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UniProtKB - Q03263 (YM8M_YEAST)

Entry version 142 (23 Feb 2022)
Sequence version 1 (01 Nov 1997)
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Protein

Uncharacterized transporter YMR279C

Gene

YMR279C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.1.3.69, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized transporter YMR279C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:YMR279C
ORF Names:YM8021.05C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIII

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000004892, YMR279C

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YMR279C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 108ExtracellularSequence analysisAdd BLAST26
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 131CytoplasmicSequence analysis2
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 169ExtracellularSequence analysisAdd BLAST17
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 203CytoplasmicSequence analysisAdd BLAST13
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 232ExtracellularSequence analysis8
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 272CytoplasmicSequence analysisAdd BLAST19
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Topological domaini294 – 295ExtracellularSequence analysis2
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 334CytoplasmicSequence analysisAdd BLAST18
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Topological domaini356 – 372ExtracellularSequence analysisAdd BLAST17
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 398CytoplasmicSequence analysis5
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 429ExtracellularSequence analysis10
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Topological domaini451 – 461CytoplasmicSequence analysisAdd BLAST11
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 502ExtracellularSequence analysisAdd BLAST20
Transmembranei503 – 523HelicalSequence analysisAdd BLAST21
Topological domaini524 – 540CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001734291 – 540Uncharacterized transporter YMR279CAdd BLAST540

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q03263

PRoteomics IDEntifications database

More...PRIDEi		Q03263

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		35458, 58 interactors

Database of interacting proteins

More...DIPi		DIP-4642N

Protein interaction database and analysis system

More...IntActi		Q03263, 5 interactors

Molecular INTeraction database

More...MINTi		Q03263

STRING: functional protein association networks

More...STRINGi		4932.YMR279C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q03263, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q03263

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0254, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000176573

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000960_27_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q03263

Identification of Orthologs from Complete Genome Data

More...OMAi		CAGQFLV

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1250.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07690, MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50850, MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q03263-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSIFKKKTS VQGTDSEIDE KITVKAKDKV VVSTEDEEVT TIVSSTKSTQ 
        60         70         80         90        100
VTNDSPWQDP TYFSSFGKEL MFIATCMLAQ LLNQAGQTHA LCIMNVLSKS 
       110        120        130        140        150
FNSEANNQAW LMASFPLAAG SFILISGRLG DIYGLKKMLI VGYVIVIVWS 
       160        170        180        190        200
IISGLSKYSN SDAFFITSRA FQGVGIAFIL PNIMGLVGHV YKVGSFRKNI 
       210        220        230        240        250
VISFIGACAP TGGMFGGLFG GLIVTEDPNQ WPWVFYAFGI ATFLSLLMAW 
       260        270        280        290        300
YSIPNNVPTN IHGLSMDWTG SALAIIGLIL FNFVWNQAPI VGWDKPYIIV 
       310        320        330        340        350
LLIISVIFLV AFFVYESKYA EVPLLPRAMT KNRHMIMILL AVFLGWGSFG 
       360        370        380        390        400
IWTFYYVSFQ LNLRHYSPVW TGGTYFVFVI FGSMAAFFVA FSIKRLGPAL 
       410        420        430        440        450
LLCFSLMAFD AGSIMFSVLP VEQSYWKLNF AMQAILCFGM DLSFPASSII 
       460        470        480        490        500
LSDGLPMQYQ GMAGSLVNTV INYSASLCLG MGGTVEHQIN KSGNDLLKGY 
       510        520        530        540
RAAVYLGVGL ASLGVVISVT YMLENLWNRH RKSEDRSLEA
Length:540
Mass (Da):59,562
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i687D06CB0D70AF91
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z49704 Genomic DNA Translation: CAA89777.1
BK006946 Genomic DNA Translation: DAA10180.1

Protein sequence database of the Protein Information Resource

More...PIRi		S54586

NCBI Reference Sequences

More...RefSeqi		NP_014006.1, NM_001182786.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YMR279C_mRNA; YMR279C; YMR279C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		855322

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YMR279C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49704 Genomic DNA Translation: CAA89777.1
BK006946 Genomic DNA Translation: DAA10180.1
PIRiS54586
RefSeqiNP_014006.1, NM_001182786.1

3D structure databases

SMRiQ03263
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35458, 58 interactors
DIPiDIP-4642N
IntActiQ03263, 5 interactors
MINTiQ03263
STRINGi4932.YMR279C

Protein family/group databases

TCDBi2.A.1.3.69, the major facilitator superfamily (mfs)

Proteomic databases

PaxDbiQ03263
PRIDEiQ03263

Genome annotation databases

EnsemblFungiiYMR279C_mRNA; YMR279C; YMR279C
GeneIDi855322
KEGGisce:YMR279C

Organism-specific databases

SGDiS000004892, YMR279C
VEuPathDBiFungiDB:YMR279C

Phylogenomic databases

eggNOGiKOG0254, Eukaryota
GeneTreeiENSGT00940000176573
HOGENOMiCLU_000960_27_4_1
InParanoidiQ03263
OMAiCAGQFLV

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q03263
RNActiQ03263, protein

Family and domain databases

Gene3Di1.20.1250.20, 2 hits
InterProiView protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYM8M_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03263
Secondary accession number(s): D6W0A6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 23, 2022
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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