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Protein

Homeobox protein MSX-2

Gene

Msx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi142 – 201HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • activation of meiosis Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • BMP signaling pathway Source: MGI
  • BMP signaling pathway involved in heart development Source: MGI
  • bone morphogenesis Source: MGI
  • bone trabecula formation Source: MGI
  • branching involved in mammary gland duct morphogenesis Source: MGI
  • cartilage development Source: MGI
  • cellular response to estradiol stimulus Source: MGI
  • cellular response to growth factor stimulus Source: MGI
  • chondrocyte development Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic forelimb morphogenesis Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • embryonic nail plate morphogenesis Source: MGI
  • enamel mineralization Source: MGI
  • endochondral bone growth Source: MGI
  • epithelial to mesenchymal transition involved in endocardial cushion formation Source: MGI
  • frontal suture morphogenesis Source: MGI
  • mammary gland epithelium development Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of CREB transcription factor activity Source: MGI
  • negative regulation of fat cell differentiation Source: MGI
  • negative regulation of keratinocyte differentiation Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: BHF-UCL
  • negative regulation of transcription regulatory region DNA binding Source: BHF-UCL
  • odontogenesis Source: MGI
  • ossification Source: MGI
  • osteoblast development Source: MGI
  • osteoblast differentiation Source: UniProtKB
  • outflow tract morphogenesis Source: MGI
  • outflow tract septum morphogenesis Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of BMP signaling pathway Source: MGI
  • positive regulation of cell death Source: MGI
  • positive regulation of mesenchymal cell apoptotic process Source: MGI
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of timing of catagen Source: MGI
  • regulation of apoptotic process Source: MGI
  • signal transduction involved in regulation of gene expression Source: MGI
  • stem cell differentiation Source: MGI
  • transcription by RNA polymerase II Source: MGI
  • wound healing Source: MGI
  • wound healing, spreading of epidermal cells Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processOsteogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein MSX-2
Alternative name(s):
Homeobox protein Hox-8-1
Gene namesi
Name:Msx2
Synonyms:Hox-8.1, Msx-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:97169 Msx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491001 – 267Homeobox protein MSX-2Add BLAST267

Proteomic databases

PaxDbiQ03358
PRIDEiQ03358

PTM databases

iPTMnetiQ03358
PhosphoSitePlusiQ03358

Expressioni

Tissue specificityi

Expressed in mesenchymal tissue in the developing spinal cord and limbs.

Inductioni

Up-regulated by BMP2.1 Publication

Gene expression databases

BgeeiENSMUSG00000021469
CleanExiMM_MSX2
ExpressionAtlasiQ03358 baseline and differential
GenevisibleiQ03358 MM

Interactioni

Subunit structurei

Interacts with MINT. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80) (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • transcription factor binding Source: MGI

Protein-protein interaction databases

BioGridi201537, 3 interactors
IntActiQ03358, 3 interactors
STRINGi10090.ENSMUSP00000021922

Structurei

3D structure databases

ProteinModelPortaliQ03358
SMRiQ03358
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Msh homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0492 Eukaryota
ENOG410YT2J LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231922
HOVERGENiHBG005205
InParanoidiQ03358
KOiK09341
OMAiPLGYSMY
OrthoDBiEOG091G0P1V
PhylomeDBiQ03358
TreeFamiTF350699

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q03358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPTKGGDL FSSDEEGPAV LAGPGPGPGG AEGSAEERRV KVSSLPFSVE
60 70 80 90 100
ALMSDKKPPK ESPAVPPDCA SAGAVLRPLL LPGHGVRDAH SPGPLVKPFE
110 120 130 140 150
TASVKSENSE DGAPWIQEPG RYSPPPRHMS PTTCTLRKHK TNRKPRTPFT
160 170 180 190 200
TSQLLALERK FRQKQYLSIA ERAEFSSSLN LTETQVKIWF QNRRAKAKRL
210 220 230 240 250
QEAELEKLKM AAKPMLPSGF SLPFPINSPL QAASIYGASY PFHRPVLPIP
260
PVGLYATPVG YGMYHLS
Length:267
Mass (Da):28,915
Last modified:June 1, 1994 - v2
Checksum:iF2F4528D6E9C951E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11F → FF in CAA41945 (PubMed:1682128).Curated1
Sequence conflicti89A → R in AAC60657 (PubMed:8098007).Curated1
Sequence conflicti263M → I in CAA41945 (PubMed:1682128).Curated1
Sequence conflicti266L → V in CAA41945 (PubMed:1682128).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11739, L11738 Unassigned DNA Translation: AAA03477.1
S60460, S60698 Genomic DNA Translation: AAC60657.2
X59252 mRNA Translation: CAA41945.1
M38576 Genomic DNA Translation: AAA37824.1
CCDSiCCDS26522.1
PIRiA46122
PS0410
S18814
RefSeqiNP_038629.2, NM_013601.2
UniGeneiMm.1763

Genome annotation databases

EnsembliENSMUST00000021922; ENSMUSP00000021922; ENSMUSG00000021469
GeneIDi17702
KEGGimmu:17702
UCSCiuc007qnw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMSX2_MOUSE
AccessioniPrimary (citable) accession number: Q03358
Secondary accession number(s): Q63856
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 1, 1994
Last modified: June 20, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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