PLAUR

Functionⁱ

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 14688365
protein domain specific binding
Source: AgBase
Inferred from physical interactionⁱ
- 12665524
signaling receptor activity
Source: ProtInc
Traceable author statementⁱ
- 10749881
signaling receptor binding
Source: AgBase
Inferred from physical interactionⁱ
- 12665524
urokinase plasminogen activator receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood coagulation
Source: ProtInc
Traceable author statementⁱ
- 8049431
chemotaxis
Source: ProtInc
Traceable author statementⁱ
- 10749881
fibrinolysis Source: Reactome
negative regulation of apoptotic process
Source: CACAO
Inferred from mutant phenotypeⁱ
- 22984561
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Source: CACAO
Inferred from mutant phenotypeⁱ
- 22984561
negative regulation of intrinsic apoptotic signaling pathway
Source: CACAO
Inferred from mutant phenotypeⁱ
- 22984561
neutrophil degranulation Source: Reactome
positive regulation of DNA binding
Source: CACAO
Inferred from direct assayⁱ
- 22984561
positive regulation of epidermal growth factor receptor signaling pathway
Source: CACAO
Inferred from mutant phenotypeⁱ
- 22984561
positive regulation of protein phosphorylation
Source: CACAO
Inferred from mutant phenotypeⁱ
- 22984561
positive regulation of release of cytochrome c from mitochondria
Source: CACAO
Inferred from mutant phenotypeⁱ
- 22984561
regulation of proteolysis
Source: UniProtKB
Non-traceable author statementⁱ
- 1689240
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 10749881
urokinase plasminogen activator signaling pathway Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor

Molecular function

Receptor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-162791 Attachment of GPI anchor to uPAR R-HSA-6798695 Neutrophil degranulation R-HSA-75205 Dissolution of Fibrin Clot
SIGNORⁱ	Q03405

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Urokinase plasminogen activator surface receptor Short name: U-PAR Short name: uPAR Alternative name(s): Monocyte activation antigen Mo3 CD_antigen: CD87
Gene namesⁱ	Name:PLAUR Synonyms:MO3, UPAR
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000011422.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9053 PLAUR
MIMⁱ	173391 gene
neXtProtⁱ	NX_Q03405

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cell projection, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5329
Open Targets More...OpenTargetsⁱ	ENSG00000011422
PharmGKBⁱ	PA33383

Chemistry databases

ChEMBLⁱ	CHEMBL4883
Drug and drug target database More...DrugBankⁱ	DB00009 Alteplase DB00029 Anistreplase DB00015 Reteplase DB00031 Tenecteplase DB00013 Urokinase DB05476 WX-UK1

Polymorphism and mutation databases

BioMutaⁱ	PLAUR
DMDMⁱ	465003

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 22	1 PublicationAdd BLAST	22
ChainⁱPRO_0000036090	23 – 305	Urokinase plasminogen activator surface receptorAdd BLAST	283
PropeptideⁱPRO_0000036091	306 – 335	Removed in mature formSequence analysisAdd BLAST	30

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	25 ↔ 46	3 Publications
Disulfide bondⁱ	28 ↔ 34	3 Publications
Disulfide bondⁱ	39 ↔ 67	3 Publications
Glycosylationⁱ	74	N-linked (GlcNAc...) asparagine3 Publications	1
Disulfide bondⁱ	93 ↔ 98	3 Publications
Disulfide bondⁱ	117 ↔ 144	3 Publications
Disulfide bondⁱ	120 ↔ 127	3 Publications
Disulfide bondⁱ	137 ↔ 169	3 Publications
Disulfide bondⁱ	175 ↔ 192	3 Publications
Glycosylationⁱ	184	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	193 ↔ 198	3 Publications
Glycosylationⁱ	194	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	216 ↔ 244	3 Publications
Disulfide bondⁱ	219 ↔ 227	3 Publications
Glycosylationⁱ	222	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	237 ↔ 263	3 Publications
Glycosylationⁱ	255	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	269 ↔ 287	3 Publications
Disulfide bondⁱ	288 ↔ 293	3 Publications
Lipidationⁱ	305	GPI-anchor amidated glycineSequence analysis	1

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	105 – 106	Cleavage; by U-PA		2
Siteⁱ	111 – 112	Cleavage; by U-PA		2

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDⁱ	Q03405
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q03405
PaxDbⁱ	Q03405
PeptideAtlas More...PeptideAtlasⁱ	Q03405
PRIDEⁱ	Q03405
ProteomicsDBⁱ	58208 58209 [Q03405-2] 58210 [Q03405-3]

PTM databases

iPTMnetⁱ	Q03405
PhosphoSitePlusⁱ	Q03405
SwissPalmⁱ	Q03405

Miscellaneous databases

PMAP-CutDBⁱ	Q03405

PMAP-CutDBⁱ

Q03405

Expressionⁱ

Tissue specificityⁱ

Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

Gene expression databases

Bgeeⁱ	ENSG00000011422 Expressed in 221 organ(s), highest expression level in bone marrow
ExpressionAtlasⁱ	Q03405 baseline and differential
Genevisibleⁱ	Q03405 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB073533 HPA050843

HPAⁱ

CAB073533
HPA050843

Interactionⁱ

Subunit structureⁱ

Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with SORL1. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane.Curated7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ANG	P03950	5	EBI-716505,EBI-525291
PLAU	P00749	2	EBI-15695188,EBI-3905042

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 14688365
protein domain specific binding
Source: AgBase
Inferred from physical interactionⁱ
- 12665524
signaling receptor binding
Source: AgBase
Inferred from physical interactionⁱ
- 12665524

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111345, 108 interactors
ComplexPortalⁱ	CPX-487 uPA-uPAR complex CPX-501 uPA-uPAR-vitronectin complex
CORUMⁱ	Q03405
Database of interacting proteins More...DIPⁱ	DIP-137N
IntActⁱ	Q03405, 10 interactors
STRINGⁱ	9606.ENSP00000339328

Chemistry databases

BindingDBⁱ

Q03405

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	24 – 28	Combined sources	5
Beta strandⁱ	34 – 38	Combined sources	5
Beta strandⁱ	45 – 54	Combined sources	10
Beta strandⁱ	60 – 68	Combined sources	9
Beta strandⁱ	75 – 81	Combined sources	7
Beta strandⁱ	84 – 93	Combined sources	10
Turnⁱ	96 – 99	Combined sources	4
Beta strandⁱ	116 – 121	Combined sources	6
Turnⁱ	122 – 130	Combined sources	9
Beta strandⁱ	133 – 136	Combined sources	4
Beta strandⁱ	138 – 141	Combined sources	4
Beta strandⁱ	143 – 150	Combined sources	8
Beta strandⁱ	155 – 158	Combined sources	4
Beta strandⁱ	164 – 171	Combined sources	8
Beta strandⁱ	176 – 183	Combined sources	8
Beta strandⁱ	186 – 193	Combined sources	8
Turnⁱ	196 – 199	Combined sources	4
Helixⁱ	206 – 208	Combined sources	3
Beta strandⁱ	211 – 222	Combined sources	12
Turnⁱ	223 – 225	Combined sources	3
Beta strandⁱ	226 – 228	Combined sources	3
Turnⁱ	229 – 231	Combined sources	3
Beta strandⁱ	233 – 238	Combined sources	6
Beta strandⁱ	243 – 251	Combined sources	9
Turnⁱ	252 – 255	Combined sources	4
Beta strandⁱ	256 – 264	Combined sources	9
Helixⁱ	266 – 268	Combined sources	3
Beta strandⁱ	270 – 273	Combined sources	4
Helixⁱ	275 – 278	Combined sources	4
Beta strandⁱ	284 – 288	Combined sources	5
Turnⁱ	291 – 294	Combined sources	4
Helixⁱ	296 – 298	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q03405
SMRⁱ	Q03405
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q03405

EvolutionaryTraceⁱ

Q03405

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	23 – 114	UPAR/Ly6 1Add BLAST	92
Domainⁱ	115 – 213	UPAR/Ly6 2Add BLAST	99
Domainⁱ	214 – 305	UPAR/Ly6 3Add BLAST	92

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IJ50 Eukaryota ENOG410Z47S LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000049144
HOVERGENⁱ	HBG000245
InParanoidⁱ	Q03405
KEGG Orthology (KO) More...KOⁱ	K03985
OMAⁱ	VERGCAH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FQ6
PhylomeDBⁱ	Q03405
TreeFamⁱ	TF338662

Family and domain databases

InterProⁱ	View protein in InterPro IPR018363 CD59_antigen_CS IPR016054 LY6_UPA_recep-like IPR033084 U-PAR
PANTHERⁱ	PTHR10624:SF6 PTHR10624:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00021 UPAR_LY6, 2 hits
SMARTⁱ	View protein in SMART SM00134 LU, 3 hits
PROSITEⁱ	View protein in PROSITE PS00983 LY6_UPAR, 3 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q03405-1) [UniParc]FASTA Add to basket

Also known as: uPAR1, GPI-anchored

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI 
        60         70         80         90        100
VRLWEEGEEL ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ 
       110        120        130        140        150
GNSGRAVTYS RSRYLECISC GSSDMSCERG RHQSLQCRSP EEQCLDVVTH 
       160        170        180        190        200
WIQEGEEGRP KDDRHLRGCG YLPGCPGSNG FHNNDTFHFL KCCNTTKCNE 
       210        220        230        240        250
GPILELENLP QNGRQCYSCK GNSTHGCSSE ETFLIDCRGP MNQCLVATGT 
       260        270        280        290        300
HEPKNQSYMV RGCATASMCQ HAHLGDAFSM NHIDVSCCTK SGCNHPDLDV 
       310        320        330 
QYRSGAAPQP GPAHLSLTIT LLMTARLWGG TLLWT

Length:335

Mass (Da):36,978

Last modified:February 1, 1994 - v1

Checksum:ⁱAB1963EA3DC77171

GO

Isoform 2 (identifier: Q03405-2) [UniParc]FASTA Add to basket

Also known as: uPAR2, Secreted

The sequence of this isoform differs from the canonical sequence as follows:
253-335: PKNQSYMVRG...RLWGGTLLWT → RSLWGSWLPCKSTTALRPPCCEEAQATHV

« Hide

        10         20         30         40         50
MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI 
        60         70         80         90        100
VRLWEEGEEL ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ 
       110        120        130        140        150
GNSGRAVTYS RSRYLECISC GSSDMSCERG RHQSLQCRSP EEQCLDVVTH 
       160        170        180        190        200
WIQEGEEGRP KDDRHLRGCG YLPGCPGSNG FHNNDTFHFL KCCNTTKCNE 
       210        220        230        240        250
GPILELENLP QNGRQCYSCK GNSTHGCSSE ETFLIDCRGP MNQCLVATGT 
       260        270        280 
HERSLWGSWL PCKSTTALRP PCCEEAQATH V

Show »

Length:281

Mass (Da):31,263

Checksum:ⁱE6C580F279FB0316

GO

Isoform 3 (identifier: Q03405-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
158-202: Missing.
203-203: I → V

« Hide

        10         20         30         40         50
MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI 
        60         70         80         90        100
VRLWEEGEEL ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ 
       110        120        130        140        150
GNSGRAVTYS RSRYLECISC GSSDMSCERG RHQSLQCRSP EEQCLDVVTH 
       160        170        180        190        200
WIQEGEEVLE LENLPQNGRQ CYSCKGNSTH GCSSEETFLI DCRGPMNQCL 
       210        220        230        240        250
VATGTHEPKN QSYMVRGCAT ASMCQHAHLG DAFSMNHIDV SCCTKSGCNH 
       260        270        280        290
PDLDVQYRSG AAPQPGPAHL SLTITLLMTA RLWGGTLLWT

Show »

