UniProtKB - Q03431 (PTH1R_HUMAN)
Protein
Parathyroid hormone/parathyroid hormone-related peptide receptor
Gene
PTH1R
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.3 Publications
Caution
PubMed:11850620 suggests PTH1R involvement in multiple enchondromatosis. However, PubMed:15523647 shows evidence that this diseae is not caused by PTH1R.2 Publications
GO - Molecular functioni
- G protein-coupled peptide receptor activity Source: GO_Central
- parathyroid hormone receptor activity Source: UniProtKB
- peptide hormone binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein self-association Source: UniProtKB
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: UniProtKB
- aging Source: Ensembl
- bone mineralization Source: Ensembl
- bone resorption Source: Ensembl
- cell maturation Source: Ensembl
- cell surface receptor signaling pathway Source: InterPro
- cellular calcium ion homeostasis Source: GO_Central
- chondrocyte differentiation Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
- in utero embryonic development Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- osteoblast development Source: Ensembl
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of inositol phosphate biosynthetic process Source: BHF-UCL
- skeletal system development Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q03431 |
Reactomei | R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | Q03431 |
SIGNORi | Q03431 |
Protein family/group databases
TCDBi | 9.A.14.4.11, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Parathyroid hormone/parathyroid hormone-related peptide receptorAlternative name(s): PTH/PTHrP type I receptor Short name: PTH/PTHr receptor Parathyroid hormone 1 receptor Short name: PTH1 receptor |
Gene namesi | Name:PTH1R Synonyms:PTHR, PTHR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9608, PTH1R |
MIMi | 168468, gene |
neXtProti | NX_Q03431 |
VEuPathDBi | HostDB:ENSG00000160801.13 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein 1 Publication
Nucleus
- nucleus Source: ProtInc
Plasma Membrane
- apical plasma membrane Source: BHF-UCL
- basolateral plasma membrane Source: BHF-UCL
- brush border membrane Source: Ensembl
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: ProtInc
- receptor complex Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 188 | ExtracellularSequence analysisAdd BLAST | 162 | |
Transmembranei | 189 – 212 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 213 – 219 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 220 – 239 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 240 – 282 | ExtracellularSequence analysisAdd BLAST | 43 | |
Transmembranei | 283 – 306 | Helical; Name=3Sequence analysisAdd BLAST | 24 | |
Topological domaini | 307 – 320 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 321 – 342 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 343 – 361 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 362 – 382 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 383 – 409 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 410 – 428 | Helical; Name=6Sequence analysisAdd BLAST | 19 | |
Topological domaini | 429 – 440 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 441 – 463 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 464 – 593 | CytoplasmicSequence analysisAdd BLAST | 130 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Metaphyseal chondrodysplasia, Jansen type (MCDJ)6 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare autosomal dominant disorder characterized by a short-limbed dwarfism associated with hypercalcemia and normal or low serum concentrations of the two parathyroid hormones.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003582 | 223 | H → R in MCDJ; constitutively activated; constitutively increases adenylate cyclase-activating G-protein coupled receptor signaling pathway; decreases the degree of N-glycosylation; does not affect homodimerization. 4 PublicationsCorresponds to variant dbSNP:rs121434597EnsemblClinVar. | 1 | |
Natural variantiVAR_003583 | 410 | T → P in MCDJ; constitutively activated. 2 PublicationsCorresponds to variant dbSNP:rs121434598EnsemblClinVar. | 1 | |
Natural variantiVAR_038811 | 410 | T → R in MCDJ; leads to agonist-independent cAMP formation which is less pronounced than that observed with the Pro-410 mutant. 1 PublicationCorresponds to variant dbSNP:rs121434602EnsemblClinVar. | 1 | |
Natural variantiVAR_016064 | 458 | I → R in MCDJ. 1 PublicationCorresponds to variant dbSNP:rs121434600EnsemblClinVar. | 1 |
Chondrodysplasia Blomstrand type (BOCD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionSevere skeletal dysplasia.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016062 | 132 | P → L in BOCD. 1 PublicationCorresponds to variant dbSNP:rs121434599EnsemblClinVar. | 1 |
Eiken skeletal dysplasia (EISD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare skeletal dysplasia characterized by severely retarded ossification, principally of the epiphyses, pelvis, hands and feet, as well as by abnormal modeling of the bones in hands and feet, abnormal persistence of cartilage in the pelvis and mild growth retardation.
