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Protein

A-kinase anchor protein 12

Gene

AKAP12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).

Miscellaneous

Antibodies against the C-terminal of gravin can be produced by patients with myasthenia gravis (MG).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • adenylate cyclase binding Source: UniProtKB
  • protein kinase A binding Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q02952

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A-kinase anchor protein 12
Short name:
AKAP-12
Alternative name(s):
A-kinase anchor protein 250 kDa
Short name:
AKAP 250
Gravin
Myasthenia gravis autoantigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKAP12
Synonyms:AKAP250
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000131016.16

Human Gene Nomenclature Database

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HGNCi
HGNC:370 AKAP12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604698 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q02952

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9590

Open Targets

More...
OpenTargetsi
ENSG00000131016

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24664

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
AKAP12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373554

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000645192 – 1782A-kinase anchor protein 12Add BLAST1781

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine3 Publications1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei28PhosphoserineBy similarity1
Modified residuei75PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei154PhosphoserineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei248PhosphoserineBy similarity1
Modified residuei258PhosphoserineBy similarity1
Modified residuei280PhosphoserineBy similarity1
Modified residuei283PhosphoserineBy similarity1
Modified residuei286PhosphoserineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei371PhosphoserineCombined sources1
Modified residuei374PhosphotyrosineBy similarity1
Modified residuei381PhosphoserineCombined sources1
Modified residuei392PhosphoserineBy similarity1
Modified residuei483PhosphoserineCombined sources1
Modified residuei505PhosphoserineCombined sources1
Modified residuei554PhosphoserineBy similarity1
Modified residuei557PhosphoserineCombined sources1
Modified residuei598PhosphoserineCombined sources1
Modified residuei612PhosphoserineCombined sources1
Modified residuei627PhosphoserineCombined sources1
Modified residuei629PhosphoserineCombined sources1
Modified residuei642PhosphothreonineBy similarity1
Modified residuei644PhosphoserineBy similarity1
Modified residuei645PhosphoserineCombined sources1
Modified residuei648PhosphoserineBy similarity1
Modified residuei651PhosphoserineBy similarity1
Modified residuei696PhosphoserineCombined sources1
Modified residuei697PhosphoserineCombined sources1
Modified residuei698PhosphoserineCombined sources1
Modified residuei749PhosphoserineBy similarity1
Modified residuei761PhosphoserineCombined sources1
Modified residuei787PhosphoserineBy similarity1
Modified residuei806PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1051Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei1328PhosphoserineCombined sources1
Modified residuei1331PhosphoserineCombined sources1
Modified residuei1391PhosphoserineBy similarity1
Modified residuei1395PhosphoserineCombined sources1
Modified residuei1587PhosphoserineCombined sources1
Modified residuei1727PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q02952

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q02952

MaxQB - The MaxQuant DataBase

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MaxQBi
Q02952

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q02952

PeptideAtlas

More...
PeptideAtlasi
Q02952

PRoteomics IDEntifications database

More...
PRIDEi
Q02952

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58141
58142 [Q02952-2]
58143 [Q02952-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q02952

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q02952

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q02952

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Activated by lysophosphatidylcholine (lysoPC).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131016 Expressed in 231 organ(s), highest expression level in dorsal root ganglion

CleanEx database of gene expression profiles

More...
CleanExi
HS_AKAP12

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q02952 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026379
HPA006344
HPA056230

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to dimeric RII-alpha regulatory subunit of PKC.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-2562430,EBI-297353

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114958, 46 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q02952

Protein interaction database and analysis system

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IntActi
Q02952, 31 interactors

Molecular INTeraction database

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MINTi
Q02952

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000253332

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q02952

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q02952

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini604 – 634AKAP 1Add BLAST31
Domaini753 – 783AKAP 2Add BLAST31
Domaini798 – 828AKAP 3Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni266 – 557Involved in PKC-bindingCuratedAdd BLAST292
Regioni1541 – 1554RII-bindingCuratedAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi98 – 101Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Polybasic regions located between residues 266 and 557 are involved in binding PKC.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFC9 Eukaryota
ENOG4110Y3C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111244

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050472

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q02952

KEGG Orthology (KO)

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KOi
K16528

Identification of Orthologs from Complete Genome Data

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OMAi
DPQEQTS

Database of Orthologous Groups

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OrthoDBi
158752at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q02952

TreeFam database of animal gene trees

More...
TreeFami
TF105411

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028540 AKAP12
IPR001573 Pkinase-A_anch_WSK-motif
IPR018459 RII_binding_1

The PANTHER Classification System

More...
PANTHERi
PTHR23209 PTHR23209, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10522 RII_binding_1, 1 hit
PF03832 WSK, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q02952-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAGSSTEQR SPEQPPEGSS TPAEPEPSGG GPSAEAAPDT TADPAIAASD
60 70 80 90 100
PATKLLQKNG QLSTINGVAE QDELSLQEGD LNGQKGALNG QGALNSQEEE
110 120 130 140 150
EVIVTEVGQR DSEDVSKRDS DKEMATKSAV VHDITDDGQE ETPEIIEQIP
160 170 180 190 200
SSESNLEELT QPTESQANDI GFKKVFKFVG FKFTVKKDKT EKPDTVQLLT
210 220 230 240 250
VKKDEGEGAA GAGDHKDPSL GAGEAASKES EPKQSTEKPE ETLKREQSHA
260 270 280 290 300
EISPPAESGQ AVEECKEEGE EKQEKEPSKS AESPTSPVTS ETGSTFKKFF
310 320 330 340 350
TQGWAGWRKK TSFRKPKEDE VEASEKKKEQ EPEKVDTEED GKAEVASEKL
360 370 380 390 400
TASEQAHPQE PAESAHEPRL SAEYEKVELP SEEQVSGSQG PSEEKPAPLA
410 420 430 440 450
TEVFDEKIEV HQEEVVAEVH VSTVEERTEE QKTEVEETAG SVPAEELVEM
460 470 480 490 500
DAEPQEAEPA KELVKLKETC VSGEDPTQGA DLSPDEKVLS KPPEGVVSEV
510 520 530 540 550
EMLSSQERMK VQGSPLKKLF TSTGLKKLSG KKQKGKRGGG DEESGEHTQV
560 570 580 590 600
PADSPDSQEE QKGESSASSP EEPEEITCLE KGLAEVQQDG EAEEGATSDG
610 620 630 640 650
EKKREGVTPW ASFKKMVTPK KRVRRPSESD KEDELDKVKS ATLSSTESTA
660 670 680 690 700
SEMQEEMKGS VEEPKPEEPK RKVDTSVSWE ALICVGSSKK RARRGSSSDE
710 720 730 740 750
EGGPKAMGGD HQKADEAGKD KETGTDGILA GSQEHDPGQG SSSPEQAGSP
760 770 780 790 800
TEGEGVSTWE SFKRLVTPRK KSKSKLEEKS EDSIAGSGVE HSTPDTEPGK
810 820 830 840 850
EESWVSIKKF IPGRRKKRPD GKQEQAPVED AGPTGANEDD SDVPAVVPLS
860 870 880 890 900
EYDAVEREKM EAQQAQKSAE QPEQKAATEV SKELSESQVH MMAAAVADGT
910 920 930 940 950
RAATIIEERS PSWISASVTE PLEQVEAEAA LLTEEVLERE VIAEEEPPTV
960 970 980 990 1000
TEPLPENREA RGDTVVSEAE LTPEAVTAAE TAGPLGAEEG TEASAAEETT
1010 1020 1030 1040 1050
EMVSAVSQLT DSPDTTEEAT PVQEVEGGVP DIEEQERRTQ EVLQAVAEKV
1060 1070 1080 1090 1100
KEESQLPGTG GPEDVLQPVQ RAEAERPEEQ AEASGLKKET DVVLKVDAQE
1110 1120 1130 1140 1150
AKTEPFTQGK VVGQTTPESF EKAPQVTESI ESSELVTTCQ AETLAGVKSQ
1160 1170 1180 1190 1200
EMVMEQAIPP DSVETPTDSE TDGSTPVADF DAPGTTQKDE IVEIHEENEV
1210 1220 1230 1240 1250
ASGTQSGGTE AEAVPAQKER PPAPSSFVFQ EETKEQSKME DTLEHTDKEV
1260 1270 1280 1290 1300
SVETVSILSK TEGTQEADQY ADEKTKDVPF FEGLEGSIDT GITVSREKVT
1310 1320 1330 1340 1350
EVALKGEGTE EAECKKDDAL ELQSHAKSPP SPVEREMVVQ VEREKTEAEP
1360 1370 1380 1390 1400
THVNEEKLEH ETAVTVSEEV SKQLLQTVNV PIIDGAKEVS SLEGSPPPCL
1410 1420 1430 1440 1450
GQEEAVCTKI QVQSSEASFT LTAAAEEEKV LGETANILET GETLEPAGAH
1460 1470 1480 1490 1500
LVLEEKSSEK NEDFAAHPGE DAVPTGPDCQ AKSTPVIVSA TTKKGLSSDL
1510 1520 1530 1540 1550
EGEKTTSLKW KSDEVDEQVA CQEVKVSVAI EDLEPENGIL ELETKSSKLV
1560 1570 1580 1590 1600
QNIIQTAVDQ FVRTEETATE MLTSELQTQA HVIKADSQDA GQETEKEGEE
1610 1620 1630 1640 1650
PQASAQDETP ITSAKEESES TAVGQAHSDI SKDMSEASEK TMTVEVEGST
1660 1670 1680 1690 1700
VNDQQLEEVV LPSEEEGGGA GTKSVPEDDG HALLAERIEK SLVEPKEDEK
1710 1720 1730 1740 1750
GDDVDDPENQ NSALADTDAS GGLTKESPDT NGPKQKEKED AQEVELQEGK
1760 1770 1780
VHSESDKAIT PQAQEELQKQ ERESAKSELT ES
Length:1,782
Mass (Da):191,482
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB9DBA4647E6DDD5
GO
Isoform 2 (identifier: Q02952-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.
     99-106: EEEVIVTE → MLGTITIT

Show »
Length:1,684
Mass (Da):181,690
Checksum:i384AEDA06CC83D93
GO
Isoform 3 (identifier: Q02952-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.
     106-106: E → M

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Length:1,677
Mass (Da):180,990
Checksum:i8533672E99E8A1D6
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE06085 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti142 – 145TPEI → NRN in AAC51366 (PubMed:9000000).Curated4
Sequence conflicti423T → I in BAE06085 (Ref. 3) Curated1
Sequence conflicti449E → G in AAC51366 (PubMed:9000000).Curated1
Sequence conflicti695G → R in AAC51366 (PubMed:9000000).Curated1
Sequence conflicti868S → G in AAC51366 (PubMed:9000000).Curated1
Sequence conflicti946E → G in CAH18338 (PubMed:17974005).Curated1
Sequence conflicti1182A → T in CAH18338 (PubMed:17974005).Curated1
Sequence conflicti1531E → EE in CAH18338 (PubMed:17974005).Curated1
Sequence conflicti1531E → EE in BAE06085 (Ref. 3) Curated1
Sequence conflicti1531E → EE in AAB58938 (Ref. 6) Curated1
Sequence conflicti1531E → EE in AAA35931 (PubMed:1522245).Curated1
Sequence conflicti1582V → M in CAH18338 (PubMed:17974005).Curated1
Sequence conflicti1582V → M in AAA35931 (PubMed:1522245).Curated1
Sequence conflicti1602Q → L in BAA19927 (PubMed:9604001).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035115117K → ECombined sources3 PublicationsCorresponds to variant dbSNP:rs10872670Ensembl.1
Natural variantiVAR_035116216K → Q4 PublicationsCorresponds to variant dbSNP:rs3734799Ensembl.1
Natural variantiVAR_035780240E → K in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs552053449Ensembl.1
Natural variantiVAR_035117920E → G1 PublicationCorresponds to variant dbSNP:rs13212161Ensembl.1
Natural variantiVAR_056731987A → S1 PublicationCorresponds to variant dbSNP:rs1042069Ensembl.1
Natural variantiVAR_0351181096V → I. Corresponds to variant dbSNP:rs3734797Ensembl.1
Natural variantiVAR_0351191296R → L. Corresponds to variant dbSNP:rs9478198Ensembl.1
Natural variantiVAR_0351201355E → K1 PublicationCorresponds to variant dbSNP:rs12201388Ensembl.1
Natural variantiVAR_0351211600E → D1 PublicationCorresponds to variant dbSNP:rs3823310Ensembl.1
Natural variantiVAR_0351221689E → D. Corresponds to variant dbSNP:rs3734795Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0281331 – 105Missing in isoform 3. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_0041101 – 98Missing in isoform 2. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_00411199 – 106EEEVIVTE → MLGTITIT in isoform 2. 1 Publication8
Alternative sequenceiVSP_028134106E → M in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U81607 mRNA Translation: AAC51366.1
AB003476 mRNA Translation: BAA19927.1
AB210003 mRNA Translation: BAE06085.1 Different initiation.
CR749527 mRNA Translation: CAH18338.1
AL590413 Genomic DNA No translation available.
AL356535 Genomic DNA No translation available.
AL033392 Genomic DNA No translation available.
AF001504 mRNA Translation: AAB58938.1
M96322 mRNA Translation: AAA35931.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5229.1 [Q02952-1]
CCDS5230.1 [Q02952-2]

Protein sequence database of the Protein Information Resource

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PIRi
A43922
JW0057

NCBI Reference Sequences

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RefSeqi
NP_005091.2, NM_005100.3 [Q02952-1]
NP_653080.1, NM_144497.2 [Q02952-2]
XP_005267292.1, XM_005267235.2 [Q02952-3]
XP_016867006.1, XM_017011517.1 [Q02952-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.371240

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000253332; ENSP00000253332; ENSG00000131016 [Q02952-1]
ENST00000354675; ENSP00000346702; ENSG00000131016 [Q02952-2]
ENST00000359755; ENSP00000352794; ENSG00000131016 [Q02952-3]
ENST00000402676; ENSP00000384537; ENSG00000131016 [Q02952-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9590

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9590

UCSC genome browser

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UCSCi
uc003qoe.5 human [Q02952-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81607 mRNA Translation: AAC51366.1
AB003476 mRNA Translation: BAA19927.1
AB210003 mRNA Translation: BAE06085.1 Different initiation.
CR749527 mRNA Translation: CAH18338.1
AL590413 Genomic DNA No translation available.
AL356535 Genomic DNA No translation available.
AL033392 Genomic DNA No translation available.
AF001504 mRNA Translation: AAB58938.1
M96322 mRNA Translation: AAA35931.1
CCDSiCCDS5229.1 [Q02952-1]
CCDS5230.1 [Q02952-2]
PIRiA43922
JW0057
RefSeqiNP_005091.2, NM_005100.3 [Q02952-1]
NP_653080.1, NM_144497.2 [Q02952-2]
XP_005267292.1, XM_005267235.2 [Q02952-3]
XP_016867006.1, XM_017011517.1 [Q02952-1]
UniGeneiHs.371240

3D structure databases

ProteinModelPortaliQ02952
SMRiQ02952
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114958, 46 interactors
CORUMiQ02952
IntActiQ02952, 31 interactors
MINTiQ02952
STRINGi9606.ENSP00000253332

PTM databases

iPTMnetiQ02952
PhosphoSitePlusiQ02952
SwissPalmiQ02952

Polymorphism and mutation databases

BioMutaiAKAP12
DMDMi317373554

Proteomic databases

EPDiQ02952
jPOSTiQ02952
MaxQBiQ02952
PaxDbiQ02952
PeptideAtlasiQ02952
PRIDEiQ02952
ProteomicsDBi58141
58142 [Q02952-2]
58143 [Q02952-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9590
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253332; ENSP00000253332; ENSG00000131016 [Q02952-1]
ENST00000354675; ENSP00000346702; ENSG00000131016 [Q02952-2]
ENST00000359755; ENSP00000352794; ENSG00000131016 [Q02952-3]
ENST00000402676; ENSP00000384537; ENSG00000131016 [Q02952-1]
GeneIDi9590
KEGGihsa:9590
UCSCiuc003qoe.5 human [Q02952-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9590
DisGeNETi9590
EuPathDBiHostDB:ENSG00000131016.16

GeneCards: human genes, protein and diseases

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GeneCardsi
AKAP12

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0025002
HGNCiHGNC:370 AKAP12
HPAiCAB026379
HPA006344
HPA056230
MIMi604698 gene
neXtProtiNX_Q02952
OpenTargetsiENSG00000131016
PharmGKBiPA24664

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFC9 Eukaryota
ENOG4110Y3C LUCA
GeneTreeiENSGT00730000111244
HOVERGENiHBG050472
InParanoidiQ02952
KOiK16528
OMAiDPQEQTS
OrthoDBi158752at2759
PhylomeDBiQ02952
TreeFamiTF105411

Enzyme and pathway databases

SignaLinkiQ02952

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AKAP12 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AKAP12

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9590

Protein Ontology

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PROi
PR:Q02952

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000131016 Expressed in 231 organ(s), highest expression level in dorsal root ganglion
CleanExiHS_AKAP12
GenevisibleiQ02952 HS

Family and domain databases

InterProiView protein in InterPro
IPR028540 AKAP12
IPR001573 Pkinase-A_anch_WSK-motif
IPR018459 RII_binding_1
PANTHERiPTHR23209 PTHR23209, 1 hit
PfamiView protein in Pfam
PF10522 RII_binding_1, 1 hit
PF03832 WSK, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKA12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02952
Secondary accession number(s): O00310
, O00498, Q4LE68, Q5SZ80, Q5TGN1, Q68D82, Q99970
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 11, 2011
Last modified: January 16, 2019
This is version 172 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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