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Entry version 147 (25 May 2022)
Sequence version 1 (01 Nov 1997)
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Protein

Inner nuclear membrane protein HEH2

Gene

HEH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Present with 1250 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inner nuclear membrane protein HEH2
Alternative name(s):
Helix-extension-helix domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HEH2
Ordered Locus Names:YDR458C
ORF Names:D8035.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000002866, HEH2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YDR458C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei317 – 337HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1 – 133Missing : No interaction with SRP1; when associated with missing 309-I--E-663. 1 PublicationAdd BLAST133
Mutagenesisi1 – 52Missing : Interaction with SRP1; when associated with missing 309-I--E-663. 1 PublicationAdd BLAST52
Mutagenesisi124 – 137Missing : No interaction with SRP1; when associated with missing 309-I--E-663. Mislocalized to the endoplasmic reticulum. 1 PublicationAdd BLAST14
Mutagenesisi126K → T: Mislocalized to the endoplasmic reticulum. 1 Publication1
Mutagenesisi309 – 663Missing : Interaction with SRP1. 1 PublicationAdd BLAST355

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002025961 – 663Inner nuclear membrane protein HEH2Add BLAST663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei123PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q03281

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q03281

PRoteomics IDEntifications database

More...
PRIDEi
Q03281

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q03281

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SRP1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32512, 63 interactors

Database of interacting proteins

More...
DIPi
DIP-7259N

Protein interaction database and analysis system

More...
IntActi
Q03281, 6 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YDR458C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q03281, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1663
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q03281

Small Angle Scattering Biological Data Bank

More...
SASBDBi
Q03281

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q03281

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 188DisorderedSequence analysisAdd BLAST143
Regioni267 – 289DisorderedSequence analysisAdd BLAST23

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi124 – 137Nuclear localization signalSequence analysisAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi50 – 66Polar residuesSequence analysisAdd BLAST17
Compositional biasi68 – 123Basic and acidic residuesSequence analysisAdd BLAST56
Compositional biasi137 – 159Polar residuesSequence analysisAdd BLAST23
Compositional biasi160 – 184Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi267 – 285Basic and acidic residuesSequence analysisAdd BLAST19

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVG5, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171142

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010838_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q03281

Identification of Orthologs from Complete Genome Data

More...
OMAi
HAFCYPN

Family and domain databases

Database of protein disorder

More...
DisProti
DP02124

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1180, 1 hit
1.10.720.40, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...
IDEALi
IID50288

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025856, HeH/LEM_domain
IPR044780, Heh2/Src1
IPR011015, LEM/LEM-like_dom_sf
IPR041885, MAN1_winged_helix_dom
IPR018996, MSC

The PANTHER Classification System

More...
PANTHERi
PTHR47808, PTHR47808, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12949, HeH, 1 hit
PF09402, MSC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q03281-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDHRNLDPKT LKVSQLRRVL VENDVAFPAN ARKPVLVKLF EEKVRQRLQS
60 70 80 90 100
SPEASKVRTS IQKVVKSGAK NADRKKTLKS KKLESSSSES KTVKDENVET
110 120 130 140 150
NKRKREQIST DNEAKMQIQE EKSPKKKRKK RSSKANKPPE SPPQSKSDGK
160 170 180 190 200
ATSADLTSEL ETVEELHKKD SSDDKPRVKE LPKPELPNLK VSNEFLAQLN
210 220 230 240 250
KELASAATEN YDHSIKSTDL SSIRIETEEP VGPSTGAETR NESEVMENIN
260 270 280 290 300
LEVQPEVKEA KEELTKISET FDNQDEEDTS RLSSKKNIRS PKGRTRHFIA
310 320 330 340 350
NKTKRGIDIM KPFIAHLFIW LWNGAIFLSI ICPILFGLWY REQRIQVGYC
360 370 380 390 400
GHEKPLKSLA ISAFPQTERV DSVLQAYRPN CLECPEHGIC SSFMNVECEP
410 420 430 440 450
GYEPKSSILE TYGIIPFPKY CAKDESKEKE VDELVWKVNE YLKKKNAQHE
460 470 480 490 500
CGEGENLFES GETETKLYDI FSHSRPSWES QREFNDHWKN VLEILKKKDD
510 520 530 540 550
IIWLPLDFET NGKREKSKSN NTNYIYRSTS KKWVTLQCHL EGDIQEYITK
560 570 580 590 600
YGGSLFITLG VLFLIKKIQS TLDNYVQGEQ IIEKLVKEAI DKLKDVKKNK
610 620 630 640 650
GEEPFLTTVQ LRATLLSDIP NIKEQNNLWA QTKEKIMKEQ SENIELYLLE
660
ENGEIMTCWE WKE
Length:663
Mass (Da):76,377
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E11821F2542723E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U33050 Genomic DNA Translation: AAB64934.1
BK006938 Genomic DNA Translation: DAA12292.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S69626

NCBI Reference Sequences

More...
RefSeqi
NP_010746.1, NM_001180766.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR458C_mRNA; YDR458C; YDR458C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852069

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR458C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33050 Genomic DNA Translation: AAB64934.1
BK006938 Genomic DNA Translation: DAA12292.1
PIRiS69626
RefSeqiNP_010746.1, NM_001180766.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PVZX-ray2.50C/D100-137[»]
AlphaFoldDBiQ03281
SASBDBiQ03281
SMRiQ03281
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi32512, 63 interactors
DIPiDIP-7259N
IntActiQ03281, 6 interactors
STRINGi4932.YDR458C

PTM databases

iPTMnetiQ03281

Proteomic databases

MaxQBiQ03281
PaxDbiQ03281
PRIDEiQ03281

Genome annotation databases

EnsemblFungiiYDR458C_mRNA; YDR458C; YDR458C
GeneIDi852069
KEGGisce:YDR458C

Organism-specific databases

SGDiS000002866, HEH2
VEuPathDBiFungiDB:YDR458C

Phylogenomic databases

eggNOGiENOG502QVG5, Eukaryota
GeneTreeiENSGT00940000171142
HOGENOMiCLU_010838_2_0_1
InParanoidiQ03281
OMAiHAFCYPN

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q03281
RNActiQ03281, protein

Family and domain databases

DisProtiDP02124
Gene3Di1.10.10.1180, 1 hit
1.10.720.40, 1 hit
IDEALiIID50288
InterProiView protein in InterPro
IPR025856, HeH/LEM_domain
IPR044780, Heh2/Src1
IPR011015, LEM/LEM-like_dom_sf
IPR041885, MAN1_winged_helix_dom
IPR018996, MSC
PANTHERiPTHR47808, PTHR47808, 1 hit
PfamiView protein in Pfam
PF12949, HeH, 1 hit
PF09402, MSC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEH2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03281
Secondary accession number(s): D6VT82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 25, 2022
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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