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Protein

Trefoil factor 2

Gene

TFF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 2
Alternative name(s):
Spasmolysin
Spasmolytic polypeptide
Short name:
SP
Gene namesi
Name:TFF2
Synonyms:SML1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160181.8
HGNCiHGNC:11756 TFF2
MIMi182590 gene
neXtProtiNX_Q03403

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7032
OpenTargetsiENSG00000160181
PharmGKBiPA36471

Chemistry databases

DrugBankiDB03088 Pyroglutamic Acid

Polymorphism and mutation databases

BioMutaiTFF2
DMDMi2833194

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002346024 – 129Trefoil factor 2Add BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 127PROSITE-ProRule annotation
Disulfide bondi31 ↔ 58PROSITE-ProRule annotation
Disulfide bondi42 ↔ 57PROSITE-ProRule annotation
Disulfide bondi52 ↔ 69PROSITE-ProRule annotation
Disulfide bondi81 ↔ 107PROSITE-ProRule annotation
Disulfide bondi91 ↔ 106PROSITE-ProRule annotation
Disulfide bondi101 ↔ 118PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ03403
PeptideAtlasiQ03403
PRIDEiQ03403
ProteomicsDBi58207

PTM databases

iPTMnetiQ03403
PhosphoSitePlusiQ03403

Expressioni

Tissue specificityi

Stomach.

Gene expression databases

BgeeiENSG00000160181 Expressed in 94 organ(s), highest expression level in duodenum
CleanExiHS_TFF2
GenevisibleiQ03403 HS

Organism-specific databases

HPAiCAB025834
HPA036705

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FCRL4Q96PJ53EBI-4314702,EBI-4314687

Protein-protein interaction databases

BioGridi112890, 1 interactor
IntActiQ03403, 2 interactors
STRINGi9606.ENSP00000291526

Structurei

3D structure databases

ProteinModelPortaliQ03403
SMRiQ03403
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 73P-type 1PROSITE-ProRule annotationAdd BLAST45
Domaini79 – 122P-type 2PROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IZEH Eukaryota
ENOG410Y3PX LUCA
GeneTreeiENSGT00840000129881
HOGENOMiHOG000253928
HOVERGENiHBG004363
InParanoidiQ03403
KOiK22453
OMAiCVMEVSA
OrthoDBiEOG091G0XBT
PhylomeDBiQ03403
TreeFamiTF336092

Family and domain databases

CDDicd00111 Trefoil, 2 hits
InterProiView protein in InterPro
IPR017994 P_trefoil_chordata
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
PfamiView protein in Pfam
PF00088 Trefoil, 2 hits
PRINTSiPR00680 PTREFOIL
SMARTiView protein in SMART
SM00018 PD, 2 hits
PROSITEiView protein in PROSITE
PS00025 P_TREFOIL_1, 2 hits
PS51448 P_TREFOIL_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03403-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRRDAQLLA ALLVLGLCAL AGSEKPSPCQ CSRLSPHNRT NCGFPGITSD
60 70 80 90 100
QCFDNGCCFD SSVTGVPWCF HPLPKQESDQ CVMEVSDRRN CGYPGISPEE
110 120
CASRKCCFSN FIFEVPWCFF PKSVEDCHY
Length:129
Mass (Da):14,284
Last modified:November 1, 1997 - v2
Checksum:i6A296A11AD9CCC5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 19MGRRD…LGLCA → RHGTARRPAPGSAPRPGAMC (PubMed:2303034).CuratedAdd BLAST19
Sequence conflicti122K → N in CAA35995 (PubMed:2303034).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0535643R → W. Corresponds to variant dbSNP:rs7277409Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51698 mRNA Translation: CAA35995.1
U47292
, U47289, U47290, U47291 Genomic DNA Translation: AAB05397.1
AB038162 Genomic DNA Translation: BAB13730.1
BC032820 mRNA Translation: AAH32820.1
CCDSiCCDS13684.1
PIRiS12371
RefSeqiNP_005414.1, NM_005423.4
UniGeneiHs.2979

Genome annotation databases

EnsembliENST00000291526; ENSP00000291526; ENSG00000160181
GeneIDi7032
KEGGihsa:7032
UCSCiuc002zaw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51698 mRNA Translation: CAA35995.1
U47292
, U47289, U47290, U47291 Genomic DNA Translation: AAB05397.1
AB038162 Genomic DNA Translation: BAB13730.1
BC032820 mRNA Translation: AAH32820.1
CCDSiCCDS13684.1
PIRiS12371
RefSeqiNP_005414.1, NM_005423.4
UniGeneiHs.2979

3D structure databases

ProteinModelPortaliQ03403
SMRiQ03403
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112890, 1 interactor
IntActiQ03403, 2 interactors
STRINGi9606.ENSP00000291526

Chemistry databases

DrugBankiDB03088 Pyroglutamic Acid

PTM databases

iPTMnetiQ03403
PhosphoSitePlusiQ03403

Polymorphism and mutation databases

BioMutaiTFF2
DMDMi2833194

Proteomic databases

PaxDbiQ03403
PeptideAtlasiQ03403
PRIDEiQ03403
ProteomicsDBi58207

Protocols and materials databases

DNASUi7032
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291526; ENSP00000291526; ENSG00000160181
GeneIDi7032
KEGGihsa:7032
UCSCiuc002zaw.4 human

Organism-specific databases

CTDi7032
DisGeNETi7032
EuPathDBiHostDB:ENSG00000160181.8
GeneCardsiTFF2
HGNCiHGNC:11756 TFF2
HPAiCAB025834
HPA036705
MIMi182590 gene
neXtProtiNX_Q03403
OpenTargetsiENSG00000160181
PharmGKBiPA36471
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZEH Eukaryota
ENOG410Y3PX LUCA
GeneTreeiENSGT00840000129881
HOGENOMiHOG000253928
HOVERGENiHBG004363
InParanoidiQ03403
KOiK22453
OMAiCVMEVSA
OrthoDBiEOG091G0XBT
PhylomeDBiQ03403
TreeFamiTF336092

Miscellaneous databases

ChiTaRSiTFF2 human
GeneWikiiTrefoil_factor_2
GenomeRNAii7032
PROiPR:Q03403
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160181 Expressed in 94 organ(s), highest expression level in duodenum
CleanExiHS_TFF2
GenevisibleiQ03403 HS

Family and domain databases

CDDicd00111 Trefoil, 2 hits
InterProiView protein in InterPro
IPR017994 P_trefoil_chordata
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
PfamiView protein in Pfam
PF00088 Trefoil, 2 hits
PRINTSiPR00680 PTREFOIL
SMARTiView protein in SMART
SM00018 PD, 2 hits
PROSITEiView protein in PROSITE
PS00025 P_TREFOIL_1, 2 hits
PS51448 P_TREFOIL_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTFF2_HUMAN
AccessioniPrimary (citable) accession number: Q03403
Secondary accession number(s): Q15854
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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