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Entry version 104 (02 Jun 2021)
Sequence version 2 (15 Jul 1999)
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Protein

Period circadian protein

Gene

per

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

By similarity

Miscellaneous

The sequence shown here from 1-559 is that of strains SI-CA1, SI-CA2 and SI-K2. From 560-656 it is from strains Merano 4 and Australia.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBiological rhythms

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Period circadian protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:per
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila simulans (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7240 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0012888, Dsim\per

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000162609‹1 – ›656Period circadian proteinAdd BLAST›656

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated with a circadian rhythmicity, probably by the double-time protein (dbt). Phosphorylation could be implicated in the stability of per monomer and in the formation of heterodimer per-tim (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with timeless (TIM); the complex then translocates into the nucleus.

By similarity

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q03355

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini224 – 359PAS 1PROSITE-ProRule annotationAdd BLAST136
Domaini377 – 483PAS 2PROSITE-ProRule annotationAdd BLAST107
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati584 – 58511 Publication2
Repeati587 – 58821 Publication2
Repeati589 – 59031 Publication2
Repeati591 – 59241 Publication2
Repeati593 – 59451 Publication2
Repeati595 – 59661 Publication2
Repeati597 – 59871 Publication2
Repeati599 – 60081 Publication2
Repeati601 – 60291 Publication2
Repeati603 – 604101 Publication2
Repeati605 – 606111 Publication2
Repeati607 – 608121 Publication2
Repeati609 – 610131 Publication2
Repeati611 – 612141 Publication2
Repeati613 – 614151 Publication2
Repeati615 – 616161 Publication2
Repeati617 – 618171 Publication2
Repeati619 – 620181 Publication2
Repeati621 – 622191 Publication2
Repeati623 – 624201 Publication2
Repeati625 – 626211 Publication2
Repeati627 – 628221 Publication2
Repeati629 – 630231 Publication2
Repeati631 – 632241 Publication2
Repeati633 – 634251 Publication2
Repeati635 – 636261 Publication2
Repeati637 – 63827; approximate1 Publication2
Repeati639 – 640281 Publication2
Repeati641 – 642291 Publication2
Repeati643 – 644301 Publication2

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 161DisorderedSequence analysisAdd BLAST161
Regioni580 – 656DisorderedSequence analysisAdd BLAST77
Regioni584 – 64430 X 2 AA approximate tandem repeats of G-[TN]Add BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi53 – 66Nuclear localization signalSequence analysisAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 50Polar residuesSequence analysisAdd BLAST50
Compositional biasi69 – 84Polar residuesSequence analysisAdd BLAST16
Compositional biasi109 – 125Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a remarkable run of alternating Gly-Thr residues which is polymorphic in length. At least four types of Gly-Thr length exist in the natural population, (Gly-Thr)23 (shown here), (Gly-Thr)24, (Gly-Thr)25, and one minor variant (Gly-Thr)21. This Gly-Thr stretch is implicated in the maintenance of circadian period at different temperatures. Deletion of the repeat leads to a shortening of the courtship song cycle period, and thus could be important for determining features of species-specific mating behavior (By similarity).By similarity

Keywords - Domaini

Repeat

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00130, PAS, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00989, PAS, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00091, PAS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55785, SSF55785, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50112, PAS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragments.

Q03355-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
KVSDSAYSNS CSNSQSQRSG SSKSRLSGSH SSGSSGYGGK PSTQASSSDM
60 70 80 90 100
IIKRNKDKSR KKKKNKGTGQ GAGQAQTLIS ASTSLEGRDE EKPRPSGTGC
110 120 130 140 150
VEQQICRELQ DQQHGEDHSE PQATEQLQQE EEDQSGSESE ADRVEGVAKS
160 170 180 190 200
EAAQSFPIPS PLSVTIVPPS MGGCGGVGHA AGLDSGLAKF DKTWEAGPGK
210 220 230 240 250
LESMTGVGAA AAGTGQRGER VKEDSFCCVI SMHDGIVLYT TPSITDVLGY
260 270 280 290 300
PRDMWLGRSF IDFVHLKDRA TFASQITTGI PIAESRGSVP KDAKSTFCVM
310 320 330 340 350
LRRYRGLKSG GFGVIGRPVS YEPFRLGLTF REAPEEARPD NYMVSNGTNM
360 370 380 390 400
LLVICATPIK SSYKVPDEIL SQKSPKFAIR HTATGIISHV DSAAVSALGY
410 420 430 440 450
LPQDLIGRSI MDFYHHEDLS VMKETYETVM KKGQTAGASF CSKPYRFLIQ
460 470 480 490 500
NGCYVLLETE WTSFVNPWSR KLEFVVGHHR VFQGPKQCNV FEAAPTCKLK
510 520 530 540 550
ISEEAQSRNT RIKEDIVKRL AETVSRPSDT VKQEVSRRCQ ALASFMETLM
560 570 580 590 600
DEVSRADLKS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT GTGTGTGTGT
610 620 630 640 650
GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT GTGTTSSSRG

