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Entry version 160 (02 Dec 2020)
Sequence version 3 (23 Jan 2007)
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Protein

40S ribosomal protein S13

Gene

RpS13

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339, SRP-dependent cotranslational protein targeting to membrane
R-DME-72649, Translation initiation complex formation
R-DME-72689, Formation of a pool of free 40S subunits
R-DME-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-DME-72702, Ribosomal scanning and start codon recognition
R-DME-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
40S ribosomal protein S13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RpS13
Synonyms:M(2)32A, Rp17
ORF Names:CG13389
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0010265, RpS13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001156762 – 15140S ribosomal protein S13Add BLAST150

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q03334

PRoteomics IDEntifications database

More...
PRIDEi
Q03334

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0010265, Expressed in egg chamber and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q03334, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q03334, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
60275, 112 interactors

Database of interacting proteins

More...
DIPi
DIP-17858N

Protein interaction database and analysis system

More...
IntActi
Q03334, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0079328

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q03334

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0400, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_090139_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q03334

Identification of Orthologs from Complete Genome Data

More...
OMAi
WHLVKKA

Database of Orthologous Groups

More...
OrthoDBi
1387147at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q03334

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00353, Ribosomal_S15p_S13e, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01343_A, Ribosomal_S15_A, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012606, Ribosomal_S13/S15_N
IPR000589, Ribosomal_S15
IPR023029, Ribosomal_S15P
IPR009068, S15_NS1_RNA-bd

The PANTHER Classification System

More...
PANTHERi
PTHR11885, PTHR11885, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08069, Ribosomal_S13_N, 1 hit
PF00312, Ribosomal_S15, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01386, Ribosomal_S13_N, 1 hit
SM01387, Ribosomal_S15, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47060, SSF47060, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00362, RIBOSOMAL_S15, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q03334-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRMHAPGKG ISQSALPYRR TVPSWLKLNA DDVKEQIKKL GKKGLTPSKI
60 70 80 90 100
GIILRDSHGV AQVRFVNGNK ILRIMKSVGL KPDIPEDLYH MIKKAVAIRK
110 120 130 140 150
HLERNRKDKD GKFRLILVES RIHRLARYYK TKSVLPPNWK YESSTASALV

A
Length:151
Mass (Da):17,178
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i498306F4F14B76F8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2J950X2J950_DROME
40S ribosomal protein S13
RpS13 Dmel\CG13389, l(2)k09614, M(2)29B, M(2)32, M(2)32A
151Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti40 – 49LGKKGLTPSK → AGQEGSDSLQ in CAA79496 (PubMed:8506150).Curated10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z19052 mRNA Translation: CAA79496.1
X91853 Genomic DNA Translation: CAA62964.1
X91854 mRNA Translation: CAA62965.1
AE014134 Genomic DNA Translation: AAF52649.1
AE014134 Genomic DNA Translation: ABC65883.1
AY058536 mRNA Translation: AAL13765.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S70391, S33684

NCBI Reference Sequences

More...
RefSeqi
NP_001033885.1, NM_001038796.3
NP_001285747.1, NM_001298818.1
NP_476938.1, NM_057590.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0079724; FBpp0079328; FBgn0010265
FBtr0100541; FBpp0099990; FBgn0010265
FBtr0346454; FBpp0312104; FBgn0010265

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34149

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG13389

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19052 mRNA Translation: CAA79496.1
X91853 Genomic DNA Translation: CAA62964.1
X91854 mRNA Translation: CAA62965.1
AE014134 Genomic DNA Translation: AAF52649.1
AE014134 Genomic DNA Translation: ABC65883.1
AY058536 mRNA Translation: AAL13765.1
PIRiS70391, S33684
RefSeqiNP_001033885.1, NM_001038796.3
NP_001285747.1, NM_001298818.1
NP_476938.1, NM_057590.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AN1-151[»]
SMRiQ03334
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi60275, 112 interactors
DIPiDIP-17858N
IntActiQ03334, 2 interactors
STRINGi7227.FBpp0079328

Proteomic databases

PaxDbiQ03334
PRIDEiQ03334

Genome annotation databases

EnsemblMetazoaiFBtr0079724; FBpp0079328; FBgn0010265
FBtr0100541; FBpp0099990; FBgn0010265
FBtr0346454; FBpp0312104; FBgn0010265
GeneIDi34149
KEGGidme:Dmel_CG13389

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6207
FlyBaseiFBgn0010265, RpS13

Phylogenomic databases

eggNOGiKOG0400, Eukaryota
HOGENOMiCLU_090139_1_0_1
InParanoidiQ03334
OMAiWHLVKKA
OrthoDBi1387147at2759
PhylomeDBiQ03334

Enzyme and pathway databases

ReactomeiR-DME-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339, SRP-dependent cotranslational protein targeting to membrane
R-DME-72649, Translation initiation complex formation
R-DME-72689, Formation of a pool of free 40S subunits
R-DME-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-DME-72702, Ribosomal scanning and start codon recognition
R-DME-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
34149, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RpS13, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34149

Protein Ontology

More...
PROi
PR:Q03334

Gene expression databases

BgeeiFBgn0010265, Expressed in egg chamber and 39 other tissues
ExpressionAtlasiQ03334, baseline and differential
GenevisibleiQ03334, DM

Family and domain databases

CDDicd00353, Ribosomal_S15p_S13e, 1 hit
HAMAPiMF_01343_A, Ribosomal_S15_A, 1 hit
InterProiView protein in InterPro
IPR012606, Ribosomal_S13/S15_N
IPR000589, Ribosomal_S15
IPR023029, Ribosomal_S15P
IPR009068, S15_NS1_RNA-bd
PANTHERiPTHR11885, PTHR11885, 1 hit
PfamiView protein in Pfam
PF08069, Ribosomal_S13_N, 1 hit
PF00312, Ribosomal_S15, 1 hit
SMARTiView protein in SMART
SM01386, Ribosomal_S13_N, 1 hit
SM01387, Ribosomal_S15, 1 hit
SUPFAMiSSF47060, SSF47060, 1 hit
PROSITEiView protein in PROSITE
PS00362, RIBOSOMAL_S15, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRS13_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03334
Secondary accession number(s): A4V0F6, Q9VLN5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: December 2, 2020
This is version 160 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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