for

Functionⁱ

Catalytic activityⁱ

ATP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
L-seryl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
=
ADP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
O-phospho-L-seryl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
EC:
2.7.11.12
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
L-seryl-[protein]
L-serine residue
zoom
=
ADP
+
H⁺
+
O-phospho-L-seryl-[protein]
O-phospho-L-serine residue
zoom
ATP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
L-threonyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
=
ADP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
O-phospho-L-threonyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
EC:
2.7.11.12
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
L-threonyl-[protein]
L-threonine residue
zoom
=
ADP
+
H⁺
+
O-phospho-L-threonyl-[protein]
O-phospho-L-threonine residue
zoom

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	699	3',5'-cGMP 2By similarity	1
Binding siteⁱ	807	ATPPROSITE-ProRule annotation	1
Active siteⁱ	901	Proton acceptorPROSITE-ProRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	584 – 587	3',5'-cGMP 1By similarity	4
Nucleotide bindingⁱ	594 – 595	3',5'-cGMP 1By similarity	2
Nucleotide bindingⁱ	708 – 711	3',5'-cGMP 2By similarity	4
Nucleotide bindingⁱ	718 – 719	3',5'-cGMP 2By similarity	2
Nucleotide bindingⁱ	783 – 791	ATPPROSITE-ProRule annotation	9

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, cGMP, cGMP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.11.12, 1994
Reactomeⁱ	R-DME-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-DME-392517, Rap1 signalling R-DME-9648002, RAS processing

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (EC:2.7.11.12) Short name: cGK Alternative name(s): Foraging protein
Gene namesⁱ	Name:for Synonyms:DG2, PGK2, Pkg24A ORF Names:CG10033
Organismⁱ	Drosophila melanogaster (Fruit fly)
Taxonomic identifierⁱ	7227 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophila › Sophophora › melanogaster group › melanogaster subgroup
Proteomesⁱ	UP000000803 Componentⁱ: Chromosome 2L

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0000721, for
VEuPathDBⁱ	VectorBase:FBgn0000721

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086121	1 – 1088	cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3BAdd BLAST		1088

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	934	Phosphothreonine1 Publication		1
Modified residueⁱ	938	Phosphothreonine1 Publication		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q03043
PRIDEⁱ	Q03043

PTM databases

iPTMnetⁱ	Q03043

iPTMnetⁱ

Q03043

Expressionⁱ

Developmental stageⁱ

Expressed throughout development, high during embryonic and adult stages. Isoform T1 is predominantly expressed during embryo and adult stages.1 Publication

Gene expression databases

Bgeeⁱ	FBgn0000721, Expressed in spermathecum and 70 other tissues
ExpressionAtlasⁱ	Q03043, baseline and differential
Genevisibleⁱ	Q03043, DM

Interactionⁱ

Protein-protein interaction databases

BioGRIDⁱ	69303, 13 interactors
STRINGⁱ	7227.FBpp0088350

Structureⁱ

3D structure databases

AlphaFoldDBⁱ	Q03043
SMRⁱ	Q03043
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	777 – 1036	Protein kinasePROSITE-ProRule annotationAdd BLAST		260
Domainⁱ	1037 – 1088	AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST		52

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 69	DimerizationBy similarityAdd BLAST	69
Regionⁱ	15 – 39	DisorderedSequence analysisAdd BLAST	25
Regionⁱ	70 – 528	RegulatoryBy similarityAdd BLAST	459
Regionⁱ	128 – 158	DisorderedSequence analysisAdd BLAST	31
Regionⁱ	191 – 211	DisorderedSequence analysisAdd BLAST	21
Regionⁱ	305 – 336	DisorderedSequence analysisAdd BLAST	32
Regionⁱ	441 – 477	DisorderedSequence analysisAdd BLAST	37
Regionⁱ	1064 – 1088	DisorderedSequence analysisAdd BLAST	25

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	15 – 29	Polar residuesSequence analysisAdd BLAST	15
Compositional biasⁱ	141 – 158	Basic and acidic residuesSequence analysisAdd BLAST	18
Compositional biasⁱ	454 – 477	Polar residuesSequence analysisAdd BLAST	24

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0614, Eukaryota KOG0616, Eukaryota
HOGENOMⁱ	CLU_000288_73_6_1
InParanoidⁱ	Q03043
PhylomeDBⁱ	Q03043

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00038, CAP_ED, 2 hits cd05572, STKc_cGK, 1 hit
Gene3Dⁱ	2.60.120.10, 2 hits
InterProⁱ	View protein in InterPro IPR000961, AGC-kinase_C IPR002374, cGMP_dep_kinase IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR011009, Kinase-like_dom_sf IPR031831, PKcGMP_CC IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR014710, RmlC-like_jellyroll IPR008271, Ser/Thr_kinase_AS IPR035014, STKc_cGK
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00027, cNMP_binding, 2 hits PF16808, PKcGMP_CC, 1 hit PF00069, Pkinase, 1 hit
PRINTSⁱ	PR00104, CGMPKINASE
SMARTⁱ	View protein in SMART SM00100, cNMP, 2 hits SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit
SUPFAMⁱ	SSF51206, SSF51206, 2 hits SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00888, CNMP_BINDING_1, 2 hits PS00889, CNMP_BINDING_2, 2 hits PS50042, CNMP_BINDING_3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform T1 (identifier: Q03043-1) [UniParc]FASTA Add to basket

Also known as: A, H

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRFCFDRLCF ATKRPAQNSN SNAPHSSTTV DAPPRPADVD VATVPVATPA 
        60         70         80         90        100
PPPQQPVSNL FYADYQKLQP AIIDRDWERD RDTDTDTRSE AKPPDIVEHI 
       110        120        130        140        150
EPVEEQRQIH TQIQSPAEIQ IQIPPTPPAP SIQIQIQQRY RRHSSAEDRN 
       160        170        180        190        200
LNTRRNDSNI TEALRKAASM QQEPNANYQF PTDLGLVSIV NNNNNTNTHP 
       210        220        230        240        250
SGSNSGSNNN SNINNNLVGG IVTLPAAGGL IGLEHTASGL RLIPAPPTHS 
       260        270        280        290        300
DVLTHTLIYG TPPSGAQQLN QDPRSLLHQQ ELQLQQRYQQ LQQLQAQTQG 
       310        320        330        340        350
LYTSQGSPVL YHQPSPGSSQ PVAIPGATCH SPTQLQPPNT LNLQQQMQSL 
       360        370        380        390        400
RISGCTPSGT GGSATPSPVG LVDPNFIVSN YVAASPQEER FIQIIQAKEL 
       410        420        430        440        450
KIQEMQRALQ FKDNEIAELK SHLDKFQSVF PFSRGSAAGC AGTGGASGSG 
       460        470        480        490        500
AGGSGGSGPG TATGATRKSG QNFQRQRALG ISAEPQSESS LLLEHVSFPK 
       510        520        530        540        550
YDKDERSREL IKAAILDNDF MKNLDLTQIR EIVDCMYPVK YPAKNLIIKE 
       560        570        580        590        600
GDVGSIVYVM EDGRVEVSRE GKYLSTLSGA KVLGELAILY NCQRTATITA 
       610        620        630        640        650
ITECNLWAIE RQCFQTIMMR TGLIRQAEYS DFLKSVPIFK DLAEDTLIKI 
       660        670        680        690        700
SDVLEETHYQ RGDYIVRQGA RGDTFFIISK GKVRVTIKQQ DTQEEKFIRM 
       710        720        730        740        750
LGKGDFFGEK ALQGDDLRTA NIICESADGV SCLVIDRETF NQLISNLDEI 
       760        770        780        790        800
KHRYDDEGAM ERRKINEEFR DINLTDLRVI ATLGVGGFGR VELVQTNGDS 
       810        820        830        840        850
SRSFALKQMK KSQIVETRQQ QHIMSEKEIM GEANCQFIVK LFKTFKDKKY 
       860        870        880        890        900
LYMLMESCLG GELWTILRDK GNFDDSTTRF YTACVVEAFD YLHSRNIIYR 
       910        920        930        940        950
DLKPENLLLN ERGYVKLVDF GFAKKLQTGR KTWTFCGTPE YVAPEVILNR 
       960        970        980        990       1000
GHDISADYWS LGVLMFELLT GTPPFTGSDP MRTYNIILKG IDAIEFPRNI 
      1010       1020       1030       1040       1050
TRNASNLIKK LCRDNPAERL GYQRGGISEI QKHKWFDGFY WWGLQNCTLE 
      1060       1070       1080 
PPIKPAVKSV VDTTNFDDYP PDPEGPPPDD VTGWDKDF

Length:1,088

Mass (Da):121,341

Last modified:February 1, 2005 - v3

Checksum:ⁱA9450E31FF7AB8BD

GO

Isoform cD4 (identifier: Q03043-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-520: Missing.

« Hide

        10         20         30         40         50
MKNLDLTQIR EIVDCMYPVK YPAKNLIIKE GDVGSIVYVM EDGRVEVSRE 
        60         70         80         90        100
GKYLSTLSGA KVLGELAILY NCQRTATITA ITECNLWAIE RQCFQTIMMR 
       110        120        130        140        150
TGLIRQAEYS DFLKSVPIFK DLAEDTLIKI SDVLEETHYQ RGDYIVRQGA 
       160        170        180        190        200
RGDTFFIISK GKVRVTIKQQ DTQEEKFIRM LGKGDFFGEK ALQGDDLRTA 
       210        220        230        240        250
NIICESADGV SCLVIDRETF NQLISNLDEI KHRYDDEGAM ERRKINEEFR 
       260        270        280        290        300
DINLTDLRVI ATLGVGGFGR VELVQTNGDS SRSFALKQMK KSQIVETRQQ 
       310        320        330        340        350
QHIMSEKEIM GEANCQFIVK LFKTFKDKKY LYMLMESCLG GELWTILRDK 
       360        370        380        390        400
GNFDDSTTRF YTACVVEAFD YLHSRNIIYR DLKPENLLLN ERGYVKLVDF 
       410        420        430        440        450
GFAKKLQTGR KTWTFCGTPE YVAPEVILNR GHDISADYWS LGVLMFELLT 
       460        470        480        490        500
GTPPFTGSDP MRTYNIILKG IDAIEFPRNI TRNASNLIKK LCRDNPAERL 
       510        520        530        540        550
GYQRGGISEI QKHKWFDGFY WWGLQNCTLE PPIKPAVKSV VDTTNFDDYP 
       560 
PDPEGPPPDD VTGWDKDF

Show »

Length:568

Mass (Da):65,073

Checksum:ⁱA5A275D0B5A50397

GO

Isoform T3A (identifier: Q03043-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-169: Missing.

« Hide

        10         20         30         40         50
MQQEPNANYQ FPTDLGLVSI VNNNNNTNTH PSGSNSGSNN NSNINNNLVG 
        60         70         80         90        100
GIVTLPAAGG LIGLEHTASG LRLIPAPPTH SDVLTHTLIY GTPPSGAQQL 
       110        120        130        140        150
NQDPRSLLHQ QELQLQQRYQ QLQQLQAQTQ GLYTSQGSPV LYHQPSPGSS 
       160        170        180        190        200
QPVAIPGATC HSPTQLQPPN TLNLQQQMQS LRISGCTPSG TGGSATPSPV 
       210        220        230        240        250
GLVDPNFIVS NYVAASPQEE RFIQIIQAKE LKIQEMQRAL QFKDNEIAEL 
       260        270        280        290        300
KSHLDKFQSV FPFSRGSAAG CAGTGGASGS GAGGSGGSGP GTATGATRKS 
       310        320        330        340        350
GQNFQRQRAL GISAEPQSES SLLLEHVSFP KYDKDERSRE LIKAAILDND 
       360        370        380        390        400
FMKNLDLTQI REIVDCMYPV KYPAKNLIIK EGDVGSIVYV MEDGRVEVSR 
       410        420        430        440        450
EGKYLSTLSG AKVLGELAIL YNCQRTATIT AITECNLWAI ERQCFQTIMM 
       460        470        480        490        500
RTGLIRQAEY SDFLKSVPIF KDLAEDTLIK ISDVLEETHY QRGDYIVRQG 
       510        520        530        540        550
ARGDTFFIIS KGKVRVTIKQ QDTQEEKFIR MLGKGDFFGE KALQGDDLRT 
       560        570        580        590        600
ANIICESADG VSCLVIDRET FNQLISNLDE IKHRYDDEGA MERRKINEEF 
       610        620        630        640        650
RDINLTDLRV IATLGVGGFG RVELVQTNGD SSRSFALKQM KKSQIVETRQ 
       660        670        680        690        700
QQHIMSEKEI MGEANCQFIV KLFKTFKDKK YLYMLMESCL GGELWTILRD 
       710        720        730        740        750
KGNFDDSTTR FYTACVVEAF DYLHSRNIIY RDLKPENLLL NERGYVKLVD 
       760        770        780        790        800
FGFAKKLQTG RKTWTFCGTP EYVAPEVILN RGHDISADYW SLGVLMFELL 
       810        820        830        840        850
TGTPPFTGSD PMRTYNIILK GIDAIEFPRN ITRNASNLIK KLCRDNPAER 
       860        870        880        890        900
LGYQRGGISE IQKHKWFDGF YWWGLQNCTL EPPIKPAVKS VVDTTNFDDY 
       910 
PPDPEGPPPD DVTGWDKDF

Show »

Length:919

Mass (Da):102,235

Checksum:ⁱFD7DDDFC3391F3AD

GO

Isoform T3B (identifier: Q03043-3) [UniParc]FASTA Add to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
1-346: Missing.

« Hide

        10         20         30         40         50
MQSLRISGCT PSGTGGSATP SPVGLVDPNF IVSNYVAASP QEERFIQIIQ 
        60         70         80         90        100
AKELKIQEMQ RALQFKDNEI AELKSHLDKF QSVFPFSRGS AAGCAGTGGA 
       110        120        130        140        150
SGSGAGGSGG SGPGTATGAT RKSGQNFQRQ RALGISAEPQ SESSLLLEHV 
       160        170        180        190        200
SFPKYDKDER SRELIKAAIL DNDFMKNLDL TQIREIVDCM YPVKYPAKNL 
       210        220        230        240        250
IIKEGDVGSI VYVMEDGRVE VSREGKYLST LSGAKVLGEL AILYNCQRTA 
       260        270        280        290        300
TITAITECNL WAIERQCFQT IMMRTGLIRQ AEYSDFLKSV PIFKDLAEDT 
       310        320        330        340        350
LIKISDVLEE THYQRGDYIV RQGARGDTFF IISKGKVRVT IKQQDTQEEK 
       360        370        380        390        400
FIRMLGKGDF FGEKALQGDD LRTANIICES ADGVSCLVID RETFNQLISN 
       410        420        430        440        450
LDEIKHRYDD EGAMERRKIN EEFRDINLTD LRVIATLGVG GFGRVELVQT 
       460        470        480        490        500
NGDSSRSFAL KQMKKSQIVE TRQQQHIMSE KEIMGEANCQ FIVKLFKTFK 
       510        520        530        540        550
DKKYLYMLME SCLGGELWTI LRDKGNFDDS TTRFYTACVV EAFDYLHSRN 
       560        570        580        590        600
IIYRDLKPEN LLLNERGYVK LVDFGFAKKL QTGRKTWTFC GTPEYVAPEV 
       610        620        630        640        650
ILNRGHDISA DYWSLGVLMF ELLTGTPPFT GSDPMRTYNI ILKGIDAIEF 
       660        670        680        690        700
PRNITRNASN LIKKLCRDNP AERLGYQRGG ISEIQKHKWF DGFYWWGLQN 
       710        720        730        740 
CTLEPPIKPA VKSVVDTTNF DDYPPDPEGP PPDDVTGWDK DF

Show »

Length:742

Mass (Da):83,349

Checksum:ⁱ8354AAA1630DCE09

GO

Isoform cD5 (identifier: P32023-1) [UniParc]FASTA Add to basket

Also known as: E, J

The sequence of this isoform can be found in the external entry P32023.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:934

Mass (Da):105,907

GO

Isoform T2 (identifier: P32023-2) [UniParc]FASTA Add to basket

Also known as: C, D, G, T2a, T2b

The sequence of this isoform can be found in the external entry P32023.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:894

Mass (Da):101,058

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A1W5Q0S1	A0A1W5Q0S1_DROME	cGMP-dependent protein kinase cGMP-dependent protein kinase, EC 2.7.11.12	for 142251_at, anon-WO0140519.260, anon-WO02059370.47, BcDNA:GM08338, DG2	742	Annotation score:
E1JHR9	E1JHR9_DROME	cGMP-dependent protein kinase cGMP-dependent protein kinase, EC 2.7.11.12	for 142251_at, anon-WO0140519.260, anon-WO02059370.47, BcDNA:GM08338, DG2	894	Annotation score:
A0A4D6K344	A0A4D6K344_DROME	cGMP-dependent protein kinase cGMP-dependent protein kinase, EC 2.7.11.12	for 142251_at, anon-WO0140519.260, anon-WO02059370.47, BcDNA:GM08338, DG2	471	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	49	P → T in AAA28455 (PubMed:2732245).Curated	1
Sequence conflictⁱ	207	S → T in AAA28455 (PubMed:2732245).Curated	1
Sequence conflictⁱ	664	Y → H in AAA28455 (PubMed:2732245).Curated	1
Sequence conflictⁱ	664	Y → H in AAA28459 (PubMed:2732245).Curated	1
Sequence conflictⁱ	692	T → R in AAA28455 (PubMed:2732245).Curated	1
Sequence conflictⁱ	692	T → R in AAA28459 (PubMed:2732245).Curated	1
Sequence conflictⁱ	915	V → G in AAA28455 (PubMed:2732245).Curated	1
Sequence conflictⁱ	915	V → G in AAA28459 (PubMed:2732245).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_004763	1 – 520	Missing in isoform cD4. CuratedAdd BLAST	520
Alternative sequenceⁱVSP_004762	1 – 346	Missing in isoform T3B. 1 PublicationAdd BLAST	346
Alternative sequenceⁱVSP_004761	1 – 169	Missing in isoform T3A. CuratedAdd BLAST	169

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M27120 M27119 Genomic DNA Translation: AAA28455.1 M30413 mRNA Translation: AAA28459.1 AE014134 Genomic DNA Translation: AAF51082.2 AE014134 Genomic DNA Translation: AAS64613.1 AE014134 Genomic DNA Translation: AAS64614.1 AY061514 mRNA Translation: AAL29062.1
PIRⁱ	B34106
NCBI Reference Sequences More...RefSeqⁱ	NP_477487.1, NM_058139.4 [Q03043-1] NP_995626.1, NM_205904.2 [Q03043-1] NP_995628.1, NM_205906.2 [Q03043-1]

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0089304; FBpp0088350; FBgn0000721 [Q03043-1] FBtr0089310; FBpp0088922; FBgn0000721 [Q03043-1] FBtr0089312; FBpp0088923; FBgn0000721 [Q03043-1] FBtr0446099; FBpp0402801; FBgn0000721 [Q03043-3] FBtr0473363; FBpp0422967; FBgn0000721 [Q03043-4] FBtr0473364; FBpp0422968; FBgn0000721 [Q03043-4]
GeneIDⁱ	44817
UCSC genome browser More...UCSCⁱ	CG10033-RA, d. melanogaster [Q03043-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q03043	cGMP-dependent protein kinase		DROME		742	UniRef100_Q03043
Isoform T3B of cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B		DROME		742
Isoform T3A of cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B		DROME		919
Q03043-4	cGMP-dependent protein kinase		DROYA		1089	UniRef100_Q03043-4
cGMP-dependent protein kinase		DROME		471
P32023-2	cGMP-dependent protein kinase		DROME		894	UniRef100_E1JHR9

Protein	Similar proteins		Species	Score	Length	Source
Q03043	cGMP-dependent protein kinase		DROME		742	UniRef90_Q03043
Isoform T3B of cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B		DROME		742
Isoform T3A of cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B		DROME		919
cGMP-dependent protein kinase		DROME		1087
cGMP-dependent protein kinase		DROME		742
+1
Q03043-4	cGMP-dependent protein kinase		DROYA		1089	UniRef90_Q03043-4
cGMP-dependent protein kinase		DROME		471
cGMP-dependent protein kinase		DROMA		1084
cGMP-dependent protein kinase		DROSI		1079
cGMP-dependent protein kinase		DROER		1072
+3
P32023-2	cGMP-dependent protein kinase		DROME		894	UniRef90_E1JHR9

Protein	Similar proteins		Species	Score	Length	Source
Q03043	cGMP-dependent protein kinase		DROME		742	UniRef50_Q03043
cGMP-dependent protein kinase		DROKI		1087
cGMP-dependent protein kinase		ZEUCU		1192
cGMP-dependent protein kinase		DROBS		1046
cGMP-dependent protein kinase		DRORH		1084
+65
P32023-2	cGMP-dependent protein kinase, isozyme 2 forms cD5/T2		DROME		934	UniRef50_P32023
cGMP-dependent protein kinase		DROTK		898
cGMP-dependent protein kinase		DROAN		907
cGMP-dependent protein kinase		DROBP		900
cGMP-dependent protein kinase		AEDAL		471
+51

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M27120 M27119 Genomic DNA Translation: AAA28455.1 M30413 mRNA Translation: AAA28459.1 AE014134 Genomic DNA Translation: AAF51082.2 AE014134 Genomic DNA Translation: AAS64613.1 AE014134 Genomic DNA Translation: AAS64614.1 AY061514 mRNA Translation: AAL29062.1
PIRⁱ	B34106
RefSeqⁱ	NP_477487.1, NM_058139.4 [Q03043-1] NP_995626.1, NM_205904.2 [Q03043-1] NP_995628.1, NM_205906.2 [Q03043-1]

3D structure databases

AlphaFoldDBⁱ	Q03043
SMRⁱ	Q03043
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	69303, 13 interactors
STRINGⁱ	7227.FBpp0088350

PTM databases

iPTMnetⁱ	Q03043

iPTMnetⁱ

Q03043

Proteomic databases

PaxDbⁱ	Q03043
PRIDEⁱ	Q03043

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	44817

DNASUⁱ

44817

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0089304; FBpp0088350; FBgn0000721 [Q03043-1] FBtr0089310; FBpp0088922; FBgn0000721 [Q03043-1] FBtr0089312; FBpp0088923; FBgn0000721 [Q03043-1] FBtr0446099; FBpp0402801; FBgn0000721 [Q03043-3] FBtr0473363; FBpp0422967; FBgn0000721 [Q03043-4] FBtr0473364; FBpp0422968; FBgn0000721 [Q03043-4]
GeneIDⁱ	44817
UCSCⁱ	CG10033-RA, d. melanogaster [Q03043-1]

Organism-specific databases

CTDⁱ	44817
FlyBaseⁱ	FBgn0000721, for
VEuPathDBⁱ	VectorBase:FBgn0000721

Phylogenomic databases

eggNOGⁱ	KOG0614, Eukaryota KOG0616, Eukaryota
HOGENOMⁱ	CLU_000288_73_6_1
InParanoidⁱ	Q03043
PhylomeDBⁱ	Q03043

Enzyme and pathway databases

BRENDAⁱ	2.7.11.12, 1994
Reactomeⁱ	R-DME-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-DME-392517, Rap1 signalling R-DME-9648002, RAS processing

Miscellaneous databases

BioGRID-ORCSⁱ	44817, 0 hits in 3 CRISPR screens
ChiTaRSⁱ	for, fly
GenomeRNAiⁱ	44817

Gene expression databases

Bgeeⁱ	FBgn0000721, Expressed in spermathecum and 70 other tissues
ExpressionAtlasⁱ	Q03043, baseline and differential
Genevisibleⁱ	Q03043, DM

Family and domain databases

CDDⁱ	cd00038, CAP_ED, 2 hits cd05572, STKc_cGK, 1 hit
Gene3Dⁱ	2.60.120.10, 2 hits
InterProⁱ	View protein in InterPro IPR000961, AGC-kinase_C IPR002374, cGMP_dep_kinase IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR011009, Kinase-like_dom_sf IPR031831, PKcGMP_CC IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR014710, RmlC-like_jellyroll IPR008271, Ser/Thr_kinase_AS IPR035014, STKc_cGK
Pfamⁱ	View protein in Pfam PF00027, cNMP_binding, 2 hits PF16808, PKcGMP_CC, 1 hit PF00069, Pkinase, 1 hit
PRINTSⁱ	PR00104, CGMPKINASE
SMARTⁱ	View protein in SMART SM00100, cNMP, 2 hits SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit
SUPFAMⁱ	SSF51206, SSF51206, 2 hits SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00888, CNMP_BINDING_1, 2 hits PS00889, CNMP_BINDING_2, 2 hits PS50042, CNMP_BINDING_3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KGP24_DROME
Accessionⁱ	Q03043Primary (citable) accession number: Q03043 Secondary accession number(s): A4V042 , Q24304, Q9I7Q1, Q9VQT2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	February 1, 2005
	Last modified:	May 25, 2022
	This is version 196 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Drosophila annotation project

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q03043 (KGP24_DROME)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Plasma Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