UniProtKB - Q03412 (UNC7_CAEEL)
Protein
Innexin unc-7
Gene
unc-7
Organism
Caenorhabditis elegans
Status
Functioni
Structural component of the gap junctions (By similarity). Required for coordinated locomotion (PubMed:7681023). Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt (PubMed:17891142). Plays a role in regulating male mating behavior by positively regulating inhibitory neuronal signaling transduction between chemosensory and mechanosensory neurons, and thus ensuring spicule insertion attempts are confined to the hermaphrodite vulva during copulation (PubMed:26156999).By similarity3 Publications
GO - Molecular functioni
- gap junction channel activity Source: WormBase
- gap junction hemi-channel activity Source: UniProtKB
GO - Biological processi
- cellular response to dopamine Source: UniProtKB
- gap junction assembly Source: WormBase
- ion transmembrane transport Source: WormBase
- locomotion Source: UniProtKB
- oviposition Source: WormBase
- regulation of locomotion involved in locomotory behavior Source: UniProtKB
- regulation of male mating behavior Source: UniProtKB
- regulation of neuronal signal transduction Source: UniProtKB
- regulation of pharyngeal pumping Source: WormBase
- response to anesthetic Source: WormBase
- spicule insertion Source: UniProtKB
Keywordsi
Molecular function | Ion channel |
Biological process | Ion transport, Transport |
Protein family/group databases
TCDBi | 1.A.25.1.2, the gap junction-forming innexin (innexin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Innexin unc-7Alternative name(s): Uncoordinated protein 7 |
Gene namesi | ORF Names:R07D5.1Imported |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | R07D5.1a ; CE06279 ; WBGene00006747 ; unc-7 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein PROSITE-ProRule annotation
Other locations
Plasma Membrane
- neuron projection membrane Source: WormBase
- plasma membrane Source: WormBase
Other locations
- cell-cell junction Source: WormBase
- gap junction Source: UniProtKB
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 151 – 171 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 221 – 241 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 320 – 340 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 405 – 425 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePathology & Biotechi
Disruption phenotypei
Restores pharyngeal pumping but not impaired locomotion in 33 percent of animals overexpressing lin-3.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 59 | A → T in rg396; increases backwards movements. Defects in male mating behavior with spicule protrusion impairments. Impairs dopamine signaling. 1 Publication | 1 | |
Mutagenesisi | 216 – 522 | Missing in e5; defects in male mating behavior with spicule protrusion impairments. Impairs dopamine signaling. 1 PublicationAdd BLAST | 307 | |
Mutagenesisi | 224 | P → L in hs9; defects in male mating behavior with spicule protrusion impairments. Impairs dopamine signaling. 1 Publication | 1 | |
Mutagenesisi | 238 | C → Y in hs10; defects in male mating behavior with spicule protrusion impairments. Impairs dopamine signaling. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208517 | 1 – 522 | Innexin unc-7Add BLAST | 522 |
Proteomic databases
EPDi | Q03412 |
PaxDbi | Q03412 |
Expressioni
Tissue specificityi
In hermaphrodites, expressed in all premotor and motor neurons, and in tail neurons (PubMed:26156999). In males, expressed in the anal depressor, gubernacular erector, gubernacular retractor and anterior oblique muscles, SPC, PCA, PCB, HOA, ray, head ganglion and ventral cord neurons (PubMed:26156999).1 Publication
Developmental stagei
Present in all developmental stages but most abundant in L1-L3 larvae.
Gene expression databases
Bgeei | WBGene00006747, Expressed in multi-cellular organism and 4 other tissues |
ExpressionAtlasi | Q03412, baseline and differential |
Interactioni
Subunit structurei
Heterooligomer of unc-7 and unc-9.
