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Entry version 150 (12 Aug 2020)
Sequence version 2 (18 Apr 2006)
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Protein

Tumor necrosis factor alpha-induced protein 2

Gene

TNFAIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role as a mediator of inflammation and angiogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SNARE binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q03169

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.L.1.1.1, the tunneling nanotube (tnt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 2
Short name:
TNF alpha-induced protein 2
Alternative name(s):
Primary response gene B94 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFAIP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185215.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11895, TNFAIP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603300, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q03169

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7127

Open Targets

More...
OpenTargetsi
ENSG00000185215

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36592

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q03169, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNFAIP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
93141326

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001189321 – 654Tumor necrosis factor alpha-induced protein 2Add BLAST654

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q03169

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q03169

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q03169

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q03169

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q03169

PeptideAtlas

More...
PeptideAtlasi
Q03169

PRoteomics IDEntifications database

More...
PRIDEi
Q03169

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58199

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q03169

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q03169

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q03169

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Differentially expressed in development and capillary tube-like formation in vitro.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By TNF and other proinflammatory factors.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185215, Expressed in granulocyte and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q03169, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q03169, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000185215, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112982, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q03169, 4 interactors

Molecular INTeraction database

More...
MINTi
Q03169

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000452634

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q03169, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q03169

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 25Poly-Glu4
Compositional biasi28 – 54Lys-rich (basic)Add BLAST27
Compositional biasi105 – 110Poly-Ala6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC6 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2286, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182797

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016260_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q03169

KEGG Orthology (KO)

More...
KOi
K19989

Identification of Orthologs from Complete Genome Data

More...
OMAi
NLLHMGK

Database of Orthologous Groups

More...
OrthoDBi
391172at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q03169

TreeFam database of animal gene trees

More...
TreeFami
TF314979

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010326, EXOC3/Sec6

The PANTHER Classification System

More...
PANTHERi
PTHR21292, PTHR21292, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06046, Sec6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q03169-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEASSEDLV PPLEAGAAPY REEEEAAKKK KEKKKKSKGL ANVFCVFTKG
60 70 80 90 100
KKKKGQPSSA EPEDAAGSRQ GLDGPPPTVE ELKAALERGQ LEAARPLLAL
110 120 130 140 150
ERELAAAAAA GGVSEEELVR RQSKVEALYE LLRDQVLGVL RRPLEAPPER
160 170 180 190 200
LRQALAVVAE QEREDRQAAA AGPGTSGLAA TRPRRWLQLW RRGVAEAAEE
210 220 230 240 250
RMGQRPAAGA EVPESVFLHL GRTMKEDLEA VVERLKPLFP AEFGVVAAYA
260 270 280 290 300
ESYHQHFAAH LAAVAQFELC ERDTYMLLLW VQNLYPNDII NSPKLVGELQ
310 320 330 340 350
GMGLGSLLPP RQIRLLEATF LSSEAANVRE LMDRALELEA RRWAEDVPPQ
360 370 380 390 400
RLDGHCHSEL AIDIIQITSQ AQAKAESITL DLGSQIKRVL LVELPAFLRS
410 420 430 440 450
YQRAFNEFLE RGKQLTNYRA NVIANINNCL SFRMSMEQNW QVPQDTLSLL
460 470 480 490 500
LGPLGELKSH GFDTLLQNLH EDLKPLFKRF THTRWAAPVE TLENIIATVD
510 520 530 540 550
TRLPEFSELQ GCFREELMEA LHLHLVKEYI IQLSKGRLVL KTAEQQQQLA
560 570 580 590 600
GYILANADTI QHFCTQHGSP ATWLQPALPT LAEIIRLQDP SAIKIEVATY
610 620 630 640 650
ATCYPDFSKG HLSAILAIKG NLSNSEVKRI RSILDVSMGA QEPSRPLFSL

