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Protein

Urokinase plasminogen activator surface receptor

Gene

PLAUR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • protein domain specific binding Source: AgBase
  • signaling receptor activity Source: ProtInc
  • signaling receptor binding Source: AgBase
  • urokinase plasminogen activator receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-162791 Attachment of GPI anchor to uPAR
R-HSA-6798695 Neutrophil degranulation
R-HSA-75205 Dissolution of Fibrin Clot
SIGNORiQ03405

Names & Taxonomyi

Protein namesi
Recommended name:
Urokinase plasminogen activator surface receptor
Short name:
U-PAR
Short name:
uPAR
Alternative name(s):
Monocyte activation antigen Mo3
CD_antigen: CD87
Gene namesi
Name:PLAUR
Synonyms:MO3, UPAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000011422.11
HGNCiHGNC:9053 PLAUR
MIMi173391 gene
neXtProtiNX_Q03405

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5329
OpenTargetsiENSG00000011422
PharmGKBiPA33383

Chemistry databases

ChEMBLiCHEMBL4883
DrugBankiDB00009 Alteplase
DB00029 Anistreplase
DB00015 Reteplase
DB00031 Tenecteplase
DB00013 Urokinase
DB05476 WX-UK1

Polymorphism and mutation databases

BioMutaiPLAUR
DMDMi465003

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000003609023 – 305Urokinase plasminogen activator surface receptorAdd BLAST283
PropeptideiPRO_0000036091306 – 335Removed in mature formSequence analysisAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 463 Publications
Disulfide bondi28 ↔ 343 Publications
Disulfide bondi39 ↔ 673 Publications
Glycosylationi74N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi93 ↔ 983 Publications
Disulfide bondi117 ↔ 1443 Publications
Disulfide bondi120 ↔ 1273 Publications
Disulfide bondi137 ↔ 1693 Publications
Disulfide bondi175 ↔ 1923 Publications
Glycosylationi184N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi193 ↔ 1983 Publications
Glycosylationi194N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi216 ↔ 2443 Publications
Disulfide bondi219 ↔ 2273 Publications
Glycosylationi222N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi237 ↔ 2633 Publications
Glycosylationi255N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi269 ↔ 2873 Publications
Disulfide bondi288 ↔ 2933 Publications
Lipidationi305GPI-anchor amidated glycineSequence analysis1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei105 – 106Cleavage; by U-PA2
Sitei111 – 112Cleavage; by U-PA2

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ03405
MaxQBiQ03405
PaxDbiQ03405
PeptideAtlasiQ03405
PRIDEiQ03405
ProteomicsDBi58208
58209 [Q03405-2]
58210 [Q03405-3]

PTM databases

iPTMnetiQ03405
PhosphoSitePlusiQ03405
SwissPalmiQ03405

Miscellaneous databases

PMAP-CutDBiQ03405

Expressioni

Tissue specificityi

Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

Gene expression databases

BgeeiENSG00000011422 Expressed in 221 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ03405 baseline and differential
GenevisibleiQ03405 HS

Organism-specific databases

HPAiCAB073533
HPA050843

Interactioni

Subunit structurei

Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with SORL1. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane.Curated7 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111345, 108 interactors
ComplexPortaliCPX-487 uPA-uPAR complex
CPX-501 uPA-uPAR-vitronectin complex
CORUMiQ03405
DIPiDIP-137N
IntActiQ03405, 10 interactors
STRINGi9606.ENSP00000339328

Chemistry databases

BindingDBiQ03405

Structurei

Secondary structure

1335
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ03405
SMRiQ03405
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03405

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 114UPAR/Ly6 1Add BLAST92
Domaini115 – 213UPAR/Ly6 2Add BLAST99
Domaini214 – 305UPAR/Ly6 3Add BLAST92

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJ50 Eukaryota
ENOG410Z47S LUCA
GeneTreeiENSGT00510000049144
HOVERGENiHBG000245
InParanoidiQ03405
KOiK03985
OMAiEVVERGC
OrthoDBiEOG091G0FQ6
PhylomeDBiQ03405
TreeFamiTF338662

Family and domain databases

InterProiView protein in InterPro
IPR018363 CD59_antigen_CS
IPR016054 LY6_UPA_recep-like
IPR033084 U-PAR
PANTHERiPTHR10624:SF6 PTHR10624:SF6, 1 hit
PfamiView protein in Pfam
PF00021 UPAR_LY6, 2 hits
SMARTiView protein in SMART
SM00134 LU, 3 hits
PROSITEiView protein in PROSITE
PS00983 LY6_UPAR, 3 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q03405-1) [UniParc]FASTAAdd to basket
Also known as: uPAR1, GPI-anchored

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI
60 70 80 90 100
VRLWEEGEEL ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ
110 120 130 140 150
GNSGRAVTYS RSRYLECISC GSSDMSCERG RHQSLQCRSP EEQCLDVVTH
160 170 180 190 200
WIQEGEEGRP KDDRHLRGCG YLPGCPGSNG FHNNDTFHFL KCCNTTKCNE
210 220 230 240 250
GPILELENLP QNGRQCYSCK GNSTHGCSSE ETFLIDCRGP MNQCLVATGT
260 270 280 290 300
HEPKNQSYMV RGCATASMCQ HAHLGDAFSM NHIDVSCCTK SGCNHPDLDV
310 320 330
QYRSGAAPQP GPAHLSLTIT LLMTARLWGG TLLWT
Length:335
Mass (Da):36,978
Last modified:February 1, 1994 - v1
Checksum:iAB1963EA3DC77171
GO
Isoform 2 (identifier: Q03405-2) [UniParc]FASTAAdd to basket
Also known as: uPAR2, Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     253-335: PKNQSYMVRG...RLWGGTLLWT → RSLWGSWLPCKSTTALRPPCCEEAQATHV

Show »
Length:281
Mass (Da):31,263
Checksum:iE6C580F279FB0316
GO
Isoform 3 (identifier: Q03405-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-202: Missing.
     203-203: I → V

Show »
Length:290
Mass (Da):32,016
Checksum:i60F14E2A2AFB67AC
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R1I2M0R1I2_HUMAN
Urokinase plasminogen activator sur...
PLAUR
286Annotation score:
M0R383M0R383_HUMAN
Urokinase plasminogen activator sur...
PLAUR
154Annotation score:
M0R2E9M0R2E9_HUMAN
Urokinase plasminogen activator sur...
PLAUR
152Annotation score:
M0QX27M0QX27_HUMAN
Urokinase plasminogen activator sur...
PLAUR
78Annotation score:
M0QYS6M0QYS6_HUMAN
Urokinase plasminogen activator sur...
PLAUR
133Annotation score:
M0QYR6M0QYR6_HUMAN
Urokinase plasminogen activator sur...
PLAUR
226Annotation score:
M0R0Y4M0R0Y4_HUMAN
Urokinase plasminogen activator sur...
PLAUR
185Annotation score:
M0R0H5M0R0H5_HUMAN
Urokinase plasminogen activator sur...
PLAUR
152Annotation score:
M0R0L1M0R0L1_HUMAN
Urokinase plasminogen activator sur...
PLAUR
46Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28C → N AA sequence (PubMed:1689240).Curated1
Sequence conflicti165H → P in AAK31795 (Ref. 13) Curated1
Sequence conflicti213G → E AA sequence (PubMed:7539799).Curated1
Sequence conflicti249G → D in AAF71751 (PubMed:11051819).Curated1
Sequence conflicti252E → G in AAF71751 (PubMed:11051819).Curated1
Isoform 3 (identifier: Q03405-3)
Sequence conflicti158V → I no nucleotide entry (PubMed:8131971).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01632255E → G1 PublicationCorresponds to variant dbSNP:rs4251813Ensembl.1
Natural variantiVAR_01632386T → A1 PublicationCorresponds to variant dbSNP:rs399145Ensembl.1
Natural variantiVAR_016324105R → Q1 PublicationCorresponds to variant dbSNP:rs4251878Ensembl.1
Natural variantiVAR_016325220K → R1 PublicationCorresponds to variant dbSNP:rs2302524Ensembl.1
Natural variantiVAR_016326281N → K1 PublicationCorresponds to variant dbSNP:rs4251921Ensembl.1
Natural variantiVAR_052698297D → A. Corresponds to variant dbSNP:rs16976608Ensembl.1
Natural variantiVAR_014922317L → P1 PublicationCorresponds to variant dbSNP:rs4760Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046345158 – 202Missing in isoform 3. 2 PublicationsAdd BLAST45
Alternative sequenceiVSP_046346203I → V in isoform 3. 2 Publications1
Alternative sequenceiVSP_006715253 – 335PKNQS…TLLWT → RSLWGSWLPCKSTTALRPPC CEEAQATHV in isoform 2. 2 PublicationsAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51675 mRNA Translation: CAA35981.1
M83246 mRNA Translation: AAA59862.1
X74039 mRNA Translation: CAA52191.1
U09346 Genomic DNA Translation: AAA17979.1
U09347 mRNA Translation: AAA17978.1
U08839 mRNA Translation: AAB60333.1
U09937
, U09931, U09932, U09933, U09935, U09936 Genomic DNA Translation: AAB60690.1
AY194849 Genomic DNA Translation: AAN86351.1
AK290774 mRNA Translation: BAF83463.1
CR456952 mRNA Translation: CAG33233.1
AC005525 Genomic DNA Translation: AAC32739.1
AC006953 Genomic DNA Translation: AAD17387.1
AC006953 Genomic DNA Translation: AAD17388.1
CH471126 Genomic DNA Translation: EAW57220.1
BC002788 mRNA Translation: AAH02788.1
AF257789 mRNA Translation: AAF71751.1
AY029180 mRNA Translation: AAK31795.1
S78532 Genomic DNA Translation: AAD14289.1
CCDSiCCDS12628.1 [Q03405-1]
CCDS33041.1 [Q03405-2]
CCDS33042.1 [Q03405-3]
PIRiI52614
S12376 A39743
S39495
RefSeqiNP_001005376.1, NM_001005376.2 [Q03405-2]
NP_001005377.1, NM_001005377.2 [Q03405-3]
NP_001287966.1, NM_001301037.1
NP_002650.1, NM_002659.3 [Q03405-1]
UniGeneiHs.466871

Genome annotation databases

EnsembliENST00000221264; ENSP00000221264; ENSG00000011422 [Q03405-3]
ENST00000339082; ENSP00000342049; ENSG00000011422 [Q03405-2]
ENST00000340093; ENSP00000339328; ENSG00000011422 [Q03405-1]
GeneIDi5329
KEGGihsa:5329
UCSCiuc002oxd.3 human [Q03405-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51675 mRNA Translation: CAA35981.1
M83246 mRNA Translation: AAA59862.1
X74039 mRNA Translation: CAA52191.1
U09346 Genomic DNA Translation: AAA17979.1
U09347 mRNA Translation: AAA17978.1
U08839 mRNA Translation: AAB60333.1
U09937
, U09931, U09932, U09933, U09935, U09936 Genomic DNA Translation: AAB60690.1
AY194849 Genomic DNA Translation: AAN86351.1
AK290774 mRNA Translation: BAF83463.1
CR456952 mRNA Translation: CAG33233.1
AC005525 Genomic DNA Translation: AAC32739.1
AC006953 Genomic DNA Translation: AAD17387.1
AC006953 Genomic DNA Translation: AAD17388.1
CH471126 Genomic DNA Translation: EAW57220.1
BC002788 mRNA Translation: AAH02788.1
AF257789 mRNA Translation: AAF71751.1
AY029180 mRNA Translation: AAK31795.1
S78532 Genomic DNA Translation: AAD14289.1
CCDSiCCDS12628.1 [Q03405-1]
CCDS33041.1 [Q03405-2]
CCDS33042.1 [Q03405-3]
PIRiI52614
S12376 A39743
S39495
RefSeqiNP_001005376.1, NM_001005376.2 [Q03405-2]
NP_001005377.1, NM_001005377.2 [Q03405-3]
NP_001287966.1, NM_001301037.1
NP_002650.1, NM_002659.3 [Q03405-1]
UniGeneiHs.466871

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YWHX-ray2.70A/C/E/G/I/K/M/O23-335[»]
2FD6X-ray1.90U23-297[»]
2I9BX-ray2.80E/F/G/H23-299[»]
3BT1X-ray2.80U23-303[»]
3BT2X-ray2.50U23-303[»]
3U73X-ray3.19U23-305[»]
3U74X-ray2.39U23-305[»]
4K24X-ray4.50U23-303[»]
4QTIX-ray3.00U23-305[»]
ProteinModelPortaliQ03405
SMRiQ03405
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111345, 108 interactors
ComplexPortaliCPX-487 uPA-uPAR complex
CPX-501 uPA-uPAR-vitronectin complex
CORUMiQ03405
DIPiDIP-137N
IntActiQ03405, 10 interactors
STRINGi9606.ENSP00000339328

Chemistry databases

BindingDBiQ03405
ChEMBLiCHEMBL4883
DrugBankiDB00009 Alteplase
DB00029 Anistreplase
DB00015 Reteplase
DB00031 Tenecteplase
DB00013 Urokinase
DB05476 WX-UK1

PTM databases

iPTMnetiQ03405
PhosphoSitePlusiQ03405
SwissPalmiQ03405

Polymorphism and mutation databases

BioMutaiPLAUR
DMDMi465003

Proteomic databases

EPDiQ03405
MaxQBiQ03405
PaxDbiQ03405
PeptideAtlasiQ03405
PRIDEiQ03405
ProteomicsDBi58208
58209 [Q03405-2]
58210 [Q03405-3]

Protocols and materials databases

DNASUi5329
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221264; ENSP00000221264; ENSG00000011422 [Q03405-3]
ENST00000339082; ENSP00000342049; ENSG00000011422 [Q03405-2]
ENST00000340093; ENSP00000339328; ENSG00000011422 [Q03405-1]
GeneIDi5329
KEGGihsa:5329
UCSCiuc002oxd.3 human [Q03405-1]

Organism-specific databases

CTDi5329
DisGeNETi5329
EuPathDBiHostDB:ENSG00000011422.11
GeneCardsiPLAUR
HGNCiHGNC:9053 PLAUR
HPAiCAB073533
HPA050843
MIMi173391 gene
neXtProtiNX_Q03405
OpenTargetsiENSG00000011422
PharmGKBiPA33383
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ50 Eukaryota
ENOG410Z47S LUCA
GeneTreeiENSGT00510000049144
HOVERGENiHBG000245
InParanoidiQ03405
KOiK03985
OMAiEVVERGC
OrthoDBiEOG091G0FQ6
PhylomeDBiQ03405
TreeFamiTF338662

Enzyme and pathway databases

ReactomeiR-HSA-162791 Attachment of GPI anchor to uPAR
R-HSA-6798695 Neutrophil degranulation
R-HSA-75205 Dissolution of Fibrin Clot
SIGNORiQ03405

Miscellaneous databases

ChiTaRSiPLAUR human
EvolutionaryTraceiQ03405
GeneWikiiUrokinase_receptor
GenomeRNAii5329
PMAP-CutDBiQ03405
PROiPR:Q03405
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000011422 Expressed in 221 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ03405 baseline and differential
GenevisibleiQ03405 HS

Family and domain databases

InterProiView protein in InterPro
IPR018363 CD59_antigen_CS
IPR016054 LY6_UPA_recep-like
IPR033084 U-PAR
PANTHERiPTHR10624:SF6 PTHR10624:SF6, 1 hit
PfamiView protein in Pfam
PF00021 UPAR_LY6, 2 hits
SMARTiView protein in SMART
SM00134 LU, 3 hits
PROSITEiView protein in PROSITE
PS00983 LY6_UPAR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiUPAR_HUMAN
AccessioniPrimary (citable) accession number: Q03405
Secondary accession number(s): A8K409
, Q12876, Q15845, Q16887, Q6IB52, Q9BWT0, Q9NYC8, Q9UD69, Q9UEA6, Q9UM92, Q9UMV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 193 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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