Innexin unc-7

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• gap junction channel activity Source: WormBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory nervous system."
    Starich T.A., Xu J., Skerrett I.M., Nicholson B.J., Shaw J.E.
    Neural Dev 4:16-16(2009) [PubMed] [Europe PMC] [Abstract]
• gap junction hemi-channel activity Source: UniProtKB

GO - Biological processⁱ

• gap junction assembly Source: WormBase <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "eat-5 and unc-7 represent a multigene family in Caenorhabditis elegans involved in cell-cell coupling."
    Starich T.A., Lee R.Y., Panzarella C., Avery L., Shaw J.E.
    J. Cell Biol. 134:537-548(1996) [PubMed] [Europe PMC] [Abstract]
• ion transmembrane transport Source: WormBaseInferred from direct assayⁱ
  • "Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory nervous system."
    Starich T.A., Xu J., Skerrett I.M., Nicholson B.J., Shaw J.E.
    Neural Dev 4:16-16(2009) [PubMed] [Europe PMC] [Abstract]
• locomotion Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.1

    "Molecular and genetic analysis of unc-7, a Caenorhabditis elegans gene required for coordinated locomotion."
    Starich T.A., Herman R.K., Shaw J.E.
    Genetics 133:527-541(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
• oviposition Source: WormBaseInferred from mutant phenotypeⁱ
  • "The C. elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells."
    Barnes T.M., Hekimi S.
    J. Neurochem. 69:2251-2260(1997) [PubMed] [Europe PMC] [Abstract]
• regulation of pharyngeal pumping Source: WormBaseInferred from mutant phenotypeⁱ
  • "Mechanosensory inputs influence Caenorhabditis elegans pharyngeal activity via ivermectin sensitivity genes."
    Keane J., Avery L.
    Genetics 164:153-162(2003) [PubMed] [Europe PMC] [Abstract]
• response to anesthetic Source: WormBase <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • Ref.1

    "Molecular and genetic analysis of unc-7, a Caenorhabditis elegans gene required for coordinated locomotion."
    Starich T.A., Herman R.K., Shaw J.E.
    Genetics 133:527-541(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MLGSSSNPEP PLLSRIIGVP PPPPPRAPTT ALVLRVPTVD SPSKKKQQPD 
        60         70         80         90        100
TRNKYQETAL RDKKTRTPLE KARHLDNLPS YQAQKLLDGS HQLRIDSHHV 
       110        120        130        140        150
GSAGHGAGQG HGHKKEFGPA MILYYLASAF RALYPRLDDD FVDKLNYYYT 
       160        170        180        190        200
TTILASFALL VSAKQYVGFP IQCWVPATFT DAMEQYTENY CWVQNTYWVP 
       210        220        230        240        250
MQEDIPREIY SRRNRQIGYY QWVPFILAIE ALLFYVPCIL WRGLLYWHSG 
       260        270        280        290        300
INLQGLVQMA CDARLMDSEI KTRTVYTMAR HMQDEVQLTN IDRQGHSRSC 
       310        320        330        340        350
FSNLQLGANC GRHCGCYVTM LYIGIKVLYS ANVLLQFFLL NHLLGSNDLA 
       360        370        380        390        400
YGFSLLKDLM HAIEWEQTGM FPRVTLCDFE VRVLGNIHRH TVQCVLMINM 
       410        420        430        440        450
FNEKIFLFLW FWFLTCGIVT VCNTMYWILI MFIPSQGMSF VRKYLRVLPD 
       460        470        480        490        500
HPAKPIADDV TLRKFTNNFL RKDGVFMLRM ISTHAGELMS SELILALWQD 
       510        520 
FNNVDRSPTQ FWDAEHGQGT ID                               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Caenorhabditis elegans
   Caenorhabditis elegans: entries, gene names and cross-references to WormBase