IKVG
Length:654
Mass (Da):72,661
Last modified:April 18, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BB18E96B193CC3D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKI8H0YKI8_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP2
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKR7H0YKR7_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP2
243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLC0H0YLC0_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP2
347Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YM45H0YM45_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP2
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKY9H0YKY9_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP2
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YL88H0YL88_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP2
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038742110A → AA1 Publication1
Natural variantiVAR_020772282Q → E2 PublicationsCorresponds to variant dbSNP:rs1132339Ensembl.1
Natural variantiVAR_020773565T → I1 PublicationCorresponds to variant dbSNP:rs2229727Ensembl.1
Natural variantiVAR_020774580T → M1 PublicationCorresponds to variant dbSNP:rs2234146Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M92357 mRNA Translation: AAA35582.1
AL161669 Genomic DNA No translation available.
AY273786 Genomic DNA Translation: AAP12649.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9979.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I56134

NCBI Reference Sequences

More...
RefSeqi
NP_006282.2, NM_006291.2
XP_011535416.1, XM_011537114.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333007; ENSP00000332326; ENSG00000185215
ENST00000560869; ENSP00000452634; ENSG00000185215

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7127

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7127

UCSC genome browser

More...
UCSCi
uc001ymm.1, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92357 mRNA Translation: AAA35582.1
AL161669 Genomic DNA No translation available.
AY273786 Genomic DNA Translation: AAP12649.1
CCDSiCCDS9979.1
PIRiI56134
RefSeqiNP_006282.2, NM_006291.2
XP_011535416.1, XM_011537114.2

3D structure databases

SMRiQ03169
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112982, 5 interactors
IntActiQ03169, 4 interactors
MINTiQ03169
STRINGi9606.ENSP00000452634

Protein family/group databases

TCDBi1.L.1.1.1, the tunneling nanotube (tnt) family

PTM databases

iPTMnetiQ03169
PhosphoSitePlusiQ03169
SwissPalmiQ03169

Polymorphism and mutation databases

BioMutaiTNFAIP2
DMDMi93141326

Proteomic databases

EPDiQ03169
jPOSTiQ03169
MassIVEiQ03169
MaxQBiQ03169
PaxDbiQ03169
PeptideAtlasiQ03169
PRIDEiQ03169
ProteomicsDBi58199

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3892, 185 antibodies

Genome annotation databases

EnsembliENST00000333007; ENSP00000332326; ENSG00000185215
ENST00000560869; ENSP00000452634; ENSG00000185215
GeneIDi7127
KEGGihsa:7127
UCSCiuc001ymm.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7127
DisGeNETi7127
EuPathDBiHostDB:ENSG00000185215.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNFAIP2
HGNCiHGNC:11895, TNFAIP2
HPAiENSG00000185215, Low tissue specificity
MIMi603300, gene
neXtProtiNX_Q03169
OpenTargetsiENSG00000185215
PharmGKBiPA36592

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2286, Eukaryota
GeneTreeiENSGT00950000182797
HOGENOMiCLU_016260_2_0_1
InParanoidiQ03169
KOiK19989
OMAiNLLHMGK
OrthoDBi391172at2759
PhylomeDBiQ03169
TreeFamiTF314979

Enzyme and pathway databases

PathwayCommonsiQ03169

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
7127, 58 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TNFAIP2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7127
PharosiQ03169, Tbio

Protein Ontology

More...
PROi
PR:Q03169
RNActiQ03169, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185215, Expressed in granulocyte and 210 other tissues
ExpressionAtlasiQ03169, baseline and differential
GenevisibleiQ03169, HS

Family and domain databases

InterProiView protein in InterPro
IPR010326, EXOC3/Sec6
PANTHERiPTHR21292, PTHR21292, 1 hit
PfamiView protein in Pfam
PF06046, Sec6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNAP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03169
Secondary accession number(s): Q86VI0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 18, 2006
Last modified: August 12, 2020
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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