GSTAIP
Length:656
Mass (Da):69,118
Last modified:July 15, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A5E059006AF9A4A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11
<p>This subsection of the 'Sequence' section is used to indicate that two residues in a sequence are not consecutive and that there is an undetermined number of unsequenced residues between them.<p><a href='/help/non_cons' target='_top'>More...</a></p>Non-adjacent residuesi559 – 560Curated2
Non-terminal residuei6561

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti57D → H in strain: SI-LI2. 1
Natural varianti68T → A in strain: SI-K1, SI-K2, SI-LI1 and SI-LI2. 1
Natural varianti77T → A in strain: SI-K1. 1
Natural varianti165T → S in strain: SI-LI1 and SI-LI2. 1
Natural varianti230I → M in strain: SI-LI1. 1
Natural varianti311G → A in strain: SI-K2. 1
Natural varianti634N → T in strain: Merano 7, Merano 8 and Kenscoff. 1
Natural varianti636 – 638TNS → N in strain: Merano 8. 3
Natural varianti637 – 638NS → GN in strain: Merano 7 and Kenscoff. 2
Natural varianti641 – 642GT → NS in strain: Merano 7, Merano 8 and Kenscoff. 2
Natural varianti646S → T in strain: Merano 8 and Kenscoff. 1
Natural varianti653T → A in strain: Merano 7 and Merano 8. 1
Natural varianti655I → V in strain: Merano 7 and Merano 8. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L07826 Genomic DNA Translation: AAA28768.1
L07828 Genomic DNA Translation: AAA28766.1
L07829 Genomic DNA Translation: AAA28755.1
L07830 Genomic DNA Translation: AAA28756.1
L07831 Genomic DNA Translation: AAA28757.1
L07832 Genomic DNA Translation: AAA28779.1
U11800 Genomic DNA Translation: AAA77674.1
U11801 Genomic DNA Translation: AAA77675.1
U11802 Genomic DNA Translation: AAA77676.1
S53293 Genomic DNA Translation: AAB25025.2
S53295 Genomic DNA Translation: AAB25027.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S52950
S52953
S52954
S52955
S52956

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07826 Genomic DNA Translation: AAA28768.1
L07828 Genomic DNA Translation: AAA28766.1
L07829 Genomic DNA Translation: AAA28755.1
L07830 Genomic DNA Translation: AAA28756.1
L07831 Genomic DNA Translation: AAA28757.1
L07832 Genomic DNA Translation: AAA28779.1
U11800 Genomic DNA Translation: AAA77674.1
U11801 Genomic DNA Translation: AAA77675.1
U11802 Genomic DNA Translation: AAA77676.1
S53293 Genomic DNA Translation: AAB25025.2
S53295 Genomic DNA Translation: AAB25027.2
PIRiS52950
S52953
S52954
S52955
S52956

3D structure databases

SMRiQ03355
ModBaseiSearch...

Organism-specific databases

FlyBaseiFBgn0012888, Dsim\per

Family and domain databases

CDDicd00130, PAS, 2 hits
InterProiView protein in InterPro
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
PfamiView protein in Pfam
PF00989, PAS, 2 hits
SMARTiView protein in SMART
SM00091, PAS, 2 hits
SUPFAMiSSF55785, SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50112, PAS, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPER_DROSI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03355
Secondary accession number(s): Q24626
, Q24627, Q24628, Q26282, Q26284
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 15, 1999
Last modified: June 2, 2021
This is version 104 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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