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UniProtKB - Q03405 (UPAR_HUMAN)

Entry version 211 (29 Sep 2021)
Sequence version 1 (01 Feb 1994)
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Protein

Urokinase plasminogen activator surface receptor

Gene

PLAUR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q03405

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-162791, Attachment of GPI anchor to uPAR
R-HSA-6798695, Neutrophil degranulation
R-HSA-75205, Dissolution of Fibrin Clot

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q03405

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Urokinase plasminogen activator surface receptor
Short name:
U-PAR
Short name:
uPAR
Alternative name(s):
Monocyte activation antigen Mo3
CD_antigen: CD87
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLAUR
Synonyms:MO3, UPAR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9053, PLAUR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		173391, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q03405

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000011422

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5329

Open Targets

More...OpenTargetsi		ENSG00000011422

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33383

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q03405, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4883

Drug and drug target database

More...DrugBanki		DB00009, Alteplase
DB06245, Lanoteplase
DB00031, Tenecteplase
DB00013, Urokinase
DB05476, WX-UK1

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PLAUR

Domain mapping of disease mutations (DMDM)

More...DMDMi		465003

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003609023 – 305Urokinase plasminogen activator surface receptorAdd BLAST283
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000036091306 – 335Removed in mature formSequence analysisAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 463 Publications
Disulfide bondi28 ↔ 343 Publications
Disulfide bondi39 ↔ 673 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi74N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi93 ↔ 983 Publications
Disulfide bondi117 ↔ 1443 Publications
Disulfide bondi120 ↔ 1273 Publications
Disulfide bondi137 ↔ 1693 Publications
Disulfide bondi175 ↔ 1923 Publications
Glycosylationi184N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi193 ↔ 1983 Publications
Glycosylationi194N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi216 ↔ 2443 Publications
Disulfide bondi219 ↔ 2273 Publications
Glycosylationi222N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi237 ↔ 2633 Publications
Glycosylationi255N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi269 ↔ 2873 Publications
Disulfide bondi288 ↔ 2933 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi305GPI-anchor amidated glycineSequence analysis1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei105 – 106Cleavage; by U-PA2
Sitei111 – 112Cleavage; by U-PA2

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q03405

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q03405

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q03405

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q03405

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q03405

PeptideAtlas

More...PeptideAtlasi		Q03405

PRoteomics IDEntifications database

More...PRIDEi		Q03405

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58208 [Q03405-1]
58209 [Q03405-2]
58210 [Q03405-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q03405, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q03405

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q03405

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q03405

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000011422, Expressed in bone marrow and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q03405, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q03405, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000011422, Tissue enhanced (blood, bone marrow)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (Probable).

Interacts with MRC2.

Interacts (via the UPAR/Ly6 domains) with SRPX2.

Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane.

Interacts with SORL1 (via N-terminal ectodomain); this interaction decreases PLAUR internalization (PubMed:14764453, PubMed:23486467). The ternary complex composed of PLAUR-PLAU-SERPINE1 also interacts with SORL1 (PubMed:15053742).

Curated9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111345, 114 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-487, uPA-uPAR complex
CPX-501, uPA-uPAR-vitronectin complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q03405

Database of interacting proteins

More...DIPi		DIP-137N

Protein interaction database and analysis system

More...IntActi		Q03405, 73 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000339328

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q03405

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q03405, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1335
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Small Angle Scattering Biological Data Bank

More...SASBDBi		Q03405

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q03405

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q03405

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 114UPAR/Ly6 1Add BLAST92
Domaini115 – 213UPAR/Ly6 2Add BLAST99
Domaini214 – 305UPAR/Ly6 3Add BLAST92

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S36D, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153599

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_072612_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q03405

Identification of Orthologs from Complete Genome Data

More...OMAi		CATASWC

Database of Orthologous Groups

More...OrthoDBi		1102918at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q03405

TreeFam database of animal gene trees

More...TreeFami		TF338662

Family and domain databases

Conserved Domains Database

More...CDDi		cd00117, LU, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018363, CD59_antigen_CS
IPR016054, LY6_UPA_recep-like
IPR033084, U-PAR

The PANTHER Classification System

More...PANTHERi		PTHR10624:SF6, PTHR10624:SF6, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00021, UPAR_LY6, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00134, LU, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00983, LY6_UPAR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q03405-1) [UniParc]FASTAAdd to basket
Also known as: uPAR1, GPI-anchored

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI 
        60         70         80         90        100
VRLWEEGEEL ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ 
       110        120        130        140        150
GNSGRAVTYS RSRYLECISC GSSDMSCERG RHQSLQCRSP EEQCLDVVTH 
       160        170        180        190        200
WIQEGEEGRP KDDRHLRGCG YLPGCPGSNG FHNNDTFHFL KCCNTTKCNE 
       210        220        230        240        250
GPILELENLP QNGRQCYSCK GNSTHGCSSE ETFLIDCRGP MNQCLVATGT 
       260        270        280        290        300
HEPKNQSYMV RGCATASMCQ HAHLGDAFSM NHIDVSCCTK SGCNHPDLDV 
       310        320        330 
QYRSGAAPQP GPAHLSLTIT LLMTARLWGG TLLWT
Length:335
Mass (Da):36,978
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB1963EA3DC77171
GO
Isoform 2 (identifier: Q03405-2) [UniParc]FASTAAdd to basket
Also known as: uPAR2, Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     253-335: PKNQSYMVRG...RLWGGTLLWT → RSLWGSWLPCKSTTALRPPCCEEAQATHV

Show »
Length:281
Mass (Da):31,263
Checksum:iE6C580F279FB0316
GO
Isoform 3 (identifier: Q03405-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-202: Missing.
     203-203: I → V

Show »
Length:290
Mass (Da):32,016
Checksum:i60F14E2A2AFB67AC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R1I2M0R1I2_HUMAN
Urokinase plasminogen activator sur...
PLAUR
286Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX27M0QX27_HUMAN
Urokinase plasminogen activator sur...
PLAUR
78Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R383M0R383_HUMAN
Urokinase plasminogen activator sur...
PLAUR
154Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYS6M0QYS6_HUMAN
Urokinase plasminogen activator sur...
PLAUR
133Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0H5M0R0H5_HUMAN
Urokinase plasminogen activator sur...
PLAUR
152Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYR6M0QYR6_HUMAN
Urokinase plasminogen activator sur...
PLAUR
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0Y4M0R0Y4_HUMAN
Urokinase plasminogen activator sur...
PLAUR
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2E9M0R2E9_HUMAN
Urokinase plasminogen activator sur...
PLAUR
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0L1M0R0L1_HUMAN
Urokinase plasminogen activator sur...
PLAUR
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28C → N AA sequence (PubMed:1689240).Curated1
Sequence conflicti165H → P in AAK31795 (Ref. 13) Curated1
Sequence conflicti213G → E AA sequence (PubMed:7539799).Curated1
Sequence conflicti249G → D in AAF71751 (PubMed:11051819).Curated1
Sequence conflicti252E → G in AAF71751 (PubMed:11051819).Curated1
Isoform 3 (identifier: Q03405-3)
Sequence conflicti158V → I no nucleotide entry (PubMed:8131971).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01632255E → G1 PublicationCorresponds to variant dbSNP:rs4251813Ensembl.1
Natural variantiVAR_01632386T → A1 PublicationCorresponds to variant dbSNP:rs399145Ensembl.1
Natural variantiVAR_016324105R → Q1 PublicationCorresponds to variant dbSNP:rs4251878Ensembl.1
Natural variantiVAR_016325220K → R1 PublicationCorresponds to variant dbSNP:rs2302524Ensembl.1
Natural variantiVAR_016326281N → K1 PublicationCorresponds to variant dbSNP:rs4251921Ensembl.1
Natural variantiVAR_052698297D → A. Corresponds to variant dbSNP:rs16976608Ensembl.1
Natural variantiVAR_014922317L → P1 PublicationCorresponds to variant dbSNP:rs4760Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_046345158 – 202Missing in isoform 3. 2 PublicationsAdd BLAST45
Alternative sequenceiVSP_046346203I → V in isoform 3. 2 Publications1
Alternative sequenceiVSP_006715253 – 335PKNQS…TLLWT → RSLWGSWLPCKSTTALRPPC CEEAQATHV in isoform 2. 2 PublicationsAdd BLAST83

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X51675 mRNA Translation: CAA35981.1
M83246 mRNA Translation: AAA59862.1
X74039 mRNA Translation: CAA52191.1
U09346 Genomic DNA Translation: AAA17979.1
U09347 mRNA Translation: AAA17978.1
U08839 mRNA Translation: AAB60333.1
U09937 U09936 Genomic DNA Translation: AAB60690.1
AY194849 Genomic DNA Translation: AAN86351.1
AK290774 mRNA Translation: BAF83463.1
CR456952 mRNA Translation: CAG33233.1
AC005525 Genomic DNA Translation: AAC32739.1
AC006953 Genomic DNA Translation: AAD17387.1
AC006953 Genomic DNA Translation: AAD17388.1
CH471126 Genomic DNA Translation: EAW57220.1
BC002788 mRNA Translation: AAH02788.1
AF257789 mRNA Translation: AAF71751.1
AY029180 mRNA Translation: AAK31795.1
S78532 Genomic DNA Translation: AAD14289.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12628.1 [Q03405-1]
CCDS33041.1 [Q03405-2]
CCDS33042.1 [Q03405-3]

Protein sequence database of the Protein Information Resource

More...PIRi		I52614
S12376, A39743
S39495

NCBI Reference Sequences

More...RefSeqi		NP_001005376.1, NM_001005376.2 [Q03405-2]
NP_001005377.1, NM_001005377.2 [Q03405-3]
NP_001287966.1, NM_001301037.1
NP_002650.1, NM_002659.3 [Q03405-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000221264; ENSP00000221264; ENSG00000011422 [Q03405-3]
ENST00000339082; ENSP00000342049; ENSG00000011422 [Q03405-2]
ENST00000340093; ENSP00000339328; ENSG00000011422 [Q03405-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5329

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5329

UCSC genome browser

More...UCSCi		uc002oxd.3, human [Q03405-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51675 mRNA Translation: CAA35981.1
M83246 mRNA Translation: AAA59862.1
X74039 mRNA Translation: CAA52191.1
U09346 Genomic DNA Translation: AAA17979.1
U09347 mRNA Translation: AAA17978.1
U08839 mRNA Translation: AAB60333.1
U09937 U09936 Genomic DNA Translation: AAB60690.1
AY194849 Genomic DNA Translation: AAN86351.1
AK290774 mRNA Translation: BAF83463.1
CR456952 mRNA Translation: CAG33233.1
AC005525 Genomic DNA Translation: AAC32739.1
AC006953 Genomic DNA Translation: AAD17387.1
AC006953 Genomic DNA Translation: AAD17388.1
CH471126 Genomic DNA Translation: EAW57220.1
BC002788 mRNA Translation: AAH02788.1
AF257789 mRNA Translation: AAF71751.1
AY029180 mRNA Translation: AAK31795.1
S78532 Genomic DNA Translation: AAD14289.1
CCDSiCCDS12628.1 [Q03405-1]
CCDS33041.1 [Q03405-2]
CCDS33042.1 [Q03405-3]
PIRiI52614
S12376, A39743
S39495
RefSeqiNP_001005376.1, NM_001005376.2 [Q03405-2]
NP_001005377.1, NM_001005377.2 [Q03405-3]
NP_001287966.1, NM_001301037.1
NP_002650.1, NM_002659.3 [Q03405-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YWHX-ray2.70A/C/E/G/I/K/M/O23-335[»]
2FD6X-ray1.90U23-297[»]
2I9BX-ray2.80E/F/G/H23-299[»]
3BT1X-ray2.80U23-303[»]
3BT2X-ray2.50U23-303[»]
3U73X-ray3.19U23-305[»]
3U74X-ray2.39U23-305[»]
4K24X-ray4.50U23-303[»]
4QTIX-ray3.00U23-305[»]
SASBDBiQ03405
SMRiQ03405
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111345, 114 interactors
ComplexPortaliCPX-487, uPA-uPAR complex
CPX-501, uPA-uPAR-vitronectin complex
CORUMiQ03405
DIPiDIP-137N
IntActiQ03405, 73 interactors
STRINGi9606.ENSP00000339328

Chemistry databases

BindingDBiQ03405
ChEMBLiCHEMBL4883
DrugBankiDB00009, Alteplase
DB06245, Lanoteplase
DB00031, Tenecteplase
DB00013, Urokinase
DB05476, WX-UK1

PTM databases

GlyGeniQ03405, 5 sites
iPTMnetiQ03405
PhosphoSitePlusiQ03405
SwissPalmiQ03405

Genetic variation databases

BioMutaiPLAUR
DMDMi465003

Proteomic databases

EPDiQ03405
jPOSTiQ03405
MassIVEiQ03405
MaxQBiQ03405
PaxDbiQ03405
PeptideAtlasiQ03405
PRIDEiQ03405
ProteomicsDBi58208 [Q03405-1]
58209 [Q03405-2]
58210 [Q03405-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q03405, 18 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31096, 644 antibodies

The DNASU plasmid repository

More...DNASUi		5329

Genome annotation databases

EnsembliENST00000221264; ENSP00000221264; ENSG00000011422 [Q03405-3]
ENST00000339082; ENSP00000342049; ENSG00000011422 [Q03405-2]
ENST00000340093; ENSP00000339328; ENSG00000011422 [Q03405-1]
GeneIDi5329
KEGGihsa:5329
UCSCiuc002oxd.3, human [Q03405-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5329
DisGeNETi5329

GeneCards: human genes, protein and diseases

More...GeneCardsi		PLAUR
HGNCiHGNC:9053, PLAUR
HPAiENSG00000011422, Tissue enhanced (blood, bone marrow)
MIMi173391, gene
neXtProtiNX_Q03405
OpenTargetsiENSG00000011422
PharmGKBiPA33383
VEuPathDBiHostDB:ENSG00000011422

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S36D, Eukaryota
GeneTreeiENSGT00940000153599
HOGENOMiCLU_072612_0_0_1
InParanoidiQ03405
OMAiCATASWC
OrthoDBi1102918at2759
PhylomeDBiQ03405
TreeFamiTF338662

Enzyme and pathway databases

PathwayCommonsiQ03405
ReactomeiR-HSA-162791, Attachment of GPI anchor to uPAR
R-HSA-6798695, Neutrophil degranulation
R-HSA-75205, Dissolution of Fibrin Clot
SIGNORiQ03405

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5329, 6 hits in 1017 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PLAUR, human
EvolutionaryTraceiQ03405

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Urokinase_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5329
PharosiQ03405, Tchem

Protein Ontology

More...PROi		PR:Q03405
RNActiQ03405, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000011422, Expressed in bone marrow and 233 other tissues
ExpressionAtlasiQ03405, baseline and differential
GenevisibleiQ03405, HS

Family and domain databases

CDDicd00117, LU, 3 hits
InterProiView protein in InterPro
IPR018363, CD59_antigen_CS
IPR016054, LY6_UPA_recep-like
IPR033084, U-PAR
PANTHERiPTHR10624:SF6, PTHR10624:SF6, 1 hit
PfamiView protein in Pfam
PF00021, UPAR_LY6, 2 hits
SMARTiView protein in SMART
SM00134, LU, 3 hits
PROSITEiView protein in PROSITE
PS00983, LY6_UPAR, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUPAR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03405
Secondary accession number(s): A8K409
, Q12876, Q15845, Q16887, Q6IB52, Q9BWT0, Q9NYC8, Q9UD69, Q9UEA6, Q9UM92, Q9UMV0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 29, 2021
This is version 211 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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