UniProtKB - Q03431 (PTH1R_HUMAN)
Protein
Parathyroid hormone/parathyroid hormone-related peptide receptor
Gene
PTH1R
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.3 Publications
GO - Molecular functioni
- G protein-coupled peptide receptor activity Source: GO_Central
- parathyroid hormone receptor activity Source: UniProtKB
- peptide hormone binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein self-association Source: UniProtKB
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: UniProtKB
- aging Source: Ensembl
- bone mineralization Source: Ensembl
- bone resorption Source: Ensembl
- cell maturation Source: Ensembl
- cell surface receptor signaling pathway Source: InterPro
- cellular calcium ion homeostasis Source: GO_Central
- chondrocyte differentiation Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
- negative regulation of cell population proliferation Source: Ensembl
- osteoblast development Source: Ensembl
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of inositol phosphate biosynthetic process Source: BHF-UCL
- skeletal system development Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-418555 G alpha (s) signalling events |
SignaLinki | Q03431 |
SIGNORi | Q03431 |
Protein family/group databases
TCDBi | 9.A.14.4.11 the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Parathyroid hormone/parathyroid hormone-related peptide receptorAlternative name(s): PTH/PTHrP type I receptor Short name: PTH/PTHr receptor Parathyroid hormone 1 receptor Short name: PTH1 receptor |
Gene namesi | Name:PTH1R Synonyms:PTHR, PTHR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000160801.13 |
HGNCi | HGNC:9608 PTH1R |
MIMi | 168468 gene |
neXtProti | NX_Q03431 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein 1 Publication
Nucleus
- nucleus Source: ProtInc
Plasma Membrane
- apical plasma membrane Source: BHF-UCL
- basolateral plasma membrane Source: BHF-UCL
- brush border membrane Source: Ensembl
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- cytoplasm Source: ProtInc
- receptor complex Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 188 | ExtracellularSequence analysisAdd BLAST | 162 | |
Transmembranei | 189 – 212 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 213 – 219 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 220 – 239 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 240 – 282 | ExtracellularSequence analysisAdd BLAST | 43 | |
Transmembranei | 283 – 306 | Helical; Name=3Sequence analysisAdd BLAST | 24 | |
Topological domaini | 307 – 320 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 321 – 342 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 343 – 361 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 362 – 382 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 383 – 409 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 410 – 428 | Helical; Name=6Sequence analysisAdd BLAST | 19 | |
Topological domaini | 429 – 440 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 441 – 463 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 464 – 593 | CytoplasmicSequence analysisAdd BLAST | 130 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Jansen metaphyseal chondrodysplasia (JMC)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare autosomal dominant disorder characterized by a short-limbed dwarfism associated with hypercalcemia and normal or low serum concentrations of the two parathyroid hormones.
See also OMIM:156400Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003582 | 223 | H → R in JMC; constitutively activated; constitutively increases adenylate cyclase-activating G-protein coupled receptor signaling pathway; decreases the degree of N-glycosylation; does not affect homodimerization. 4 PublicationsCorresponds to variant dbSNP:rs121434597EnsemblClinVar. | 1 | |
Natural variantiVAR_003583 | 410 | T → P in JMC; constitutively activated. 2 PublicationsCorresponds to variant dbSNP:rs121434598EnsemblClinVar. | 1 | |
Natural variantiVAR_038811 | 410 | T → R in JMC; leads to agonist-independent cAMP formation which is less pronounced than that observed with the Pro-410 mutant. 1 PublicationCorresponds to variant dbSNP:rs121434602EnsemblClinVar. | 1 | |
Natural variantiVAR_016064 | 458 | I → R in JMC. 1 PublicationCorresponds to variant dbSNP:rs121434600EnsemblClinVar. | 1 |
Chondrodysplasia Blomstrand type (BOCD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSevere skeletal dysplasia.
See also OMIM:215045Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016062 | 132 | P → L in BOCD. 1 PublicationCorresponds to variant dbSNP:rs121434599EnsemblClinVar. | 1 |
Enchondromatosis multiple (ENCHOM)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by multiple formation of enchondromas, benign neoplasms derived from mesodermal cells that form cartilage. Enchondromas remain within the substance of a cartilage or bone. Clinical problems caused by enchondromas include skeletal deformity and the potential for malignant change to osteosarcoma.
See also OMIM:166000Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016063 | 150 | R → C in ENCHOM; Ollier type; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121434601EnsemblClinVar. | 1 |
Eiken skeletal dysplasia (EISD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare skeletal dysplasia characterized by severely retarded ossification, principally of the epiphyses, pelvis, hands and feet, as well as by abnormal modeling of the bones in hands and feet, abnormal persistence of cartilage in the pelvis and mild growth retardation.
See also OMIM:600002Primary failure of tooth eruption (PFE)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare condition that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption.
See also OMIM:125350Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 135 | I → K: Abolishes hormone binding and homodimerization. 1 Publication | 1 | |
Mutagenesisi | 137 | D → A: Abolishes hormone binding. No effect on homodimerization. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, DwarfismOrganism-specific databases
DisGeNETi | 5745 |
MalaCardsi | PTH1R |
MIMi | 125350 phenotype 156400 phenotype 166000 phenotype 215045 phenotype 600002 phenotype |
OpenTargetsi | ENSG00000160801 |
Orphaneti | 50945 Blomstrand lethal chondrodysplasia 79106 Eiken syndrome 296 Enchondromatosis 33067 Metaphyseal chondrodysplasia, Jansen type 412206 Primary failure of tooth eruption |
PharmGKBi | PA33953 |
Chemistry databases
ChEMBLi | CHEMBL1793 |
DrugBanki | DB05829 Parathyroid hormone DB06285 Teriparatide |
GuidetoPHARMACOLOGYi | 331 |
Polymorphism and mutation databases
BioMutai | PTH1R |
DMDMi | 417555 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000012845 | 27 – 593 | Parathyroid hormone/parathyroid hormone-related peptide receptorAdd BLAST | 567 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 48 ↔ 117 | Combined sources3 Publications | ||
Disulfide bondi | 108 ↔ 148 | Combined sources3 Publications | ||
Disulfide bondi | 131 ↔ 170 | Combined sources3 Publications | ||
Glycosylationi | 151 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 161 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 166 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 176 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 551 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q03431 |
PaxDbi | Q03431 |
PeptideAtlasi | Q03431 |
PRIDEi | Q03431 |
ProteomicsDBi | 58212 |
TopDownProteomicsi | Q03431 |
2D gel databases
REPRODUCTION-2DPAGEi | Q03431 |
PTM databases
iPTMneti | Q03431 |
PhosphoSitePlusi | Q03431 |
Miscellaneous databases
PMAP-CutDBi | Q03431 |
Expressioni
Tissue specificityi
Expressed in most tissues. Most abundant in kidney, bone and liver.1 Publication
Gene expression databases
Bgeei | ENSG00000160801 Expressed in 174 organ(s), highest expression level in adult mammalian kidney |
ExpressionAtlasi | Q03431 baseline and differential |
Genevisiblei | Q03431 HS |
Organism-specific databases
HPAi | HPA007978 |
Interactioni
Subunit structurei
Interacts (via N-terminal extracellular domain) with PTHLH and PTH (PubMed:8397094, PubMed:10913300, PubMed:18375760, PubMed:19674967). Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer (PubMed:19674967, PubMed:20172855).6 Publications
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
CTNNB1 | P35222 | 4 | EBI-2860297,EBI-491549 |
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
- protein self-association Source: UniProtKB
Protein-protein interaction databases
BioGridi | 111717, 52 interactors |
CORUMi | Q03431 |
IntActi | Q03431, 9 interactors |
MINTi | Q03431 |
STRINGi | 9606.ENSP00000321999 |
Chemistry databases
BindingDBi | Q03431 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BL1 | NMR | - | A | 168-197 | [»] | |
1ET2 | model | - | S | 168-469 | [»] | |
1ET3 | model | - | S | 168-469 | [»] | |
3C4M | X-ray | 1.95 | A/B | 29-187 | [»] | |
3H3G | X-ray | 1.94 | A | 29-187 | [»] | |
3L2J | X-ray | 3.24 | A/B | 29-187 | [»] | |
4Z8J | X-ray | 0.95 | B | 586-593 | [»] | |
5EMB | X-ray | 0.85 | B | 586-593 | [»] | |
ProteinModelPortali | Q03431 | |||||
SMRi | Q03431 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q03431 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 474 – 477 | Important for interaction with G proteins | 4 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4564 Eukaryota ENOG410XRS2 LUCA |
GeneTreei | ENSGT00940000158574 |
HOGENOMi | HOG000008248 |
HOVERGENi | HBG008318 |
InParanoidi | Q03431 |
KOi | K04585 |
OMAi | KKWIIQV |
OrthoDBi | 828211at2759 |
PhylomeDBi | Q03431 |
TreeFami | TF315710 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR002170 GPCR_2_parathyroid_rcpt IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS |
PANTHERi | PTHR12011:SF24 PTHR12011:SF24, 1 hit |
Pfami | View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit |
PRINTSi | PR00249 GPCRSECRETIN PR00393 PTRHORMONER |
SMARTi | View protein in SMART SM00008 HormR, 1 hit |
SUPFAMi | SSF111418 SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q03431-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTARIAPGL ALLLCCPVLS SAYALVDADD VMTKEEQIFL LHRAQAQCEK
60 70 80 90 100
RLKEVLQRPA SIMESDKGWT SASTSGKPRK DKASGKLYPE SEEDKEAPTG
110 120 130 140 150
SRYRGRPCLP EWDHILCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR
160 170 180 190 200
NGSWELVPGH NRTWANYSEC VKFLTNETRE REVFDRLGMI YTVGYSVSLA
210 220 230 240 250
SLTVAVLILA YFRRLHCTRN YIHMHLFLSF MLRAVSIFVK DAVLYSGATL
260 270 280 290 300
DEAERLTEEE LRAIAQAPPP PATAAAGYAG CRVAVTFFLY FLATNYYWIL
310 320 330 340 350
VEGLYLHSLI FMAFFSEKKY LWGFTVFGWG LPAVFVAVWV SVRATLANTG
360 370 380 390 400
CWDLSSGNKK WIIQVPILAS IVLNFILFIN IVRVLATKLR ETNAGRCDTR
410 420 430 440 450
QQYRKLLKST LVLMPLFGVH YIVFMATPYT EVSGTLWQVQ MHYEMLFNSF
460 470 480 490 500
QGFFVAIIYC FCNGEVQAEI KKSWSRWTLA LDFKRKARSG SSSYSYGPMV
510 520 530 540 550
SHTSVTNVGP RVGLGLPLSP RLLPTATTNG HPQLPGHAKP GTPALETLET
560 570 580 590
TPPAMAAPKD DGFLNGSCSG LDEEASGPER PPALLQEEWE TVM
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF2Z314 | F2Z314_HUMAN | Parathyroid hormone/parathyroid hor... | PTH1R | 333 | Annotation score: | ||
E7EWE7 | E7EWE7_HUMAN | Parathyroid hormone/parathyroid hor... | PTH1R | 527 | Annotation score: | ||
H7C0Q3 | H7C0Q3_HUMAN | Parathyroid hormone/parathyroid hor... | PTH1R | 182 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 471 | K → N (PubMed:8397094).Curated | 1 | |
Sequence conflicti | 473 | S → C (PubMed:8397094).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016062 | 132 | P → L in BOCD. 1 PublicationCorresponds to variant dbSNP:rs121434599EnsemblClinVar. | 1 | |
Natural variantiVAR_016063 | 150 | R → C in ENCHOM; Ollier type; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121434601EnsemblClinVar. | 1 | |
Natural variantiVAR_003582 | 223 | H → R in JMC; constitutively activated; constitutively increases adenylate cyclase-activating G-protein coupled receptor signaling pathway; decreases the degree of N-glycosylation; does not affect homodimerization. 4 PublicationsCorresponds to variant dbSNP:rs121434597EnsemblClinVar. | 1 | |
Natural variantiVAR_003583 | 410 | T → P in JMC; constitutively activated. 2 PublicationsCorresponds to variant dbSNP:rs121434598EnsemblClinVar. | 1 | |
Natural variantiVAR_038811 | 410 | T → R in JMC; leads to agonist-independent cAMP formation which is less pronounced than that observed with the Pro-410 mutant. 1 PublicationCorresponds to variant dbSNP:rs121434602EnsemblClinVar. | 1 | |
Natural variantiVAR_016064 | 458 | I → R in JMC. 1 PublicationCorresponds to variant dbSNP:rs121434600EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L04308 mRNA Translation: AAA36525.1 X68596 mRNA Translation: CAA48589.1 U22409 U22408 Genomic DNA Translation: AAB60657.1 U17418 mRNA Translation: AAA56774.1 AY449732 mRNA Translation: AAR18076.1 BC112221 mRNA Translation: AAI12222.1 BC112247 mRNA Translation: AAI12248.1 |
CCDSi | CCDS2747.1 |
PIRi | I38139 A49191 |
RefSeqi | NP_000307.1, NM_000316.2 NP_001171673.1, NM_001184744.1 XP_016862422.1, XM_017006933.1 |
UniGenei | Hs.1019 |
Genome annotation databases
Ensembli | ENST00000313049; ENSP00000321999; ENSG00000160801 ENST00000418619; ENSP00000411424; ENSG00000160801 ENST00000430002; ENSP00000413774; ENSG00000160801 ENST00000449590; ENSP00000402723; ENSG00000160801 |
GeneIDi | 5745 |
KEGGi | hsa:5745 |
UCSCi | uc003cqm.4 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L04308 mRNA Translation: AAA36525.1 X68596 mRNA Translation: CAA48589.1 U22409 U22408 Genomic DNA Translation: AAB60657.1 U17418 mRNA Translation: AAA56774.1 AY449732 mRNA Translation: AAR18076.1 BC112221 mRNA Translation: AAI12222.1 BC112247 mRNA Translation: AAI12248.1 |
