UniProtKB - Q03060 (CREM_HUMAN)
cAMP-responsive element modulator
CREM
Functioni
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).
1 PublicationMay play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.
By similarityGO - Molecular functioni
- cAMP response element binding protein binding Source: UniProtKB
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- rhythmic process Source: UniProtKB-KW
- signal transduction Source: ProtInc
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding, Repressor |
Biological process | Biological rhythms, Differentiation, Spermatogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q03060 |
Reactomei | R-HSA-400253, Circadian Clock [Q03060-6] |
SignaLinki | Q03060 |
SIGNORi | Q03060 |
Names & Taxonomyi
Protein namesi | Recommended name: cAMP-responsive element modulatorCuratedAlternative name(s): Inducible cAMP early repressor Short name: ICER |
Gene namesi | Name:CREMImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2352, CREM |
MIMi | 123812, gene |
neXtProti | NX_Q03060 |
VEuPathDBi | HostDB:ENSG00000095794 |
Subcellular locationi
Nucleus
Nucleus
- ATF4-CREB1 transcription factor complex Source: GO_Central
- nucleus Source: ProtInc
Other locations
- chromatin Source: NTNU_SB
- cytoplasm Source: UniProtKB-SubCell
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 1390 |
OpenTargetsi | ENSG00000095794 |
PharmGKBi | PA26871 |
Miscellaneous databases
Pharosi | Q03060, Tbio |
Genetic variation databases
BioMutai | CREM |
DMDMi | 259016392 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076607 | 1 – 345 | cAMP-responsive element modulatorAdd BLAST | 345 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 102 | PhosphoserineBy similarity | 1 | |
Modified residuei | 129 | PhosphoserineCombined sources | 1 | |
Modified residuei | 271 | PhosphoserineCombined sources | 1 | |
Modified residuei | 274 | PhosphoserineCombined sources | 1 | |
Modified residuei | 277 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q03060 |
MassIVEi | Q03060 |
MaxQBi | Q03060 |
PeptideAtlasi | Q03060 |
PRIDEi | Q03060 |
ProteomicsDBi | 12335 19066 1908 20564 58163 [Q03060-5] 58164 [Q03060-1] 58165 [Q03060-10] 58166 [Q03060-11] 58167 [Q03060-12] 58168 [Q03060-13] 58169 [Q03060-14] 58170 [Q03060-15] 58171 [Q03060-16] 58172 [Q03060-17] 58173 [Q03060-19] 58174 [Q03060-2] 58175 [Q03060-20] 58176 [Q03060-21] 58177 [Q03060-22] 58178 [Q03060-23] 58179 [Q03060-24] 58180 [Q03060-25] 58181 [Q03060-6] 58182 [Q03060-7] 58183 [Q03060-8] 58184 [Q03060-9] 65804 65805 8870 |
PTM databases
GlyGeni | Q03060, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q03060 |
PhosphoSitePlusi | Q03060 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000095794, Expressed in right testis and 232 other tissues |
ExpressionAtlasi | Q03060, baseline and differential |
Genevisiblei | Q03060, HS |
Organism-specific databases
HPAi | ENSG00000095794, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Binds DNA as a dimer.
Interacts with FHL5 (By similarity).
Interacts with CDC34 (PubMed:10373550). May interact with TSSK4 (By similarity).
By similarity1 PublicationBinary interactionsi
Q03060
With | #Exp. | IntAct |
---|---|---|
DNMT3A [Q9Y6K1] | 2 | EBI-3907794,EBI-923653 |
Isoform 22 [Q03060-25]
GO - Molecular functioni
- cAMP response element binding protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107780, 44 interactors |
IntActi | Q03060, 32 interactors |
MINTi | Q03060 |
Miscellaneous databases
RNActi | Q03060, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 88 – 147 | KIDPROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 286 – 345 | bZIPPROSITE-ProRule annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 287 – 312 | Basic motifPROSITE-ProRule annotationAdd BLAST | 26 | |
Regioni | 314 – 335 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000156952 |
HOGENOMi | CLU_142602_0_0_1 |
InParanoidi | Q03060 |
OMAi | MSKCSRK |
OrthoDBi | 957343at2759 |
PhylomeDBi | Q03060 |
TreeFami | TF106464 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR003102, Coactivator_CBP_pKID IPR001630, Leuzip_CREB |
PANTHERi | PTHR45879, PTHR45879, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF02173, pKID, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit PS50953, KID, 1 hit |
s (29+)i Sequence
Sequence statusi: Complete.
This entry describes 29 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 29 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTMETVESQH DGSITASLTE SKSAHVQTQT GQNSIPALAQ VSVAGSGTRR
60 70 80 90 100
GSPAVTLVQL PSGQTIHVQG VIQTPQPWVI QSSEIHTVQV AAIAETDESA
110 120 130 140 150
ESEGVIDSHK RREILSRRPS YRKILNELSS DVPGVPKIEE ERSEEEGTPP
160 170 180 190 200
SIATMAVPTS IYQTSTGQYI AIAQGGTIQI SNPGSDGVQG LQALTMTNSG
210 220 230 240 250
APPPGATIVQ YAAQSADGTQ QFFVPGSQVV VQDEETELAP SHMAAATGDM
260 270 280 290 300
PTYQIRAPTA ALPQGVVMAA SPGSLHSPQQ LAEEATRKRE LRLMKNREAA
310 320 330 340
KECRRRKKEY VKCLESRVAV LEVQNKKLIE ELETLKDICS PKTDY
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MSKCARKKYIKTNPRQM
233-244: Missing.
301-345: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MSKCARKKYIKTNPRQM
42-90: Missing.
170-245: IAIAQGGTIQ...TELAPSHMAA → T
The sequence of this isoform differs from the canonical sequence as follows:
1-89: MTMETVESQH...IQSSEIHTVQ → M
233-244: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-232: MTMETVESQH...FVPGSQVVVQ → MAVTGDDT
301-345: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
The sequence of this isoform differs from the canonical sequence as follows:
1-244: MTMETVESQH...ETELAPSHMA → MAVTGDDT
301-345: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
The sequence of this isoform differs from the canonical sequence as follows:
1-232: MTMETVESQH...FVPGSQVVVQ → MAVTGDDT
The sequence of this isoform differs from the canonical sequence as follows:
1-244: MTMETVESQH...ETELAPSHMA → MAVTGDDT
The sequence of this isoform differs from the canonical sequence as follows:
1-89: MTMETVESQH...IQSSEIHTVQ → MWWHQHNLCFRRPIEEDYSSGDVEEK
233-244: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-89: MTMETVESQH...IQSSEIHTVQ → MWWHQHNLCFRRPIEEDYSSGDVEEK
170-232: Missing.
245-245: A → T
The sequence of this isoform differs from the canonical sequence as follows:
1-89: MTMETVESQH...IQSSEIHTVQ → M
170-232: Missing.
245-245: A → T
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MSKCARKKYIKTNPRQM
42-90: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MSKCARKKYIKTNPRQM
42-90: Missing.
233-244: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MSKCARKKYIKTNPRQM
42-169: Missing.
233-244: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MSKCARKKYIKTNPRQM
42-232: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MSKCARKKYIKTNPRQM
170-244: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MSKCARKKYIKTNPRQM
170-244: Missing.
301-345: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
The sequence of this isoform differs from the canonical sequence as follows:
1-89: MTMETVESQH...IQSSEIHTVQ → MWWHQHNLCFRRPIEEDYSSGDVEEK
The sequence of this isoform differs from the canonical sequence as follows:
1-242: Missing.
301-345: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
The sequence of this isoform differs from the canonical sequence as follows:
1-244: MTMETVESQH...ETELAPSHMA → MNRTQELSGQLS
301-345: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
The sequence of this isoform differs from the canonical sequence as follows:
42-90: Missing.
170-186: IAIAQGGTIQISNPGSD → SMYAAIRYDTVLALSLL
187-345: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MSKCARKKYIKTNPRQM
42-90: Missing.
170-233: IAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQVVVQD → N
301-345: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
The sequence of this isoform differs from the canonical sequence as follows:
1-244: MTMETVESQH...ETELAPSHMA → MNRTQELSGQLS
The sequence of this isoform differs from the canonical sequence as follows:
1-195: Missing.
233-244: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-232: MTMETVESQH...FVPGSQVVVQ → MNRTQELSGQLS
The sequence of this isoform differs from the canonical sequence as follows:
42-90: Missing.
170-245: IAIAQGGTIQ...TELAPSHMAA → T
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MSKCARKKYIKTNPRQM
42-90: Missing.
233-244: Missing.
301-345: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MSKCARKKYIKTNPRQM
42-90: Missing.
170-245: IAIAQGGTIQ...TELAPSHMAA → T
301-345: KECRRRKKEY...KDICSPKTDY → RECRRKKKEY...LKDLYCHKVE
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSU8 | A0A0A0MSU8_HUMAN | cAMP-responsive element modulator | CREM | 156 | Annotation score: | ||
C9K092 | C9K092_HUMAN | cAMP-responsive element modulator | CREM | 193 | Annotation score: | ||
G5E998 | G5E998_HUMAN | cAMP-responsive element modulator | CREM | 269 | Annotation score: | ||
J3KR46 | J3KR46_HUMAN | cAMP-responsive element modulator | CREM | 219 | Annotation score: | ||
E9PB41 | E9PB41_HUMAN | cAMP-responsive element modulator | CREM | 96 | Annotation score: | ||
C9IYM9 | C9IYM9_HUMAN | cAMP-responsive element modulator | CREM | 186 | Annotation score: | ||
E9PAR2 | E9PAR2_HUMAN | cAMP-responsive element modulator | CREM | 95 | Annotation score: | ||
C9J5A7 | C9J5A7_HUMAN | cAMP-responsive element modulator | CREM | 78 | Annotation score: | ||
C9J2J0 | C9J2J0_HUMAN | cAMP-responsive element modulator | CREM | 115 | Annotation score: | ||
F8WB03 | F8WB03_HUMAN | cAMP-responsive element modulator | CREM | 62 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 33 | N → I in AAC60616 (PubMed:1461747).Curated | 1 | ||
Sequence conflicti | 33 | N → I in AAC60617 (PubMed:1461747).Curated | 1 | ||
Sequence conflicti | 39 | A → R in CAA78858 (PubMed:7916662).Curated | 1 | ||
Sequence conflicti | 41 – 45 | VSVAG → CSELR in AAC60616 (PubMed:1461747).Curated | 5 | ||
Sequence conflicti | 41 – 45 | VSVAG → CSELR in AAC60617 (PubMed:1461747).Curated | 5 | ||
Sequence conflicti | 276 | H → R in BAA03562 (PubMed:8206879).Curated | 1 | ||
Sequence conflicti | 276 | H → R in BAA03564 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 276 | H → R in BAA03565 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 276 | H → R in BAA03566 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 276 | H → R in BAA03567 (Ref. 4) Curated | 1 | ||
Isoform 6 (identifier: Q03060-8) | |||||
Sequence conflicti | 7 | D → E in AAC19383 (Ref. 4) Curated | 1 | ||
Sequence conflicti | 112 | K → R in AAC19383 (Ref. 4) Curated | 1 | ||
Isoform 8 (identifier: Q03060-10) | |||||
Sequence conflicti | 7 | D → E in AAB03751 (PubMed:8622971).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055561 | 254 | Q → R1 PublicationCorresponds to variant dbSNP:rs1804604Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059697 | 1 – 244 | MTMET…PSHMA → MNRTQELSGQLS in isoform 21 and isoform 24. 1 PublicationAdd BLAST | 244 | |
Alternative sequenceiVSP_059698 | 1 – 244 | MTMET…PSHMA → MAVTGDDT in isoform 7 and isoform 9. 1 PublicationAdd BLAST | 244 | |
Alternative sequenceiVSP_059699 | 1 – 242 | Missing in isoform 20. 1 PublicationAdd BLAST | 242 | |
Alternative sequenceiVSP_059700 | 1 – 232 | MTMET…QVVVQ → MNRTQELSGQLS in isoform 26. Add BLAST | 232 | |
Alternative sequenceiVSP_059701 | 1 – 232 | MTMET…QVVVQ → MAVTGDDT in isoform 6 and isoform 8. 3 PublicationsAdd BLAST | 232 | |
Alternative sequenceiVSP_059702 | 1 – 195 | Missing in isoform 25. Add BLAST | 195 | |
Alternative sequenceiVSP_059703 | 1 – 89 | MTMET…IHTVQ → MWWHQHNLCFRRPIEEDYSS GDVEEK in isoform 10, isoform 11 and isoform 19. 1 PublicationAdd BLAST | 89 | |
Alternative sequenceiVSP_059704 | 1 – 89 | MTMET…IHTVQ → M in isoform 5 and isoform 12. Add BLAST | 89 | |
Alternative sequenceiVSP_059705 | 1 | M → MSKCARKKYIKTNPRQM in isoform 2, isoform 3, isoform 4, isoform 13, isoform 14, isoform 15, isoform 16, isoform 17, isoform 18, isoform 23, isoform 28 and isoform 29. 3 Publications | 1 | |
Alternative sequenceiVSP_059706 | 42 – 232 | Missing in isoform 16. Add BLAST | 191 | |
Alternative sequenceiVSP_059707 | 42 – 169 | Missing in isoform 15. Add BLAST | 128 | |
Alternative sequenceiVSP_059708 | 42 – 90 | Missing in isoform 4, isoform 13, isoform 14, isoform 22, isoform 23, isoform 27, isoform 28 and isoform 29. 3 PublicationsAdd BLAST | 49 | |
Alternative sequenceiVSP_059709 | 170 – 245 | IAIAQ…SHMAA → T in isoform 4, isoform 27 and isoform 29. Add BLAST | 76 | |
Alternative sequenceiVSP_059710 | 170 – 244 | Missing in isoform 17 and isoform 18. Add BLAST | 75 | |
Alternative sequenceiVSP_059711 | 170 – 233 | IAIAQ…VVVQD → N in isoform 23. 1 PublicationAdd BLAST | 64 | |
Alternative sequenceiVSP_059712 | 170 – 232 | Missing in isoform 11 and isoform 12. 1 PublicationAdd BLAST | 63 | |
Alternative sequenceiVSP_059713 | 170 – 186 | IAIAQ…NPGSD → SMYAAIRYDTVLALSLL in isoform 22. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_059714 | 187 – 345 | Missing in isoform 22. 1 PublicationAdd BLAST | 159 | |
Alternative sequenceiVSP_059715 | 233 – 244 | Missing in isoform 2, isoform 3, isoform 5, isoform 10, isoform 14, isoform 15, isoform 25 and isoform 28. 5 PublicationsAdd BLAST | 12 | |
Alternative sequenceiVSP_059716 | 245 | A → T in isoform 12 and isoform 11. 1 Publication | 1 | |
Alternative sequenceiVSP_059717 | 301 – 345 | KECRR…PKTDY → RECRRKKKEYVKCLENRVAV LENQNKTLIEELKALKDLYC HKVE in isoform 3, isoform 6, isoform 7, isoform 18, isoform 20, isoform 21, isoform 23, isoform 28 and isoform 29. 4 PublicationsAdd BLAST | 45 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q03060 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107780, 44 interactors |
IntActi | Q03060, 32 interactors |
MINTi | Q03060 |
PTM databases
GlyGeni | Q03060, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q03060 |
PhosphoSitePlusi | Q03060 |
Genetic variation databases
BioMutai | CREM |
DMDMi | 259016392 |
Proteomic databases
jPOSTi | Q03060 |
MassIVEi | Q03060 |
MaxQBi | Q03060 |
PeptideAtlasi | Q03060 |
PRIDEi | Q03060 |
ProteomicsDBi | 12335 19066 1908 20564 58163 [Q03060-5] 58164 [Q03060-1] 58165 [Q03060-10] 58166 [Q03060-11] 58167 [Q03060-12] 58168 [Q03060-13] 58169 [Q03060-14] 58170 [Q03060-15] 58171 [Q03060-16] 58172 [Q03060-17] 58173 [Q03060-19] 58174 [Q03060-2] 58175 [Q03060-20] 58176 [Q03060-21] 58177 [Q03060-22] 58178 [Q03060-23] 58179 [Q03060-24] 58180 [Q03060-25] 58181 [Q03060-6] 58182 [Q03060-7] 58183 [Q03060-8] 58184 [Q03060-9] 65804 65805 8870 |
Protocols and materials databases
Antibodypediai | 4333, 425 antibodies from 36 providers |
DNASUi | 1390 |
Genome annotation databases
Organism-specific databases
CTDi | 1390 |
DisGeNETi | 1390 |
GeneCardsi | CREM |
HGNCi | HGNC:2352, CREM |
HPAi | ENSG00000095794, Tissue enhanced (testis) |
MIMi | 123812, gene |
neXtProti | NX_Q03060 |
OpenTargetsi | ENSG00000095794 |
PharmGKBi | PA26871 |
VEuPathDBi | HostDB:ENSG00000095794 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156952 |
HOGENOMi | CLU_142602_0_0_1 |
InParanoidi | Q03060 |
OMAi | MSKCSRK |
OrthoDBi | 957343at2759 |
PhylomeDBi | Q03060 |
TreeFami | TF106464 |
Enzyme and pathway databases
PathwayCommonsi | Q03060 |
Reactomei | R-HSA-400253, Circadian Clock [Q03060-6] |
SignaLinki | Q03060 |
SIGNORi | Q03060 |
Miscellaneous databases
BioGRID-ORCSi | 1390, 5 hits in 1072 CRISPR screens |
ChiTaRSi | CREM, human |
GeneWikii | CAMP_responsive_element_modulator |
GenomeRNAii | 1390 |
Pharosi | Q03060, Tbio |
PROi | PR:Q03060 |
RNActi | Q03060, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000095794, Expressed in right testis and 232 other tissues |
ExpressionAtlasi | Q03060, baseline and differential |
Genevisiblei | Q03060, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR003102, Coactivator_CBP_pKID IPR001630, Leuzip_CREB |
PANTHERi | PTHR45879, PTHR45879, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF02173, pKID, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit PS50953, KID, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CREM_HUMAN | |
Accessioni | Q03060Primary (citable) accession number: Q03060 Secondary accession number(s): A8K014 Q9NZB9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | September 12, 2018 | |
Last modified: | February 23, 2022 | |
This is version 206 of the entry and version 6 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families