Related information in OMIMPrimary failure of tooth eruption (PFE)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionRare condition that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption.
Related information in OMIMMutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 135 | I → K: Abolishes hormone binding and homodimerization. 1 Publication | 1 | |
Mutagenesisi | 137 | D → A: Abolishes hormone binding. No effect on homodimerization. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, DwarfismOrganism-specific databases
DisGeNETi | 5745 |
MalaCardsi | PTH1R |
MIMi | 125350, phenotype 156400, phenotype 215045, phenotype 600002, phenotype |
OpenTargetsi | ENSG00000160801 |
Orphaneti | 50945, Blomstrand lethal chondrodysplasia 79106, Eiken syndrome 33067, Metaphyseal chondrodysplasia, Jansen type 296, Ollier disease 412206, Primary failure of tooth eruption |
PharmGKBi | PA33953 |
Miscellaneous databases
Pharosi | Q03431, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1793 |
DrugBanki | DB05084, Abaloparatide DB05829, Parathyroid hormone DB06285, Teriparatide |
DrugCentrali | Q03431 |
GuidetoPHARMACOLOGYi | 331 |
Genetic variation databases
BioMutai | PTH1R |
DMDMi | 417555 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000012845 | 27 – 593 | Parathyroid hormone/parathyroid hormone-related peptide receptorAdd BLAST | 567 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 48 ↔ 117 | Combined sources3 Publications | ||
Disulfide bondi | 108 ↔ 148 | Combined sources3 Publications | ||
Disulfide bondi | 131 ↔ 170 | Combined sources3 Publications | ||
Glycosylationi | 151 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 161 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 166 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 176 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 551 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q03431 |
PaxDbi | Q03431 |
PeptideAtlasi | Q03431 |
PRIDEi | Q03431 |
ProteomicsDBi | 58212 |
TopDownProteomicsi | Q03431 |
2D gel databases
REPRODUCTION-2DPAGEi | Q03431 |
PTM databases
GlyGeni | Q03431, 4 sites |
iPTMneti | Q03431 |
PhosphoSitePlusi | Q03431 |
Expressioni
Tissue specificityi
Expressed in most tissues. Most abundant in kidney, bone and liver.1 Publication
Gene expression databases
Bgeei | ENSG00000160801, Expressed in adult mammalian kidney and 185 other tissues |
ExpressionAtlasi | Q03431, baseline and differential |
Genevisiblei | Q03431, HS |
Organism-specific databases
HPAi | ENSG00000160801, Tissue enriched (kidney) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsQ03431
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
- protein self-association Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111717, 60 interactors |
CORUMi | Q03431 |
IntActi | Q03431, 37 interactors |
MINTi | Q03431 |
STRINGi | 9606.ENSP00000321999 |
Chemistry databases
BindingDBi | Q03431 |
Miscellaneous databases
RNActi | Q03431, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q03431 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q03431 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 474 – 477 | Important for interaction with G proteins | 4 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000158574 |
InParanoidi | Q03431 |
OMAi | SGTLWQI |
OrthoDBi | 651627at2759 |
PhylomeDBi | Q03431 |
TreeFami | TF315710 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR002170, GPCR_2_parathyroid_rcpt IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS |
PANTHERi | PTHR45620:SF27, PTHR45620:SF27, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00393, PTRHORMONER |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q03431-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTARIAPGL ALLLCCPVLS SAYALVDADD VMTKEEQIFL LHRAQAQCEK
