Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 40

Gene

Hivep1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor which binds specifically to the palindromic sequence 5'-GGGAAATCCC-3' in the alpha-A crystallin promoter.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri407 – 429C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 459C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri950 – 980CCHC HIVEP-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri2074 – 2096C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2102 – 2126C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
  • DNA binding Source: MGI
  • HMG box domain binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 40
Alternative name(s):
Alpha A-crystallin-binding protein 1
Short name:
Alpha A-CRYBP1
Alpha A-crystallin-binding protein I
Transcription factor alphaA-CRYBP1
Gene namesi
Name:Hivep1
Synonyms:Cryabp1, Znf40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96100 Hivep1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473701 – 2688Zinc finger protein 40Add BLAST2688

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei141PhosphoserineBy similarity1
Modified residuei430PhosphothreonineBy similarity1
Modified residuei477PhosphoserineBy similarity1
Modified residuei493PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei665PhosphoserineBy similarity1
Modified residuei676PhosphoserineBy similarity1
Modified residuei1030PhosphoserineBy similarity1
Modified residuei1045PhosphoserineBy similarity1
Modified residuei1148PhosphoserineBy similarity1
Modified residuei1253PhosphothreonineBy similarity1
Modified residuei1721PhosphoserineBy similarity1
Modified residuei1726PhosphoserineBy similarity1
Modified residuei1735PhosphoserineBy similarity1
Modified residuei1739PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03172
PaxDbiQ03172
PRIDEiQ03172

PTM databases

iPTMnetiQ03172
PhosphoSitePlusiQ03172

Interactioni

Subunit structurei

Interacts with UTP4.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Mapk1P630854EBI-646850,EBI-397697

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ03172
IntActiQ03172, 1 interactor
STRINGi10090.ENSMUSP00000056147

Structurei

3D structure databases

ProteinModelPortaliQ03172
SMRiQ03172
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi165 – 170Poly-Ser6
Compositional biasi799 – 802Poly-Ser4
Compositional biasi851 – 854Poly-Pro4
Compositional biasi1482 – 1486Poly-Ser5
Compositional biasi2179 – 2182Poly-Asp4

Domaini

Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There is a fifth zinc-finger in-between.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri407 – 429C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 459C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri950 – 980CCHC HIVEP-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri2074 – 2096C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2102 – 2126C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000169307
HOVERGENiHBG018160
InParanoidiQ03172
PhylomeDBiQ03172

