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Entry version 181 (12 Aug 2020)
Sequence version 3 (31 May 2011)
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Protein

Cyclic AMP-responsive element-binding protein 5

Gene

CREB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the cAMP response element and activates transcription.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri16 – 40C2H2-typePROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q02930

SIGNOR Signaling Network Open Resource

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SIGNORi
Q02930

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 5
Short name:
CREB-5
Short name:
cAMP-responsive element-binding protein 5
Alternative name(s):
cAMP-response element-binding protein A
Short name:
CRE-BPa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CREB5
Synonyms:CREBPA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000146592.16

Human Gene Nomenclature Database

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HGNCi
HGNC:16844, CREB5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
618262, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q02930

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
9586

Open Targets

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OpenTargetsi
ENSG00000146592

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134930491

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q02930, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CREB5

Domain mapping of disease mutations (DMDM)

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DMDMi
334302918

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000766041 – 508Cyclic AMP-responsive element-binding protein 5Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei59PhosphothreonineCombined sources1
Modified residuei61PhosphothreonineCombined sources1
Modified residuei137PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q02930

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q02930

MaxQB - The MaxQuant DataBase

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MaxQBi
Q02930

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q02930

PeptideAtlas

More...
PeptideAtlasi
Q02930

PRoteomics IDEntifications database

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PRIDEi
Q02930

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
58137 [Q02930-1]
58138 [Q02930-2]
58139 [Q02930-3]
58140 [Q02930-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q02930

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q02930

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000146592, Expressed in tendon and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q02930, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q02930, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000146592, Tissue enhanced (blood, brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

CREB5 - isoform 3 [Q02930-3]
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]6EBI-10192698,EBI-10173507
AJUBA [Q96IF1]3EBI-10192698,EBI-949782
AKAP8L [Q9ULX6]3EBI-10192698,EBI-357530
ALPP [P05187]3EBI-10192698,EBI-1211484
ANAPC11 - isoform 2 [Q9NYG5-2]3EBI-10192698,EBI-12224467
BATF3 [Q9NR55]5EBI-10192698,EBI-10312707
CDPF1 [Q6NVV7]3EBI-10192698,EBI-2802782
CERCAM [Q5T4B2]3EBI-10192698,EBI-12261896
CIB4 [A0PJX0]3EBI-10192698,EBI-12868028
CNFN [Q9BYD5]3EBI-10192698,EBI-12819063
COL8A1 [P27658]6EBI-10192698,EBI-747133
itself3EBI-10192698,EBI-10192698
CYP21A2 [Q08AG9]3EBI-10192698,EBI-14156412
CYSRT1 [A8MQ03]3EBI-10192698,EBI-3867333
EFEMP2 [O95967]8EBI-10192698,EBI-743414
FBLN1 - isoform C [P23142-4]3EBI-10192698,EBI-11956479
FHL3 [Q13643]3EBI-10192698,EBI-741101
FOS [P01100]3EBI-10192698,EBI-852851
FOS [Q6FG41]3EBI-10192698,EBI-10198738
FOSB [P53539]3EBI-10192698,EBI-2806743
FOSL1 [P15407]6EBI-10192698,EBI-744510
FOSL2 [P15408]13EBI-10192698,EBI-3893419
FRS3 [O43559]3EBI-10192698,EBI-725515
FST [P19883]5EBI-10192698,EBI-1571188
HOXA1 [P49639]5EBI-10192698,EBI-740785
HSD3B7 [Q9H2F3]3EBI-10192698,EBI-3918847
ID3 [Q02535]5EBI-10192698,EBI-1387094
IGFBP6 [P24592]3EBI-10192698,EBI-947015
INTS11 [Q5TA45]3EBI-10192698,EBI-748258
JDP2 [Q8WYK2]3EBI-10192698,EBI-1248415
KIFC3 [Q9BVG8]3EBI-10192698,EBI-2125614
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-10192698,EBI-14069005
KPRP [Q5T749]5EBI-10192698,EBI-10981970
KRT15 [P19012]3EBI-10192698,EBI-739566
KRT31 [Q15323]3EBI-10192698,EBI-948001
KRT40 [Q6A162]6EBI-10192698,EBI-10171697
KRT83 [P78385]3EBI-10192698,EBI-10221390
KRT85 [P78386]3EBI-10192698,EBI-1049371
KRT86 [O43790]3EBI-10192698,EBI-9996498
KRTAP1-5 [Q9BYS1]5EBI-10192698,EBI-11741292
KRTAP10-10 [P60014]3EBI-10192698,EBI-11955579
KRTAP10-11 [P60412]6EBI-10192698,EBI-10217483
KRTAP10-5 [P60370]6EBI-10192698,EBI-10172150
KRTAP10-7 [P60409]4EBI-10192698,EBI-10172290
KRTAP10-8 [P60410]10EBI-10192698,EBI-10171774
KRTAP10-9 [P60411]8EBI-10192698,EBI-10172052
KRTAP12-3 [P60328]3EBI-10192698,EBI-11953334
KRTAP19-2 [Q3LHN2]3EBI-10192698,EBI-12196745
KRTAP19-3 [Q7Z4W3]3EBI-10192698,EBI-12020132
KRTAP19-5 [Q3LI72]3EBI-10192698,EBI-1048945
KRTAP19-6 [Q3LI70]3EBI-10192698,EBI-12805508
KRTAP2-4 [Q9BYR9]3EBI-10192698,EBI-14065470
KRTAP3-1 [Q9BYR8]3EBI-10192698,EBI-9996449
KRTAP3-2 [Q9BYR7]8EBI-10192698,EBI-751260
KRTAP4-1 [A0A087WY89]3EBI-10192698,EBI-11957260
KRTAP4-12 [Q9BQ66]9EBI-10192698,EBI-739863
KRTAP4-2 [Q9BYR5]9EBI-10192698,EBI-10172511
KRTAP4-4 [Q9BYR3]3EBI-10192698,EBI-11958132
KRTAP4-5 [Q9BYR2]3EBI-10192698,EBI-11993254
KRTAP5-11 [Q6L8G4]3EBI-10192698,EBI-11993296
KRTAP5-2 [Q701N4]3EBI-10192698,EBI-11958178
KRTAP5-4 [Q6L8H1]3EBI-10192698,EBI-11963072
KRTAP5-6 [Q6L8G9]6EBI-10192698,EBI-10250562
KRTAP5-7 [Q6L8G8]3EBI-10192698,EBI-11987425
KRTAP5-9 [P26371]3EBI-10192698,EBI-3958099
KRTAP6-1 [Q3LI64]5EBI-10192698,EBI-12111050
KRTAP6-2 [Q3LI66]5EBI-10192698,EBI-11962084
KRTAP7-1 [Q8IUC3]3EBI-10192698,EBI-18394498
KRTAP8-1 [Q8IUC2]3EBI-10192698,EBI-10261141
KRTAP9-2 [Q9BYQ4]13EBI-10192698,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-10192698,EBI-1043191
KRTAP9-4 [Q9BYQ2]5EBI-10192698,EBI-10185730
KRTAP9-8 [Q9BYQ0]5EBI-10192698,EBI-11958364
LCE1C [Q5T751]3EBI-10192698,EBI-12224199
LCE2A [Q5TA79]3EBI-10192698,EBI-10246607
LCE2C [Q5TA81]3EBI-10192698,EBI-11973993
LCE4A [Q5TA78]3EBI-10192698,EBI-10246358
LCE5A [Q5TCM9]3EBI-10192698,EBI-11955689
LGALS13 [Q9UHV8]3EBI-10192698,EBI-3957707
LITAF [Q99732]3EBI-10192698,EBI-725647
LMX1B - isoform 2 [O60663-2]3EBI-10192698,EBI-10258690
MDFI [Q99750]8EBI-10192698,EBI-724076
MLLT6 [P55198]3EBI-10192698,EBI-740216
MMADHC [Q9H3L0]5EBI-10192698,EBI-11111575
MTUS2 [Q5JR59]3EBI-10192698,EBI-742948
NADSYN1 [Q6IA69]3EBI-10192698,EBI-748610
NOTCH2NLA [Q7Z3S9]3EBI-10192698,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-10192698,EBI-22310682
PCSK5 - isoform PC6A [Q92824-2]6EBI-10192698,EBI-11956269
PLA2G10 [O15496]3EBI-10192698,EBI-726466
PRDM14 [Q9GZV8]3EBI-10192698,EBI-3957793
RBCK1 [Q9BYM8]3EBI-10192698,EBI-2340624
RBP3 [P10745]3EBI-10192698,EBI-12806054
RBPMS [Q93062]3EBI-10192698,EBI-740322
RBPMS - isoform C [Q93062-3]3EBI-10192698,EBI-740343
RCHY1 [Q96PM5]3EBI-10192698,EBI-947779
RGS17 [Q9UGC6]3EBI-10192698,EBI-3918154
RGS20 [O76081]3EBI-10192698,EBI-1052678
RGS20 - isoform 5 [O76081-6]6EBI-10192698,EBI-10178530
RIMBP3 [Q9UFD9]3EBI-10192698,EBI-10182375
RNF208 [Q9H0X6]3EBI-10192698,EBI-751555
SIVA1 - isoform 2 [O15304-2]3EBI-10192698,EBI-12372219
SNAPC5 - isoform 2 [O75971-2]3EBI-10192698,EBI-12004298
SPATA12 [Q7Z6I5]3EBI-10192698,EBI-10696971
SPOPL [Q6IQ16]3EBI-10192698,EBI-2822161
SPRED1 [Q7Z699]3EBI-10192698,EBI-5235340
SPRY1 [O43609]8EBI-10192698,EBI-3866665
SPRY2 [O43597]3EBI-10192698,EBI-742487
SPRY3 [O43610]3EBI-10192698,EBI-12290641
SPRY4 [Q9C004]3EBI-10192698,EBI-354861
TP53BP1 [Q12888]3EBI-10192698,EBI-396540
TRAF2 [Q12933]6EBI-10192698,EBI-355744
TRIM23 [P36406]3EBI-10192698,EBI-740098
TRIM27 [P14373]3EBI-10192698,EBI-719493
TRIM42 [Q8IWZ5]6EBI-10192698,EBI-5235829
TRIP6 [Q15654]3EBI-10192698,EBI-742327
TSGA10 [Q9BZW7]3EBI-10192698,EBI-744794
TSPAN4 [O14817]3EBI-10192698,EBI-8652667
TSR2 [Q969E8]3EBI-10192698,EBI-746981
UFSP1 [Q6NVU6]3EBI-10192698,EBI-12068150
UNKL - isoform 5 [Q9H9P5-5]3EBI-10192698,EBI-12817837
WWOX - isoform 5 [Q9NZC7-5]3EBI-10192698,EBI-12040603
ZMAT5 [Q9UDW3]3EBI-10192698,EBI-7850213
ZNF330 [Q9Y3S2]3EBI-10192698,EBI-373456