60 70 80 90 100
RLKEVLQRPA SIMESDKGWT SASTSGKPRK DKASGKLYPE SEEDKEAPTG
110 120 130 140 150
SRYRGRPCLP EWDHILCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR
160 170 180 190 200
NGSWELVPGH NRTWANYSEC VKFLTNETRE REVFDRLGMI YTVGYSVSLA
210 220 230 240 250
SLTVAVLILA YFRRLHCTRN YIHMHLFLSF MLRAVSIFVK DAVLYSGATL
260 270 280 290 300
DEAERLTEEE LRAIAQAPPP PATAAAGYAG CRVAVTFFLY FLATNYYWIL
310 320 330 340 350
VEGLYLHSLI FMAFFSEKKY LWGFTVFGWG LPAVFVAVWV SVRATLANTG
360 370 380 390 400
CWDLSSGNKK WIIQVPILAS IVLNFILFIN IVRVLATKLR ETNAGRCDTR
410 420 430 440 450
QQYRKLLKST LVLMPLFGVH YIVFMATPYT EVSGTLWQVQ MHYEMLFNSF
460 470 480 490 500
QGFFVAIIYC FCNGEVQAEI KKSWSRWTLA LDFKRKARSG SSSYSYGPMV
510 520 530 540 550
SHTSVTNVGP RVGLGLPLSP RLLPTATTNG HPQLPGHAKP GTPALETLET
560 570 580 590
TPPAMAAPKD DGFLNGSCSG LDEEASGPER PPALLQEEWE TVM
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EWE7 | E7EWE7_HUMAN | PTH/PTHrP type I receptor | PTH1R | 527 | Annotation score: | ||
F2Z314 | F2Z314_HUMAN | PTH/PTHrP type I receptor | PTH1R | 333 | Annotation score: | ||
H7C0Q3 | H7C0Q3_HUMAN | Parathyroid hormone/parathyroid hor... | PTH1R | 182 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 471 | K → N (PubMed:8397094).Curated | 1 | |
Sequence conflicti | 473 | S → C (PubMed:8397094).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016062 | 132 | P → L in BOCD. 1 PublicationCorresponds to variant dbSNP:rs121434599EnsemblClinVar. | 1 | |
Natural variantiVAR_016063 | 150 | R → C1 PublicationCorresponds to variant dbSNP:rs121434601EnsemblClinVar. | 1 | |
Natural variantiVAR_003582 | 223 | H → R in MCDJ; constitutively activated; constitutively increases adenylate cyclase-activating G-protein coupled receptor signaling pathway; decreases the degree of N-glycosylation; does not affect homodimerization. 4 PublicationsCorresponds to variant dbSNP:rs121434597EnsemblClinVar. | 1 | |
Natural variantiVAR_003583 | 410 | T → P in MCDJ; constitutively activated. 2 PublicationsCorresponds to variant dbSNP:rs121434598EnsemblClinVar. | 1 | |
Natural variantiVAR_038811 | 410 | T → R in MCDJ; leads to agonist-independent cAMP formation which is less pronounced than that observed with the Pro-410 mutant. 1 PublicationCorresponds to variant dbSNP:rs121434602EnsemblClinVar. | 1 | |
Natural variantiVAR_016064 | 458 | I → R in MCDJ. 1 PublicationCorresponds to variant dbSNP:rs121434600EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L04308 mRNA Translation: AAA36525.1 X68596 mRNA Translation: CAA48589.1 U22409 , U22401, U22402, U22403, U22404, U22405, U22406, U22407, U22408 Genomic DNA Translation: AAB60657.1 U17418 mRNA Translation: AAA56774.1 AY449732 mRNA Translation: AAR18076.1 BC112221 mRNA Translation: AAI12222.1 BC112247 mRNA Translation: AAI12248.1 |
CCDSi | CCDS2747.1 |
PIRi | I38139, A49191 |
RefSeqi | NP_000307.1, NM_000316.2 NP_001171673.1, NM_001184744.1 XP_016862422.1, XM_017006933.1 |
Genome annotation databases
Ensembli | ENST00000313049; ENSP00000321999; ENSG00000160801 ENST00000418619; ENSP00000411424; ENSG00000160801 ENST00000430002; ENSP00000413774; ENSG00000160801 ENST00000449590; ENSP00000402723; ENSG00000160801 |
GeneIDi | 5745 |
KEGGi | hsa:5745 |
UCSCi | uc003cqm.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L04308 mRNA Translation: AAA36525.1 X68596 mRNA Translation: CAA48589.1 U22409 , U22401, U22402, U22403, U22404, U22405, U22406, U22407, U22408 Genomic DNA Translation: AAB60657.1 U17418 mRNA Translation: AAA56774.1 AY449732 mRNA Translation: AAR18076.1 BC112221 mRNA Translation: AAI12222.1 BC112247 mRNA Translation: AAI12248.1 |
CCDSi | CCDS2747.1 |
PIRi | I38139, A49191 |
RefSeqi | NP_000307.1, NM_000316.2 NP_001171673.1, NM_001184744.1 XP_016862422.1, XM_017006933.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BL1 | NMR | - | A | 168-197 | [»] | |
