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UniProtKB - Q03393 (PTPS_HUMAN)
Protein
6-pyruvoyl tetrahydrobiopterin synthase
Gene
PTS
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
1 PublicationMiscellaneous
The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit.
Catalytic activityi
- 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H+ + triphosphate1 PublicationEC:4.2.3.121 Publication
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Kineticsi
- KM=8.1 µM for 7,8-dihydroneopterin triphosphate1 Publication
- Vmax=120 nmol/min/mg enzyme1 Publication
: tetrahydrobiopterin biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate. This subpathway is part of the pathway tetrahydrobiopterin biosynthesis, which is itself part of Cofactor biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrobiopterin biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 24 | ZincPROSITE-ProRule annotation | 1 | |
Active sitei | 43 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Metal bindingi | 49 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 51 | ZincPROSITE-ProRule annotation | 1 | |
Active sitei | 90 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 134 | Charge relay systemPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 6-pyruvoyltetrahydropterin synthase activity Source: ProtInc
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cellular amino acid metabolic process Source: ProtInc
- central nervous system development Source: ProtInc
- tetrahydrobiopterin biosynthetic process Source: ProtInc
Keywordsi
Molecular function | Lyase |
Biological process | Tetrahydrobiopterin biosynthesis |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 4.2.3.12, 2681 |
PathwayCommonsi | Q03393 |
Reactomei | R-HSA-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
SABIO-RKi | Q03393 |
SignaLinki | Q03393 |
SIGNORi | Q03393 |
UniPathwayi | UPA00849;UER00819 |
Names & Taxonomyi
Protein namesi | Recommended name: 6-pyruvoyl tetrahydrobiopterin synthase (EC:4.2.3.12)Short name: PTP synthase Short name: PTPS |
Gene namesi | Name:PTS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9689, PTS |
MIMi | 612719, gene |
neXtProti | NX_Q03393 |
VEuPathDBi | HostDB:ENSG00000150787 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrion Source: LIFEdb
Other locations
- cytoplasm Source: LIFEdb
Pathology & Biotechi
Involvement in diseasei
Hyperphenylalaninemia, BH4-deficient, A (HPABH4A)12 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by hyperphenylalaninemia, depletion of the neurotransmitters dopamine and serotonin, and progressive cognitive and motor deficits. Neurological symptoms are unresponsive to the classic phenylalanine-low diet.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_006816 | 16 | R → C in HPABH4A; severe decrease in activity; diminishes phosphorylation by PKG. 3 PublicationsCorresponds to variant dbSNP:rs104894274EnsemblClinVar. | 1 | |
Natural variantiVAR_006817 | 25 | R → G in HPABH4A; severe form. 1 PublicationCorresponds to variant dbSNP:rs1167104933EnsemblClinVar. | 1 | |
Natural variantiVAR_006818 | 25 | R → Q in HPABH4A; abolishes activity; no effect on phosphorylation by PKG. 3 PublicationsCorresponds to variant dbSNP:rs104894273EnsemblClinVar. | 1 | |
Natural variantiVAR_058265 | 26 | L → F in HPABH4A. 1 PublicationCorresponds to variant dbSNP:rs1317230624Ensembl. | 1 | |
Natural variantiVAR_006819 | 35 | E → G in HPABH4A. Corresponds to variant dbSNP:rs1328320990Ensembl. | 1 | |
Natural variantiVAR_006820 | 36 | N → K in HPABH4A. Corresponds to variant dbSNP:rs1449216377EnsemblClinVar. | 1 | |
Natural variantiVAR_008040 | 47 | N → D in HPABH4A; transient phenotype due to partial PTS deficiency; total loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104894278EnsemblClinVar. | 1 | |
Natural variantiVAR_006821 | 52 | N → S in HPABH4A; severe form. 2 PublicationsCorresponds to variant dbSNP:rs104894275EnsemblClinVar. | 1 | |
Natural variantiVAR_006822 | 56 | V → M in HPABH4A; mild form. 1 PublicationCorresponds to variant dbSNP:rs104894277EnsemblClinVar. | 1 | |
Natural variantiVAR_006823 | 57 | Missing in HPABH4A. 3 PublicationsCorresponds to variant dbSNP:rs770387277Ensembl. | 1 | |
Natural variantiVAR_006824 | 67 | T → M in HPABH4A. 2 PublicationsCorresponds to variant dbSNP:rs370340361EnsemblClinVar. | 1 | |
Natural variantiVAR_006825 | 70 | V → D in HPABH4A. 1 PublicationCorresponds to variant dbSNP:rs1592880489EnsemblClinVar. | 1 | |
Natural variantiVAR_006826 | 87 | P → L in HPABH4A. 2 PublicationsCorresponds to variant dbSNP:rs765406631EnsemblClinVar. | 1 | |
Natural variantiVAR_006827 | 87 | P → S in HPABH4A; severe form. 2 PublicationsCorresponds to variant dbSNP:rs104894276EnsemblClinVar. | 1 | |
Natural variantiVAR_006828 | 96 | D → N in HPABH4A; severe form. 1 PublicationCorresponds to variant dbSNP:rs104894280EnsemblClinVar. | 1 | |
Natural variantiVAR_058266 | 97 | V → M in HPABH4A. 1 PublicationCorresponds to variant dbSNP:rs750455879EnsemblClinVar. | 1 | |
Natural variantiVAR_058267 | 99 | Y → C in HPABH4A. 1 PublicationCorresponds to variant dbSNP:rs1555198458EnsemblClinVar. | 1 | |
Natural variantiVAR_006829 | 100 | F → V in HPABH4A. | 1 | |
Natural variantiVAR_006830 | 106 | T → M in HPABH4A. 1 PublicationCorresponds to variant dbSNP:rs200712908EnsemblClinVar. | 1 | |
Natural variantiVAR_006831 | 114 | I → V in HPABH4A. 2 PublicationsCorresponds to variant dbSNP:rs1555198495EnsemblClinVar. | 1 | |
Natural variantiVAR_008041 | 116 | D → G in HPABH4A; transient phenotype due to partial PTS deficiency; mild decrease of activity. 1 PublicationCorresponds to variant dbSNP:rs104894279EnsemblClinVar. | 1 | |
Natural variantiVAR_058268 | 124 | V → L in HPABH4A. 1 PublicationCorresponds to variant dbSNP:rs150726932EnsemblClinVar. | 1 | |
Natural variantiVAR_006832 | 129 | K → E in HPABH4A. 1 PublicationCorresponds to variant dbSNP:rs1040441824Ensembl. | 1 | |
Natural variantiVAR_058269 | 136 | D → G in HPABH4A. 1 Publication | 1 | |
Natural variantiVAR_006833 | 136 | D → V in HPABH4A. 2 Publications | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 19 | S → A: Decrease in activity; abolishes phosphorylation by PKG. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, PhenylketonuriaOrganism-specific databases
DisGeNETi | 5805 |
MalaCardsi | PTS |
MIMi | 261640, phenotype |
OpenTargetsi | ENSG00000150787 |
Orphaneti | 13, 6-pyruvoyl-tetrahydropterin synthase deficiency |
PharmGKBi | PA34032 |
Miscellaneous databases
Pharosi | Q03393, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4630823 |
DrugBanki | DB03886, Biopterin DB00688, Mycophenolate mofetil |
Genetic variation databases
BioMutai | PTS |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057914 | 1 – 145 | 6-pyruvoyl tetrahydrobiopterin synthaseAdd BLAST | 145 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | Phosphoserine; by PKGCombined sources1 Publication | 1 | |
Modified residuei | 28 | PhosphoserineBy similarity | 1 | |
Modified residuei | 128 | PhosphotyrosineCombined sources | 1 |
Post-translational modificationi
Phosphorylation of Ser-19 is required for maximal enzyme activity.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q03393 |
jPOSTi | Q03393 |
MassIVEi | Q03393 |
MaxQBi | Q03393 |
PaxDbi | Q03393 |
PeptideAtlasi | Q03393 |
PRIDEi | Q03393 |
ProteomicsDBi | 58205 |
TopDownProteomicsi | Q03393 |
PTM databases
iPTMneti | Q03393 |
PhosphoSitePlusi | Q03393 |
Expressioni
Gene expression databases
Bgeei | ENSG00000150787, Expressed in metanephros and 244 other tissues |
ExpressionAtlasi | Q03393, baseline and differential |
Genevisiblei | Q03393, HS |
Organism-specific databases
HPAi | ENSG00000150787, Low tissue specificity |
Interactioni
Subunit structurei
Homohexamer formed of two homotrimers in a head to head fashion.
Binary interactionsi
Q03393
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 111769, 44 interactors |
IntActi | Q03393, 20 interactors |
MINTi | Q03393 |
STRINGi | 9606.ENSP00000280362 |
Chemistry databases
BindingDBi | Q03393 |
Miscellaneous databases
RNActi | Q03393, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q03393 |
SMRi | Q03393 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q03393 |
Family & Domainsi
Sequence similaritiesi
Belongs to the PTPS family.Curated
Phylogenomic databases
eggNOGi | KOG4105, Eukaryota |
GeneTreei | ENSGT00390000002752 |
HOGENOMi | CLU_111016_2_0_1 |
InParanoidi | Q03393 |
OMAi | NVAIFIW |
OrthoDBi | 1502673at2759 |
PhylomeDBi | Q03393 |
TreeFami | TF105796 |
Family and domain databases
Gene3Di | 3.30.479.10, 1 hit |
InterProi | View protein in InterPro IPR007115, 6-PTP_synth/QueD IPR038418, 6-PTP_synth/QueD_sf IPR022470, PTPS_Cys_AS IPR022469, PTPS_His_AS |
PANTHERi | PTHR12589, PTHR12589, 1 hit |
Pfami | View protein in Pfam PF01242, PTPS, 1 hit |
PIRSFi | PIRSF006113, PTP_synth, 1 hit |
TIGRFAMsi | TIGR00039, 6PTHBS, 1 hit |
PROSITEi | View protein in PROSITE PS00987, PTPS_1, 1 hit PS00988, PTPS_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q03393-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTEGGGRRC QAQVSRRISF SASHRLYSKF LSDEENLKLF GKCNNPNGHG
60 70 80 90 100
HNYKVVVTVH GEIDPATGMV MNLADLKKYM EEAIMQPLDH KNLDMDVPYF
110 120 130 140
ADVVSTTENV AVYIWDNLQK VLPVGVLYKV KVYETDNNIV VYKGE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PNN3 | E9PNN3_HUMAN | 6-pyruvoyl tetrahydrobiopterin synt... | PTS | 77 | Annotation score: | ||
E9PKY8 | E9PKY8_HUMAN | 6-pyruvoyltetrahydropterin synthase | PTS PTPS | 55 | Annotation score: | ||
E9PJM0 | E9PJM0_HUMAN | 6-pyruvoyltetrahydropterin synthase | PTS | 61 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 114 | I → M in AAH18029 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_006816 | 16 | R → C in HPABH4A; severe decrease in activity; diminishes phosphorylation by PKG. 3 PublicationsCorresponds to variant dbSNP:rs104894274EnsemblClinVar. | 1 | |
Natural variantiVAR_006817 | 25 | R → G in HPABH4A; severe form. 1 PublicationCorresponds to variant dbSNP:rs1167104933EnsemblClinVar. | 1 | |
Natural variantiVAR_006818 | 25 | R → Q in HPABH4A; abolishes activity; no effect on phosphorylation by PKG. 3 PublicationsCorresponds to variant dbSNP:rs104894273EnsemblClinVar. | 1 | |
Natural variantiVAR_058265 | 26 | L → F in HPABH4A. 1 PublicationCorresponds to variant dbSNP:rs1317230624Ensembl. | 1 | |
Natural variantiVAR_006819 | 35 | E → G in HPABH4A. Corresponds to variant dbSNP:rs1328320990Ensembl. | 1 | |
Natural variantiVAR_006820 | 36 | N → K in HPABH4A. Corresponds to variant dbSNP:rs1449216377EnsemblClinVar. | 1 | |
Natural variantiVAR_008040 | 47 | N → D in HPABH4A; transient phenotype due to partial PTS deficiency; total loss of activity. 1 PublicationCorresponds to variant dbSNP:rs104894278EnsemblClinVar. | 1 | |
Natural variantiVAR_006821 | 52 | N → S in HPABH4A; severe form. 2 PublicationsCorresponds to variant dbSNP:rs104894275EnsemblClinVar. | 1 | |
Natural variantiVAR_006822 | 56 | V → M in HPABH4A; mild form. 1 PublicationCorresponds to variant dbSNP:rs104894277EnsemblClinVar. | 1 | |
Natural variantiVAR_006823 | 57 | Missing in HPABH4A. 3 PublicationsCorresponds to variant dbSNP:rs770387277Ensembl. | 1 | |
Natural variantiVAR_006824 | 67 | T → M in HPABH4A. 2 PublicationsCorresponds to variant dbSNP:rs370340361EnsemblClinVar. | 1 | |
Natural variantiVAR_006825 | 70 | V → D in HPABH4A. 1 PublicationCorresponds to variant dbSNP:rs1592880489EnsemblClinVar. | 1 | |
Natural variantiVAR_006826 | 87 | P → L in HPABH4A. 2 PublicationsCorresponds to variant dbSNP:rs765406631EnsemblClinVar. | 1 | |
Natural variantiVAR_006827 | 87 | P → S in HPABH4A; severe form. 2 PublicationsCorresponds to variant dbSNP:rs104894276EnsemblClinVar. | 1 | |
Natural variantiVAR_006828 | 96 | D → N in HPABH4A; severe form. 1 PublicationCorresponds to variant dbSNP:rs104894280EnsemblClinVar. | 1 | |
Natural variantiVAR_058266 | 97 | V → M in HPABH4A. 1 PublicationCorresponds to variant dbSNP:rs750455879EnsemblClinVar. | 1 | |
Natural variantiVAR_058267 | 99 | Y → C in HPABH4A. 1 PublicationCorresponds to variant dbSNP:rs1555198458EnsemblClinVar. | 1 | |
Natural variantiVAR_006829 | 100 | F → V in HPABH4A. | 1 | |
Natural variantiVAR_006830 | 106 | T → M in HPABH4A. 1 PublicationCorresponds to variant dbSNP:rs200712908EnsemblClinVar. | 1 | |
Natural variantiVAR_006831 | 114 | I → V in HPABH4A. 2 PublicationsCorresponds to variant dbSNP:rs1555198495EnsemblClinVar. | 1 | |
Natural variantiVAR_008041 | 116 | D → G in HPABH4A; transient phenotype due to partial PTS deficiency; mild decrease of activity. 1 PublicationCorresponds to variant dbSNP:rs104894279EnsemblClinVar. | 1 | |
Natural variantiVAR_058268 | 124 | V → L in HPABH4A. 1 PublicationCorresponds to variant dbSNP:rs150726932EnsemblClinVar. | 1 | |
Natural variantiVAR_006832 | 129 | K → E in HPABH4A. 1 PublicationCorresponds to variant dbSNP:rs1040441824Ensembl. | 1 | |
Natural variantiVAR_058269 | 136 | D → G in HPABH4A. 1 Publication | 1 | |
Natural variantiVAR_006833 | 136 | D → V in HPABH4A. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M97655 mRNA Translation: AAA51541.1 D17400 mRNA Translation: BAA04224.1 D25234 Genomic DNA Translation: BAA04959.1 L76259 Genomic DNA Translation: AAB64229.1 U63383 , U63380, U63381, U63382 Genomic DNA Translation: AAC16970.1 AB042297 Genomic DNA Translation: BAA95486.1 EF445018 Genomic DNA Translation: ACA06065.1 CH471065 Genomic DNA Translation: EAW67195.1 BC009686 mRNA Translation: AAH09686.1 BC018029 mRNA Translation: AAH18029.1 |
CCDSi | CCDS8359.1 |
PIRi | JC1405 |
RefSeqi | NP_000308.1, NM_000317.2 |
Genome annotation databases
Ensembli | ENST00000280362.8; ENSP00000280362.3; ENSG00000150787.8 |
GeneIDi | 5805 |
KEGGi | hsa:5805 |
MANE-Selecti | ENST00000280362.8; ENSP00000280362.3; NM_000317.3; NP_000308.1 |
UCSCi | uc001pnj.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M97655 mRNA Translation: AAA51541.1 D17400 mRNA Translation: BAA04224.1 D25234 Genomic DNA Translation: BAA04959.1 L76259 Genomic DNA Translation: AAB64229.1 U63383 , U63380, U63381, U63382 Genomic DNA Translation: AAC16970.1 AB042297 Genomic DNA Translation: BAA95486.1 EF445018 Genomic DNA Translation: ACA06065.1 CH471065 Genomic DNA Translation: EAW67195.1 BC009686 mRNA Translation: AAH09686.1 BC018029 mRNA Translation: AAH18029.1 |
CCDSi | CCDS8359.1 |
PIRi | JC1405 |
RefSeqi | NP_000308.1, NM_000317.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3I2B | X-ray | 2.30 | A/B/C/D/E/F/G/H/I/J/K/L | 7-145 | [»] | |
AlphaFoldDBi | Q03393 | |||||
SMRi | Q03393 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111769, 44 interactors |
IntActi | Q03393, 20 interactors |
MINTi | Q03393 |
STRINGi | 9606.ENSP00000280362 |
Chemistry databases
BindingDBi | Q03393 |
ChEMBLi | CHEMBL4630823 |
DrugBanki | DB03886, Biopterin DB00688, Mycophenolate mofetil |
PTM databases
iPTMneti | Q03393 |
PhosphoSitePlusi | Q03393 |
Genetic variation databases
BioMutai | PTS |
Proteomic databases
EPDi | Q03393 |
jPOSTi | Q03393 |
MassIVEi | Q03393 |
MaxQBi | Q03393 |
PaxDbi | Q03393 |
PeptideAtlasi | Q03393 |
PRIDEi | Q03393 |
ProteomicsDBi | 58205 |
TopDownProteomicsi | Q03393 |
Protocols and materials databases
Antibodypediai | 780, 210 antibodies from 27 providers |
DNASUi | 5805 |
Genome annotation databases
Ensembli | ENST00000280362.8; ENSP00000280362.3; ENSG00000150787.8 |
GeneIDi | 5805 |
KEGGi | hsa:5805 |
MANE-Selecti | ENST00000280362.8; ENSP00000280362.3; NM_000317.3; NP_000308.1 |
UCSCi | uc001pnj.5, human |
Organism-specific databases
CTDi | 5805 |
DisGeNETi | 5805 |
GeneCardsi | PTS |
HGNCi | HGNC:9689, PTS |
HPAi | ENSG00000150787, Low tissue specificity |
MalaCardsi | PTS |
MIMi | 261640, phenotype 612719, gene |
neXtProti | NX_Q03393 |
OpenTargetsi | ENSG00000150787 |
Orphaneti | 13, 6-pyruvoyl-tetrahydropterin synthase deficiency |
PharmGKBi | PA34032 |
VEuPathDBi | HostDB:ENSG00000150787 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4105, Eukaryota |
GeneTreei | ENSGT00390000002752 |
HOGENOMi | CLU_111016_2_0_1 |
InParanoidi | Q03393 |
OMAi | NVAIFIW |
OrthoDBi | 1502673at2759 |
PhylomeDBi | Q03393 |
TreeFami | TF105796 |
Enzyme and pathway databases
UniPathwayi | UPA00849;UER00819 |
BRENDAi | 4.2.3.12, 2681 |
PathwayCommonsi | Q03393 |
Reactomei | R-HSA-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
SABIO-RKi | Q03393 |
SignaLinki | Q03393 |
SIGNORi | Q03393 |
Miscellaneous databases
BioGRID-ORCSi | 5805, 10 hits in 1083 CRISPR screens |
ChiTaRSi | PTS, human |
EvolutionaryTracei | Q03393 |
GeneWikii | PTS_(gene) |
GenomeRNAii | 5805 |
Pharosi | Q03393, Tbio |
PROi | PR:Q03393 |
RNActi | Q03393, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000150787, Expressed in metanephros and 244 other tissues |
ExpressionAtlasi | Q03393, baseline and differential |
Genevisiblei | Q03393, HS |
Family and domain databases
Gene3Di | 3.30.479.10, 1 hit |
InterProi | View protein in InterPro IPR007115, 6-PTP_synth/QueD IPR038418, 6-PTP_synth/QueD_sf IPR022470, PTPS_Cys_AS IPR022469, PTPS_His_AS |
PANTHERi | PTHR12589, PTHR12589, 1 hit |
Pfami | View protein in Pfam PF01242, PTPS, 1 hit |
PIRSFi | PIRSF006113, PTP_synth, 1 hit |
TIGRFAMsi | TIGR00039, 6PTHBS, 1 hit |
PROSITEi | View protein in PROSITE PS00987, PTPS_1, 1 hit PS00988, PTPS_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PTPS_HUMAN | |
Accessioni | Q03393Primary (citable) accession number: Q03393 Secondary accession number(s): B0YJ87, Q8WVG8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | May 25, 2022 | |
This is version 210 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families