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR034729 ZF_CCHC_HIVEP
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SM00451 ZnF_U1, 2 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS51811 ZF_CCHC_HIVEP, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q03172-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRTKQIHPR NLRDKIEEAQ KELNGAEVSK KEVLEAGVKG TSESLKGVKR
60 70 80 90 100
KKIVAENHLK KIPKSPLRNP LQTKHKQNTE EPPFSVLPSA SESHKKHNCV
110 120 130 140 150
PAKQGRQFTK QNGETPGMTA ESSESGDLVS PKKTSSPHQR SELRRWRSEG
160 170 180 190 200
SDPTRLSGLD GQRDSSSSSS KARTDNSECS SPCCSTTPPS YTSTAFDVLL
210 220 230 240 250
KAMEPELSTL SQKGSSCAIK TEKLRPNKTV RSPSKLKNSS LDAPNATSPD
260 270 280 290 300
LVVESPCPPC TSYPVHVAST QKSEQVAAQC VSHLYSSQDH LVPKLSQQNQ
310 320 330 340 350
QLPGHLGFTG SLTNLHTLES TKLEPIYNTA VTSTVGLTSP STRTQVTPPH
360 370 380 390 400
QQMDSVSPLS VSPASSTQSP PGPIYSSAHV ASVVSQSVEQ MCSLLLRDQK
410 420 430 440 450
PKKQGKYICE YCNRACAKPS VLLKHIRSHT GERPYPCVTC GFSFKTKSNL
460 470 480 490 500
YKHKKSHAHT IKLGLVLQPE AGGLFLSQEC PKALSVHSDI EDSGESDEEG
510 520 530 540 550
LADGRQNNPC VKDLQPVQTM KTVSNPESLP KLIPSNSDHV VRGFSSQDRP
560 570 580 590 600
SDSQAPTELP KVVVHPVSMP PLKTDCLQVA NPNPELPSPQ SPRDLHVASI
610 620 630 640 650
LSHSASVSSL EMDESCHQKG DVIQSEGKPD SHSGTAHAQL QRQQATEDPQ
660 670 680 690 700
EQQGKLLLSP RSLGSTDSGY FSRSESADQA VSPPTPFART FPTMDPDPAK
710 720 730 740 750
NGGAPGPRIS APAPSALATG EKSSVVTGQM RPPLATKTLE ERISKLISDN
760 770 780 790 800
EALVDDKQLD SVKPRRTSLS RRGSIDSPKS YIFKDSFQFD LKPMGRRTSS
810 820 830 840 850
SSDIPKSPFT PTEKSKQVFL LSVPSLDCLP ITRSNSMPTT GYSAIPANII
860 870 880 890 900
PPPPSLRGSQ SFDDKIGTLY DDVFVSGPNP SMPPSGHHRP LVRQAAVEDS
910 920 930 940 950
TASESHVPGS GQSVDESCQG CPSSSEAGPV QSKAAQTPHL EKKKSHQGRG
960 970 980 990 1000
TMFECETCRN RYRKLENFEN HKKFYCSELH GPKTKAAVRE AEHGPAPGGA
1010 1020 1030 1040 1050
QPQVLHYRVA APTAVWEQTP QIRKRRKMKS VGDEEDLQPH ESGRSPESAD
1060 1070 1080 1090 1100
ALQLQPVPGA APSPSKHTSA TAADQAHRGV QLVARGPERA LPLKQCPMVE
1110 1120 1130 1140 1150
QQLNAAAQDK MEVKRQGGGI SVIQHTNSLS RPNSFDKPEP LEGGITFSLQ
1160 1170 1180 1190 1200
ELGRTGMPGA LKVIGMAPEE GHPPQDAMHQ TALSHNLRGE PRESARKIPS
1210 1220 1230 1240 1250
ERYVLGQPLR LVRQHNIQVP EILVTEEPDR DLEAQSHDEE KSEKFTWPQR
1260 1270 1280 1290 1300
SETLSKLPTE KLPPKKKRLR LAEIEHSSTE SSFESTLSRS LSRESSLSHA
1310 1320 1330 1340 1350
SSFSASLDLE DISKVELAPK IDFPSKAEFL LIPLGSNTLS VPGSHREMRR
1360 1370 1380 1390 1400
AASEQISCVP TLMEVSDFRS KSFDCGSIAP SHVVPALVES QPSYSPSAVG
1410 1420 1430 1440 1450
GTAHVPLLER RRGPLIRQIS LNIASDSHLS PGSAAALQTI VLPSVNTVPF
1460 1470 1480 1490 1500
QAPRLPDMAS ADCPAHTVHP QALAKDLQAE ISSSSSTDTF PPQQLFGAHL
1510 1520 1530 1540 1550
LNKTNTSLSH QNTPLPLPVS AQGGKPDAAP TACVSSTGEG SFAPKYQLQC
1560 1570 1580 1590 1600
QAFTSDQGCS APLRSSPNQV LPGQAGADPC PASEAPPAKA ADPMAKPCPL
1610 1620 1630 1640 1650
PPLELGLPRD EVLQKQLPSF VLPVPQKRNV TVDCFTPVTS LPQILVTQDL
1660 1670 1680 1690 1700
PNMPICQTNQ SLVPVSEEQN SMPKSQNYLQ NASPTPEKEL ACKTVLPEVG
1710 1720 1730 1740 1750
QSVPVSESSP TVQKVSVGRL SPQQESSASS KRMLSPANSL DIAMEKHQKR
1760 1770 1780 1790 1800
AKDENGAVCS TNIRALELPS SRANESHKQK KPVLVRQLCT TEPLEGAALE
1810 1820 1830 1840 1850
QGACSASGRS SNKAANLTQV LPTDSLSSRP STFAVTDHVN ELQEFKNTKV
1860 1870 1880 1890 1900
STSLTPTVGS FPAPSESACV LPLKSIDNNQ EKGSPGVRHE ENKVIQGQRP
1910 1920 1930 1940 1950
PLVSGLSLVS SSDTQQPSFP SLKTATSFTW CYLLRQKALP LAQNDQKTSA
1960 1970 1980 1990 2000
YTGWTVSSSN PNPLGLPTKV ALSLLNSKQK TGKSLYCQAI TTHSKSDLVV
2010 2020 2030 2040 2050
YSSKWKNNLS KRALGNQKAT VVEFSNKDDS EINSEQDKEN SLIKSEPRRI
2060 2070 2080 2090 2100
KIFDGGYKSN EDYVYVRGRG RGKYICEECG IRCKKPSMLK KHIRTHTDVR
2110 2120 2130 2140 2150
PYHCSYCNFS FKTKGNLTKH MKSKAHSKKC VDLGVSVGLI DEQDTEESDE
2160 2170 2180 2190 2200
KQRFGCERSG YDLEESDGPD EDDNDNEEDD DDSQAESGLS AAPSVTASPQ
2210 2220 2230 2240 2250
HLPSRSGLQD PGSVEEELRV SSCFSGVHTD PMDILPRALL TKMTVLSTVQ
2260 2270 2280 2290 2300
SSPNRTDLPA KARQSTEKDE HEQAPPADTP RSPGHQLSVH SSESDVLRSP
2310 2320 2330 2340 2350
AAGNPAAGSP GAAVQDSSVG LPPAVAQLNP QPAARISSSV SPHPDSQDQK
2360 2370 2380 2390 2400
QQIILQPPPG LPSPQTHLFS HLPLHSQQQS RTPYNMVPVG GIHVVTAGLT
2410 2420 2430 2440 2450
YSTFVPIQAG PMQLTIPAVS VIHRTVGTSG DTITEASGSP NRPTGVAELS
2460 2470 2480 2490 2500
SVVPCIPIGQ IHVPGLQNLS PPALQSLTSL GMETVNLVGL ANATVGPQGH
2510 2520 2530 2540 2550
PPGLALNAVG LQVLANAPAQ SSPAPPAHIQ GLQILNIALP TLIPSVGPVA
2560 2570 2580 2590 2600
VGTTGTPETT APNSKAMELQ MPAGQGHSAE PPQGSPEGPQ ETPQTVSGPS
2610 2620 2630 2640 2650
ADHARPEDST KMDTKKGPSA GHVLPGRSPA QAQPAPTPEA LQKVATSAPP
2660 2670 2680
SLPTDRAAPR PPVPHRQPIV HFSDVSSDDD EDRLVIAT
Length:2,688
Mass (Da):288,344
Last modified:October 1, 1996 - v1
Checksum:i5EAD46C3A7008BE6
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VPM9F8VPM9_MOUSE
Zinc finger protein 40
Hivep1
2,688Annotation score:
A0A1Y7VJI1A0A1Y7VJI1_MOUSE
Zinc finger protein 40
Hivep1
115Annotation score:
A0A1Y7VJI7A0A1Y7VJI7_MOUSE
Zinc finger protein 40
Hivep1
241Annotation score:
A0A1Y7VLH2A0A1Y7VLH2_MOUSE
Zinc finger protein 40
Hivep1
83Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36829
, L36825, L36826, L36827, L36828 Genomic DNA Translation: AAA98810.1
X68946 mRNA Translation: CAA48762.1
CCDSiCCDS36643.1
PIRiI49477
UniGeneiMm.4808

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36829
, L36825, L36826, L36827, L36828 Genomic DNA Translation: AAA98810.1
X68946 mRNA Translation: CAA48762.1
CCDSiCCDS36643.1
PIRiI49477
UniGeneiMm.4808

3D structure databases

ProteinModelPortaliQ03172
SMRiQ03172
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ03172
IntActiQ03172, 1 interactor
STRINGi10090.ENSMUSP00000056147

PTM databases

iPTMnetiQ03172
PhosphoSitePlusiQ03172

Proteomic databases

MaxQBiQ03172
PaxDbiQ03172
PRIDEiQ03172

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96100 Hivep1

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000169307
HOVERGENiHBG018160
InParanoidiQ03172
PhylomeDBiQ03172

Miscellaneous databases

PROiPR:Q03172
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR034729 ZF_CCHC_HIVEP
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SM00451 ZnF_U1, 2 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS51811 ZF_CCHC_HIVEP, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZEP1_MOUSE
AccessioniPrimary (citable) accession number: Q03172
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again