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Entry version 179 (08 May 2019)
Sequence version 1 (01 Nov 1996)
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Protein

E3 ubiquitin-protein ligase TOM1

Gene

TOM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable ubiquitin ligase protein involved in many cellular processes, such as transcription regulation, maintenance of nuclear structure, cell cycle, mRNA export and rRNA maturation. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Involved in transcription regulation by interacting, and probably mediating, ubiquitination of some subunit of the SAGA complex. Required for SPT7 ubiquitination. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins. Required for the shuttling of hnRNP protein NAB2, probably by mediating ubiquitination of a protein associated with NAB2. Also required for full induction of the general stress and heat-shock responses. Involved in 18S rRNA maturation by affecting several early steps in the rRNA processing pathway.5 Publications

Miscellaneous

Present with 350 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3235Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ubiquitin protein ligase activity Source: GO_Central
  • ubiquitin-protein transferase activity Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processCell cycle, mRNA transport, rRNA processing, Transcription, Transcription regulation, Transport, Ubl conjugation pathway

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-29985-MONOMER

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-SCE-6798695 Neutrophil degranulation
R-SCE-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TOM1 (EC:2.3.2.26)
Alternative name(s):
HECT-type E3 ubiquitin transferase TOM1
Suppressor of snRNA protein 2
Temperature-dependent organization in mitotic nucleus protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOM1
Synonyms:SSR2
Ordered Locus Names:YDR457W
ORF Names:D8035.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YDR457W

Saccharomyces Genome Database

More...
SGDi
S000002865 TOM1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi3235C → A: Loss of function. Induces a decrease in transcription activation. 3 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001203481 – 3268E3 ubiquitin-protein ligase TOM1Add BLAST3268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1890PhosphoserineCombined sources1
Modified residuei2096PhosphothreonineCombined sources1
Modified residuei2119PhosphoserineCombined sources1
Modified residuei2376PhosphoserineCombined sources1
Modified residuei2406PhosphoserineCombined sources1
Modified residuei2418PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q03280

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q03280

PRoteomics IDEntifications database

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PRIDEi
Q03280

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q03280

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the ADA3/NGG1 subunit of the SAGA complex. Interacts with KRR1.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
32511, 708 interactors

Database of interacting proteins

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DIPi
DIP-5927N

Protein interaction database and analysis system

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IntActi
Q03280, 6 interactors

Molecular INTeraction database

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MINTi
Q03280

STRING: functional protein association networks

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STRINGi
4932.YDR457W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q03280

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2932 – 3268HECTPROSITE-ProRule annotationAdd BLAST337

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1879 – 2054Asp-richAdd BLAST176

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPL family. TOM1/PTR1 subfamily.Curated

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000156319

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000093627

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q03280

KEGG Orthology (KO)

