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Protein

Mitochondrial fusion and transport protein UGO1

Gene

UGO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for mitochondrial fusion as well as normal mitochondrial morphology by bridging the essential interaction between FZO1 and MGM1. May coordinate fusion of inner and outer membranes during mitochondrial fusion.2 Publications

GO - Molecular functioni

GO - Biological processi

  • mitochondrial fusion Source: SGD
  • mitochondrial transport Source: GO_Central

Enzyme and pathway databases

BioCyciYEAST:G3O-29997-MONOMER

Protein family/group databases

TCDBi9.B.25.1.1 the mitochondrial inner/outer membrane fusion (mmf) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial fusion and transport protein UGO1
Gene namesi
Name:UGO1Imported
Ordered Locus Names:YDR470C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR470C
SGDiS000002878 UGO1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 293CytoplasmicSequence analysisAdd BLAST293
Transmembranei294 – 314Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini315 – 502Mitochondrial intermembraneSequence analysisAdd BLAST188

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002709851 – 502Mitochondrial fusion and transport protein UGO1Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ03327
PaxDbiQ03327
PRIDEiQ03327

PTM databases

iPTMnetiQ03327

Interactioni

Subunit structurei

Interacts with FZO1 through its cytoplasmic domain and with MGM1 through its mitochondrial intermembrane space domain.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32523, 87 interactors
ComplexPortaliCPX-161 FZO1:MGM1:UGO1 complex
IntActiQ03327, 6 interactors
MINTiQ03327
STRINGi4932.YDR470C

Structurei

3D structure databases

ProteinModelPortaliQ03327
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati288 – 383SolcarSequence analysisAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 294Binds FZO11 PublicationAdd BLAST294
Regioni312 – 502Binds MGM11 PublicationAdd BLAST191

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000141868
InParanoidiQ03327
KOiK17967
OMAiGVWRANN
OrthoDBiEOG092C1SCV

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR023395 Mt_carrier_dom_sf
SUPFAMiSSF103506 SSF103506, 2 hits

Sequencei

Sequence statusi: Complete.

Q03327-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNNNVTEAT SRAQIRPYYD PDSFNAGYSA VFKPDEGVVD PHGYTIASKL
60 70 80 90 100
NVINSSPTTK RMANALFKSS PMKKLSNSVN DGLSLEGSNG EITGLNNFEW
110 120 130 140 150
AELVNIQKWR KIFEQLLDMF FRKYFQLLIQ QPFDVARLLI QVGEFKIFKT
160 170 180 190 200
TVDTNKPQAP IILRDEEGDG AAREGEEDAY DEEEIDFFPI ERKIAEANST
210 220 230 240 250
APIMAEETDH SHHEPTDISL TIAPQSLHTI DVINALFDQE GIRGLWKANN
260 270 280 290 300
TTFIYNFLSL SIDTWFTGLL SSFLGVPDPY FMEVINSPDI SKSFILALGA
310 320 330 340 350
GVFTSIILLP VDLIRTRLIV TSFKKKKNVK TDGKNMVTNT RSLRQLIRCW
360 370 380 390 400
SWRKNGVSIP LDMWSLTILQ SINNSFFNKL FDLVIYNQFH IEKYSQTVMY
410 420 430 440 450
NTMKFFSKSL ELFIKLPLEN LLRRCQLNYL LNDQRLSFKV DSTELIVKPK
460 470 480 490 500
KYNGIWDVIR NNSNTNRGQL WNGWKVGVIS LICGYGLQMM NKVDINMEQE

KF
Length:502
Mass (Da):57,543
Last modified:July 27, 2011 - v3
Checksum:i6417C4730DACD8F6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114E → G in AAB64924 (PubMed:9169867).Curated1
Sequence conflicti114E → G no nucleotide entry (PubMed:10930523).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33050 Genomic DNA Translation: AAB64924.2
BK006938 Genomic DNA Translation: DAA12304.2
PIRiS69637
RefSeqiNP_010758.3, NM_001180778.2

Genome annotation databases

EnsemblFungiiYDR470C; YDR470C; YDR470C
GeneIDi852081
KEGGisce:YDR470C

Similar proteinsi

Entry informationi

Entry nameiUGO1_YEAST
AccessioniPrimary (citable) accession number: Q03327
Secondary accession number(s): D6VT94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 27, 2011
Last modified: July 18, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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