UniProtKB - Q03405 (UPAR_HUMAN)
Urokinase plasminogen activator surface receptor
PLAUR
Functioni
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- protein domain specific binding Source: AgBase
- signaling receptor activity Source: ProtInc
- signaling receptor binding Source: AgBase
- urokinase plasminogen activator receptor activity Source: UniProtKB
GO - Biological processi
- blood coagulation Source: ProtInc
- chemotaxis Source: ProtInc
- fibrinolysis Source: Reactome
- negative regulation of apoptotic process Source: CACAO
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: CACAO
- negative regulation of intrinsic apoptotic signaling pathway Source: CACAO
- neutrophil degranulation Source: Reactome
- positive regulation of DNA binding Source: CACAO
- positive regulation of epidermal growth factor receptor signaling pathway Source: CACAO
- positive regulation of homotypic cell-cell adhesion Source: ARUK-UCL
- positive regulation of protein phosphorylation Source: CACAO
- positive regulation of release of cytochrome c from mitochondria Source: CACAO
- regulation of proteolysis Source: UniProtKB
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | Q03405 |
Reactomei | R-HSA-162791, Attachment of GPI anchor to uPAR R-HSA-6798695, Neutrophil degranulation R-HSA-75205, Dissolution of Fibrin Clot |
SIGNORi | Q03405 |
Names & Taxonomyi
Protein namesi | Recommended name: Urokinase plasminogen activator surface receptorShort name: U-PAR Short name: uPAR Alternative name(s): Monocyte activation antigen Mo3 CD_antigen: CD87 |
Gene namesi | Name:PLAUR Synonyms:MO3, UPAR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000011422.11 |
HGNCi | HGNC:9053, PLAUR |
MIMi | 173391, gene |
neXtProti | NX_Q03405 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
- invadopodium membrane 1 Publication
Note: Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.1 Publication
Plasma membrane
- Cell membrane By similarity; GPI-anchor By similarity
Extracellular region or secreted
- Secreted By similarity
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
- endoplasmic reticulum membrane Source: Reactome
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: Ensembl
- invadopodium membrane Source: UniProtKB-SubCell
- plasma membrane Source: AgBase
Other locations
- anchored component of membrane Source: UniProtKB-KW
- cell surface Source: CAFA
- extrinsic component of membrane Source: ProtInc
- focal adhesion Source: UniProtKB
- integral component of membrane Source: UniProtKB
- specific granule membrane Source: Reactome
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 5329 |
OpenTargetsi | ENSG00000011422 |
PharmGKBi | PA33383 |
Miscellaneous databases
Pharosi | Q03405, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4883 |
DrugBanki | DB00009, Alteplase DB06245, Lanoteplase DB00031, Tenecteplase DB00013, Urokinase DB05476, WX-UK1 |
Polymorphism and mutation databases
BioMutai | PLAUR |
DMDMi | 465003 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | 1 PublicationAdd BLAST | 22 | |
ChainiPRO_0000036090 | 23 – 305 | Urokinase plasminogen activator surface receptorAdd BLAST | 283 | |
PropeptideiPRO_0000036091 | 306 – 335 | Removed in mature formSequence analysisAdd BLAST | 30 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 25 ↔ 46 | 3 Publications | ||
Disulfide bondi | 28 ↔ 34 | 3 Publications | ||
Disulfide bondi | 39 ↔ 67 | 3 Publications | ||
Glycosylationi | 74 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Disulfide bondi | 93 ↔ 98 | 3 Publications | ||
Disulfide bondi | 117 ↔ 144 | 3 Publications | ||
Disulfide bondi | 120 ↔ 127 | 3 Publications | ||
Disulfide bondi | 137 ↔ 169 | 3 Publications | ||
Disulfide bondi | 175 ↔ 192 | 3 Publications | ||
Glycosylationi | 184 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 193 ↔ 198 | 3 Publications | ||
Glycosylationi | 194 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 216 ↔ 244 | 3 Publications | ||
Disulfide bondi | 219 ↔ 227 | 3 Publications | ||
Glycosylationi | 222 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 237 ↔ 263 | 3 Publications | ||
Glycosylationi | 255 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 269 ↔ 287 | 3 Publications | ||
Disulfide bondi | 288 ↔ 293 | 3 Publications | ||
Lipidationi | 305 | GPI-anchor amidated glycineSequence analysis | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 105 – 106 | Cleavage; by U-PA | 2 | |
Sitei | 111 – 112 | Cleavage; by U-PA | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
EPDi | Q03405 |
jPOSTi | Q03405 |
MassIVEi | Q03405 |
MaxQBi | Q03405 |
PaxDbi | Q03405 |
PeptideAtlasi | Q03405 |
PRIDEi | Q03405 |
ProteomicsDBi | 58208 [Q03405-1] 58209 [Q03405-2] 58210 [Q03405-3] |
PTM databases
GlyGeni | Q03405, 5 sites |
iPTMneti | Q03405 |
PhosphoSitePlusi | Q03405 |
SwissPalmi | Q03405 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000011422, Expressed in bone marrow and 232 other tissues |
ExpressionAtlasi | Q03405, baseline and differential |
Genevisiblei | Q03405, HS |
Organism-specific databases
HPAi | ENSG00000011422, Tissue enhanced (blood, bone marrow) |
Interactioni
Subunit structurei
Monomer (Probable).
Interacts with MRC2.
Interacts (via the UPAR/Ly6 domains) with SRPX2.
Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane.
Interacts with SORL1 (via N-terminal ectodomain); this interaction decreases PLAUR internalization (PubMed:14764453, PubMed:23486467). The ternary complex composed of PLAUR-PLAU-SERPINE1 also interacts with SORL1 (PubMed:15053742).
Curated9 PublicationsBinary interactionsi
Hide detailsQ03405
With | #Exp. | IntAct |
---|---|---|
ANG [P03950] | 5 | EBI-716505,EBI-525291 |
Isoform 1 [Q03405-1]
With | #Exp. | IntAct |
---|---|---|
PLAU [P00749] | 2 | EBI-15695188,EBI-3905042 |
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- protein domain specific binding Source: AgBase
- signaling receptor binding Source: AgBase
Protein-protein interaction databases
BioGRIDi | 111345, 111 interactors |
ComplexPortali | CPX-487, uPA-uPAR complex CPX-501, uPA-uPAR-vitronectin complex |
CORUMi | Q03405 |
DIPi | DIP-137N |
IntActi | Q03405, 69 interactors |
STRINGi | 9606.ENSP00000339328 |
Chemistry databases
BindingDBi | Q03405 |
Miscellaneous databases
RNActi | Q03405, protein |
Structurei
Secondary structure
3D structure databases
SASBDBi | Q03405 |
SMRi | Q03405 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q03405 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 114 | UPAR/Ly6 1Add BLAST | 92 | |
Domaini | 115 – 213 | UPAR/Ly6 2Add BLAST | 99 | |
Domaini | 214 – 305 | UPAR/Ly6 3Add BLAST | 92 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502S36D, Eukaryota |
GeneTreei | ENSGT00940000153599 |
HOGENOMi | CLU_072612_0_0_1 |
InParanoidi | Q03405 |
OMAi | CATASWC |
OrthoDBi | 1102918at2759 |
PhylomeDBi | Q03405 |
TreeFami | TF338662 |
Family and domain databases
CDDi | cd00117, LU, 3 hits |
InterProi | View protein in InterPro IPR018363, CD59_antigen_CS IPR016054, LY6_UPA_recep-like IPR033084, U-PAR |
PANTHERi | PTHR10624:SF6, PTHR10624:SF6, 1 hit |
Pfami | View protein in Pfam PF00021, UPAR_LY6, 2 hits |
SMARTi | View protein in SMART SM00134, LU, 3 hits |
PROSITEi | View protein in PROSITE PS00983, LY6_UPAR, 3 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI
60 70 80 90 100
VRLWEEGEEL ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ
110 120 130 140 150
GNSGRAVTYS RSRYLECISC GSSDMSCERG RHQSLQCRSP EEQCLDVVTH
160 170 180 190 200
WIQEGEEGRP KDDRHLRGCG YLPGCPGSNG FHNNDTFHFL KCCNTTKCNE
210 220 230 240 250
GPILELENLP QNGRQCYSCK GNSTHGCSSE ETFLIDCRGP MNQCLVATGT
260 270 280 290 300
HEPKNQSYMV RGCATASMCQ HAHLGDAFSM NHIDVSCCTK SGCNHPDLDV
310 320 330
QYRSGAAPQP GPAHLSLTIT LLMTARLWGG TLLWT
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R1I2 | M0R1I2_HUMAN | Urokinase plasminogen activator sur... | PLAUR | 286 | Annotation score: | ||
M0R383 | M0R383_HUMAN | Urokinase plasminogen activator sur... | PLAUR | 154 | Annotation score: | ||
M0QX27 | M0QX27_HUMAN | Urokinase plasminogen activator sur... | PLAUR | 78 | Annotation score: | ||
M0QYS6 | M0QYS6_HUMAN | Urokinase plasminogen activator sur... | PLAUR | 133 | Annotation score: | ||