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KOi
K10592

Identification of Orthologs from Complete Genome Data

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OMAi
LLNCPNF

Family and domain databases

Conserved Domains Database

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CDDi
cd00078 HECTc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR010309 E3_Ub_ligase_DUF908
IPR010314 E3_Ub_ligase_DUF913
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR025527 HUWE1/Rev1_UBM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06012 DUF908, 1 hit
PF06025 DUF913, 1 hit
PF00632 HECT, 1 hit
PF14377 UBM, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00119 HECTc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 1 hit
SSF56204 SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237 HECT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q03280-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLFTRCEKA RKEKLAAGYK PLVDYLIDCD TPTFLERIEA IQEWDRSRDD
60 70 80 90 100
LYVWIPILDR MDGLLLKVAE KYKYKQDPKK ECEVKLVEME AHDVDYCLKM
110 120 130 140 150
LKFTRRLLLN TENRFVYSSG DVLMYLLNCP NFTIKLAVMR ILAILGERFV
160 170 180 190 200
IAREKIVAHN IFGDHNLRKK TLKLALSLSS SVMDEDGEHF SLVDLYFDKK
210 220 230 240 250
KVPQKWRKLR FTHYTSNDFK KSSQQKNNIN ETQTSIKKVT MTTQELCEHS
260 270 280 290 300
LQQIFDKGMA LLPAESWFDF SIKASVAKAF SDDSGENIDL RNIIIETKLN
310 320 330 340 350
AIAFVNTIFS PPQVSSKLFE LDPYAFNSLT DLISLSETKI PKELRTDALF
360 370 380 390 400
TLECISLKHV WCSDIIRNLG GNISHGLLFQ ILRYIAKTLR EATDEIDEEY
410 420 430 440 450
NVRFFYLISN LADVKPLHES LFAAGLIPTL LEIVSIRNCP YKRTLASATH
460 470 480 490 500
LLETFIDNSE TTTEFIENDG FTMLITSVAN EIDFTLAHPE TWQPPKYSVV
510 520 530 540 550
YYSISFRELA YIRSLLKLVL KLLSTDSGDR IRNLIDSPIL VSLKKILENK
560 570 580 590 600
LVFGLTLITY TLDVVQKVIN SEPTIYPVLV EAGLIPYVID NFPKLIGPSA
610 620 630 640 650
ELLSLLPDVV SAICLNPEGL KQVKEKGLIN NLFDFLLDAD HARILTGGDR
660 670 680 690 700
STEYGTDIDE LARHYPDLKA NIVEALCNVI RKMPSTFRNE REFLFTSPKD
710 720 730 740 750
QKYFFHRKNE EILTDKEEHE PAYWELLDKG TMLDTFTSVL FGMSLGNGSF
760 770 780 790 800
SQVPQHLEAR DFLAIIFMEN PPYEYFTSVA ISNVTEVLQY LDEKYEDYAF
810 820 830 840 850
MDVMKVLNDQ LENLNDFLNS PNDRSFFLER DGENSVRSCH SKLCRLAAIL
860 870 880 890 900
NIVTNVYIDL TTLSCKRIMQ IYSYFDKRGF SLIKNLKLLF QKCALEEMYI
910 920 930 940 950
RQHMPDSVIT ETMPLPIVDV SGDGPPLQIY IDDPKKGDQK GKITSVKTRN
960 970 980 990 1000
TLQMRTILYT LQSNTAILFR CFLRLSHSRN MDLEHKDLTT EVHIFENVVE
1010 1020 1030 1040 1050
NVIEMLKATE LEGHLPYILV LLNFNTFVFT IPKASPNSTE ILQTIPAYIF
1060 1070 1080 1090 1100
YQKGGYLLYL HIIRDLFTRM TKIKDLSSLD NINYIDESNG ILTLSCLINA
1110 1120 1130 1140 1150
LTFYNKSMQT ETMENVQSIG KYYVSIDDDY NIMKALTVPI KVMALAMILD
1160 1170 1180 1190 1200
LDKSDSLFKT QSRNVPYSVF KQLLSMLKNI FTNVNIYTKE LYELHWDLIF
1210 1220 1230 1240 1250
PPIKKISLFE QVGIPGDVAA NYLTDTGDDL PADNSIGLFS PEQWEKYKKL
1260 1270 1280 1290 1300
IGEDKSIYYP QPMQAQYYKG CSSKELDELR DTFFNDGLPS RIFTVLPFYP
1310 1320 1330 1340 1350
KLVNAFAKTL LQIFTKYDEP TEVFAGRILD RILETDLDDP ATLSSLIHLF
1360 1370 1380 1390 1400
GIFLNEKYIY QKASHLMQRF IEYLEKSLKP EHVNTPWFSK ALYVYEIILA
1410 1420 1430 1440 1450
KSELPHLEEL SKDVLLRYPL LSMAKVFRIP DPMKQKLFDI LIRVSDISNF
1460 1470 1480 1490 1500
YSALATSRIL IFYSRDELYA NNIARSGILS RLLKVIGSFQ KLDKINFLES
1510 1520 1530 1540 1550
SFLLLTRRCF ETTENVDALI RAEINRSFTA RPLGGGDDAV RELTTILEEK
1560 1570 1580 1590 1600
AHVVMRSPSQ FIDVLCETAR FHEFDDQGAL VDYSLKRFLG EKDKNTQASS
1610 1620 1630 1640 1650
TEKSDIYERT GIMHLLLSQL MAASEKDWLS EPANSSDLPE NKKAQLDPSR
1660 1670 1680 1690 1700
NPVCAYMIFL LKLLVELVSS YNQCKFEFLT FSRRNTYAER PRPRTTAINF
1710 1720 1730 1740 1750
FLYRLLDKPV GTDHDKHEAK RREVIGMLAR SVIIGFLATV QDDRTTKTDV
1760 1770 1780 1790 1800
KLADPHMNFI RKFAIEAIIK AIRNATSSSK LLESNHLKLD MWFRIITSMV
1810 1820 1830 1840 1850
YVQAPYLRQL LDSNKVEADQ YQLCKLVIDL GLPSVITEAM ASIDLNYPFS
1860 1870 1880 1890 1900
KKIFNVAVEA LNTISSTRNN FSEHFKIEDH DEVEDEVDES DKEEIPDMFK
1910 1920 1930 1940 1950
NSALGMYDVE DIEEDDDDDT SLIGDDDAMA FVDSDNGFEV VFSDEDDDMG
1960 1970 1980 1990 2000
EEDADDARSD SEENELSSEM QSSTADGTDV DYEVDDADGL IINIDQPSGD
2010 2020 2030 2040 2050
DEEMADYDAN ISHSSHSENE DDASMDVIEV YDDELSSGYD VDLSDYDVDE
2060 2070 2080 2090 2100
SDWDSGLSSL SISDEDSESS EDEPINSTRM GDSRRRWLIA EGVELTDDSQ
2110 2120 2130 2140 2150
GESEEDDRGV FRGIEHIFSN ENEPLFRVHD EMRHRNHHRS INRTHFHSAM
2160 2170 2180 2190 2200
SAPSLSLLNR GRRNQSNLIN PLGPTGLEQV ENDISDQVTV AGSGSRPRSH
2210 2220 2230 2240 2250
HLHFSEVLVS GSFFDEPVLD GIILKSTVSR WKDIFDMFYD SKTYANCIIP
2260 2270 2280 2290 2300
TVINRLYKVS LALQKDLENK REQEKLKNKN LLFNEAKVES HNSSDAISVE
2310 2320 2330 2340 2350
QDDIQESNVT HDDHEPVYVT IQGSEVDIGG TDIDPEFMNA LPDDIRADVF
2360 2370 2380 2390 2400
AQHVRERRAE ARLNSDHNVH SREIDSDFLE AIPEDIREGI LDTEAEEQRM
2410 2420 2430 2440 2450
FGRIGSSADV IRADDDVSNN DEEVENGLDH GNSNDRNNAD PEKKKPARIY
2460 2470 2480 2490 2500
FAPLIDRAGI ASLMKSVFIS KPYIQREIYH ELFYRLCSSK QNRNDLMNTF
2510 2520 2530 2540 2550
LFILSEGIID QHSLEKVYNI ISSRAMGHAK TTTVRQLPSD CTPLTVANQT
2560 2570 2580 2590 2600
IEILQSLIDA DSRLKYFLIA EHDNLIVNKA NNKSRKEALP DKKLRWPLWH
2610 2620 2630 2640 2650
LFSLLDRKLI TDESVLMDLL TRILQVCTKT LAVLSTSSNG KENLSKKFHL
2660 2670 2680 2690 2700
PSFDEDDLMK ILSIIMLDSC TTRVFQQTLN IIYNLSKLQG CMSIFTKHLV
2710 2720 2730 2740 2750
SLAISIMSKL KSALDGLSRE VGTITTGMEI NSELLQKFTL PSSDQAKLLK
2760 2770 2780 2790 2800
ILTTVDFLYT HKRKEEERNV KDLQSLYDKM NGGPVWSSLS ECLSQFEKSQ
2810 2820 2830 2840 2850
AINTSATILL PLIESLMVVC RRSDLSQNRN TAVKYEDAKL LDFSKTRVEN
2860 2870 2880 2890 2900
LFFPFTDAHK KLLNQMIRSN PKLMSGPFAL LVKNPKVLDF DNKRYFFNAK
2910 2920 2930 2940 2950
LKSDNQERPK LPITVRREQV FLDSYRALFF KTNDEIKNSK LEITFKGESG
2960 2970 2980 2990 3000
VDAGGVTREW YQVLSRQMFN PDYALFLPVP SDKTTFHPNR TSGINPEHLS
3010 3020 3030 3040 3050
FFKFIGMIIG KAIRDQCFLD CHFSREVYKN ILGRPVSLKD MESLDPDYYK
3060 3070 3080 3090 3100
SLVWILENDI TDIIEETFSV ETDDYGEHKV INLIEGGKDI IVTEANKQDY
3110 3120 3130 3140 3150
VKKVVEYKLQ TSVKEQMDNF LVGFYALISK DLITIFDEQE LELLISGLPD
3160 3170 3180 3190 3200
IDVDDWKNNT TYVNYTATCK EVSYFWRAVR SFDAEERAKL LQFVTGTSKV
3210 3220 3230 3240 3250
PLNGFKELSG VNGVCKFSIH RDFGSSERLP SSHTCFNQLN LPPYESYETL
3260
RGSLLLAINE GHEGFGLA
Length:3,268
Mass (Da):374,185
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F71F3493D70A6C9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U33050 Genomic DNA Translation: AAB64910.1
D63905 Genomic DNA Translation: BAA21482.1
BK006938 Genomic DNA Translation: DAA12291.1