Length:290

Mass (Da):32,016

Checksum:ⁱ60F14E2A2AFB67AC

GO

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

M0R1I2	M0R1I2_HUMAN	Urokinase plasminogen activator sur... Urokinase plasminogen activator surface receptor	PLAUR	286	Annotation score:
M0QYS6	M0QYS6_HUMAN	Urokinase plasminogen activator sur... Urokinase plasminogen activator surface receptor	PLAUR	133	Annotation score:
M0QYR6	M0QYR6_HUMAN	Urokinase plasminogen activator sur... Urokinase plasminogen activator surface receptor	PLAUR	226	Annotation score:
M0R383	M0R383_HUMAN	Urokinase plasminogen activator sur... Urokinase plasminogen activator surface receptor	PLAUR	154	Annotation score:
M0QX27	M0QX27_HUMAN	Urokinase plasminogen activator sur... Urokinase plasminogen activator surface receptor	PLAUR	78	Annotation score:
M0R2E9	M0R2E9_HUMAN	Urokinase plasminogen activator sur... Urokinase plasminogen activator surface receptor	PLAUR	152	Annotation score:
M0R0H5	M0R0H5_HUMAN	Urokinase plasminogen activator sur... Urokinase plasminogen activator surface receptor	PLAUR	152	Annotation score:
M0R0Y4	M0R0Y4_HUMAN	Urokinase plasminogen activator sur... Urokinase plasminogen activator surface receptor	PLAUR	185	Annotation score:
M0R0L1	M0R0L1_HUMAN	Urokinase plasminogen activator sur... Urokinase plasminogen activator surface receptor	PLAUR	46	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	28	C → N AA sequence (PubMed:1689240).Curated	1
Sequence conflictⁱ	165	H → P in AAK31795 (Ref. 13) Curated	1
Sequence conflictⁱ	213	G → E AA sequence (PubMed:7539799).Curated	1
Sequence conflictⁱ	249	G → D in AAF71751 (PubMed:11051819).Curated	1
Sequence conflictⁱ	252	E → G in AAF71751 (PubMed:11051819).Curated	1
Isoform 3 (identifier: Q03405-3)
Sequence conflictⁱ	158	V → I no nucleotide entry (PubMed:8131971).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_016322	55	E → G1 PublicationCorresponds to variant dbSNP:rs4251813Ensembl.	1
Natural variantⁱVAR_016323	86	T → A1 PublicationCorresponds to variant dbSNP:rs399145Ensembl.	1
Natural variantⁱVAR_016324	105	R → Q1 PublicationCorresponds to variant dbSNP:rs4251878Ensembl.	1
Natural variantⁱVAR_016325	220	K → R1 PublicationCorresponds to variant dbSNP:rs2302524Ensembl.	1
Natural variantⁱVAR_016326	281	N → K1 PublicationCorresponds to variant dbSNP:rs4251921Ensembl.	1
Natural variantⁱVAR_052698	297	D → A. Corresponds to variant dbSNP:rs16976608Ensembl.	1
Natural variantⁱVAR_014922	317	L → P1 PublicationCorresponds to variant dbSNP:rs4760Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_046345	158 – 202	Missing in isoform 3. 2 PublicationsAdd BLAST	45
Alternative sequenceⁱVSP_046346	203	I → V in isoform 3. 2 Publications	1
Alternative sequenceⁱVSP_006715	253 – 335	PKNQS…TLLWT → RSLWGSWLPCKSTTALRPPC CEEAQATHV in isoform 2. 2 PublicationsAdd BLAST	83

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X51675 mRNA Translation: CAA35981.1 M83246 mRNA Translation: AAA59862.1 X74039 mRNA Translation: CAA52191.1 U09346 Genomic DNA Translation: AAA17979.1 U09347 mRNA Translation: AAA17978.1 U08839 mRNA Translation: AAB60333.1 U09937 U09936 Genomic DNA Translation: AAB60690.1 AY194849 Genomic DNA Translation: AAN86351.1 AK290774 mRNA Translation: BAF83463.1 CR456952 mRNA Translation: CAG33233.1 AC005525 Genomic DNA Translation: AAC32739.1 AC006953 Genomic DNA Translation: AAD17387.1 AC006953 Genomic DNA Translation: AAD17388.1 CH471126 Genomic DNA Translation: EAW57220.1 BC002788 mRNA Translation: AAH02788.1 AF257789 mRNA Translation: AAF71751.1 AY029180 mRNA Translation: AAK31795.1 S78532 Genomic DNA Translation: AAD14289.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12628.1 [Q03405-1] CCDS33041.1 [Q03405-2] CCDS33042.1 [Q03405-3]
PIRⁱ	I52614 S12376 A39743 S39495
NCBI Reference Sequences More...RefSeqⁱ	NP_001005376.1, NM_001005376.2 [Q03405-2] NP_001005377.1, NM_001005377.2 [Q03405-3] NP_001287966.1, NM_001301037.1 NP_002650.1, NM_002659.3 [Q03405-1]
UniGeneⁱ	Hs.466871

Genome annotation databases

Ensemblⁱ	ENST00000221264; ENSP00000221264; ENSG00000011422 [Q03405-3] ENST00000339082; ENSP00000342049; ENSG00000011422 [Q03405-2] ENST00000340093; ENSP00000339328; ENSG00000011422 [Q03405-1]
GeneIDⁱ	5329
KEGGⁱ	hsa:5329
UCSC genome browser More...UCSCⁱ	uc002oxd.3 human [Q03405-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q03405	U-plasminogen activator receptor form 2-human [AA 1-206] (Fragment)		HUMAN		251	UniRef100_Q03405
Urokinase plasminogen activator surface receptor (Fragment)		HUMAN		226
Urokinase plasminogen activator surface receptor (Fragment)		HUMAN		152
UPI000020258F		HUMAN		211
UPI00042D7321		HUMAN		283

