Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 140 (11 Dec 2019)
Sequence version 2 (15 May 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Adenylate cyclase, aggregation specific

Gene

acaA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Coordinates cell aggregation by synthesizing the cAMP that influences differentiation and morphogenesis of cells within a developing multicellular structure.6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 PublicationNote: Binds 2 magnesium ions per subunit.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Regulated by cyclic AMP receptor 1 through a guanine nucleotide binding protein and protein CRAC. Both positively and negatively regulated by extracellular cAMP; this regulation is part of the mechanism that establishes the oscillatory cAMP waves during aggregation.4 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.2 mM for cAMP1 Publication
  1. Vmax=20 pmol/min/mg enzyme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi443Magnesium 1PROSITE-ProRule annotation1
Metal bindingi443Magnesium 2PROSITE-ProRule annotation1
Metal bindingi444Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi488Magnesium 1PROSITE-ProRule annotation1
Metal bindingi488Magnesium 2PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processcAMP biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-163615 PKA activation
R-DDI-170660 Adenylate cyclase activating pathway
R-DDI-170670 Adenylate cyclase inhibitory pathway
R-DDI-418597 G alpha (z) signalling events
R-DDI-5610787 Hedgehog 'off' state

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenylate cyclase, aggregation specific (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:acaA
Synonyms:aca
ORF Names:DDB_G0281545
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0281545 acaA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 219CytoplasmicSequence analysisAdd BLAST219
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 962CytoplasmicSequence analysisAdd BLAST589
Transmembranei963 – 979HelicalSequence analysisAdd BLAST17
Transmembranei992 – 1012HelicalSequence analysisAdd BLAST21
Transmembranei1018 – 1038HelicalSequence analysisAdd BLAST21
Transmembranei1071 – 1091HelicalSequence analysisAdd BLAST21
Transmembranei1105 – 1125HelicalSequence analysisAdd BLAST21
Transmembranei1378 – 1398HelicalSequence analysisAdd BLAST21
Topological domaini1399 – 1407CytoplasmicSequence analysis9

GO - Cellular componenti

Keywords - Cellular componenti

Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No cAMP synthesis. Cells are unable to aggregate, stimulation with cAMP pulses restores aggregation but slug and fruiting body formation remains very inefficient. When placed in a cAMP gradient mutants lacking ACA acquire polarity and migrate along the gradient but fail to align in a head to tail fashion and form streams. They are also unable to suppress lateral pseudopod formation, resulting in abnormal turns and inefficient chemotaxis. Transfer of the temperature-sensitive mutant tsaca2 to a temperature of 28 degrees Celsius leads to developmental arrest that is reversible when the temperature is shifted down to 22 degrees Celsius. In mutants with a constitutively active ACA, localization to the uropodium in polarized cells is reduced and these mutants fail to stream in a cAMP gradient.5 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi306F → L in temperature-sensitive mutant tsaca2. 1 Publication1
Mutagenesisi394L → S: Constitutive activity. 1 Publication1
Mutagenesisi498S → G in temperature-sensitive mutant tsaca2. 1 Publication1
Mutagenesisi504K → E in temperature-sensitive mutant tsaca2. 1 Publication1
Mutagenesisi593E → V in temperature-sensitive mutant tsaca2. 1 Publication1
Mutagenesisi649I → T in temperature-sensitive mutant tsaca2. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001957141 – 1407Adenylate cyclase, aggregation specificAdd BLAST1407

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q03100

PRoteomics IDEntifications database

More...
PRIDEi
Q03100

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed throughout the structure in the tipped mound and finger. Expressed primarily in the prestalk region of the slug. In the early culminant expression is increased in the posterior prespore and anterior-most regions and expands into the developing stalk. In the mid and late culminant it is expressed throughout the stalk.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during development. First detected at 3 hours of development. Levels increase during aggregation and peak at 6 hours. Levels decrease after tight aggregate formation.4 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0214814

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q03100

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini438 – 661Guanylate cyclase 1PROSITE-ProRule annotationAdd BLAST224
Domaini1189 – 1311Guanylate cyclase 2PROSITE-ProRule annotationAdd BLAST123

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi65 – 74Poly-Gly10
Compositional biasi88 – 113Asn-richAdd BLAST26
Compositional biasi532 – 576Asn-richAdd BLAST45
Compositional biasi535 – 576Asn-richAdd BLAST42
Compositional biasi753 – 872Asn-richAdd BLAST120
Compositional biasi753 – 785Poly-AsnAdd BLAST33
Compositional biasi847 – 864Poly-AsnAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3619 Eukaryota
COG2114 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q03100

Identification of Orthologs from Complete Genome Data

More...
OMAi
YKCLPLM

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.1230, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR029787 Nucleotide_cyclase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00211 Guanylate_cyc, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00044 CYCc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55073 SSF55073, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q03100-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSSPMFND HAIARSKYAL NSVLQQTNEL HDGNGGGGYT PSSPHLGGVS
60 70 80 90 100
LNKSQNQPYT QYNNGGGGGG GGGGHINPMH LNLNSITNNH NNHHNHHPNT
110 120 130 140 150
LSTPHNNNHN NNNHSTSHHP HSNSVANGGH LSQSITQQRG GLADLANAVI
160 170 180 190 200
NRKNRSDSVQ TKMKPTDSAS NIESWAKVEK FSSSIFDSEK SKKSNIFQKY
210 220 230 240 250
TLRLKNSYEK GYLHQHYNSQ IMLLRITNLI GIVAVSYGFT KEAIFMLIAI
260 270 280 290 300
RILCFNLFAF SIFLSFLRNR ELYKKLFHPL FLFSFTTFFI TILLEYKTTT
310 320 330 340 350
TTLILFLYVV IFCCLYALGC LLFIWMVMCN LMNAICFIIF IFLESTLDRN
360 370 380 390 400
NLISFVIYIL TMFLVGASHL YVLEKFRKES FIAEKKLIKE SNILKNEKEK
410 420 430 440 450
SSKLLNNILP DFIIENIVYD FEKRDIVIPE PEEYKSCSIL CFDIVQFTNM
460 470 480 490 500
SAKLDSPSRL VDLLTQVFRE FDTVVLRNGC QKIKTDGDAY ICACGLKSKK
510 520 530 540 550
KAKKQMPNSK STPLLQSTSS TSVNNIDLDK DNKDNNNNNN NNKNSNNNFK
560 570 580 590 600
NKNNIINNNN NSNSNNNNNN NSNNNNINNS GNDDDDEEIE DSELEHFEKL
610 620 630 640 650
IDVAIEIMNL DVLKETGNTE GIQVQFRCGI AAGSVYGGVI GSQKYQFDIW
660 670 680 690 700
GDTIARSHTL EQLGQPGKVH VGETIMTHKN WLKKWQYNYN IVSNSECKDQ
710 720 730 740 750
EHDYEFHKAH GECITSYFVD WKDDYREKKK KDLSCDFSIN KVLNAETIES
760 770 780 790 800
KSNNNNYNNN NYNNNNYNNN YNNNNLNNNS NNNNNEYGSS SSSSSVLGEA
810 820 830 840 850
VTEQIDCNNT NPPLQHKKSQ SILTNNENDI VSPSLTSNSP ILDTTVNNNN
860 870 880 890 900
NNNNTNNNNK NQNNIYGNNN NNEEDFKIKS KSNSSFEIEM SNIKKPKSRF
910 920 930 940 950
IDRVMGILHH VKISNDKIDK EIIQIDEDFV KVTKLRKYFL FFENLTTEKF
960 970 980 990 1000
FHKYVIINNV VETKFFLVIG LILHLMFYLD DHIMDSAPYF NSNVIYLVMG
1010 1020 1030 1040 1050
IAFLVYIGLS FTRIFRTPLV YQIAFFILLC AFGVCTVLEL IRFQNPLARS
1060 1070 1080 1090 1100
SLTRVCATLF YLNVFHSLNF LSVLFLNLFI FSFFIICSIL ISPTLTNHLY
1110 1120 1130 1140 1150
ETDYIGFVIV LLIQICSSYG MKLAMRKAWV VNCKINFKTI SVNKEKDKFN
1160 1170 1180 1190 1200
FLLKSIFPQS ALTKLRDMID TPNIETKGIV YVQPHQDVSI MFIQIAGFQE
1210 1220 1230 1240 1250
YDEPKDLIKK LNDIFSFFDG LLNQKYGGTV EKIKTIGNTY MAVSGLDGSP
1260 1270 1280 1290 1300
SFLEKMSDFA LDVKAYTNSV AISRVVRIGI SHGPLVAGCI GISRAKFDVW
1310 1320 1330 1340 1350
GDTANTASRM QSNAQDNEIM VTHSVYERLN KLFYFDDEKE ILVKGKGKMV
1360 1370 1380 1390 1400
THVLKGKKDL EQTNKWFTKP PEVWEVNATP AGIASPLSGT LLGEIGSFTT

PRFHLSS
Length:1,407
Mass (Da):159,702
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7A115B4AE417007
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti567 – 568NN → TT in AAA33163 (PubMed:1348970).Curated2
Sequence conflicti578 – 579NN → TT in AAA33163 (PubMed:1348970).Curated2
Sequence conflicti940L → Y in AAA33163 (PubMed:1348970).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L05499 L05498 Genomic DNA Translation: AAA33163.1
AAFI02000042 Genomic DNA Translation: EAL66534.2

Protein sequence database of the Protein Information Resource

More...
PIRi
B42239

NCBI Reference Sequences

More...
RefSeqi
XP_640636.2, XM_635544.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL66534; EAL66534; DDB_G0281545

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8623247

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0281545

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05499 L05498 Genomic DNA Translation: AAA33163.1
AAFI02000042 Genomic DNA Translation: EAL66534.2
PIRiB42239
RefSeqiXP_640636.2, XM_635544.2

3D structure databases

SMRiQ03100
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0214814

Proteomic databases

PaxDbiQ03100
PRIDEiQ03100

Genome annotation databases

EnsemblProtistsiEAL66534; EAL66534; DDB_G0281545
GeneIDi8623247
KEGGiddi:DDB_G0281545

Organism-specific databases

dictyBaseiDDB_G0281545 acaA

Phylogenomic databases

eggNOGiKOG3619 Eukaryota
COG2114 LUCA
InParanoidiQ03100
OMAiYKCLPLM

Enzyme and pathway databases

ReactomeiR-DDI-163615 PKA activation
R-DDI-170660 Adenylate cyclase activating pathway
R-DDI-170670 Adenylate cyclase inhibitory pathway
R-DDI-418597 G alpha (z) signalling events
R-DDI-5610787 Hedgehog 'off' state

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q03100

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 3 hits
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYAA_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03100
Secondary accession number(s): Q54TF5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: May 15, 2007
Last modified: December 11, 2019
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again