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Protein

Mitochondrial 2-oxodicarboxylate carrier 1

Gene

ODC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate. The main physiological role is probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.

Miscellaneous

Present with 2840 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • dicarboxylic acid transmembrane transporter activity Source: SGD

GO - Biological processi

  • mitochondrial transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-34033-MONOMER
ReactomeiR-SCE-71064 Lysine catabolism

Protein family/group databases

TCDBi2.A.29.2.8 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxodicarboxylate carrier 1
Gene namesi
Name:ODC1
Ordered Locus Names:YPL134C
ORF Names:LPI11C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL134C
SGDiS000006055 ODC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei78 – 97Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei126 – 146Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei179 – 199Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei219 – 239Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei281 – 301Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906481 – 310Mitochondrial 2-oxodicarboxylate carrier 1Add BLAST310

Proteomic databases

MaxQBiQ03028
PaxDbiQ03028
PRIDEiQ03028

Interactioni

Protein-protein interaction databases

BioGridi36047, 68 interactors
DIPiDIP-8776N
STRINGi4932.YPL134C

Structurei

3D structure databases

ProteinModelPortaliQ03028
SMRiQ03028
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 108Solcar 1Add BLAST100
Repeati120 – 204Solcar 2Add BLAST85
Repeati213 – 300Solcar 3Add BLAST88

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000111119
HOGENOMiHOG000168307
InParanoidiQ03028
KOiK15110
OMAiCVETPKR
OrthoDBiEOG092C3CGH

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q03028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSIDNRPLP FIYQFTAGAI AGVSELLVMY PLDVVKTRMQ LQVTTKGHPA
60 70 80 90 100
VVAAKAAVDH YTGVMDCLTK IVKKEGFSHL YKGITSPILM EAPKRAIKFS
110 120 130 140 150
GNDTFQTFYK KIFPTPNGEM TQKIAIYSGA SAGAVEAFVV APFELVKIRL
160 170 180 190 200
QDVNSQFKTP IEVVKNSVVK GGVLSLFNGL EATIWRHVLW NAGYFGIIFQ
210 220 230 240 250
IRKLLPAAKT STEKTRNDLI AGAIGGTVGC LLNTPFDVVK SRIQRSSGPL
260 270 280 290 300
RKYNWSLPSV LLVYREEGFK ALYKGFAPKV MRLAPGGGLL LVVFTNVMDF
310
FREVKYGKKQ
Length:310
Mass (Da):34,206
Last modified:November 1, 1996 - v1
Checksum:i8EB7D6231BC2BCEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA Translation: AAB68225.1
BK006949 Genomic DNA Translation: DAA11299.1
PIRiS69050
RefSeqiNP_015191.1, NM_001183948.1

Genome annotation databases

EnsemblFungiiYPL134C; YPL134C; YPL134C
GeneIDi855969
KEGGisce:YPL134C

Similar proteinsi

Entry informationi

Entry nameiODC1_YEAST
AccessioniPrimary (citable) accession number: Q03028
Secondary accession number(s): D6W3N3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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