CCDSi | CCDS2747.1 |
PIRi | I38139 A49191 |
RefSeqi | NP_000307.1, NM_000316.2 NP_001171673.1, NM_001184744.1 XP_016862422.1, XM_017006933.1 |
UniGenei | Hs.1019 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BL1 | NMR | - | A | 168-197 | [»] | |
1ET2 | model | - | S | 168-469 | [»] | |
1ET3 | model | - | S | 168-469 | [»] | |
3C4M | X-ray | 1.95 | A/B | 29-187 | [»] | |
3H3G | X-ray | 1.94 | A | 29-187 | [»] | |
3L2J | X-ray | 3.24 | A/B | 29-187 | [»] | |
4Z8J | X-ray | 0.95 | B | 586-593 | [»] | |
5EMB | X-ray | 0.85 | B | 586-593 | [»] | |
ProteinModelPortali | Q03431 | |||||
SMRi | Q03431 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 111717, 52 interactors |
CORUMi | Q03431 |
IntActi | Q03431, 9 interactors |
MINTi | Q03431 |
STRINGi | 9606.ENSP00000321999 |
Chemistry databases
BindingDBi | Q03431 |
ChEMBLi | CHEMBL1793 |
DrugBanki | DB05829 Parathyroid hormone DB06285 Teriparatide |
GuidetoPHARMACOLOGYi | 331 |
Protein family/group databases
TCDBi | 9.A.14.4.11 the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
iPTMneti | Q03431 |
PhosphoSitePlusi | Q03431 |
Polymorphism and mutation databases
BioMutai | PTH1R |
DMDMi | 417555 |
2D gel databases
REPRODUCTION-2DPAGEi | Q03431 |
Proteomic databases
jPOSTi | Q03431 |
PaxDbi | Q03431 |
PeptideAtlasi | Q03431 |
PRIDEi | Q03431 |
ProteomicsDBi | 58212 |
TopDownProteomicsi | Q03431 |
Protocols and materials databases
DNASUi | 5745 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000313049; ENSP00000321999; ENSG00000160801 ENST00000418619; ENSP00000411424; ENSG00000160801 ENST00000430002; ENSP00000413774; ENSG00000160801 ENST00000449590; ENSP00000402723; ENSG00000160801 |
GeneIDi | 5745 |
KEGGi | hsa:5745 |
UCSCi | uc003cqm.4 human |
Organism-specific databases
CTDi | 5745 |
DisGeNETi | 5745 |
EuPathDBi | HostDB:ENSG00000160801.13 |
GeneCardsi | PTH1R |
HGNCi | HGNC:9608 PTH1R |
HPAi | HPA007978 |
MalaCardsi | PTH1R |
MIMi | 125350 phenotype 156400 phenotype 166000 phenotype 168468 gene 215045 phenotype 600002 phenotype |
neXtProti | NX_Q03431 |
OpenTargetsi | ENSG00000160801 |
Orphaneti | 50945 Blomstrand lethal chondrodysplasia 79106 Eiken syndrome 296 Enchondromatosis 33067 Metaphyseal chondrodysplasia, Jansen type 412206 Primary failure of tooth eruption |
PharmGKBi | PA33953 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4564 Eukaryota ENOG410XRS2 LUCA |
GeneTreei | ENSGT00940000158574 |
HOGENOMi | HOG000008248 |
HOVERGENi | HBG008318 |
InParanoidi | Q03431 |
KOi | K04585 |
OMAi | KKWIIQV |
OrthoDBi | 828211at2759 |
PhylomeDBi | Q03431 |
TreeFami | TF315710 |
Enzyme and pathway databases
Reactomei | R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-418555 G alpha (s) signalling events |
SignaLinki | Q03431 |
SIGNORi | Q03431 |
Miscellaneous databases
EvolutionaryTracei | Q03431 |
GeneWikii | Parathyroid_hormone_1_receptor |
GenomeRNAii | 5745 |
PMAP-CutDBi | Q03431 |
PROi | PR:Q03431 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160801 Expressed in 174 organ(s), highest expression level in adult mammalian kidney |
ExpressionAtlasi | Q03431 baseline and differential |
Genevisiblei | Q03431 HS |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR002170 GPCR_2_parathyroid_rcpt IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS |
PANTHERi | PTHR12011:SF24 PTHR12011:SF24, 1 hit |
Pfami | View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit |
PRINTSi | PR00249 GPCRSECRETIN PR00393 PTRHORMONER |
SMARTi | View protein in SMART SM00008 HormR, 1 hit |
SUPFAMi | SSF111418 SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | PTH1R_HUMAN | |
Accessioni | Q03431Primary (citable) accession number: Q03431 Secondary accession number(s): Q2M1U3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | February 13, 2019 | |
This is version 197 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries