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Protein

Mitochondrial 2-oxoglutarate/malate carrier protein

Gene

SLC25A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • oxoglutarate:malate antiporter activity Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-70263 Gluconeogenesis

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.29.2.13 the mitochondrial carrier (mc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial 2-oxoglutarate/malate carrier protein
Short name:
OGCP
Alternative name(s):
Solute carrier family 25 member 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC25A11
Synonyms:SLC20A4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000108528.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10981 SLC25A11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604165 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q02978

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 42Helical; Name=1Sequence analysisAdd BLAST19
Transmembranei83 – 101Helical; Name=2Sequence analysisAdd BLAST19
Transmembranei119 – 140Helical; Name=3Sequence analysisAdd BLAST22
Transmembranei183 – 202Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei222 – 240Helical; Name=5Sequence analysisAdd BLAST19
Transmembranei281 – 300Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8402

Open Targets

More...
OpenTargetsi
ENSG00000108528

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35857

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC25A11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20141580

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000906252 – 314Mitochondrial 2-oxoglutarate/malate carrier proteinAdd BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei6PhosphoserineCombined sources1
Modified residuei57N6-succinyllysineBy similarity1
Modified residuei73N6-acetyllysineCombined sources1
Modified residuei102PhosphotyrosineBy similarity1
Modified residuei256N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q02978

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q02978

PeptideAtlas

More...
PeptideAtlasi
Q02978

PRoteomics IDEntifications database

More...
PRIDEi
Q02978

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58148

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q02978-1 [Q02978-1]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q02978

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q02978

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q02978

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q02978

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000108528 Expressed in 226 organ(s), highest expression level in muscle of leg

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC25A11

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q02978 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q02978 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021167

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113990, 64 interactors

Protein interaction database and analysis system

More...
IntActi
Q02978, 24 interactors

Molecular INTeraction database

More...
MINTi
Q02978

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000225665

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q02978

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati23 – 108Solcar 1Add BLAST86
Repeati117 – 208Solcar 2Add BLAST92
Repeati217 – 306Solcar 3Add BLAST90

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0759 Eukaryota
ENOG410XQHU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158465

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000165139

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG009528

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q02978

KEGG Orthology (KO)

More...
KOi
K15104

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFTPYYF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0BQ7

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q02978

TreeFam database of animal gene trees

More...
TreeFami
TF354262

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24089 PTHR24089, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00153 Mito_carr, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103506 SSF103506, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50920 SOLCAR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q02978-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAATASAGAG GIDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVKNRMQ
60 70 80 90 100
LSGEGAKTRE YKTSFHALTS ILKAEGLRGI YTGLSAGLLR QATYTTTRLG
110 120 130 140 150
IYTVLFERLT GADGTPPGFL LKAVIGMTAG ATGAFVGTPA EVALIRMTAD
160 170 180 190 200
GRLPADQRRG YKNVFNALIR ITREEGVLTL WRGCIPTMAR AVVVNAAQLA
210 220 230 240 250
SYSQSKQFLL DSGYFSDNIL CHFCASMISG LVTTAASMPV DIAKTRIQNM
260 270 280 290 300
RMIDGKPEYK NGLDVLFKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL
310
EQMNKAYKRL FLSG
Length:314
Mass (Da):34,062
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D61F817089FF5AA
GO
Isoform 2 (identifier: Q02978-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-82: Missing.

Note: Gene prediction based on EST data.
Show »
Length:263
Mass (Da):28,494
Checksum:iBB946818247A37F1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1P8I3L1P8_HUMAN
Mitochondrial 2-oxoglutarate/malate...
SLC25A11
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12I → M in CAA46905 (PubMed:1457818).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04674532 – 82Missing in isoform 2. CuratedAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X66114 Genomic DNA Translation: CAA46905.1
AF070548 mRNA Translation: AAC28637.1
AC004771 Genomic DNA No translation available.
BC006508 mRNA Translation: AAH06508.1
BC006519 mRNA Translation: AAH06519.1
BC016294 mRNA Translation: AAH16294.1
BC017170 mRNA Translation: AAH17170.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11059.1 [Q02978-1]
CCDS54069.1 [Q02978-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A56650

NCBI Reference Sequences

More...
RefSeqi
NP_003553.2, NM_003562.4 [Q02978-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.184877

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000225665; ENSP00000225665; ENSG00000108528 [Q02978-1]
ENST00000544061; ENSP00000440804; ENSG00000108528 [Q02978-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8402

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8402

UCSC genome browser

More...
UCSCi
uc021toe.2 human [Q02978-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66114 Genomic DNA Translation: CAA46905.1
AF070548 mRNA Translation: AAC28637.1
AC004771 Genomic DNA No translation available.
BC006508 mRNA Translation: AAH06508.1
BC006519 mRNA Translation: AAH06519.1
BC016294 mRNA Translation: AAH16294.1
BC017170 mRNA Translation: AAH17170.1
CCDSiCCDS11059.1 [Q02978-1]
CCDS54069.1 [Q02978-2]
PIRiA56650
RefSeqiNP_003553.2, NM_003562.4 [Q02978-1]
UniGeneiHs.184877

3D structure databases

ProteinModelPortaliQ02978
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113990, 64 interactors
IntActiQ02978, 24 interactors
MINTiQ02978
STRINGi9606.ENSP00000225665

Protein family/group databases

TCDBi2.A.29.2.13 the mitochondrial carrier (mc) family

PTM databases

CarbonylDBiQ02978
iPTMnetiQ02978
PhosphoSitePlusiQ02978
SwissPalmiQ02978

Polymorphism and mutation databases

BioMutaiSLC25A11
DMDMi20141580

Proteomic databases

EPDiQ02978
PaxDbiQ02978
PeptideAtlasiQ02978
PRIDEiQ02978
ProteomicsDBi58148
TopDownProteomicsiQ02978-1 [Q02978-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8402
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225665; ENSP00000225665; ENSG00000108528 [Q02978-1]
ENST00000544061; ENSP00000440804; ENSG00000108528 [Q02978-2]
GeneIDi8402
KEGGihsa:8402
UCSCiuc021toe.2 human [Q02978-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8402
DisGeNETi8402
EuPathDBiHostDB:ENSG00000108528.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC25A11
HGNCiHGNC:10981 SLC25A11
HPAiHPA021167
MIMi604165 gene
neXtProtiNX_Q02978
OpenTargetsiENSG00000108528
PharmGKBiPA35857

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0759 Eukaryota
ENOG410XQHU LUCA
GeneTreeiENSGT00940000158465
HOGENOMiHOG000165139
HOVERGENiHBG009528
InParanoidiQ02978
KOiK15104
OMAiGFTPYYF
OrthoDBiEOG091G0BQ7
PhylomeDBiQ02978
TreeFamiTF354262

Enzyme and pathway databases

ReactomeiR-HSA-70263 Gluconeogenesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC25A11 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC25A11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8402

Protein Ontology

More...
PROi
PR:Q02978

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000108528 Expressed in 226 organ(s), highest expression level in muscle of leg
CleanExiHS_SLC25A11
ExpressionAtlasiQ02978 baseline and differential
GenevisibleiQ02978 HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM2OM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02978
Secondary accession number(s): F5GY65, O75537, Q969P7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 172 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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