UniProtKB - Q03401 (CRIS1_MOUSE)
Protein
Cysteine-rich secretory protein 1
Gene
Crisp1
Organism
Mus musculus (Mouse)
Status
Functioni
This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens.
Enzyme and pathway databases
Reactomei | R-MMU-6798695 Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Cysteine-rich secretory protein 1Short name: CRISP-1 Alternative name(s): Acidic epididymal glycoprotein 1 Sperm-coating glycoprotein 1 Short name: SCP 1 |
Gene namesi | Name:Crisp1 Synonyms:Aeg-1, Aeg1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102553 Crisp1 |
Subcellular locationi
Other locations
Note: Stored in secretory granules of granular convoluted tubules cells.
Extracellular region or secreted
- extracellular region Source: MGI
- extracellular space Source: GO_Central
Other locations
- transport vesicle Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasmic vesiclePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Add BLAST | 19 | |
ChainiPRO_0000006262 | 20 – 244 | Cysteine-rich secretory protein 1Add BLAST | 225 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 145 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 190 ↔ 197 | PROSITE-ProRule annotation | ||
Disulfide bondi | 193 ↔ 202 | PROSITE-ProRule annotation | ||
Disulfide bondi | 206 ↔ 239 | PROSITE-ProRule annotation | ||
Disulfide bondi | 215 ↔ 233 | PROSITE-ProRule annotation | ||
Disulfide bondi | 224 ↔ 237 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q03401 |
PeptideAtlasi | Q03401 |
PRIDEi | Q03401 |
PTM databases
iPTMneti | Q03401 |
PhosphoSitePlusi | Q03401 |
Expressioni
Tissue specificityi
Mainly found in the cauda epididymis where it is synthesized by the principal cells and secreted into the lumen. Binds to the heads of spermatozoa. Also expressed in the submandibular gland.
Developmental stagei
Exponential increase between days 25 and 30 after birth.
Inductioni
By androgens.
Gene expression databases
Bgeei | ENSMUSG00000025431 Expressed in 73 organ(s), highest expression level in parotid gland |
ExpressionAtlasi | Q03401 baseline and differential |
Genevisiblei | Q03401 MM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 170 | SCPAdd BLAST | 127 | |
Domaini | 206 – 239 | ShKTPROSITE-ProRule annotationAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the CRISP family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3017 Eukaryota COG2340 LUCA |
GeneTreei | ENSGT00940000162013 |
HOGENOMi | HOG000236338 |
InParanoidi | Q03401 |
KOi | K19919 |
OMAi | ADPCSTG |
OrthoDBi | 1528782at2759 |
PhylomeDBi | Q03401 |
TreeFami | TF316148 |
Family and domain databases
CDDi | cd05383 CAP_CRISP, 1 hit |
Gene3Di | 1.10.10.740, 1 hit 3.40.33.10, 1 hit |
InterProi | View protein in InterPro IPR018244 Allrgn_V5/Tpx1_CS IPR014044 CAP_domain IPR035940 CAP_sf IPR042076 Crisp-like_dom IPR001283 CRISP-related IPR013871 Cysteine_rich_secretory IPR034117 SCP_CRISP IPR003582 ShKT_dom |
PANTHERi | PTHR10334 PTHR10334, 1 hit |
Pfami | View protein in Pfam PF00188 CAP, 1 hit PF08562 Crisp, 1 hit |
PRINTSi | PR00837 V5TPXLIKE |
SMARTi | View protein in SMART SM00198 SCP, 1 hit |
SUPFAMi | SSF55797 SSF55797, 1 hit |
PROSITEi | View protein in PROSITE PS01009 CRISP_1, 1 hit PS01010 CRISP_2, 1 hit PS51670 SHKT, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q03401-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALMLVLFFL AAVLPPSLLQ DSSQENRLEK LSTTKMSVQE EIVSKHNQLR
60 70 80 90 100
RMVSPSGSDL LKMEWNYDAQ VNAQQWADKC TFSHSPIELR TTNLRCGENL
110 120 130 140 150
FMSSYLASWS SAIQGWYNEY KDLTYDVGPK QPDSVVGHYT QVVWNSTFQV
160 170 180 190 200
ACGVAECPKN PLRYYYVCHY CPVGNYQGRL YTPYTAGEPC ASCPDHCEDG
210 220 230 240
LCTNSCGHED KYTNCKYLKK MLSCEHELLK KGCKATCLCE GKIH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M92849 mRNA Translation: AAA37185.1 L05559 mRNA Translation: AAA37460.1 |
CCDSi | CCDS28784.1 |
PIRi | A49202 |
RefSeqi | NP_033768.3, NM_009638.3 |
Genome annotation databases
Ensembli | ENSMUST00000026498; ENSMUSP00000026498; ENSMUSG00000025431 |
GeneIDi | 11571 |
KEGGi | mmu:11571 |
UCSCi | uc008coh.2 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M92849 mRNA Translation: AAA37185.1 L05559 mRNA Translation: AAA37460.1 |
CCDSi | CCDS28784.1 |
PIRi | A49202 |
RefSeqi | NP_033768.3, NM_009638.3 |
3D structure databases
SMRi | Q03401 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000026498 |
PTM databases
iPTMneti | Q03401 |
PhosphoSitePlusi | Q03401 |
Proteomic databases
PaxDbi | Q03401 |
PeptideAtlasi | Q03401 |
PRIDEi | Q03401 |
Genome annotation databases
Ensembli | ENSMUST00000026498; ENSMUSP00000026498; ENSMUSG00000025431 |
GeneIDi | 11571 |
KEGGi | mmu:11571 |
UCSCi | uc008coh.2 mouse |
Organism-specific databases
CTDi | 167 |
MGIi | MGI:102553 Crisp1 |
Phylogenomic databases
eggNOGi | KOG3017 Eukaryota COG2340 LUCA |
GeneTreei | ENSGT00940000162013 |
HOGENOMi | HOG000236338 |
InParanoidi | Q03401 |
KOi | K19919 |
OMAi | ADPCSTG |
OrthoDBi | 1528782at2759 |
PhylomeDBi | Q03401 |
TreeFami | TF316148 |
Enzyme and pathway databases
Reactomei | R-MMU-6798695 Neutrophil degranulation |
Miscellaneous databases
ChiTaRSi | Crisp1 mouse |
PROi | PR:Q03401 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025431 Expressed in 73 organ(s), highest expression level in parotid gland |
ExpressionAtlasi | Q03401 baseline and differential |
Genevisiblei | Q03401 MM |
Family and domain databases
CDDi | cd05383 CAP_CRISP, 1 hit |
Gene3Di | 1.10.10.740, 1 hit 3.40.33.10, 1 hit |
InterProi | View protein in InterPro IPR018244 Allrgn_V5/Tpx1_CS IPR014044 CAP_domain IPR035940 CAP_sf IPR042076 Crisp-like_dom IPR001283 CRISP-related IPR013871 Cysteine_rich_secretory IPR034117 SCP_CRISP IPR003582 ShKT_dom |
PANTHERi | PTHR10334 PTHR10334, 1 hit |
Pfami | View protein in Pfam PF00188 CAP, 1 hit PF08562 Crisp, 1 hit |
PRINTSi | PR00837 V5TPXLIKE |
SMARTi | View protein in SMART SM00198 SCP, 1 hit |
SUPFAMi | SSF55797 SSF55797, 1 hit |
PROSITEi | View protein in PROSITE PS01009 CRISP_1, 1 hit PS01010 CRISP_2, 1 hit PS51670 SHKT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CRIS1_MOUSE | |
Accessioni | Q03401Primary (citable) accession number: Q03401 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | October 16, 2019 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot