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Protein

Transforming growth factor beta receptor type 3

Gene

TGFBR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

SIGNORiQ03167

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta receptor type 3
Short name:
TGF-beta receptor type 3
Short name:
TGFR-3
Alternative name(s):
Betaglycan
Transforming growth factor beta receptor III
Short name:
TGF-beta receptor type III
Gene namesi
Name:TGFBR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000069702.10
HGNCiHGNC:11774 TGFBR3
MIMi600742 gene
neXtProtiNX_Q03167

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 787ExtracellularSequence analysisAdd BLAST767
Transmembranei788 – 809HelicalSequence analysisAdd BLAST22
Topological domaini810 – 851CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7049
MalaCardsiTGFBR3
OpenTargetsiENSG00000069702
Orphaneti231160 Familial cerebral saccular aneurysm
PharmGKBiPA36487

Polymorphism and mutation databases

BioMutaiTGFBR3
DMDMi311033535

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004166321 – 851Transforming growth factor beta receptor type 3Add BLAST831

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi492N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi534O-linked (Xyl...) (glycosaminoglycan) serineBy similarity1
Glycosylationi545O-linked (Xyl...) (glycosaminoglycan) serineBy similarity1
Glycosylationi571N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi639 ↔ 705By similarity
Disulfide bondi660 ↔ 730By similarity
Glycosylationi697N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi710 ↔ 723By similarity

Post-translational modificationi

Extensively modified by glycosaminoglycan groups (GAG).

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiQ03167
PaxDbiQ03167
PeptideAtlasiQ03167
PRIDEiQ03167
ProteomicsDBi58197
58198 [Q03167-2]

PTM databases

iPTMnetiQ03167
PhosphoSitePlusiQ03167

Expressioni

Gene expression databases

BgeeiENSG00000069702 Expressed in 231 organ(s), highest expression level in renal glomerulus
CleanExiHS_TGFBR3
ExpressionAtlasiQ03167 baseline and differential
GenevisibleiQ03167 HS

Organism-specific databases

HPAiCAB018971
HPA008257

Interactioni

Subunit structurei

Interacts with TCTEX1D4.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112907, 28 interactors
DIPiDIP-5940N
IntActiQ03167, 4 interactors
MINTiQ03167
STRINGi9606.ENSP00000212355

Structurei

3D structure databases

ProteinModelPortaliQ03167
SMRiQ03167
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini455 – 730ZPPROSITE-ProRule annotationAdd BLAST276

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni737 – 751Interaction with TGF-beta ligandBy similarityAdd BLAST15

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK7K Eukaryota
ENOG410XSMK LUCA
GeneTreeiENSGT00530000063861
HOGENOMiHOG000090193
HOVERGENiHBG057515
InParanoidiQ03167
KOiK05843
OMAiDASMIWA
OrthoDBiEOG091G030O
PhylomeDBiQ03167
TreeFamiTF337375

Family and domain databases

InterProiView protein in InterPro
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PfamiView protein in Pfam
PF00100 Zona_pellucida, 1 hit
PRINTSiPR00023 ZPELLUCIDA
SMARTiView protein in SMART
SM00241 ZP, 1 hit
PROSITEiView protein in PROSITE
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q03167-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSHYVIAIF ALMSSCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS
60 70 80 90 100
GCASRGTTGL PQEVHVLNLR TAGQGPGQLQ REVTLHLNPI SSVHIHHKSV
110 120 130 140 150
VFLLNSPHPL VWHLKTERLA TGVSRLFLVS EGSVVQFSSA NFSLTAETEE
160 170 180 190 200
RNFPHGNEHL LNWARKEYGA VTSFTELKIA RNIYIKVGED QVFPPKCNIG
210 220 230 240 250
KNFLSLNYLA EYLQPKAAEG CVMSSQPQNE EVHIIELITP NSNPYSAFQV
260 270 280 290 300
DITIDIRPSQ EDLEVVKNLI LILKCKKSVN WVIKSFDVKG SLKIIAPNSI
310 320 330 340 350
GFGKESERSM TMTKSIRDDI PSTQGNLVKW ALDNGYSPIT SYTMAPVANR
360 370 380 390 400
FHLRLENNAE EMGDEEVHTI PPELRILLDP GALPALQNPP IRGGEGQNGG
410 420 430 440 450
LPFPFPDISR RVWNEEGEDG LPRPKDPVIP SIQLFPGLRE PEEVQGSVDI
460 470 480 490 500
ALSVKCDNEK MIVAVEKDSF QASGYSGMDV TLLDPTCKAK MNGTHFVLES
510 520 530 540 550
PLNGCGTRPR WSALDGVVYY NSIVIQVPAL GDSSGWPDGY EDLESGDNGF
560 570 580 590 600
PGDMDEGDAS LFTRPEIVVF NCSLQQVRNP SSFQEQPHGN ITFNMELYNT
610 620 630 640 650
DLFLVPSQGV FSVPENGHVY VEVSVTKAEQ ELGFAIQTCF ISPYSNPDRM
660 670 680 690 700
SHYTIIENIC PKDESVKFYS PKRVHFPIPQ ADMDKKRFSF VFKPVFNTSL
710 720 730 740 750
LFLQCELTLC TKMEKHPQKL PKCVPPDEAC TSLDASIIWA MMQNKKTFTK
760 770 780 790 800
PLAVIHHEAE SKEKGPSMKE PNPISPPIFH GLDTLTVMGI AFAAFVIGAL
810 820 830 840 850
LTGALWYIYS HTGETAGRQQ VPTSPPASEN SSAAHSIGST QSTPCSSSST

A
Length:851
Mass (Da):93,499
Last modified:November 2, 2010 - v3
Checksum:iAEC56C4477C003B2
GO
Isoform 2 (identifier: Q03167-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-359: Missing.

Show »
Length:850
Mass (Da):93,428
Checksum:i1469BB567BD05230
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKY4E9PKY4_HUMAN
Transforming growth factor beta rec...
TGFBR3
89Annotation score:
E9PAW7E9PAW7_HUMAN
Transforming growth factor beta rec...
TGFBR3
35Annotation score:
E9PMG7E9PMG7_HUMAN
Transforming growth factor beta rec...
TGFBR3
49Annotation score:

Sequence cautioni

The sequence AAA67061 differs from that shown. Reason: Frameshift at positions 70, 73, 349 and 350.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89P → S in BAF84034 (PubMed:14702039).Curated1
Sequence conflicti238I → V in BAF84034 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02089114S → N1 PublicationCorresponds to variant dbSNP:rs17884205Ensembl.1
Natural variantiVAR_01492015S → F3 PublicationsCorresponds to variant dbSNP:rs1805110Ensembl.1
Natural variantiVAR_020892163W → L1 PublicationCorresponds to variant dbSNP:rs17885124Ensembl.1
Natural variantiVAR_057499351F → I. Corresponds to variant dbSNP:rs11466592Ensembl.1
Natural variantiVAR_020893635A → T1 PublicationCorresponds to variant dbSNP:rs17882578Ensembl.1
Natural variantiVAR_020894765G → R1 PublicationCorresponds to variant dbSNP:rs17882828Ensembl.1
Natural variantiVAR_066625777P → S. Corresponds to variant dbSNP:rs2228363EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040018359Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07594 mRNA Translation: AAA67061.1 Frameshift.
AJ251961 mRNA Translation: CAB64374.1
AY796304 Genomic DNA Translation: AAV50003.1
AK291345 mRNA Translation: BAF84034.1
AC099334 Genomic DNA No translation available.
AL162263 Genomic DNA No translation available.
AL390780 Genomic DNA No translation available.
AL445992 Genomic DNA No translation available.
BC126116 mRNA Translation: AAI26117.1
BC136295 mRNA Translation: AAI36296.1
CCDSiCCDS30770.1 [Q03167-1]
CCDS55614.1 [Q03167-2]
PIRiJC1350
RefSeqiNP_001182612.1, NM_001195683.1 [Q03167-2]
NP_001182613.1, NM_001195684.1 [Q03167-2]
NP_003234.2, NM_003243.4 [Q03167-1]
XP_006710930.1, XM_006710867.2 [Q03167-1]
XP_006710931.1, XM_006710868.2
UniGeneiHs.482390
Hs.735919

Genome annotation databases

EnsembliENST00000212355; ENSP00000212355; ENSG00000069702 [Q03167-1]
ENST00000370399; ENSP00000359426; ENSG00000069702 [Q03167-2]
ENST00000465892; ENSP00000432638; ENSG00000069702 [Q03167-2]
ENST00000525962; ENSP00000436127; ENSG00000069702 [Q03167-1]
GeneIDi7049
KEGGihsa:7049
UCSCiuc001doh.4 human [Q03167-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07594 mRNA Translation: AAA67061.1 Frameshift.
AJ251961 mRNA Translation: CAB64374.1
AY796304 Genomic DNA Translation: AAV50003.1
AK291345 mRNA Translation: BAF84034.1
AC099334 Genomic DNA No translation available.
AL162263 Genomic DNA No translation available.
AL390780 Genomic DNA No translation available.
AL445992 Genomic DNA No translation available.
BC126116 mRNA Translation: AAI26117.1
BC136295 mRNA Translation: AAI36296.1
CCDSiCCDS30770.1 [Q03167-1]
CCDS55614.1 [Q03167-2]
PIRiJC1350
RefSeqiNP_001182612.1, NM_001195683.1 [Q03167-2]
NP_001182613.1, NM_001195684.1 [Q03167-2]
NP_003234.2, NM_003243.4 [Q03167-1]
XP_006710930.1, XM_006710867.2 [Q03167-1]
XP_006710931.1, XM_006710868.2
UniGeneiHs.482390
Hs.735919

3D structure databases

ProteinModelPortaliQ03167
SMRiQ03167
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112907, 28 interactors
DIPiDIP-5940N
IntActiQ03167, 4 interactors
MINTiQ03167
STRINGi9606.ENSP00000212355

PTM databases

iPTMnetiQ03167
PhosphoSitePlusiQ03167

Polymorphism and mutation databases

BioMutaiTGFBR3
DMDMi311033535

Proteomic databases

MaxQBiQ03167
PaxDbiQ03167
PeptideAtlasiQ03167
PRIDEiQ03167
ProteomicsDBi58197
58198 [Q03167-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000212355; ENSP00000212355; ENSG00000069702 [Q03167-1]
ENST00000370399; ENSP00000359426; ENSG00000069702 [Q03167-2]
ENST00000465892; ENSP00000432638; ENSG00000069702 [Q03167-2]
ENST00000525962; ENSP00000436127; ENSG00000069702 [Q03167-1]
GeneIDi7049
KEGGihsa:7049
UCSCiuc001doh.4 human [Q03167-1]

Organism-specific databases

CTDi7049
DisGeNETi7049
EuPathDBiHostDB:ENSG00000069702.10
GeneCardsiTGFBR3
H-InvDBiHIX0028622
HGNCiHGNC:11774 TGFBR3
HPAiCAB018971
HPA008257
MalaCardsiTGFBR3
MIMi600742 gene
neXtProtiNX_Q03167
OpenTargetsiENSG00000069702
Orphaneti231160 Familial cerebral saccular aneurysm
PharmGKBiPA36487
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK7K Eukaryota
ENOG410XSMK LUCA
GeneTreeiENSGT00530000063861
HOGENOMiHOG000090193
HOVERGENiHBG057515
InParanoidiQ03167
KOiK05843
OMAiDASMIWA
OrthoDBiEOG091G030O
PhylomeDBiQ03167
TreeFamiTF337375

Enzyme and pathway databases

SIGNORiQ03167

Miscellaneous databases

ChiTaRSiTGFBR3 human
GeneWikiiTGFBR3
GenomeRNAii7049
PROiPR:Q03167
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000069702 Expressed in 231 organ(s), highest expression level in renal glomerulus
CleanExiHS_TGFBR3
ExpressionAtlasiQ03167 baseline and differential
GenevisibleiQ03167 HS

Family and domain databases

InterProiView protein in InterPro
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PfamiView protein in Pfam
PF00100 Zona_pellucida, 1 hit
PRINTSiPR00023 ZPELLUCIDA
SMARTiView protein in SMART
SM00241 ZP, 1 hit
PROSITEiView protein in PROSITE
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTGBR3_HUMAN
AccessioniPrimary (citable) accession number: Q03167
Secondary accession number(s): A0AUW8
, A8K5N0, B9EG88, Q5T2T4, Q5U731, Q9UGI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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