CuratedProtein-protein interaction databases
STRINGi | 6239.R07D5.1a |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 20 – 25 | Poly-Pro | 6 |
Sequence similaritiesi
Belongs to the pannexin family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QVJ2, Eukaryota |
InParanoidi | Q03412 |
OMAi | WHSGINL |
PhylomeDBi | Q03412 |
Family and domain databases
InterProi | View protein in InterPro IPR000990, Innexin |
PANTHERi | PTHR11893, PTHR11893, 1 hit |
Pfami | View protein in Pfam PF00876, Innexin, 1 hit |
PRINTSi | PR01262, INNEXIN |
PROSITEi | View protein in PROSITE PS51013, PANNEXIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
Q03412-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGSSSNPEP PLLSRIIGVP PPPPPRAPTT ALVLRVPTVD SPSKKKQQPD
60 70 80 90 100
TRNKYQETAL RDKKTRTPLE KARHLDNLPS YQAQKLLDGS HQLRIDSHHV
110 120 130 140 150
GSAGHGAGQG HGHKKEFGPA MILYYLASAF RALYPRLDDD FVDKLNYYYT
160 170 180 190 200
TTILASFALL VSAKQYVGFP IQCWVPATFT DAMEQYTENY CWVQNTYWVP
210 220 230 240 250
MQEDIPREIY SRRNRQIGYY QWVPFILAIE ALLFYVPCIL WRGLLYWHSG
260 270 280 290 300
INLQGLVQMA CDARLMDSEI KTRTVYTMAR HMQDEVQLTN IDRQGHSRSC
310 320 330 340 350
FSNLQLGANC GRHCGCYVTM LYIGIKVLYS ANVLLQFFLL NHLLGSNDLA
360 370 380 390 400
YGFSLLKDLM HAIEWEQTGM FPRVTLCDFE VRVLGNIHRH TVQCVLMINM
410 420 430 440 450
FNEKIFLFLW FWFLTCGIVT VCNTMYWILI MFIPSQGMSF VRKYLRVLPD
460 470 480 490 500
HPAKPIADDV TLRKFTNNFL RKDGVFMLRM ISTHAGELMS SELILALWQD
510 520
FNNVDRSPTQ FWDAEHGQGT ID
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC8JQR7 | C8JQR7_CAEEL | Innexin | unc-7 inx, CELE_R07D5.1, R07D5.1 | 454 | Annotation score: | ||
C8JQR8 | C8JQR8_CAEEL | Innexin | unc-7 inx, CELE_R07D5.1, R07D5.1 | 402 | Annotation score: | ||
A0A1T5HUM1 | A0A1T5HUM1_CAEEL | Innexin | unc-7 inx, CELE_R07D5.1, R07D5.1 | 544 | Annotation score: | ||
A0A1T5HUM5 | A0A1T5HUM5_CAEEL | Innexin | unc-7 inx, CELE_R07D5.1, R07D5.1 | 546 | Annotation score: | ||
A0A1T5HUN4 | A0A1T5HUN4_CAEEL | Innexin | unc-7 inx, CELE_R07D5.1, R07D5.1 | 520 | Annotation score: | ||
A0A1T5HUM3 | A0A1T5HUM3_CAEEL | Innexin | unc-7 inx, CELE_R07D5.1, R07D5.1 | 463 | Annotation score: | ||
A0A1T5HUM6 | A0A1T5HUM6_CAEEL | Innexin | unc-7 inx, CELE_R07D5.1, R07D5.1 | 461 | Annotation score: | ||
A0A1T5HUM7 | A0A1T5HUM7_CAEEL | Innexin | unc-7 inx, CELE_R07D5.1, R07D5.1 | 474 | Annotation score: | ||
A0A1T5HUM9 | A0A1T5HUM9_CAEEL | Innexin | unc-7 inx, CELE_R07D5.1, R07D5.1 | 476 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z19122 Transcribed RNA Translation: CAA79529.1 BX284606 Genomic DNA Translation: CAA94607.1 |
PIRi | T24027 |
RefSeqi | NP_001257255.1, NM_001270326.1 |
Genome annotation databases
EnsemblMetazoai | R07D5.1a.1; R07D5.1a.1; WBGene00006747 |
GeneIDi | 181608 |
UCSCi | R07D5.1, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z19122 Transcribed RNA Translation: CAA79529.1 BX284606 Genomic DNA Translation: CAA94607.1 |
PIRi | T24027 |
RefSeqi | NP_001257255.1, NM_001270326.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 6239.R07D5.1a |
Protein family/group databases
TCDBi | 1.A.25.1.2, the gap junction-forming innexin (innexin) family |
Proteomic databases
EPDi | Q03412 |
PaxDbi | Q03412 |
Genome annotation databases
EnsemblMetazoai | R07D5.1a.1; R07D5.1a.1; WBGene00006747 |
GeneIDi | 181608 |
UCSCi | R07D5.1, c. elegans |
Organism-specific databases
CTDi | 181608 |
WormBasei | R07D5.1a ; CE06279 ; WBGene00006747 ; unc-7 |
Phylogenomic databases
eggNOGi | ENOG502QVJ2, Eukaryota |
InParanoidi | Q03412 |
OMAi | WHSGINL |
PhylomeDBi | Q03412 |
Miscellaneous databases
PROi | PR:Q03412 |
Gene expression databases
Bgeei | WBGene00006747, Expressed in multi-cellular organism and 4 other tissues |
ExpressionAtlasi | Q03412, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000990, Innexin |
PANTHERi | PTHR11893, PTHR11893, 1 hit |
Pfami | View protein in Pfam PF00876, Innexin, 1 hit |
PRINTSi | PR01262, INNEXIN |
PROSITEi | View protein in PROSITE PS51013, PANNEXIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UNC7_CAEEL | |
Accessioni | Q03412Primary (citable) accession number: Q03412 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | August 12, 2020 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families