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114954, 58 interactors

Protein interaction database and analysis system

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IntActi
Q02930, 129 interactors

Molecular INTeraction database

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MINTi
Q02930

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000350359

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q02930, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q02930

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini375 – 438bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni377 – 397Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni403 – 431Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 40C2H2-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1414, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156420

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021564_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q02930

KEGG Orthology (KO)

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KOi
K09047

Identification of Orthologs from Complete Genome Data

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OMAi
MLKSEVT

Database of Orthologous Groups

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OrthoDBi
978850at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q02930

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004827, bZIP
IPR016378, TF_CRE-BP1-typ
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00170, bZIP_1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF003153, ATF2_CRE-BP1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00338, BRLZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q02930-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIYEESKMNL EQERPFVCSA PGCSQRFPTE DHLMIHRHKH EMTLKFPSIK
60 70 80 90 100
TDNMLSDQTP TPTRFLKNCE EVGLFSELDC SLEHEFRKAQ EEESSKRNIS
110 120 130 140 150
MHNAVGGAMT GPGTHQLSSA RLPNHDTNVV IQQAMPSPQS SSVITQAPST
160 170 180 190 200
NRQIGPVPGS LSSLLHLHNR QRQPMPASMP GTLPNPTMPG SSAVLMPMER
210 220 230 240 250
QMSVNSSIMG MQGPNLSNPC ASPQVQPMHS EAKMRLKAAL THHPAAMSNG
260 270 280 290 300
NMNTMGHMME MMGSRQDQTP HHHMHSHPHQ HQTLPPHHPY PHQHQHPAHH
310 320 330 340 350
PHPQPHHQQN HPHHHSHSHL HAHPAHHQTS PHPPLHTGNQ AQVSPATQQM
360 370 380 390 400
QPTQTIQPPQ PTGGRRRRVV DEDPDERRRK FLERNRAAAT RCRQKRKVWV
410 420 430 440 450
MSLEKKAEEL TQTNMQLQNE VSMLKNEVAQ LKQLLLTHKD CPITAMQKES
460 470 480 490 500
QGYLSPESSP PASPVPACSQ QQVIQHNTIT TSSSVSEVVG SSTLSQLTTH

