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UniProtKB - Q03062 (HES5_RAT)
Protein
Transcription factor HES-5
Gene
Hes5
Organism
Rattus norvegicus (Rat)
Status
Functioni
Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).
By similarityGO - Molecular functioni
- chromatin binding Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: UniProtKB
- double-stranded DNA binding Source: RGD
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- anterior/posterior pattern specification Source: GO_Central
- astrocyte differentiation Source: UniProtKB
- brain development Source: UniProtKB
- camera-type eye development Source: UniProtKB
- cartilage development Source: UniProtKB
- cell adhesion Source: UniProtKB
- cell maturation Source: UniProtKB
- central nervous system myelination Source: UniProtKB
- comma-shaped body morphogenesis Source: RGD
- establishment of epithelial cell polarity Source: RGD
- forebrain radial glial cell differentiation Source: UniProtKB
- glial cell fate commitment Source: UniProtKB
- inner ear receptor cell stereocilium organization Source: RGD
- metanephric nephron tubule morphogenesis Source: RGD
- negative regulation of astrocyte differentiation Source: UniProtKB
- negative regulation of forebrain neuron differentiation Source: UniProtKB
- negative regulation of inner ear auditory receptor cell differentiation Source: RGD
- negative regulation of inner ear receptor cell differentiation Source: RGD
- negative regulation of neuron differentiation Source: UniProtKB
- negative regulation of oligodendrocyte differentiation Source: UniProtKB
- negative regulation of pro-B cell differentiation Source: UniProtKB
- negative regulation of stem cell differentiation Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- neural tube development Source: UniProtKB
- neuronal stem cell population maintenance Source: UniProtKB
- neuron differentiation Source: RGD
- Notch signaling pathway Source: UniProtKB
- oligodendrocyte development Source: UniProtKB
- positive regulation of BMP signaling pathway Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of Notch signaling pathway Source: RGD
- positive regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
- positive regulation of smooth muscle cell proliferation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
- protein-containing complex assembly Source: UniProtKB
- regulation of cell differentiation Source: UniProtKB
- regulation of epithelial cell proliferation Source: RGD
- regulation of myelination Source: UniProtKB
- regulation of neurogenesis Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- smoothened signaling pathway Source: UniProtKB
- specification of loop of Henle identity Source: RGD
- S-shaped body morphogenesis Source: RGD
- telencephalon development Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, DNA-binding, Repressor |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor HES-5Alternative name(s): Hairy and enhancer of split 5 |
Gene namesi | Name:Hes5 Synonyms:Hes-5 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621340, Hes5 |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127213 | 1 – 166 | Transcription factor HES-5Add BLAST | 166 |
Proteomic databases
PaxDbi | Q03062 |
Expressioni
Tissue specificityi
Expressed predominantly in embryonic neural lineage cells.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000013850, Expressed in frontal cortex and 15 other tissues |
Genevisiblei | Q03062, RN |
Interactioni
Subunit structurei
Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
ELMi | Q03062 |
IntActi | Q03062, 2 interactors |
MINTi | Q03062 |
STRINGi | 10116.ENSRNOP00000018769 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 72 | bHLHPROSITE-ProRule annotationAdd BLAST | 57 | |
Domaini | 88 – 119 | OrangePROSITE-ProRule annotationAdd BLAST | 32 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 125 – 166 | DisorderedSequence analysisAdd BLAST | 42 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 163 – 166 | WRPW motif | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 138 – 160 | Polar residuesSequence analysisAdd BLAST | 23 |
Domaini
Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity
Phylogenomic databases
eggNOGi | ENOG502S6S1, Eukaryota |
GeneTreei | ENSGT00940000162836 |
HOGENOMi | CLU_068550_3_1_1 |
InParanoidi | Q03062 |
OMAi | LSHCEVQ |
OrthoDBi | 1378299at2759 |
PhylomeDBi | Q03062 |
TreeFami | TF351373 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q03062-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPSTVAVEM LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH
60 70 80 90 100
QPNSKLEKAD ILEMAVSYLK HSKAFAAAAG PKSLHQDYSE GYSWCLQEAV
110 120 130 140 150
QFLTLHAASD TQMKLLYHFQ RPPAPAAPVK ETPTPGAAPQ PARSSTKAAA
160
SVSTSRQSAC GLWRPW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12516 mRNA Translation: BAA02081.1 |
PIRi | A45119 |
RefSeqi | NP_077359.1, NM_024383.1 |
Genome annotation databases
Ensembli | ENSRNOT00000018769; ENSRNOP00000018769; ENSRNOG00000013850 |
GeneIDi | 79225 |
KEGGi | rno:79225 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12516 mRNA Translation: BAA02081.1 |
PIRi | A45119 |
RefSeqi | NP_077359.1, NM_024383.1 |
3D structure databases
AlphaFoldDBi | Q03062 |
SMRi | Q03062 |
ModBasei | Search... |
Protein-protein interaction databases
ELMi | Q03062 |
IntActi | Q03062, 2 interactors |
MINTi | Q03062 |
STRINGi | 10116.ENSRNOP00000018769 |
Proteomic databases
PaxDbi | Q03062 |
Genome annotation databases
Ensembli | ENSRNOT00000018769; ENSRNOP00000018769; ENSRNOG00000013850 |
GeneIDi | 79225 |
KEGGi | rno:79225 |
Organism-specific databases
CTDi | 388585 |
RGDi | 621340, Hes5 |
Phylogenomic databases
eggNOGi | ENOG502S6S1, Eukaryota |
GeneTreei | ENSGT00940000162836 |
HOGENOMi | CLU_068550_3_1_1 |
InParanoidi | Q03062 |
OMAi | LSHCEVQ |
OrthoDBi | 1378299at2759 |
PhylomeDBi | Q03062 |
TreeFami | TF351373 |
Miscellaneous databases
PROi | PR:Q03062 |
Gene expression databases
Bgeei | ENSRNOG00000013850, Expressed in frontal cortex and 15 other tissues |
Genevisiblei | Q03062, RN |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HES5_RAT | |
Accessioni | Q03062Primary (citable) accession number: Q03062 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |