – 593	Parathyroid hormone/parathyroid hormone-related peptide receptorAdd BLAST		567

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	48 ↔ 117	Combined sources3 Publications
Disulfide bondⁱ	108 ↔ 148	Combined sources3 Publications
Disulfide bondⁱ	131 ↔ 170	Combined sources3 Publications
Glycosylationⁱ	151	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	161	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	166	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	176	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	551	PhosphothreonineCombined sources	1

Post-translational modificationⁱ

N-glycosylated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q03431
PeptideAtlas More...PeptideAtlasⁱ	Q03431
PRIDEⁱ	Q03431
ProteomicsDBⁱ	58212
TopDownProteomicsⁱ	Q03431

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	Q03431

REPRODUCTION-2DPAGEⁱ

Q03431

PTM databases

iPTMnetⁱ	Q03431
PhosphoSitePlusⁱ	Q03431

Miscellaneous databases

PMAP-CutDBⁱ	Q03431

PMAP-CutDBⁱ

Q03431

Expressionⁱ

Tissue specificityⁱ

Expressed in most tissues. Most abundant in kidney, bone and liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000160801 Expressed in 174 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_PTH1R
ExpressionAtlasⁱ	Q03431 baseline and differential
Genevisibleⁱ	Q03431 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA007978

HPAⁱ

HPA007978

Interactionⁱ

Subunit structureⁱ

Interacts (via N-terminal extracellular domain) with PTHLH and PTH (PubMed:8397094, PubMed:10913300, PubMed:18375760, PubMed:19674967). Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer (PubMed:19674967, PubMed:20172855).6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CTNNB1	P35222	4	EBI-2860297,EBI-491549

With

Entry

#Exp.

IntAct

Notes

CTNNB1

P35222

4

EBI-2860297,EBI-491549

GO - Molecular functionⁱ

protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 27160269
protein self-association
Source: UniProtKB
Inferred from direct assayⁱ
- 19674967

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111717, 52 interactors
CORUMⁱ	Q03431
IntActⁱ	Q03431, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q03431
STRINGⁱ	9606.ENSP00000321999

Chemistry databases

BindingDBⁱ

Q03431

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	34 – 55	Combined sources	22
Beta strandⁱ	126 – 130	Combined sources	5
Beta strandⁱ	143 – 148	Combined sources	6
Beta strandⁱ	152 – 154	Combined sources	3
Beta strandⁱ	160 – 163	Combined sources	4
Turnⁱ	168 – 173	Combined sources	6
Helixⁱ	180 – 185	Combined sources	6
Helixⁱ	188 – 196	Combined sources	9
Beta strandⁱ	588 – 592	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	Q03431
SMRⁱ	Q03431
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q03431

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	474 – 477	Important for interaction with G proteins		4

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 2 family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4564 Eukaryota ENOG410XRS2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118800
HOGENOMⁱ	HOG000008248
HOVERGENⁱ	HBG008318
InParanoidⁱ	Q03431
KEGG Orthology (KO) More...KOⁱ	K04585
OMAⁱ	KKWIIQV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NF8
PhylomeDBⁱ	Q03431
TreeFamⁱ	TF315710

Family and domain databases

Gene3Dⁱ	4.10.1240.10, 1 hit
InterProⁱ	View protein in InterPro IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR002170 GPCR_2_parathyroid_rcpt IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS
PANTHERⁱ	PTHR12011:SF24 PTHR12011:SF24, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit
PRINTSⁱ	PR00249 GPCRSECRETIN PR00393 PTRHORMONER
SMARTⁱ	View protein in SMART SM00008 HormR, 1 hit
SUPFAMⁱ	SSF111418 SSF111418, 1 hit
PROSITEⁱ	View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q03431-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGTARIAPGL ALLLCCPVLS SAYALVDADD VMTKEEQIFL LHRAQAQCEK 
        60         70         80         90        100
RLKEVLQRPA SIMESDKGWT SASTSGKPRK DKASGKLYPE SEEDKEAPTG 
       110        120        130        140        150
SRYRGRPCLP EWDHILCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR 
       160        170        180        190        200
NGSWELVPGH NRTWANYSEC VKFLTNETRE REVFDRLGMI YTVGYSVSLA 
       210        220        230        240        250
SLTVAVLILA YFRRLHCTRN YIHMHLFLSF MLRAVSIFVK DAVLYSGATL 
       260        270        280        290        300
DEAERLTEEE LRAIAQAPPP PATAAAGYAG CRVAVTFFLY FLATNYYWIL 
       310        320        330        340        350
VEGLYLHSLI FMAFFSEKKY LWGFTVFGWG LPAVFVAVWV SVRATLANTG 
       360        370        380        390        400
CWDLSSGNKK WIIQVPILAS IVLNFILFIN IVRVLATKLR ETNAGRCDTR 
       410        420        430        440        450
QQYRKLLKST LVLMPLFGVH YIVFMATPYT EVSGTLWQVQ MHYEMLFNSF 
       460        470        480        490        500
QGFFVAIIYC FCNGEVQAEI KKSWSRWTLA LDFKRKARSG SSSYSYGPMV 
       510        520        530        540        550
SHTSVTNVGP RVGLGLPLSP RLLPTATTNG HPQLPGHAKP GTPALETLET 
       560        570        580        590 
TPPAMAAPKD DGFLNGSCSG LDEEASGPER PPALLQEEWE TVM

Length:593

Mass (Da):66,361

Last modified:October 1, 1993 - v1

Checksum:ⁱDA1400640A6C7F2B

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F2Z314	F2Z314_HUMAN	Parathyroid hormone/parathyroid hor... Parathyroid hormone/parathyroid hormone-related peptide receptor	PTH1R	333	Annotation score:
E7EWE7	E7EWE7_HUMAN	Parathyroid hormone/parathyroid hor... Parathyroid hormone/parathyroid hormone-related peptide receptor	PTH1R	527	Annotation score:
H7C0Q3	H7C0Q3_HUMAN	Parathyroid hormone/parathyroid hor... Parathyroid hormone/parathyroid hormone-related peptide receptor	PTH1R	182	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	471	K → N (PubMed:8397094).Curated		1
Sequence conflictⁱ	473	S → C (PubMed:8397094).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_016062	132	P → L in BOCD. 1 PublicationCorresponds to variant dbSNP:rs121434599EnsemblClinVar.	1
Natural variantⁱVAR_016063	150	R → C in ENCHOM; Ollier type; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121434601EnsemblClinVar.	1
Natural variantⁱVAR_003582	223	H → R in JMC; constitutively activated; constitutively increases adenylate cyclase-activating G-protein coupled receptor signaling pathway; decreases the degree of N-glycosylation; does not affect homodimerization. 4 PublicationsCorresponds to variant dbSNP:rs121434597EnsemblClinVar.	1
Natural variantⁱVAR_003583	410	T → P in JMC; constitutively activated. 2 PublicationsCorresponds to variant dbSNP:rs121434598EnsemblClinVar.	1
Natural variantⁱVAR_038811	410	T → R in JMC; leads to agonist-independent cAMP formation which is less pronounced than that observed with the Pro-410 mutant. 1 PublicationCorresponds to variant dbSNP:rs121434602EnsemblClinVar.	1
Natural variantⁱVAR_016064	458	I → R in JMC. 1 PublicationCorresponds to variant dbSNP:rs121434600EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L04308 mRNA Translation: AAA36525.1 X68596 mRNA Translation: CAA48589.1 U22409 U22408 Genomic DNA Translation: AAB60657.1 U17418 mRNA Translation: AAA56774.1 AY449732 mRNA Translation: AAR18076.1 BC112221 mRNA Translation: AAI12222.1 BC112247 mRNA Translation: AAI12248.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2747.1
PIRⁱ	I38139 A49191
NCBI Reference Sequences More...RefSeqⁱ	NP_000307.1, NM_000316.2 NP_001171673.1, NM_001184744.1 XP_016862422.1, XM_017006933.1
UniGeneⁱ	Hs.1019

Genome annotation databases

Ensemblⁱ	ENST00000313049; ENSP00000321999; ENSG00000160801 ENST00000418619; ENSP00000411424; ENSG00000160801 ENST00000430002; ENSP00000413774; ENSG00000160801 ENST00000449590; ENSP00000402723; ENSG00000160801
GeneIDⁱ	5745
KEGGⁱ	hsa:5745
UCSC genome browser More...UCSCⁱ	uc003cqm.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q03431	Parathyroid hormone receptor 1, isoform CRA_a		HUMAN		593	UniRef100_Q03431
Parathyroid hormone/parathyroid hormone-related peptide receptor (Fragment)		HUMAN		527
UPI000387BD08		HUMAN		562

Protein	Similar proteins		Species	Score	Length	Source
Q03431	Parathyroid hormone/parathyroid hormone-related peptide receptor		CANLF		595	UniRef90_Q03431
Parathyroid hormone/parathyroid hormone-related peptide receptor		PONAB		594
Parathyroid hormone/parathyroid hormone-related peptide receptor		BOVIN		589
Parathyroid hormone receptor 1, isoform CRA_a		HUMAN		593
parathyroid hormone/parathyroid hormone-related peptide receptor isoform X1		DELLE		602
+132

Protein	Similar proteins		Species	Score	Length	Source
Q03431	Parathyroid hormone/parathyroid hormone-related peptide receptor		CANLF		595	UniRef50_Q03431
Parathyroid hormone/parathyroid hormone-related peptide receptor		PONAB		594
Parathyroid hormone/parathyroid hormone-related peptide receptor		BOVIN		589
Parathyroid hormone/parathyroid hormone-related peptide receptor		PIG		585
Parathyroid hormone receptor 1, isoform CRA_a		HUMAN		593
+195

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L04308 mRNA Translation: AAA36525.1 X68596 mRNA Translation: CAA48589.1 U22409 U22408 Genomic DNA Translation: AAB60657.1 U17418 mRNA Translation: AAA56774.1 AY449732 mRNA Translation: AAR18076.1 BC112221 mRNA Translation: AAI12222.1 BC112247 mRNA Translation: AAI12248.1
CCDSⁱ	CCDS2747.1
PIRⁱ	I38139 A49191
RefSeqⁱ	NP_000307.1, NM_000316.2 NP_001171673.1, NM_001184744.1 XP_016862422.1, XM_017006933.1
UniGeneⁱ	Hs.1019

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BL1	NMR	-	A	168-197	[»]
	1ET2	model	-	S	168-469	[»]
	1ET3	model	-	S	168-469	[»]
	3C4M	X-ray	1.95	A/B	29-187	[»]
	3H3G	X-ray	1.94	A	29-187	[»]
	3L2J	X-ray	3.24	A/B	29-187	[»]
	4Z8J	X-ray	0.95	B	586-593	[»]
	5EMB	X-ray	0.85	B	586-593	[»]
ProteinModelPortalⁱ	Q03431
SMRⁱ	Q03431
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111717, 52 interactors
CORUMⁱ	Q03431
IntActⁱ	Q03431, 9 interactors
MINTⁱ	Q03431
STRINGⁱ	9606.ENSP00000321999

Chemistry databases

BindingDBⁱ	Q03431
ChEMBLⁱ	CHEMBL1793
DrugBankⁱ	DB05829 Parathyroid hormone DB06285 Teriparatide
GuidetoPHARMACOLOGYⁱ	331

Protein family/group databases

TCDBⁱ	9.A.14.4.11 the g-protein-coupled receptor (gpcr) family
GPCRDBⁱ	Search...