M0R0H5 | M0R0H5_HUMAN | Urokinase plasminogen activator sur... | PLAUR | 152 | Annotation score: | ||
M0R0L1 | M0R0L1_HUMAN | Urokinase plasminogen activator sur... | PLAUR | 46 | Annotation score: | ||
M0QYR6 | M0QYR6_HUMAN | Urokinase plasminogen activator sur... | PLAUR | 226 | Annotation score: | ||
M0R0Y4 | M0R0Y4_HUMAN | Urokinase plasminogen activator sur... | PLAUR | 185 | Annotation score: | ||
M0R2E9 | M0R2E9_HUMAN | Urokinase plasminogen activator sur... | PLAUR | 152 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 28 | C → N AA sequence (PubMed:1689240).Curated | 1 | ||
Sequence conflicti | 165 | H → P in AAK31795 (Ref. 13) Curated | 1 | ||
Sequence conflicti | 213 | G → E AA sequence (PubMed:7539799).Curated | 1 | ||
Sequence conflicti | 249 | G → D in AAF71751 (PubMed:11051819).Curated | 1 | ||
Sequence conflicti | 252 | E → G in AAF71751 (PubMed:11051819).Curated | 1 | ||
Isoform 3 (identifier: Q03405-3) | |||||
Sequence conflicti | 158 | V → I no nucleotide entry (PubMed:8131971).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016322 | 55 | E → G1 PublicationCorresponds to variant dbSNP:rs4251813Ensembl. | 1 | |
Natural variantiVAR_016323 | 86 | T → A1 PublicationCorresponds to variant dbSNP:rs399145Ensembl. | 1 | |
Natural variantiVAR_016324 | 105 | R → Q1 PublicationCorresponds to variant dbSNP:rs4251878Ensembl. | 1 | |
Natural variantiVAR_016325 | 220 | K → R1 PublicationCorresponds to variant dbSNP:rs2302524Ensembl. | 1 | |
Natural variantiVAR_016326 | 281 | N → K1 PublicationCorresponds to variant dbSNP:rs4251921Ensembl. | 1 | |
Natural variantiVAR_052698 | 297 | D → A. Corresponds to variant dbSNP:rs16976608Ensembl. | 1 | |
Natural variantiVAR_014922 | 317 | L → P1 PublicationCorresponds to variant dbSNP:rs4760Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046345 | 158 – 202 | Missing in isoform 3. 2 PublicationsAdd BLAST | 45 | |
Alternative sequenceiVSP_046346 | 203 | I → V in isoform 3. 2 Publications | 1 | |
Alternative sequenceiVSP_006715 | 253 – 335 | PKNQS…TLLWT → RSLWGSWLPCKSTTALRPPC CEEAQATHV in isoform 2. 2 PublicationsAdd BLAST | 83 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000221264; ENSP00000221264; ENSG00000011422 [Q03405-3] ENST00000339082; ENSP00000342049; ENSG00000011422 [Q03405-2] ENST00000340093; ENSP00000339328; ENSG00000011422 [Q03405-1] |
GeneIDi | 5329 |
KEGGi | hsa:5329 |
UCSCi | uc002oxd.3, human [Q03405-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1YWH | X-ray | 2.70 | A/C/E/G/I/K/M/O | 23-335 | [»] | |
2FD6 | X-ray | 1.90 | U | 23-297 | [»] | |
2I9B | X-ray | 2.80 | E/F/G/H | 23-299 | [»] | |
3BT1 | X-ray | 2.80 | U | 23-303 | [»] | |
3BT2 | X-ray | 2.50 | U | 23-303 | [»] | |
3U73 | X-ray | 3.19 | U | 23-305 | [»] | |
3U74 | X-ray | 2.39 | U | 23-305 | [»] | |
4K24 | X-ray | 4.50 | U | 23-303 | [»] | |
4QTI | X-ray | 3.00 | U | 23-305 | [»] | |
SASBDBi | Q03405 | |||||
SMRi | Q03405 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111345, 111 interactors |
ComplexPortali | CPX-487, uPA-uPAR complex CPX-501, uPA-uPAR-vitronectin complex |
CORUMi | Q03405 |
DIPi | DIP-137N |
IntActi | Q03405, 69 interactors |
STRINGi | 9606.ENSP00000339328 |
Chemistry databases
BindingDBi | Q03405 |
ChEMBLi | CHEMBL4883 |
DrugBanki | DB00009, Alteplase DB06245, Lanoteplase DB00031, Tenecteplase DB00013, Urokinase DB05476, WX-UK1 |
PTM databases
GlyGeni | Q03405, 5 sites |
iPTMneti | Q03405 |
PhosphoSitePlusi | Q03405 |
SwissPalmi | Q03405 |
Polymorphism and mutation databases
BioMutai | PLAUR |
DMDMi | 465003 |
Proteomic databases
EPDi | Q03405 |
jPOSTi | Q03405 |
MassIVEi | Q03405 |
MaxQBi | Q03405 |
PaxDbi | Q03405 |
PeptideAtlasi | Q03405 |
PRIDEi | Q03405 |
ProteomicsDBi | 58208 [Q03405-1] 58209 [Q03405-2] 58210 [Q03405-3] |
Protocols and materials databases
ABCDi | Q03405, 18 sequenced antibodies |
Antibodypediai | 31096, 597 antibodies |
DNASUi | 5329 |
Genome annotation databases
Ensembli | ENST00000221264; ENSP00000221264; ENSG00000011422 [Q03405-3] ENST00000339082; ENSP00000342049; ENSG00000011422 [Q03405-2] ENST00000340093; ENSP00000339328; ENSG00000011422 [Q03405-1] |
GeneIDi | 5329 |
KEGGi | hsa:5329 |
UCSCi | uc002oxd.3, human [Q03405-1] |
Organism-specific databases
CTDi | 5329 |
DisGeNETi | 5329 |
EuPathDBi | HostDB:ENSG00000011422.11 |
GeneCardsi | PLAUR |
HGNCi | HGNC:9053, PLAUR |
HPAi | ENSG00000011422, Tissue enhanced (blood, bone marrow) |
MIMi | 173391, gene |
neXtProti | NX_Q03405 |
OpenTargetsi | ENSG00000011422 |
PharmGKBi | PA33383 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S36D, Eukaryota |
GeneTreei | ENSGT00940000153599 |
HOGENOMi | CLU_072612_0_0_1 |
InParanoidi | Q03405 |
OMAi | CATASWC |
OrthoDBi | 1102918at2759 |
PhylomeDBi | Q03405 |
TreeFami | TF338662 |
Enzyme and pathway databases
PathwayCommonsi | Q03405 |
Reactomei | R-HSA-162791, Attachment of GPI anchor to uPAR R-HSA-6798695, Neutrophil degranulation R-HSA-75205, Dissolution of Fibrin Clot |
SIGNORi | Q03405 |
Miscellaneous databases
BioGRID-ORCSi | 5329, 5 hits in 844 CRISPR screens |
ChiTaRSi | PLAUR, human |
EvolutionaryTracei | Q03405 |
GeneWikii | Urokinase_receptor |
GenomeRNAii | 5329 |
Pharosi | Q03405, Tchem |
PROi | PR:Q03405 |
RNActi | Q03405, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000011422, Expressed in bone marrow and 232 other tissues |
ExpressionAtlasi | Q03405, baseline and differential |
Genevisiblei | Q03405, HS |
Family and domain databases
CDDi | cd00117, LU, 3 hits |
InterProi | View protein in InterPro IPR018363, CD59_antigen_CS IPR016054, LY6_UPA_recep-like IPR033084, U-PAR |
PANTHERi | PTHR10624:SF6, PTHR10624:SF6, 1 hit |
Pfami | View protein in Pfam PF00021, UPAR_LY6, 2 hits |
SMARTi | View protein in SMART SM00134, LU, 3 hits |
PROSITEi | View protein in PROSITE PS00983, LY6_UPAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UPAR_HUMAN | |
Accessioni | Q03405Primary (citable) accession number: Q03405 Secondary accession number(s): A8K409 Q9UMV0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 207 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries