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Protein

C-C motif chemokine 7

Gene

Ccl7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity (By similarity).By similarity

GO - Molecular functioni

  • CCR1 chemokine receptor binding Source: Ensembl
  • CCR2 chemokine receptor binding Source: BHF-UCL
  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: GO_Central
  • heparin binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionCytokine, Heparin-binding
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 7
Alternative name(s):
Intercrine/chemokine MARC
Monocyte chemoattractant protein 3
Monocyte chemotactic protein 3
Short name:
MCP-3
Protein FIC
Small-inducible cytokine A7
Gene namesi
Name:Ccl7
Synonyms:Fic, Mcp3, Scya7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:99512 Ccl7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000518424 – 97C-C motif chemokine 7Add BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ03366
PeptideAtlasiQ03366
PRIDEiQ03366

Expressioni

Gene expression databases

BgeeiENSMUSG00000035373 Expressed in 79 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiMM_CCL7
ExpressionAtlasiQ03366 baseline and differential
GenevisibleiQ03366 MM

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203131, 1 interactor
STRINGi10090.ENSMUSP00000021011

Structurei

3D structure databases

ProteinModelPortaliQ03366
SMRiQ03366
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036686
HOVERGENiHBG017871
InParanoidiQ03366
KOiK05509
OMAiTTCCYRF
OrthoDBiEOG091G14KV
PhylomeDBiQ03366
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03366-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRISATLLCL LLIAAAFSIQ VWAQPDGPNA STCCYVKKQK IPKRNLKSYR
60 70 80 90
RITSSRCPWE AVIFKTKKGM EVCAEAHQKW VEEAIAYLDM KTPTPKP
Length:97
Mass (Da):10,999
Last modified:October 1, 1993 - v1
Checksum:iB94FDA6DF1EF6140
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57 – 63Missing in CAA49662 (PubMed:7989769).Curated7
Sequence conflicti74A → R in AAA37516 (PubMed:8455595).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12297 mRNA Translation: CAA78169.1
L04694 mRNA Translation: AAA37516.1
S71251 mRNA Translation: AAB30997.1
X70058 Genomic DNA Translation: CAA49662.1
AF128193 mRNA Translation: AAF22534.1
AF128194 mRNA Translation: AAF22535.1
AK078827 mRNA Translation: BAC37413.1
BC061126 mRNA Translation: AAH61126.1
CCDSiCCDS36245.1
PIRiA48093
RefSeqiNP_038682.1, NM_013654.3
UniGeneiMm.341574

Genome annotation databases

EnsembliENSMUST00000021011; ENSMUSP00000021011; ENSMUSG00000035373
GeneIDi20306
KEGGimmu:20306
UCSCiuc007kmq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12297 mRNA Translation: CAA78169.1
L04694 mRNA Translation: AAA37516.1
S71251 mRNA Translation: AAB30997.1
X70058 Genomic DNA Translation: CAA49662.1
AF128193 mRNA Translation: AAF22534.1
AF128194 mRNA Translation: AAF22535.1
AK078827 mRNA Translation: BAC37413.1
BC061126 mRNA Translation: AAH61126.1
CCDSiCCDS36245.1
PIRiA48093
RefSeqiNP_038682.1, NM_013654.3
UniGeneiMm.341574

3D structure databases

ProteinModelPortaliQ03366
SMRiQ03366
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203131, 1 interactor
STRINGi10090.ENSMUSP00000021011

Proteomic databases

PaxDbiQ03366
PeptideAtlasiQ03366
PRIDEiQ03366

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021011; ENSMUSP00000021011; ENSMUSG00000035373
GeneIDi20306
KEGGimmu:20306
UCSCiuc007kmq.2 mouse

Organism-specific databases

CTDi6354
MGIiMGI:99512 Ccl7

Phylogenomic databases

eggNOGiENOG410J1ST Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036686
HOVERGENiHBG017871
InParanoidiQ03366
KOiK05509
OMAiTTCCYRF
OrthoDBiEOG091G14KV
PhylomeDBiQ03366
TreeFamiTF334888

Miscellaneous databases

PROiPR:Q03366
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035373 Expressed in 79 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiMM_CCL7
ExpressionAtlasiQ03366 baseline and differential
GenevisibleiQ03366 MM

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL7_MOUSE
AccessioniPrimary (citable) accession number: Q03366
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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