Transcription factor HES-5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players."
    Liu A., Li J., Marin-Husstege M., Kageyama R., Fan Y., Gelinas C., Casaccia-Bonnefil P.
    EMBO J. 25:4833-4842(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: UniProtKB
• double-stranded DNA binding Source: RGDInferred from direct assayⁱ
  • Ref.1

    "Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system."
    Akazawa C., Sasai Y., Nakanishi S., Kageyama R.
    J. Biol. Chem. 267:21879-21885(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
• protein dimerization activity Source: InterPro
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• anterior/posterior pattern specification Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• astrocyte differentiation Source: UniProtKB
• brain development Source: UniProtKB
• camera-type eye development Source: UniProtKB
• cartilage development Source: UniProtKB
• cell adhesion Source: UniProtKB
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell maturation Source: UniProtKB
• central nervous system myelination Source: UniProtKB
• comma-shaped body morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Segmental expression of Notch and Hairy genes in nephrogenesis."
    Chen L., Al-Awqati Q.
    Am. J. Physiol. Renal Physiol. 288:F939-52(2005) [PubMed] [Europe PMC] [Abstract]
• establishment of epithelial cell polarity Source: RGDInferred from sequence orthologyⁱ
  • "Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development."
    Tateya T., Imayoshi I., Tateya I., Ito J., Kageyama R.
    Dev. Biol. 352:329-340(2011) [PubMed] [Europe PMC] [Abstract]
• forebrain radial glial cell differentiation Source: UniProtKBInferred from direct assayⁱ
  • "Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain."
    Ohtsuka T., Sakamoto M., Guillemot F., Kageyama R.
    J. Biol. Chem. 276:30467-30474(2001) [PubMed] [Europe PMC] [Abstract]
• glial cell fate commitment Source: UniProtKB
• inner ear receptor cell stereocilium organization Source: RGDInferred from sequence orthologyⁱ
  • "Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development."
    Tateya T., Imayoshi I., Tateya I., Ito J., Kageyama R.
    Dev. Biol. 352:329-340(2011) [PubMed] [Europe PMC] [Abstract]
• metanephric nephron tubule morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis."
    Piscione T.D., Wu M.Y., Quaggin S.E.
    Gene Expr. Patterns 4:707-711(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of astrocyte differentiation Source: UniProtKB
• negative regulation of forebrain neuron differentiation Source: UniProtKBInferred from direct assayⁱ
  • "Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain."
    Ohtsuka T., Sakamoto M., Guillemot F., Kageyama R.
    J. Biol. Chem. 276:30467-30474(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of inner ear auditory receptor cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear."
    Zine A., Aubert A., Qiu J., Therianos S., Guillemot F., Kageyama R., de Ribaupierre F.
    J. Neurosci. 21:4712-4720(2001) [PubMed] [Europe PMC] [Abstract]
  • "Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development."
    Tateya T., Imayoshi I., Tateya I., Ito J., Kageyama R.
    Dev. Biol. 352:329-340(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of inner ear receptor cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice."
    Zine A., de Ribaupierre F.
    Hear. Res. 170:22-31(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuron differentiation Source: UniProtKB
• negative regulation of oligodendrocyte differentiation Source: UniProtKB
• negative regulation of pro-B cell differentiation Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations."
    Kawamata S., Du C., Li K., Lavau C.
    Oncogene 21:3855-3863(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of stem cell differentiation Source: UniProtKB
• negative regulation of transcription, DNA-templated Source: RGDInferred from direct assayⁱ
  • Ref.1

    "Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system."
    Akazawa C., Sasai Y., Nakanishi S., Kageyama R.
    J. Biol. Chem. 267:21879-21885(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
• negative regulation of transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • "Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations."
    Kawamata S., Du C., Li K., Lavau C.
    Oncogene 21:3855-3863(2002) [PubMed] [Europe PMC] [Abstract]
• neural tube development Source: UniProtKB
• neuronal stem cell population maintenance Source: UniProtKBInferred from direct assayⁱ
  • "Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain."
    Ohtsuka T., Sakamoto M., Guillemot F., Kageyama R.
    J. Biol. Chem. 276:30467-30474(2001) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • Ref.1

    "Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system."
    Akazawa C., Sasai Y., Nakanishi S., Kageyama R.
    J. Biol. Chem. 267:21879-21885(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
• Notch signaling pathway Source: UniProtKB
• oligodendrocyte development Source: UniProtKB
• positive regulation of BMP signaling pathway Source: UniProtKB
• positive regulation of cell population proliferation Source: UniProtKB
• positive regulation of Notch signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice."
    Zine A., de Ribaupierre F.
    Hear. Res. 170:22-31(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
• positive regulation of smooth muscle cell proliferation Source: UniProtKB
• positive regulation of transcription, DNA-templated Source: UniProtKB
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis."
    Kinameri E., Inoue T., Aruga J., Imayoshi I., Kageyama R., Shimogori T., Moore A.W.
    PLoS ONE 3:e3859-e3859(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
• protein-containing complex assembly Source: UniProtKB
• regulation of cell differentiation Source: UniProtKB
• regulation of epithelial cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development."
    Tateya T., Imayoshi I., Tateya I., Ito J., Kageyama R.
    Dev. Biol. 352:329-340(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of myelination Source: UniProtKB
• regulation of neurogenesis Source: UniProtKB
• smoothened signaling pathway Source: UniProtKB
• specification of loop of Henle identity Source: RGDInferred from sequence orthologyⁱ
  • "Segmental expression of Notch and Hairy genes in nephrogenesis."
    Chen L., Al-Awqati Q.
    Am. J. Physiol. Renal Physiol. 288:F939-52(2005) [PubMed] [Europe PMC] [Abstract]
• S-shaped body morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Segmental expression of Notch and Hairy genes in nephrogenesis."
    Chen L., Al-Awqati Q.
    Am. J. Physiol. Renal Physiol. 288:F939-52(2005) [PubMed] [Europe PMC] [Abstract]
• telencephalon development Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protein dimerization activity Source: InterPro

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAPSTVAVEM LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH 
        60         70         80         90        100
QPNSKLEKAD ILEMAVSYLK HSKAFAAAAG PKSLHQDYSE GYSWCLQEAV 
       110        120        130        140        150
QFLTLHAASD TQMKLLYHFQ RPPAPAAPVK ETPTPGAAPQ PARSSTKAAA 
       160 
SVSTSRQSAC GLWRPW                                      

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