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Entry version 162 (07 Oct 2020)
Sequence version 1 (01 Nov 1997)
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Protein

Protein ECM5

Gene

ECM5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in cell wall organization and biogenesis.

Miscellaneous

Present with 259 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1238 – 1290PHD-typePROSITE-ProRule annotationAdd BLAST53

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell wall biogenesis/degradation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ECM5
Alternative name(s):
Extracellular matrix protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ECM5
Ordered Locus Names:YMR176W
ORF Names:YM8010.06
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIII

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YMR176W

Saccharomyces Genome Database

More...
SGDi
S000004788, ECM5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002005971 – 1411Protein ECM5Add BLAST1411

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q03214

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q03214

PRoteomics IDEntifications database

More...
PRIDEi
Q03214

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q03214

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35354, 67 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1372, SNT2C histone deacetylase complex

Database of interacting proteins

More...
DIPi
DIP-6678N

Protein interaction database and analysis system

More...
IntActi
Q03214, 6 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YMR176W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q03214, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini118 – 159JmjNPROSITE-ProRule annotationAdd BLAST42
Domaini185 – 279ARIDPROSITE-ProRule annotationAdd BLAST95
Domaini476 – 695JmjCPROSITE-ProRule annotationAdd BLAST220

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1238 – 1290PHD-typePROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1246, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159220

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_250352_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q03214

Identification of Orthologs from Complete Genome Data

More...
OMAi
KWAPVAP

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.60, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001606, ARID_dom
IPR036431, ARID_dom_sf
IPR003347, JmjC_dom
IPR003349, JmjN
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01388, ARID, 1 hit
PF00628, PHD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00501, BRIGHT, 1 hit
SM00558, JmjC, 1 hit
SM00249, PHD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46774, SSF46774, 1 hit
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51011, ARID, 1 hit
PS51184, JMJC, 1 hit
PS51183, JMJN, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q03214-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGHDSVTKI SHILNEPVNE KVMVQNGFHE SSKIADIELE IQERPSIKQW
60 70 80 90 100
ESPRSAVIPT SNHNFSPFLY TQFKSRGAAP FAPETIKSVD LVELPEGVPA
110 120 130 140 150
RVFHEKTGLF YQISPHSIPT FILAKKELPD PIKFYELVED LGSVYGCVKL
160 170 180 190 200
KIIPDADKFT QLNVDVDRLW FKARKQFFNS NEFQRTKIVD FYAKLYNFHN
210 220 230 240 250
KIKKSTLTRI PSIDKRTLDL YRLRSCVKLR GGFNAVCEKK LWAQIGRELG
260 270 280 290 300
YSGRIMSSLS TSLRSAYAKI LLDFDIYEEE EQAARNNEKN EDMVESEIFR
310 320 330 340 350
HSNSRSRDEE EPLHKKAKIH RDVFRAGSIN HEFKRMRDIK HIKGFPTYFN
360 370 380 390 400
SLTEFKLGYT QSTETTLPGY DFTFWENGME IYDKSKYETK TSPVYNLRQY
410 420 430 440 450
YEKSLAVFTA IVAKFGSSYP DLFAKHTTLP QKEFERLYFH LLSEHFIDFE
460 470 480 490 500
IDTGLGLPCS MRSPGNNSSN EKFAIKNILD QWNLDNIPLN ELSLLQHLDL
510 520 530 540 550
DMANFTRTTY DIGMLFSCQG WSVSDHFLPS IDFNHLGSTK LVYSIAPKDM
560 570 580 590 600
EKFEALIARG KSEWDTIQSR PRYSTSDDEL KSFIETDFYK SFLDAEQSAD
610 620 630 640 650
YSNTGDNSKN SFPEDKIAGN TLHDGSQSDF IFEPNFILAN GIKLYKTTQE
660 670 680 690 700
QGSYIFKFPK AFTCSIGSGF YLSQNAKFAP SSWLRFSSEA AKWTSKMGFL
710 720 730 740 750
PGLDVNQLLI NALLNSNNPV LRKKCRDLIS NYVVEEAENS KKLGELIGTV
760 770 780 790 800
DVVYNKLNYI SDISLESTGL SKIVVTHGAL QRNLSLKEFV VLLEKPENGA
810 820 830 840 850
HSICGIPIRD QSGNLNVCLH SYFDSASLGI ALDGLDKPPT SYLLVHNEDF
860 870 880 890 900
EKKWDVLMTS TFRNRTVPLN IIQYLISHTD SNTEFNRMLR SNFDDSLLLI
910 920 930 940 950
EKCKKFIKTF VDVSCSVKDV DFGNGFNLRH LPLKFSDNMA DNLESLYESV
960 970 980 990 1000
RKCSIEFSEK PTIIRLYHVS RQFPIDNRDI IDGNNLDLLK ELYQKSLTIP
1010 1020 1030 1040 1050
LKVSYWTKLT RKICRLEWLS VYEHIFIERC DIKNEDPAKY SLPLLYSYFE
1060 1070 1080 1090 1100
FGLKYCDSED IDKLGEVRKL ILKYQDMMQK VRVFLKKDPP SKISLSDLED
1110 1120 1130 1140 1150
VLLDIEEYRL PIQSSFFSEL DYVIREIENA KKMNDVNILY NTDNIDKIDE
1160 1170 1180 1190 1200
LIRKNDPKFV KFANQFNGSR LDKRPLASDN SGSVKAKQEL KVFKLWNQHL
1210 1220 1230 1240 1250
DQIMQKNKFI EILPSIFRCL DLKSDKYIPL ESCSKRQTKY CFCRRVEEGT
1260 1270 1280 1290 1300
AMVECEICKE WYHVDCISNG ELVPPDDPNV LFVCSICTPP CMAVDNIEGV
1310 1320 1330 1340 1350
TFELDDLKRI LVESLKLSLI PDPPILKNLF DVFAFALNFK NEMEKELFTN
1360 1370 1380 1390 1400
GYVNQLSSTH KIKYYLRKLK GSQCGFTNLT DPLRKHCQVK DAEAIKWLTD
1410
NGRIIITGIP N
Length:1,411
Mass (Da):162,701
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18768BD29934D9F9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49808 Genomic DNA Translation: CAA89909.1
BK006946 Genomic DNA Translation: DAA10073.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S55123

NCBI Reference Sequences

More...
RefSeqi
NP_013901.1, NM_001182682.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YMR176W_mRNA; YMR176W; YMR176W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855214

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YMR176W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49808 Genomic DNA Translation: CAA89909.1
BK006946 Genomic DNA Translation: DAA10073.1
PIRiS55123
RefSeqiNP_013901.1, NM_001182682.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi35354, 67 interactors
ComplexPortaliCPX-1372, SNT2C histone deacetylase complex
DIPiDIP-6678N
IntActiQ03214, 6 interactors
STRINGi4932.YMR176W

PTM databases

iPTMnetiQ03214

Proteomic databases

MaxQBiQ03214
PaxDbiQ03214
PRIDEiQ03214

Genome annotation databases

EnsemblFungiiYMR176W_mRNA; YMR176W; YMR176W
GeneIDi855214
KEGGisce:YMR176W

Organism-specific databases

EuPathDBiFungiDB:YMR176W
SGDiS000004788, ECM5

Phylogenomic databases

eggNOGiKOG1246, Eukaryota
GeneTreeiENSGT00940000159220
HOGENOMiCLU_250352_0_0_1
InParanoidiQ03214
OMAiKWAPVAP

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q03214
RNActiQ03214, protein

Family and domain databases

Gene3Di1.10.150.60, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001606, ARID_dom
IPR036431, ARID_dom_sf
IPR003347, JmjC_dom
IPR003349, JmjN
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01388, ARID, 1 hit
PF00628, PHD, 1 hit
SMARTiView protein in SMART
SM00501, BRIGHT, 1 hit
SM00558, JmjC, 1 hit
SM00249, PHD, 1 hit
SUPFAMiSSF46774, SSF46774, 1 hit
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51011, ARID, 1 hit
PS51184, JMJC, 1 hit
PS51183, JMJN, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiECM5_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03214
Secondary accession number(s): D6VZZ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 7, 2020
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
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