UniProtKB - Q03190 (CXA4_RAT)
Protein
Gap junction alpha-4 protein
Gene
Gja4
Organism
Rattus norvegicus (Rat)
Status
Functioni
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
GO - Molecular functioni
- gap junction channel activity Source: GO_Central
GO - Biological processi
- blood vessel development Source: RGD
- calcium ion transport Source: RGD
- cell-cell signaling Source: RGD
- cell communication Source: RGD
- endothelium development Source: RGD
- response to pain Source: RGD
Enzyme and pathway databases
Reactomei | R-RNO-190861, Gap junction assembly |
Names & Taxonomyi
Protein namesi | Recommended name: Gap junction alpha-4 proteinAlternative name(s): Connexin-37 Short name: Cx37 |
Gene namesi | Name:Gja4 Synonyms:Cxn-37 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2691, Gja4 |
Subcellular locationi
Plasma membrane
Other locations
Plasma Membrane
- connexin complex Source: RGD
Other locations
- gap junction Source: RGD
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 20 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 21 – 40 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 41 – 76 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 77 – 99 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 100 – 148 | CytoplasmicSequence analysisAdd BLAST | 49 | |
Transmembranei | 149 – 171 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 172 – 208 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 209 – 231 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 232 – 333 | CytoplasmicSequence analysisAdd BLAST | 102 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057817 | 1 – 333 | Gap junction alpha-4 proteinAdd BLAST | 333 |
Proteomic databases
PaxDbi | Q03190 |
PRIDEi | Q03190 |
PTM databases
iPTMneti | Q03190 |
Expressioni
Tissue specificityi
Highly expressed in lung.
Gene expression databases
Bgeei | ENSRNOG00000014357, Expressed in lung and 21 other tissues |
Genevisiblei | Q03190, RN |
Interactioni
Subunit structurei
A connexon is composed of a hexamer of connexins.
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019246 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QU20, Eukaryota |
GeneTreei | ENSGT01010000222355 |
HOGENOMi | CLU_037388_4_2_1 |
InParanoidi | Q03190 |
OMAi | HLRIRGA |
OrthoDBi | 903777at2759 |
PhylomeDBi | Q03190 |
TreeFami | TF329606 |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002263, Connexin37 IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01134, CONNEXINA4 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q03190-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS
60 70 80 90 100
DFECNTAQPG CTNVCYDQAF PISHIRYWVL QFLFVSTPTL IYLGHVIYLS
110 120 130 140 150
RREERLRQKE GELRALPSKD PHVERALAAI EHQMAKISVA EDGRLRIRGA
160 170 180 190 200
LMGTYVISVL CKSVLEAGFL YGQWRLYGWT MEPVFVCQRA PCPHVVDCYV
210 220 230 240 250
SRPTEKTIFI IFMLVVGVIS LVLNLLELVH LLCRCVSREI KARRDHDTRP
260 270 280 290 300
AQGSASDPYP EQVFFYLPMG EGPSSPPCPT YNGLSSTEQN WANLTTEERL
310 320 330
TSTRPPPFVN AAPQGGQKSS SRPNSSASKK QYV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M76532 Genomic DNA Translation: AAA40999.1 BC078837 mRNA Translation: AAH78837.1 BC086576 mRNA Translation: AAH86576.1 |
PIRi | B42053 |
RefSeqi | NP_067686.1, NM_021654.2 |
Genome annotation databases
Ensembli | ENSRNOT00000019246; ENSRNOP00000019246; ENSRNOG00000014357 |
GeneIDi | 25655 |
KEGGi | rno:25655 |
UCSCi | RGD:2691, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M76532 Genomic DNA Translation: AAA40999.1 BC078837 mRNA Translation: AAH78837.1 BC086576 mRNA Translation: AAH86576.1 |
PIRi | B42053 |
RefSeqi | NP_067686.1, NM_021654.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019246 |
PTM databases
iPTMneti | Q03190 |
Proteomic databases
PaxDbi | Q03190 |
PRIDEi | Q03190 |
Genome annotation databases
Ensembli | ENSRNOT00000019246; ENSRNOP00000019246; ENSRNOG00000014357 |
GeneIDi | 25655 |
KEGGi | rno:25655 |
UCSCi | RGD:2691, rat |
Organism-specific databases
CTDi | 2701 |
RGDi | 2691, Gja4 |
Phylogenomic databases
eggNOGi | ENOG502QU20, Eukaryota |
GeneTreei | ENSGT01010000222355 |
HOGENOMi | CLU_037388_4_2_1 |
InParanoidi | Q03190 |
OMAi | HLRIRGA |
OrthoDBi | 903777at2759 |
PhylomeDBi | Q03190 |
TreeFami | TF329606 |
Enzyme and pathway databases
Reactomei | R-RNO-190861, Gap junction assembly |
Miscellaneous databases
PROi | PR:Q03190 |
Gene expression databases
Bgeei | ENSRNOG00000014357, Expressed in lung and 21 other tissues |
Genevisiblei | Q03190, RN |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002263, Connexin37 IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01134, CONNEXINA4 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXA4_RAT | |
Accessioni | Q03190Primary (citable) accession number: Q03190 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families