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UniProtKB - Q03338 (PRP3_YEAST)
Protein
U4/U6 small nuclear ribonucleoprotein PRP3
Gene
PRP3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
1 PublicationMiscellaneous
Present with 432 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- mRNA splicing, via spliceosome Source: GO_Central
- spliceosomal snRNP assembly Source: SGD
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Names & Taxonomyi
Protein namesi | Recommended name: U4/U6 small nuclear ribonucleoprotein PRP3Alternative name(s): Pre-mRNA-splicing factor 3 |
Gene namesi | Name:PRP3 Synonyms:RNA3 Ordered Locus Names:YDR473C ORF Names:D8035.16 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002881, PRP3 |
VEuPathDBi | FungiDB:YDR473C |
Subcellular locationi
Nucleus
Nucleus
- spliceosomal complex Source: UniProtKB-KW
- U4/U6 x U5 tri-snRNP complex Source: SGD
Keywords - Cellular componenti
Nucleus, SpliceosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097037 | 1 – 469 | U4/U6 small nuclear ribonucleoprotein PRP3Add BLAST | 469 |
Proteomic databases
MaxQBi | Q03338 |
PaxDbi | Q03338 |
PRIDEi | Q03338 |
PTM databases
iPTMneti | Q03338 |
Interactioni
Subunit structurei
Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
2 PublicationsBinary interactionsi
Q03338
With | #Exp. | IntAct |
---|---|---|
PRP4 [P20053] | 4 | EBI-421,EBI-219 |
Protein-protein interaction databases
BioGRIDi | 32526, 188 interactors |
ComplexPortali | CPX-25, U4/U6.U5 tri-small nuclear ribonucleoprotein complex CPX-31, U4 small nuclear ribonucleoprotein complex CPX-32, U4/U6 small nuclear ribonucleoprotein complex |
DIPi | DIP-5266N |
IntActi | Q03338, 29 interactors |
MINTi | Q03338 |
STRINGi | 4932.YDR473C |
Miscellaneous databases
RNActi | Q03338, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q03338 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 45 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 26 – 42 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Phylogenomic databases
eggNOGi | KOG2769, Eukaryota |
GeneTreei | ENSGT00390000011497 |
HOGENOMi | CLU_015750_2_0_1 |
InParanoidi | Q03338 |
OMAi | CVMHPRF |
Family and domain databases
InterProi | View protein in InterPro IPR010541, DUF1115 IPR013881, Pre-mRNA_splic_Prp3 IPR027104, Prp3 |
PANTHERi | PTHR14212, PTHR14212, 1 hit |
Pfami | View protein in Pfam PF06544, DUF1115, 1 hit PF08572, PRP3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q03338-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPPRNTYEKG NPKRQNSPYY KPSFLRREET TNDEEKFQGH GLKTELHSAL
60 70 80 90 100
KSSNLNLIRR TYQTGENPYL SDPHDRGSSS RFNRRYERGL KFYQKGEISK
110 120 130 140 150
RIAQERTLQK QQEEEELKRK LKQEEDEKDK RKLIESGDLP NLELHEDKFL
160 170 180 190 200
LDLSKFKIYY DNNHGYEWWD TAYLDEKGEL MEKYDMNGTS PAEEKLAEDI
210 220 230 240 250
DEVDDDDDDE HPSIRYVAHP LPEKINEAKV SIKAYLTQHE RKRLRRNRRK
260 270 280 290 300
MAREAREIKI KLGLLPKPEP KVKLSNMMSV FENDQNITDP TAWEKVVKDQ
310 320 330 340 350
VDLRKRKHLE ENERRHEDAI KRRKEAVNMN VEKPTVYHCK VFQFKNLQNP
360 370 380 390 400
KIRFKLKMNS KELSLKGLCL RIRDDGPGII IVVGNEKSCK FYENLVMKRI
410 420 430 440 450
KWNEDFELHT NTGDIKMDMH NNSISKTWEG YLQDCKFKGW FMKVCNDQDS
460
LLRTLGQFDS EHFYSPVQT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33050 Genomic DNA Translation: AAB64932.1 BK006938 Genomic DNA Translation: DAA12307.1 |
PIRi | S69640 |
RefSeqi | NP_010761.3, NM_001180781.3 |
Genome annotation databases
EnsemblFungii | YDR473C_mRNA; YDR473C; YDR473C |
GeneIDi | 852084 |
KEGGi | sce:YDR473C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33050 Genomic DNA Translation: AAB64932.1 BK006938 Genomic DNA Translation: DAA12307.1 |
PIRi | S69640 |
RefSeqi | NP_010761.3, NM_001180781.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3JCM | electron microscopy | 3.80 | K | 1-469 | [»] | |
4YHU | X-ray | 2.70 | A/B/C | 296-469 | [»] | |
4YHV | X-ray | 2.00 | A | 325-469 | [»] | |
4YHW | X-ray | 3.25 | A/B | 296-469 | [»] | |
5GAN | electron microscopy | 3.60 | G | 1-469 | [»] | |
5GAP | electron microscopy | 3.60 | G | 1-469 | [»] | |
5NRL | electron microscopy | 7.20 | G | 1-469 | [»] | |
5ZWM | electron microscopy | 3.40 | J | 1-469 | [»] | |
5ZWO | electron microscopy | 3.90 | J | 1-469 | [»] | |
SMRi | Q03338 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 32526, 188 interactors |
ComplexPortali | CPX-25, U4/U6.U5 tri-small nuclear ribonucleoprotein complex CPX-31, U4 small nuclear ribonucleoprotein complex CPX-32, U4/U6 small nuclear ribonucleoprotein complex |
DIPi | DIP-5266N |
IntActi | Q03338, 29 interactors |
MINTi | Q03338 |
STRINGi | 4932.YDR473C |
PTM databases
iPTMneti | Q03338 |
Proteomic databases
MaxQBi | Q03338 |
PaxDbi | Q03338 |
PRIDEi | Q03338 |
Genome annotation databases
EnsemblFungii | YDR473C_mRNA; YDR473C; YDR473C |
GeneIDi | 852084 |
KEGGi | sce:YDR473C |
Organism-specific databases
SGDi | S000002881, PRP3 |
VEuPathDBi | FungiDB:YDR473C |
Phylogenomic databases
eggNOGi | KOG2769, Eukaryota |
GeneTreei | ENSGT00390000011497 |
HOGENOMi | CLU_015750_2_0_1 |
InParanoidi | Q03338 |
OMAi | CVMHPRF |
Miscellaneous databases
PROi | PR:Q03338 |
RNActi | Q03338, protein |
Family and domain databases
InterProi | View protein in InterPro IPR010541, DUF1115 IPR013881, Pre-mRNA_splic_Prp3 IPR027104, Prp3 |
PANTHERi | PTHR14212, PTHR14212, 1 hit |
Pfami | View protein in Pfam PF06544, DUF1115, 1 hit PF08572, PRP3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PRP3_YEAST | |
Accessioni | Q03338Primary (citable) accession number: Q03338 Secondary accession number(s): D6VT97 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2003 |
Last sequence update: | November 1, 1996 | |
Last modified: | September 29, 2021 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references