Protein sequence database of the Protein Information Resource

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PIRi
S69625

NCBI Reference Sequences

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RefSeqi
NP_010745.3, NM_001180765.3

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
YDR457W_mRNA; YDR457W_mRNA; YDR457W

Database of genes from NCBI RefSeq genomes

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GeneIDi
852068

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
sce:YDR457W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33050 Genomic DNA Translation: AAB64910.1
D63905 Genomic DNA Translation: BAA21482.1
BK006938 Genomic DNA Translation: DAA12291.1
PIRiS69625
RefSeqiNP_010745.3, NM_001180765.3

3D structure databases

SMRiQ03280
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32511, 708 interactors
DIPiDIP-5927N
IntActiQ03280, 6 interactors
MINTiQ03280
STRINGi4932.YDR457W

PTM databases

iPTMnetiQ03280

Proteomic databases

MaxQBiQ03280
PaxDbiQ03280
PRIDEiQ03280

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR457W_mRNA; YDR457W_mRNA; YDR457W
GeneIDi852068
KEGGisce:YDR457W

Organism-specific databases

EuPathDBiFungiDB:YDR457W
SGDiS000002865 TOM1

Phylogenomic databases

GeneTreeiENSGT00940000156319
HOGENOMiHOG000093627
InParanoidiQ03280
KOiK10592
OMAiLLNCPNF

Enzyme and pathway databases

UniPathwayi
UPA00143

BioCyciYEAST:G3O-29985-MONOMER
ReactomeiR-SCE-6798695 Neutrophil degranulation
R-SCE-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q03280

Family and domain databases

CDDicd00078 HECTc, 1 hit
Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR010309 E3_Ub_ligase_DUF908
IPR010314 E3_Ub_ligase_DUF913
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR025527 HUWE1/Rev1_UBM
PfamiView protein in Pfam
PF06012 DUF908, 1 hit
PF06025 DUF913, 1 hit
PF00632 HECT, 1 hit
PF14377 UBM, 2 hits
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOM1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03280
Secondary accession number(s): D6VT81, Q7LIK7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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