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Protein

Palmitoyltransferase PFA5

Gene

PFA5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

  • protein palmitoylation Source: UniProtKB

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-29987-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase PFA5 (EC:2.3.1.225)
Alternative name(s):
Protein fatty acyltransferase 5
Gene namesi
Name:PFA5
Ordered Locus Names:YDR459C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR459C
SGDiS000002867 PFA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 55LumenalSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 173CytoplasmicSequence analysisAdd BLAST97
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 217LumenalSequence analysisAdd BLAST23
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 374CytoplasmicSequence analysisAdd BLAST136

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129831 – 374Palmitoyltransferase PFA5Add BLAST374

Post-translational modificationi

Autopalmitoylated.

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ03289
PRIDEiQ03289

Interactioni

Protein-protein interaction databases

BioGridi32513, 48 interactors
DIPiDIP-5400N
IntActiQ03289, 1 interactor
STRINGi4932.YDR459C

Structurei

3D structure databases

ProteinModelPortaliQ03289
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 179DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000001066
InParanoidiQ03289
KOiK18932
OMAiELCVYTI
OrthoDBiEOG092C2QRJ

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q03289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSWNIRIR RRSWFRFILP IIVLGLLCYG TWAYCHKLCY EQVDKRLRQK
60 70 80 90 100
SVSVGLICAV CFLDVVVIFI WLQIVILVGP GTQPHVAPFL ILPIASEEKT
110 120 130 140 150
SNTSQNTSVE YDAVVPPKCY QSDPHGYPIW CSECQSLKME RTHHSSELGH
160 170 180 190 200
CIPRFDHYCM WIGTVIGRDN YRLFVQFAAY FSTLLLIMWV SICVYIRIIT
210 220 230 240 250
QHNHNYSPNL NANIISTLVF AILGWLLTAS LLASSIFYMS QNKTSLEAII
260 270 280 290 300
DSKRKKFGTR KIFCYYSEAN KLRFVVEFDR SEFHSFWDKK SILANIKDFM
310 320 330 340 350
GSNILMWIIP LGKPYTSRCK SDGKSGSKTT LVEILGPYEE TLSDYTIQAI
360 370
EDKISRGEYL ATLRASGDDS DPAY
Length:374
Mass (Da):42,923
Last modified:November 1, 1996 - v1
Checksum:i2AAB3E78B2FD0F89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33050 Genomic DNA Translation: AAB64921.1
BK006938 Genomic DNA Translation: DAA12293.1
PIRiS69627
RefSeqiNP_010747.1, NM_001180767.1

Genome annotation databases

EnsemblFungiiYDR459C; YDR459C; YDR459C
GeneIDi852070
KEGGisce:YDR459C

Similar proteinsi

Entry informationi

Entry nameiPFA5_YEAST
AccessioniPrimary (citable) accession number: Q03289
Secondary accession number(s): D6VT83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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