1ET2 | model | - | S | 168-469 | [»] | |
1ET3 | model | - | S | 168-469 | [»] | |
3C4M | X-ray | 1.95 | A/B | 29-187 | [»] | |
3H3G | X-ray | 1.94 | A | 29-187 | [»] | |
3L2J | X-ray | 3.24 | A/B | 29-187 | [»] | |
4Z8J | X-ray | 0.95 | B | 586-593 | [»] | |
5EMB | X-ray | 0.85 | B | 586-593 | [»] | |
6NBF | electron microscopy | 3.00 | R | 27-502 | [»] | |
6NBH | electron microscopy | 3.50 | R | 27-502 | [»] | |
6NBI | electron microscopy | 4.00 | R | 27-502 | [»] | |
SMRi | Q03431 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111717, 60 interactors |
CORUMi | Q03431 |
IntActi | Q03431, 37 interactors |
MINTi | Q03431 |
STRINGi | 9606.ENSP00000321999 |
Chemistry databases
BindingDBi | Q03431 |
ChEMBLi | CHEMBL1793 |
DrugBanki | DB05084, Abaloparatide DB05829, Parathyroid hormone DB06285, Teriparatide |
DrugCentrali | Q03431 |
GuidetoPHARMACOLOGYi | 331 |
Protein family/group databases
TCDBi | 9.A.14.4.11, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | Q03431, 4 sites |
iPTMneti | Q03431 |
PhosphoSitePlusi | Q03431 |
Genetic variation databases
BioMutai | PTH1R |
DMDMi | 417555 |
2D gel databases
REPRODUCTION-2DPAGEi | Q03431 |
Proteomic databases
MassIVEi | Q03431 |
PaxDbi | Q03431 |
PeptideAtlasi | Q03431 |
PRIDEi | Q03431 |
ProteomicsDBi | 58212 |
TopDownProteomicsi | Q03431 |
Protocols and materials databases
ABCDi | Q03431, 23 sequenced antibodies |
Antibodypediai | 1960, 402 antibodies |
DNASUi | 5745 |
Genome annotation databases
Ensembli | ENST00000313049; ENSP00000321999; ENSG00000160801 ENST00000418619; ENSP00000411424; ENSG00000160801 ENST00000430002; ENSP00000413774; ENSG00000160801 ENST00000449590; ENSP00000402723; ENSG00000160801 |
GeneIDi | 5745 |
KEGGi | hsa:5745 |
UCSCi | uc003cqm.4, human |
Organism-specific databases
CTDi | 5745 |
DisGeNETi | 5745 |
GeneCardsi | PTH1R |
HGNCi | HGNC:9608, PTH1R |
HPAi | ENSG00000160801, Tissue enriched (kidney) |
MalaCardsi | PTH1R |
MIMi | 125350, phenotype 156400, phenotype 168468, gene 215045, phenotype 600002, phenotype |
neXtProti | NX_Q03431 |
OpenTargetsi | ENSG00000160801 |
Orphaneti | 50945, Blomstrand lethal chondrodysplasia 79106, Eiken syndrome 33067, Metaphyseal chondrodysplasia, Jansen type 296, Ollier disease 412206, Primary failure of tooth eruption |
PharmGKBi | PA33953 |
VEuPathDBi | HostDB:ENSG00000160801.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000158574 |
InParanoidi | Q03431 |
OMAi | SGTLWQI |
OrthoDBi | 651627at2759 |
PhylomeDBi | Q03431 |
TreeFami | TF315710 |
Enzyme and pathway databases
PathwayCommonsi | Q03431 |
Reactomei | R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | Q03431 |
SIGNORi | Q03431 |
Miscellaneous databases
BioGRID-ORCSi | 5745, 8 hits in 883 CRISPR screens |
ChiTaRSi | PTH1R, human |
EvolutionaryTracei | Q03431 |
GeneWikii | Parathyroid_hormone_1_receptor |
GenomeRNAii | 5745 |
Pharosi | Q03431, Tclin |
PROi | PR:Q03431 |
RNActi | Q03431, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160801, Expressed in adult mammalian kidney and 185 other tissues |
ExpressionAtlasi | Q03431, baseline and differential |
Genevisiblei | Q03431, HS |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR002170, GPCR_2_parathyroid_rcpt IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS |
PANTHERi | PTHR45620:SF27, PTHR45620:SF27, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00393, PTRHORMONER |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTH1R_HUMAN | |
Accessioni | Q03431Primary (citable) accession number: Q03431 Secondary accession number(s): Q2M1U3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | February 10, 2021 | |
This is version 213 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families