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Entry version 196 (25 May 2022)
Sequence version 3 (01 Feb 2005)
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Protein

cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B

Gene

for

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei6993',5'-cGMP 2By similarity1
Binding sitei807ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei901Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi584 – 5873',5'-cGMP 1By similarity4
Nucleotide bindingi594 – 5953',5'-cGMP 1By similarity2
Nucleotide bindingi708 – 7113',5'-cGMP 2By similarity4
Nucleotide bindingi718 – 7193',5'-cGMP 2By similarity2
Nucleotide bindingi783 – 791ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, cGMP, cGMP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.12, 1994

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-DME-392517, Rap1 signalling
R-DME-9648002, RAS processing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (EC:2.7.11.12)
Short name:
cGK
Alternative name(s):
Foraging protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:for
Synonyms:DG2, PGK2, Pkg24A
ORF Names:CG10033
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

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FlyBasei
FBgn0000721, for

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0000721

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000861211 – 1088cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3BAdd BLAST1088

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei934Phosphothreonine1 Publication1
Modified residuei938Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q03043

PRoteomics IDEntifications database

More...
PRIDEi
Q03043

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q03043

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout development, high during embryonic and adult stages. Isoform T1 is predominantly expressed during embryo and adult stages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000721, Expressed in spermathecum and 70 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q03043, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q03043, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
69303, 13 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0088350

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q03043

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q03043

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini777 – 1036Protein kinasePROSITE-ProRule annotationAdd BLAST260
Domaini1037 – 1088AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 69DimerizationBy similarityAdd BLAST69
Regioni15 – 39DisorderedSequence analysisAdd BLAST25
Regioni70 – 528RegulatoryBy similarityAdd BLAST459
Regioni128 – 158DisorderedSequence analysisAdd BLAST31
Regioni191 – 211DisorderedSequence analysisAdd BLAST21
Regioni305 – 336DisorderedSequence analysisAdd BLAST32
Regioni441 – 477DisorderedSequence analysisAdd BLAST37
Regioni1064 – 1088DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 29Polar residuesSequence analysisAdd BLAST15
Compositional biasi141 – 158Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi454 – 477Polar residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0614, Eukaryota
KOG0616, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_73_6_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q03043

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q03043

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00038, CAP_ED, 2 hits
cd05572, STKc_cGK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961, AGC-kinase_C
IPR002374, cGMP_dep_kinase
IPR018490, cNMP-bd-like
IPR018488, cNMP-bd_CS
IPR000595, cNMP-bd_dom
IPR011009, Kinase-like_dom_sf
IPR031831, PKcGMP_CC
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR014710, RmlC-like_jellyroll
IPR008271, Ser/Thr_kinase_AS
IPR035014, STKc_cGK

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00027, cNMP_binding, 2 hits
PF16808, PKcGMP_CC, 1 hit
PF00069, Pkinase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00104, CGMPKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00100, cNMP, 2 hits
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51206, SSF51206, 2 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00888, CNMP_BINDING_1, 2 hits
PS00889, CNMP_BINDING_2, 2 hits
PS50042, CNMP_BINDING_3, 2 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform T1 (identifier: Q03043-1) [UniParc]FASTAAdd to basket
Also known as: A, H

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRFCFDRLCF ATKRPAQNSN SNAPHSSTTV DAPPRPADVD VATVPVATPA
60 70 80 90 100
PPPQQPVSNL FYADYQKLQP AIIDRDWERD RDTDTDTRSE AKPPDIVEHI
110 120 130 140 150
EPVEEQRQIH TQIQSPAEIQ IQIPPTPPAP SIQIQIQQRY RRHSSAEDRN
160 170 180 190 200
LNTRRNDSNI TEALRKAASM QQEPNANYQF PTDLGLVSIV NNNNNTNTHP
210 220 230 240 250
SGSNSGSNNN SNINNNLVGG IVTLPAAGGL IGLEHTASGL RLIPAPPTHS
260 270 280 290 300
DVLTHTLIYG TPPSGAQQLN QDPRSLLHQQ ELQLQQRYQQ LQQLQAQTQG
310 320 330 340 350
LYTSQGSPVL YHQPSPGSSQ PVAIPGATCH SPTQLQPPNT LNLQQQMQSL
360 370 380 390 400
RISGCTPSGT GGSATPSPVG LVDPNFIVSN YVAASPQEER FIQIIQAKEL
410 420 430 440 450
KIQEMQRALQ FKDNEIAELK SHLDKFQSVF PFSRGSAAGC AGTGGASGSG
460 470 480 490 500
AGGSGGSGPG TATGATRKSG QNFQRQRALG ISAEPQSESS LLLEHVSFPK
510 520 530 540 550
YDKDERSREL IKAAILDNDF MKNLDLTQIR EIVDCMYPVK YPAKNLIIKE
560 570 580 590 600
GDVGSIVYVM EDGRVEVSRE GKYLSTLSGA KVLGELAILY NCQRTATITA
610 620 630 640 650
ITECNLWAIE RQCFQTIMMR TGLIRQAEYS DFLKSVPIFK DLAEDTLIKI
660 670 680 690 700
SDVLEETHYQ RGDYIVRQGA RGDTFFIISK GKVRVTIKQQ DTQEEKFIRM
710 720 730 740 750
LGKGDFFGEK ALQGDDLRTA NIICESADGV SCLVIDRETF NQLISNLDEI
760 770 780 790 800
KHRYDDEGAM ERRKINEEFR DINLTDLRVI ATLGVGGFGR VELVQTNGDS
810 820 830 840 850
SRSFALKQMK KSQIVETRQQ QHIMSEKEIM GEANCQFIVK LFKTFKDKKY
860 870 880 890 900
LYMLMESCLG GELWTILRDK GNFDDSTTRF YTACVVEAFD YLHSRNIIYR
910 920 930 940 950
DLKPENLLLN ERGYVKLVDF GFAKKLQTGR KTWTFCGTPE YVAPEVILNR
960 970 980 990 1000
GHDISADYWS LGVLMFELLT GTPPFTGSDP MRTYNIILKG IDAIEFPRNI
1010 1020 1030 1040 1050
TRNASNLIKK LCRDNPAERL GYQRGGISEI QKHKWFDGFY WWGLQNCTLE
1060 1070 1080
PPIKPAVKSV VDTTNFDDYP PDPEGPPPDD VTGWDKDF
Length:1,088
Mass (Da):121,341
Last modified:February 1, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9450E31FF7AB8BD
GO
Isoform cD4 (identifier: Q03043-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-520: Missing.

Show »
Length:568
Mass (Da):65,073
Checksum:iA5A275D0B5A50397
GO
Isoform T3A (identifier: Q03043-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.

Show »
Length:919
Mass (Da):102,235
Checksum:iFD7DDDFC3391F3AD
GO
Isoform T3B (identifier: Q03043-3) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-346: Missing.

Show »
Length:742
Mass (Da):83,349
Checksum:i8354AAA1630DCE09
GO
Isoform cD5 (identifier: P32023-1) [UniParc]FASTAAdd to basket
Also known as: E, J
The sequence of this isoform can be found in the external entry P32023.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:934
Mass (Da):105,907
GO
Isoform T2 (identifier: P32023-2) [UniParc]FASTAAdd to basket
Also known as: C, D, G, T2a, T2b
The sequence of this isoform can be found in the external entry P32023.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:894
Mass (Da):101,058
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W5Q0S1A0A1W5Q0S1_DROME
cGMP-dependent protein kinase
for 142251_at, anon-WO0140519.260, anon-WO02059370.47, BcDNA:GM08338, DG2
742Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JHR9E1JHR9_DROME
cGMP-dependent protein kinase
for 142251_at, anon-WO0140519.260, anon-WO02059370.47, BcDNA:GM08338, DG2
894Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A4D6K344A0A4D6K344_DROME
cGMP-dependent protein kinase
for 142251_at, anon-WO0140519.260, anon-WO02059370.47, BcDNA:GM08338, DG2
471Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49P → T in AAA28455 (PubMed:2732245).Curated1
Sequence conflicti207S → T in AAA28455 (PubMed:2732245).Curated1
Sequence conflicti664Y → H in AAA28455 (PubMed:2732245).Curated1
Sequence conflicti664Y → H in AAA28459 (PubMed:2732245).Curated1
Sequence conflicti692T → R in AAA28455 (PubMed:2732245).Curated1
Sequence conflicti692T → R in AAA28459 (PubMed:2732245).Curated1
Sequence conflicti915V → G in AAA28455 (PubMed:2732245).Curated1
Sequence conflicti915V → G in AAA28459 (PubMed:2732245).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0047631 – 520Missing in isoform cD4. CuratedAdd BLAST520
Alternative sequenceiVSP_0047621 – 346Missing in isoform T3B. 1 PublicationAdd BLAST346
Alternative sequenceiVSP_0047611 – 169Missing in isoform T3A. CuratedAdd BLAST169

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M27120 M27119 Genomic DNA Translation: AAA28455.1
M30413 mRNA Translation: AAA28459.1
AE014134 Genomic DNA Translation: AAF51082.2
AE014134 Genomic DNA Translation: AAS64613.1
AE014134 Genomic DNA Translation: AAS64614.1
AY061514 mRNA Translation: AAL29062.1

Protein sequence database of the Protein Information Resource

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PIRi
B34106

NCBI Reference Sequences

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RefSeqi
NP_477487.1, NM_058139.4 [Q03043-1]
NP_995626.1, NM_205904.2 [Q03043-1]
NP_995628.1, NM_205906.2 [Q03043-1]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0089304; FBpp0088350; FBgn0000721 [Q03043-1]
FBtr0089310; FBpp0088922; FBgn0000721 [Q03043-1]
FBtr0089312; FBpp0088923; FBgn0000721 [Q03043-1]
FBtr0446099; FBpp0402801; FBgn0000721 [Q03043-3]
FBtr0473363; FBpp0422967; FBgn0000721 [Q03043-4]
FBtr0473364; FBpp0422968; FBgn0000721 [Q03043-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
44817

UCSC genome browser

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UCSCi
CG10033-RA, d. melanogaster [Q03043-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27120 M27119 Genomic DNA Translation: AAA28455.1
M30413 mRNA Translation: AAA28459.1
AE014134 Genomic DNA Translation: AAF51082.2
AE014134 Genomic DNA Translation: AAS64613.1
AE014134 Genomic DNA Translation: AAS64614.1
AY061514 mRNA Translation: AAL29062.1
PIRiB34106
RefSeqiNP_477487.1, NM_058139.4 [Q03043-1]
NP_995626.1, NM_205904.2 [Q03043-1]
NP_995628.1, NM_205906.2 [Q03043-1]

3D structure databases

AlphaFoldDBiQ03043
SMRiQ03043
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi69303, 13 interactors
STRINGi7227.FBpp0088350

PTM databases

iPTMnetiQ03043

Proteomic databases

PaxDbiQ03043
PRIDEiQ03043

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
44817

Genome annotation databases

EnsemblMetazoaiFBtr0089304; FBpp0088350; FBgn0000721 [Q03043-1]
FBtr0089310; FBpp0088922; FBgn0000721 [Q03043-1]
FBtr0089312; FBpp0088923; FBgn0000721 [Q03043-1]
FBtr0446099; FBpp0402801; FBgn0000721 [Q03043-3]
FBtr0473363; FBpp0422967; FBgn0000721 [Q03043-4]
FBtr0473364; FBpp0422968; FBgn0000721 [Q03043-4]
GeneIDi44817
UCSCiCG10033-RA, d. melanogaster [Q03043-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
44817
FlyBaseiFBgn0000721, for
VEuPathDBiVectorBase:FBgn0000721

Phylogenomic databases

eggNOGiKOG0614, Eukaryota
KOG0616, Eukaryota
HOGENOMiCLU_000288_73_6_1
InParanoidiQ03043
PhylomeDBiQ03043

Enzyme and pathway databases

BRENDAi2.7.11.12, 1994
ReactomeiR-DME-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-DME-392517, Rap1 signalling
R-DME-9648002, RAS processing

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
44817, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
for, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
44817

Gene expression databases

BgeeiFBgn0000721, Expressed in spermathecum and 70 other tissues
ExpressionAtlasiQ03043, baseline and differential
GenevisibleiQ03043, DM

Family and domain databases

CDDicd00038, CAP_ED, 2 hits
cd05572, STKc_cGK, 1 hit
Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR000961, AGC-kinase_C
IPR002374, cGMP_dep_kinase
IPR018490, cNMP-bd-like
IPR018488, cNMP-bd_CS
IPR000595, cNMP-bd_dom
IPR011009, Kinase-like_dom_sf
IPR031831, PKcGMP_CC
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR014710, RmlC-like_jellyroll
IPR008271, Ser/Thr_kinase_AS
IPR035014, STKc_cGK
PfamiView protein in Pfam
PF00027, cNMP_binding, 2 hits
PF16808, PKcGMP_CC, 1 hit
PF00069, Pkinase, 1 hit
PRINTSiPR00104, CGMPKINASE
SMARTiView protein in SMART
SM00100, cNMP, 2 hits
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF51206, SSF51206, 2 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00888, CNMP_BINDING_1, 2 hits
PS00889, CNMP_BINDING_2, 2 hits
PS50042, CNMP_BINDING_3, 2 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKGP24_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03043
Secondary accession number(s): A4V042
, Q24304, Q9I7Q1, Q9VQT2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 2005
Last modified: May 25, 2022
This is version 196 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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