Protein	Similar proteins		Species	Score	Length	Source
Q03405	Urokinase plasminogen activator surface receptor		MACFA		335	UniRef90_Q03405
Urokinase plasminogen activator surface receptor		CHLAE		335
U-plasminogen activator receptor form 2-human [AA 1-206] (Fragment)		HUMAN		251
Uncharacterized protein		RHIRO		336
Uncharacterized protein		CERAT		335
+28
Q03405-2	Uncharacterized protein		RHIRO		282	UniRef90_Q03405-2
Uncharacterized protein		RHIBE		282
PLAUR isoform 5		PANTR		281
Uncharacterized protein		COLAP		281
PLAUR isoform 1		PONAB		281
+10
Q03405-3	PLAUR isoform 6		PONAB		290	UniRef90_Q03405-3
Uncharacterized protein		NOMLE		290
PLAUR isoform 1		PANTR		290
Uncharacterized protein		PANPA		290
UPI000CEFE0FA		PONAB		331

Protein	Similar proteins		Species	Score	Length	Source
Q03405	Urokinase plasminogen activator surface receptor		MACFA		335	UniRef50_Q03405
Urokinase plasminogen activator surface receptor		CHLAE		335
Urokinase plasminogen activator surface receptor		AOTTR		336
Urokinase plasminogen activator surface receptor		BOVIN		330
Urokinase plasminogen activator surface receptor		PANTR		335
+166
Q03405-2	Isoform 3 of Urokinase plasminogen activator surface receptor		HUMAN		290	UniRef50_Q03405-3
PLAUR isoform 6		PONAB		290
Uncharacterized protein		NOMLE		290
PLAUR isoform 1		PANTR		290
Uncharacterized protein		PANPA		290
+29
Q03405-3	PLAUR isoform 6		PONAB		290	UniRef50_Q03405-3
Uncharacterized protein		NOMLE		290
PLAUR isoform 1		PANTR		290
Uncharacterized protein		PANPA		290
Uncharacterized protein		RHIRO		290
+29

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X51675 mRNA Translation: CAA35981.1 M83246 mRNA Translation: AAA59862.1 X74039 mRNA Translation: CAA52191.1 U09346 Genomic DNA Translation: AAA17979.1 U09347 mRNA Translation: AAA17978.1 U08839 mRNA Translation: AAB60333.1 U09937 U09936 Genomic DNA Translation: AAB60690.1 AY194849 Genomic DNA Translation: AAN86351.1 AK290774 mRNA Translation: BAF83463.1 CR456952 mRNA Translation: CAG33233.1 AC005525 Genomic DNA Translation: AAC32739.1 AC006953 Genomic DNA Translation: AAD17387.1 AC006953 Genomic DNA Translation: AAD17388.1 CH471126 Genomic DNA Translation: EAW57220.1 BC002788 mRNA Translation: AAH02788.1 AF257789 mRNA Translation: AAF71751.1 AY029180 mRNA Translation: AAK31795.1 S78532 Genomic DNA Translation: AAD14289.1
CCDSⁱ	CCDS12628.1 [Q03405-1] CCDS33041.1 [Q03405-2] CCDS33042.1 [Q03405-3]
PIRⁱ	I52614 S12376 A39743 S39495
RefSeqⁱ	NP_001005376.1, NM_001005376.2 [Q03405-2] NP_001005377.1, NM_001005377.2 [Q03405-3] NP_001287966.1, NM_001301037.1 NP_002650.1, NM_002659.3 [Q03405-1]
UniGeneⁱ	Hs.466871

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1YWH	X-ray	2.70	A/C/E/G/I/K/M/O	23-335	[»]
	2FD6	X-ray	1.90	U	23-297	[»]
	2I9B	X-ray	2.80	E/F/G/H	23-299	[»]
	3BT1	X-ray	2.80	U	23-303	[»]
	3BT2	X-ray	2.50	U	23-303	[»]
	3U73	X-ray	3.19	U	23-305	[»]
	3U74	X-ray	2.39	U	23-305	[»]
	4K24	X-ray	4.50	U	23-303	[»]
	4QTI	X-ray	3.00	U	23-305	[»]
ProteinModelPortalⁱ	Q03405
SMRⁱ	Q03405
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111345, 108 interactors
ComplexPortalⁱ	CPX-487 uPA-uPAR complex CPX-501 uPA-uPAR-vitronectin complex
CORUMⁱ	Q03405
DIPⁱ	DIP-137N
IntActⁱ	Q03405, 10 interactors
STRINGⁱ	9606.ENSP00000339328

Chemistry databases

BindingDBⁱ	Q03405
ChEMBLⁱ	CHEMBL4883
DrugBankⁱ	DB00009 Alteplase DB00029 Anistreplase DB00015 Reteplase DB00031 Tenecteplase DB00013 Urokinase DB05476 WX-UK1

PTM databases

iPTMnetⁱ	Q03405
PhosphoSitePlusⁱ	Q03405
SwissPalmⁱ	Q03405

Polymorphism and mutation databases

BioMutaⁱ	PLAUR
DMDMⁱ	465003

Proteomic databases

EPDⁱ	Q03405
MaxQBⁱ	Q03405
PaxDbⁱ	Q03405
PeptideAtlasⁱ	Q03405
PRIDEⁱ	Q03405
ProteomicsDBⁱ	58208 58209 [Q03405-2] 58210 [Q03405-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5329
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000221264; ENSP00000221264; ENSG00000011422 [Q03405-3] ENST00000339082; ENSP00000342049; ENSG00000011422 [Q03405-2] ENST00000340093; ENSP00000339328; ENSG00000011422 [Q03405-1]
GeneIDⁱ	5329
KEGGⁱ	hsa:5329
UCSCⁱ	uc002oxd.3 human [Q03405-1]

Organism-specific databases

CTDⁱ	5329
DisGeNETⁱ	5329
EuPathDBⁱ	HostDB:ENSG00000011422.11
GeneCardsⁱ	PLAUR
HGNCⁱ	HGNC:9053 PLAUR
HPAⁱ	CAB073533 HPA050843
MIMⁱ	173391 gene
neXtProtⁱ	NX_Q03405
OpenTargetsⁱ	ENSG00000011422
PharmGKBⁱ	PA33383
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJ50 Eukaryota ENOG410Z47S LUCA
GeneTreeⁱ	ENSGT00510000049144
HOVERGENⁱ	HBG000245
InParanoidⁱ	Q03405
KOⁱ	K03985
OMAⁱ	VERGCAH
OrthoDBⁱ	EOG091G0FQ6
PhylomeDBⁱ	Q03405
TreeFamⁱ	TF338662

Enzyme and pathway databases

Reactomeⁱ	R-HSA-162791 Attachment of GPI anchor to uPAR R-HSA-6798695 Neutrophil degranulation R-HSA-75205 Dissolution of Fibrin Clot
SIGNORⁱ	Q03405

Miscellaneous databases

ChiTaRSⁱ	PLAUR human
EvolutionaryTraceⁱ	Q03405
GeneWikiⁱ	Urokinase_receptor
GenomeRNAiⁱ	5329
PMAP-CutDBⁱ	Q03405
Protein Ontology More...PROⁱ	PR:Q03405
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000011422 Expressed in 221 organ(s), highest expression level in bone marrow
ExpressionAtlasⁱ	Q03405 baseline and differential
Genevisibleⁱ	Q03405 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR018363 CD59_antigen_CS IPR016054 LY6_UPA_recep-like IPR033084 U-PAR
PANTHERⁱ	PTHR10624:SF6 PTHR10624:SF6, 1 hit
Pfamⁱ	View protein in Pfam PF00021 UPAR_LY6, 2 hits
SMARTⁱ	View protein in SMART SM00134 LU, 3 hits
PROSITEⁱ	View protein in PROSITE PS00983 LY6_UPAR, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UPAR_HUMAN
Accessionⁱ	Q03405Primary (citable) accession number: Q03405 Secondary accession number(s): A8K409 Q9UMV0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	February 1, 1994
	Last modified:	September 12, 2018
	This is version 192 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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Help

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Supporting data

UniProtKB - Q03405 (UPAR_HUMAN)

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Urokinase plasminogen activator surface receptor

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

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Plasma membrane

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Plasma Membrane

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Keywords - Cellular componenti

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Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

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Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