UniProtKB - Q03419 (IZH1_YEAST)
Protein
ADIPOR-like receptor IZH1
Gene
IZH1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels.1 Publication
GO - Molecular functioni
- signaling receptor activity Source: GO_Central
GO - Biological processi
- cellular zinc ion homeostasis Source: SGD
Names & Taxonomyi
Protein namesi | Recommended name: ADIPOR-like receptor IZH1Alternative name(s): Implicated in zinc homeostasis protein 1 |
Gene namesi | Name:IZH1 Ordered Locus Names:YDR492W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002900, IZH1 |
VEuPathDBi | FungiDB:YDR492W |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 89 | LumenalBy similarityAdd BLAST | 89 | |
Transmembranei | 90 – 110 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 111 – 117 | CytoplasmicBy similarity | 7 | |
Transmembranei | 118 – 138 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 139 – 156 | LumenalBy similarityAdd BLAST | 18 | |
Transmembranei | 157 – 177 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 178 – 181 | CytoplasmicBy similarity | 4 | |
Transmembranei | 182 – 202 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 203 – 218 | LumenalBy similarityAdd BLAST | 16 | |
Transmembranei | 219 – 239 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 240 – 245 | CytoplasmicBy similarity | 6 | |
Transmembranei | 246 – 266 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 267 – 279 | LumenalBy similarityAdd BLAST | 13 | |
Transmembranei | 280 – 300 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 301 – 316 | CytoplasmicBy similarityAdd BLAST | 16 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000240373 | 1 – 316 | ADIPOR-like receptor IZH1Add BLAST | 316 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 79 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 207 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q03419 |
PRIDEi | Q03419 |
Expressioni
Inductioni
Expression is regulated by the zinc metabolism transcription factor ZAP1 via its promoter ZRE element (zinc-responsive element).2 Publications
Interactioni
Protein-protein interaction databases
BioGRIDi | 32543, 73 interactors |
DIPi | DIP-8787N |
STRINGi | 4932.YDR492W |
Miscellaneous databases
RNActi | Q03419, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ADIPOR family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0748, Eukaryota |
GeneTreei | ENSGT00940000170813 |
HOGENOMi | CLU_023075_2_0_1 |
InParanoidi | Q03419 |
OMAi | FCCVAGI |
Family and domain databases
InterProi | View protein in InterPro IPR004254, AdipoR/HlyIII-related |
PANTHERi | PTHR20855, PTHR20855, 1 hit |
Pfami | View protein in Pfam PF03006, HlyIII, 1 hit |
i Sequence
Sequence statusi: Complete.
Q03419-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSITTTRRRN QDSVCCKATR ASIKVEAVSG QTVFEKQKLL HNFDELPEWQ
60 70 80 90 100
KDNDKILTGY VRETLSWKKC LYSLFYWNNE TVNIYTHLVP AIVYFVFAIT
110 120 130 140 150
LTNYFLIPVF PSTSWSDYTV INIFLMGAFS CLMCSSCFHC MKQHSEKQSN
160 170 180 190 200
FWSKLDYLGI ISLISCSMIP IIYFGYFDHI SYFSLFTIVT LVLATFCTVC
210 220 230 240 250
VLHDKFNTST FRPFRAMFFI LFGFSGLLPL TTGFFKFGIQ GVLNRIKVSF
260 270 280 290 300
VFWEALFYIS GAVIYGFRIP ETLAPGKFDF FGSSHQIFHI MVVLGSVCHL
310
KAIIDSYKLM HSHIHP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 139 | H → R in AAS56819 (PubMed:17322287).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33050 Genomic DNA Translation: AAB64908.1 AY558493 Genomic DNA Translation: AAS56819.1 BK006938 Genomic DNA Translation: DAA12324.1 |
PIRi | S69659 |
RefSeqi | NP_010780.1, NM_001180800.1 |
Genome annotation databases
EnsemblFungii | YDR492W_mRNA; YDR492W; YDR492W |
GeneIDi | 852102 |
KEGGi | sce:YDR492W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33050 Genomic DNA Translation: AAB64908.1 AY558493 Genomic DNA Translation: AAS56819.1 BK006938 Genomic DNA Translation: DAA12324.1 |
PIRi | S69659 |
RefSeqi | NP_010780.1, NM_001180800.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 32543, 73 interactors |
DIPi | DIP-8787N |
STRINGi | 4932.YDR492W |
Proteomic databases
PaxDbi | Q03419 |
PRIDEi | Q03419 |
Genome annotation databases
EnsemblFungii | YDR492W_mRNA; YDR492W; YDR492W |
GeneIDi | 852102 |
KEGGi | sce:YDR492W |
Organism-specific databases
SGDi | S000002900, IZH1 |
VEuPathDBi | FungiDB:YDR492W |
Phylogenomic databases
eggNOGi | KOG0748, Eukaryota |
GeneTreei | ENSGT00940000170813 |
HOGENOMi | CLU_023075_2_0_1 |
InParanoidi | Q03419 |
OMAi | FCCVAGI |
Miscellaneous databases
PROi | PR:Q03419 |
RNActi | Q03419, protein |
Family and domain databases
InterProi | View protein in InterPro IPR004254, AdipoR/HlyIII-related |
PANTHERi | PTHR20855, PTHR20855, 1 hit |
Pfami | View protein in Pfam PF03006, HlyIII, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IZH1_YEAST | |
Accessioni | Q03419Primary (citable) accession number: Q03419 Secondary accession number(s): D6VTB4, Q6Q557 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names - SIMILARITY comments
Index of protein domains and families