RTDLNPIL
Length:508
Mass (Da):56,918
Last modified:May 31, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF96F33AE562F1AD
GO
Isoform 2 (identifier: Q02930-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Show »
Length:501
Mass (Da):56,037
Checksum:i9D67856759DB9957
GO
Isoform 3 (identifier: Q02930-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Show »
Length:475
Mass (Da):53,063
Checksum:iBD75DF80FE7145E9
GO
Isoform 4 (identifier: Q02930-4) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MIYEESKMNLEQERPF → MFCTSGGNSASVMSMR
     17-155: Missing.

Show »
Length:369
Mass (Da):41,161
Checksum:i7DC1C71C6A74DEB5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JN33C9JN33_HUMAN
Cyclic AMP-responsive element-bindi...
CREB5
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9KVC5H9KVC5_HUMAN
Cyclic AMP-responsive element-bindi...
CREB5
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFV2H0YFV2_HUMAN
Cyclic AMP-responsive element-bindi...
CREB5
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16F → S in AAA52072 (PubMed:8440710).Curated1
Sequence conflicti16F → S in AAC37525 (PubMed:8378084).Curated1
Sequence conflicti211 – 212MQ → IE in AAA52072 (PubMed:8440710).Curated2
Sequence conflicti211 – 212MQ → IE in AAC37525 (PubMed:8378084).Curated2
Sequence conflicti211 – 212MQ → IE in AAC37526 (PubMed:8378084).Curated2
Sequence conflicti211 – 212MQ → IE in AAC37527 (PubMed:8378084).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0500111 – 33Missing in isoform 3. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_0500121 – 16MIYEE…QERPF → MFCTSGGNSASVMSMR in isoform 4. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_0500101 – 7Missing in isoform 2. 1 Publication7
Alternative sequenceiVSP_05001317 – 155Missing in isoform 4. 3 PublicationsAdd BLAST139

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L05515 mRNA Translation: AAA52072.1
L05911 mRNA Translation: AAC37525.1
L05912 mRNA Translation: AAC37527.1
L05913 mRNA Translation: AAC37526.1
AK292916 mRNA Translation: BAF85605.1
AK300455 mRNA Translation: BAG62175.1
AK316187 mRNA Translation: BAH14558.1
AB451409 mRNA Translation: BAG70223.1
AC003074 Genomic DNA Translation: AAS00387.1
AC005105 Genomic DNA Translation: AAP22329.1
AC005013 Genomic DNA No translation available.
AC006331 Genomic DNA No translation available.
AC006367 Genomic DNA No translation available.
AC006980 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93908.1
CH471073 Genomic DNA Translation: EAW93910.1
BC059400 mRNA Translation: AAH59400.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43562.1 [Q02930-3]
CCDS43563.1 [Q02930-4]
CCDS5417.1 [Q02930-1]
CCDS5418.1 [Q02930-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A45477
I78877

NCBI Reference Sequences

More...
RefSeqi
NP_001011666.1, NM_001011666.2 [Q02930-4]
NP_004895.2, NM_004904.3 [Q02930-2]
NP_878901.2, NM_182898.3 [Q02930-1]
NP_878902.2, NM_182899.4 [Q02930-3]
XP_005249963.1, XM_005249906.1 [Q02930-2]
XP_016868295.1, XM_017012806.1 [Q02930-2]
XP_016868297.1, XM_017012808.1 [Q02930-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357727; ENSP00000350359; ENSG00000146592 [Q02930-1]
ENST00000396298; ENSP00000379592; ENSG00000146592 [Q02930-4]
ENST00000396299; ENSP00000379593; ENSG00000146592 [Q02930-3]
ENST00000396300; ENSP00000379594; ENSG00000146592 [Q02930-2]
ENST00000409603; ENSP00000387197; ENSG00000146592 [Q02930-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9586

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9586

UCSC genome browser

More...
UCSCi
uc003szo.4, human [Q02930-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05515 mRNA Translation: AAA52072.1
L05911 mRNA Translation: AAC37525.1
L05912 mRNA Translation: AAC37527.1
L05913 mRNA Translation: AAC37526.1
AK292916 mRNA Translation: BAF85605.1
AK300455 mRNA Translation: BAG62175.1
AK316187 mRNA Translation: BAH14558.1
AB451409 mRNA Translation: BAG70223.1
AC003074 Genomic DNA Translation: AAS00387.1
AC005105 Genomic DNA Translation: AAP22329.1
AC005013 Genomic DNA No translation available.
AC006331 Genomic DNA No translation available.
AC006367 Genomic DNA No translation available.
AC006980 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93908.1
CH471073 Genomic DNA Translation: EAW93910.1
BC059400 mRNA Translation: AAH59400.2
CCDSiCCDS43562.1 [Q02930-3]
CCDS43563.1 [Q02930-4]
CCDS5417.1 [Q02930-1]
CCDS5418.1 [Q02930-2]
PIRiA45477
I78877
RefSeqiNP_001011666.1, NM_001011666.2 [Q02930-4]
NP_004895.2, NM_004904.3 [Q02930-2]
NP_878901.2, NM_182898.3 [Q02930-1]
NP_878902.2, NM_182899.4 [Q02930-3]
XP_005249963.1, XM_005249906.1 [Q02930-2]
XP_016868295.1, XM_017012806.1 [Q02930-2]
XP_016868297.1, XM_017012808.1 [Q02930-1]

3D structure databases

SMRiQ02930
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114954, 58 interactors
IntActiQ02930, 129 interactors
MINTiQ02930
STRINGi9606.ENSP00000350359

PTM databases

iPTMnetiQ02930
PhosphoSitePlusiQ02930

Polymorphism and mutation databases

BioMutaiCREB5
DMDMi334302918

Proteomic databases

jPOSTiQ02930
MassIVEiQ02930
MaxQBiQ02930
PaxDbiQ02930
PeptideAtlasiQ02930
PRIDEiQ02930
ProteomicsDBi58137 [Q02930-1]
58138 [Q02930-2]
58139 [Q02930-3]
58140 [Q02930-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
12490, 208 antibodies

Genome annotation databases

EnsembliENST00000357727; ENSP00000350359; ENSG00000146592 [Q02930-1]
ENST00000396298; ENSP00000379592; ENSG00000146592 [Q02930-4]
ENST00000396299; ENSP00000379593; ENSG00000146592 [Q02930-3]
ENST00000396300; ENSP00000379594; ENSG00000146592 [Q02930-2]
ENST00000409603; ENSP00000387197; ENSG00000146592 [Q02930-3]
GeneIDi9586
KEGGihsa:9586
UCSCiuc003szo.4, human [Q02930-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9586
DisGeNETi9586
EuPathDBiHostDB:ENSG00000146592.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CREB5
HGNCiHGNC:16844, CREB5
HPAiENSG00000146592, Tissue enhanced (blood, brain)
MIMi618262, gene
neXtProtiNX_Q02930
OpenTargetsiENSG00000146592
PharmGKBiPA134930491

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1414, Eukaryota
GeneTreeiENSGT00940000156420
HOGENOMiCLU_021564_0_0_1
InParanoidiQ02930
KOiK09047
OMAiMLKSEVT
OrthoDBi978850at2759
PhylomeDBiQ02930

Enzyme and pathway databases

PathwayCommonsiQ02930
SIGNORiQ02930

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
9586, 8 hits in 902 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CREB5, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CREB5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9586
PharosiQ02930, Tbio

Protein Ontology

More...
PROi
PR:Q02930
RNActiQ02930, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000146592, Expressed in tendon and 216 other tissues
ExpressionAtlasiQ02930, baseline and differential
GenevisibleiQ02930, HS

Family and domain databases

InterProiView protein in InterPro
IPR004827, bZIP
IPR016378, TF_CRE-BP1-typ
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00170, bZIP_1, 1 hit
PIRSFiPIRSF003153, ATF2_CRE-BP1, 1 hit
SMARTiView protein in SMART
SM00338, BRLZ, 1 hit
SUPFAMiSSF57667, SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCREB5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02930
Secondary accession number(s): A8KA51
, B4DU13, B5BUH3, C9JK47, Q05886, Q06246, Q75N02, Q86UJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 31, 2011
Last modified: August 12, 2020
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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