PTM databases

iPTMnetⁱ	Q03431
PhosphoSitePlusⁱ	Q03431

Polymorphism and mutation databases

BioMutaⁱ	PTH1R
DMDMⁱ	417555

2D gel databases

REPRODUCTION-2DPAGEⁱ	Q03431

REPRODUCTION-2DPAGEⁱ

Q03431

Proteomic databases

PaxDbⁱ	Q03431
PeptideAtlasⁱ	Q03431
PRIDEⁱ	Q03431
ProteomicsDBⁱ	58212
TopDownProteomicsⁱ	Q03431

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5745
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000313049; ENSP00000321999; ENSG00000160801 ENST00000418619; ENSP00000411424; ENSG00000160801 ENST00000430002; ENSP00000413774; ENSG00000160801 ENST00000449590; ENSP00000402723; ENSG00000160801
GeneIDⁱ	5745
KEGGⁱ	hsa:5745
UCSCⁱ	uc003cqm.4 human

Organism-specific databases

CTDⁱ	5745
DisGeNETⁱ	5745
EuPathDBⁱ	HostDB:ENSG00000160801.13
GeneCardsⁱ	PTH1R
HGNCⁱ	HGNC:9608 PTH1R
HPAⁱ	HPA007978
MalaCardsⁱ	PTH1R
MIMⁱ	125350 phenotype 156400 phenotype 166000 phenotype 168468 gene 215045 phenotype 600002 phenotype
neXtProtⁱ	NX_Q03431
OpenTargetsⁱ	ENSG00000160801
Orphanetⁱ	50945 Blomstrand lethal chondrodysplasia 79106 Eiken syndrome 296 Enchondromatosis 33067 Metaphyseal chondrodysplasia, Jansen type 412206 Primary failure of tooth eruption
PharmGKBⁱ	PA33953
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4564 Eukaryota ENOG410XRS2 LUCA
GeneTreeⁱ	ENSGT00760000118800
HOGENOMⁱ	HOG000008248
HOVERGENⁱ	HBG008318
InParanoidⁱ	Q03431
KOⁱ	K04585
OMAⁱ	KKWIIQV
OrthoDBⁱ	EOG091G0NF8
PhylomeDBⁱ	Q03431
TreeFamⁱ	TF315710

Enzyme and pathway databases

Reactomeⁱ	R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-418555 G alpha (s) signalling events
SignaLinkⁱ	Q03431
SIGNORⁱ	Q03431

Miscellaneous databases

EvolutionaryTraceⁱ	Q03431
GeneWikiⁱ	Parathyroid_hormone_1_receptor
GenomeRNAiⁱ	5745
PMAP-CutDBⁱ	Q03431
Protein Ontology More...PROⁱ	PR:Q03431
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000160801 Expressed in 174 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_PTH1R
ExpressionAtlasⁱ	Q03431 baseline and differential
Genevisibleⁱ	Q03431 HS

Family and domain databases

Gene3Dⁱ	4.10.1240.10, 1 hit
InterProⁱ	View protein in InterPro IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR002170 GPCR_2_parathyroid_rcpt IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS
PANTHERⁱ	PTHR12011:SF24 PTHR12011:SF24, 1 hit
Pfamⁱ	View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit
PRINTSⁱ	PR00249 GPCRSECRETIN PR00393 PTRHORMONER
SMARTⁱ	View protein in SMART SM00008 HormR, 1 hit
SUPFAMⁱ	SSF111418 SSF111418, 1 hit
PROSITEⁱ	View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PTH1R_HUMAN
Accessionⁱ	Q03431Primary (citable) accession number: Q03431 Secondary accession number(s): Q2M1U3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	October 1, 1993
	Last modified:	November 7, 2018
	This is version 194 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - Q03431 (PTH1R_HUMAN)

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Parathyroid hormone/parathyroid hormone-related peptide receptor

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

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Organism-specific databases

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Topology

Keywords - Cellular componenti

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Organism-specific databases

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Polymorphism and mutation databases

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Keywords - PTMi

Proteomic databases

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Gene expression databases

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Secondary structure

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

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Experimental Info

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Sequence databases

Genome annotation databases

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Sequence databases

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2D gel databases

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Enzyme and pathway databases

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Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