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Entry version 167 (23 Feb 2022)
Sequence version 1 (01 Nov 1996)
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Protein

GLC7-interacting protein 3

Gene

GIP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Present with 656 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GLC7-interacting protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GIP3
Ordered Locus Names:YPL137C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000006058, GIP3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YPL137C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002386231 – 1276GLC7-interacting protein 3Add BLAST1276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei68PhosphoserineCombined sources1
Modified residuei99PhosphothreonineCombined sources1
Modified residuei103PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei260PhosphoserineCombined sources1
Modified residuei264PhosphothreonineCombined sources1
Modified residuei269PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q03016

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q03016

PRoteomics IDEntifications database

More...
PRIDEi
Q03016

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q03016

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with phosphatase 1 (GLC7).

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36045, 77 interactors

Protein interaction database and analysis system

More...
IntActi
Q03016, 8 interactors

Molecular INTeraction database

More...
MINTi
Q03016

STRING: functional protein association networks

More...
STRINGi
4932.YPL137C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q03016, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 239DisorderedSequence analysisAdd BLAST239
Regioni394 – 417DisorderedSequence analysisAdd BLAST24
Regioni1016 – 1036DisorderedSequence analysisAdd BLAST21
Regioni1119 – 1167DisorderedSequence analysisAdd BLAST49
Regioni1221 – 1247DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi26 – 73Polar residuesSequence analysisAdd BLAST48
Compositional biasi87 – 112Polar residuesSequence analysisAdd BLAST26
Compositional biasi126 – 234Polar residuesSequence analysisAdd BLAST109
Compositional biasi396 – 413Polar residuesSequence analysisAdd BLAST18
Compositional biasi1017 – 1036Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1119 – 1166Polar residuesSequence analysisAdd BLAST48
Compositional biasi1221 – 1246Polar residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GIP3/HER1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QYHN, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176518

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007231_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q03016

Identification of Orthologs from Complete Genome Data

More...
OMAi
NILIKCK

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032675, LRR_dom_sf

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q03016-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITNTEFDVP VDWLYKGKSR RKTNTKPSRP STSPASSSST SSSKNGDNST
60 70 80 90 100
SGNRSSNDKP RARSSSVSNA ALCNTEKPDL KRNDGNTSAS DTDNIPLLTP
110 120 130 140 150
INSGNRSDSA DIDNPATVDA IDLIDNDDNG SSTQFVRKKR STSISNAVVS
160 170 180 190 200
SKPRLASSAI NATASSSVGK GKHPPISSPS NATLKRSNST SGEKTKRSIF
210 220 230 240 250
GSLFSKRSTS SSASTAKKPL PVVNTSTTEN ESGGIKAVAT PDPRVKEISS
260 270 280 290 300
PMRGVAPTAS KPQTPILPSP ALAVKDLSTV SLKRVSFAVD KFESDPPQQL
310 320 330 340 350
PSRTPKKGNI LIPDDMISEV PSISVGISSS NQSAKSTNSN IKGPLYTKKS
360 370 380 390 400
KEYILALENQ KLALREAAKH QQEAHFAANR IAFEVANFKT ASDAGGKLTE
410 420 430 440 450
KSSEGTITKQ REEVSPPNVE ADRELENNKL AENLSKAGID KPIHMHEHYF
460 470 480 490 500
KEPDQDKYQD GHSIENNEVT LDVIYTRCCH LREILPIPST LRQVKDKTAP
510 520 530 540 550
LQILKFLNPK PTLIDILSFC DFITIAPIHT IVFDNVALNQ DMFRIIISAL
560 570 580 590 600
VNSTVLDKLS LRNVRIDQDG WKLLCKFLLL NKSLNKLDIS QTKIKSDLAE
610 620 630 640 650
SLYRHNMDWN LFTDVLSQRS HKPIEELLFN GIQFSKIPYS CFARLLTSFA
660 670 680 690 700
TQKNFPESGI RLGLAGATTS NISQDCLKFI FNWMSQYNVQ GVDLAFNDLS
710 720 730 740 750
TMIKPMVGKL SALSYDNLRY FILNSTNIST SYDLALLLKY LSKLPNLIFL
760 770 780 790 800
DLSNLSQCFP DILPYMYKYL PRFPNLKRIH LDSNNLTLKE LAVVCNILIK
810 820 830 840 850
CKSLSHVSMT NQNVENFYLM NGTDSPVQQT NTDGDLDSSS TLDVKGQFAK
860 870 880 890 900
NSFSSTLYAF ARDSPNLIGL DFDYDLISEE IQSRIALCLM RNMKRTMDST
910 920 930 940 950
FQLDELDSQD DLLFDGSLVT MTAESVLEKL NLLSDKSTKV KKDTTKRYLL
960 970 980 990 1000
KKYIEKFHIL HHNVQHTIDT MFEKRKSGEL PLQEKENLVR LLLLEQNLCN
1010 1020 1030 1040 1050
ILELFSHNPN LNDVLGSSRD DSKESVDSSE DSKLPALKHV ESGYHVPEEK
1060 1070 1080 1090 1100
IQPENDVITA RPHLMATDSG KTIDVFTGKP LVFKHTSSST SVGCKKQEEE
1110 1120 1130 1140 1150
EGELHKWGFF VQQQRSLYPE NESTRQTPFA SGDTPINTET AGKSTSSPSV
1160 1170 1180 1190 1200
STSNNETATT SLFSPANPKI LPKIPSGAVL RSAIMKAKGI DSIDDLIQNV
1210 1220 1230 1240 1250
NSNNIELENI YGESIQNSAS TFTPGVDSDV SAPNTDKGSV ETLPAVSTDD
1260 1270
PNCEVKVTAT YDKLLNNLSM ERSIRL
Length:1,276
Mass (Da):140,891
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i32F84A311C92699A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U43703 Genomic DNA Translation: AAB68223.1
BK006949 Genomic DNA Translation: DAA11297.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S69048

NCBI Reference Sequences

More...
RefSeqi
NP_015188.1, NM_001183951.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPL137C_mRNA; YPL137C; YPL137C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855967

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPL137C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43703 Genomic DNA Translation: AAB68223.1
BK006949 Genomic DNA Translation: DAA11297.1
PIRiS69048
RefSeqiNP_015188.1, NM_001183951.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi36045, 77 interactors
IntActiQ03016, 8 interactors
MINTiQ03016
STRINGi4932.YPL137C

PTM databases

iPTMnetiQ03016

Proteomic databases

MaxQBiQ03016
PaxDbiQ03016
PRIDEiQ03016

Genome annotation databases

EnsemblFungiiYPL137C_mRNA; YPL137C; YPL137C
GeneIDi855967
KEGGisce:YPL137C

Organism-specific databases

SGDiS000006058, GIP3
VEuPathDBiFungiDB:YPL137C

Phylogenomic databases

eggNOGiENOG502QYHN, Eukaryota
GeneTreeiENSGT00940000176518
HOGENOMiCLU_007231_0_0_1
InParanoidiQ03016
OMAiNILIKCK

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q03016
RNActiQ03016, protein

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675, LRR_dom_sf

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGIP3_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q03016
Secondary accession number(s): D6W3N1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: February 23, 2022
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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