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Protein

Cyclic AMP-responsive element-binding protein 5

Gene

CREB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the cAMP response element and activates transcription.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 40C2H2-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription by RNA polymerase II Source: ProtInc

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ02930

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 5
Short name:
CREB-5
Short name:
cAMP-responsive element-binding protein 5
Alternative name(s):
CRE-BPa
Gene namesi
Name:CREB5
Synonyms:CREBPA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000146592.16
HGNCiHGNC:16844 CREB5
neXtProtiNX_Q02930

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9586
OpenTargetsiENSG00000146592
PharmGKBiPA134930491

Polymorphism and mutation databases

BioMutaiCREB5
DMDMi334302918

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766041 – 508Cyclic AMP-responsive element-binding protein 5Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei59PhosphothreonineCombined sources1
Modified residuei61PhosphothreonineCombined sources1
Modified residuei137PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ02930
PaxDbiQ02930
PeptideAtlasiQ02930
PRIDEiQ02930
ProteomicsDBi58137
58138 [Q02930-2]
58139 [Q02930-3]
58140 [Q02930-4]

PTM databases

iPTMnetiQ02930
PhosphoSitePlusiQ02930

Expressioni

Gene expression databases

BgeeiENSG00000146592
CleanExiHS_CREB5
ExpressionAtlasiQ02930 baseline and differential
GenevisibleiQ02930 HS

Organism-specific databases

HPAiHPA050020
HPA061622

Interactioni

Subunit structurei

Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114954, 53 interactors
IntActiQ02930, 129 interactors
MINTiQ02930
STRINGi9606.ENSP00000350359

Structurei

3D structure databases

ProteinModelPortaliQ02930
SMRiQ02930
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini375 – 438bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni377 – 397Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni403 – 431Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 40C2H2-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00390000020106
HOGENOMiHOG000220894
HOVERGENiHBG004300
InParanoidiQ02930
KOiK09047
OMAiISMHNTV
OrthoDBiEOG091G0AO8
PhylomeDBiQ02930

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR016378 TF_CRE-BP1-typ
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PIRSFiPIRSF003153 ATF2_CRE-BP1, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q02930-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIYEESKMNL EQERPFVCSA PGCSQRFPTE DHLMIHRHKH EMTLKFPSIK
60 70 80 90 100
TDNMLSDQTP TPTRFLKNCE EVGLFSELDC SLEHEFRKAQ EEESSKRNIS
110 120 130 140 150
MHNAVGGAMT GPGTHQLSSA RLPNHDTNVV IQQAMPSPQS SSVITQAPST
160 170 180 190 200
NRQIGPVPGS LSSLLHLHNR QRQPMPASMP GTLPNPTMPG SSAVLMPMER
210 220 230 240 250
QMSVNSSIMG MQGPNLSNPC ASPQVQPMHS EAKMRLKAAL THHPAAMSNG
260 270 280 290 300
NMNTMGHMME MMGSRQDQTP HHHMHSHPHQ HQTLPPHHPY PHQHQHPAHH
310 320 330 340 350
PHPQPHHQQN HPHHHSHSHL HAHPAHHQTS PHPPLHTGNQ AQVSPATQQM
360 370 380 390 400
QPTQTIQPPQ PTGGRRRRVV DEDPDERRRK FLERNRAAAT RCRQKRKVWV
410 420 430 440 450
MSLEKKAEEL TQTNMQLQNE VSMLKNEVAQ LKQLLLTHKD CPITAMQKES
460 470 480 490 500
QGYLSPESSP PASPVPACSQ QQVIQHNTIT TSSSVSEVVG SSTLSQLTTH

RTDLNPIL
Length:508
Mass (Da):56,918
Last modified:May 31, 2011 - v3
Checksum:iDF96F33AE562F1AD
GO
Isoform 2 (identifier: Q02930-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Show »
Length:501
Mass (Da):56,037
Checksum:i9D67856759DB9957
GO
Isoform 3 (identifier: Q02930-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Show »
Length:475
Mass (Da):53,063
Checksum:iBD75DF80FE7145E9
GO
Isoform 4 (identifier: Q02930-4) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MIYEESKMNLEQERPF → MFCTSGGNSASVMSMR
     17-155: Missing.

Show »
Length:369
Mass (Da):41,161
Checksum:i7DC1C71C6A74DEB5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16F → S in AAA52072 (PubMed:8440710).Curated1
Sequence conflicti16F → S in AAC37525 (PubMed:8378084).Curated1
Sequence conflicti211 – 212MQ → IE in AAA52072 (PubMed:8440710).Curated2
Sequence conflicti211 – 212MQ → IE in AAC37525 (PubMed:8378084).Curated2
Sequence conflicti211 – 212MQ → IE in AAC37526 (PubMed:8378084).Curated2
Sequence conflicti211 – 212MQ → IE in AAC37527 (PubMed:8378084).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0500111 – 33Missing in isoform 3. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_0500121 – 16MIYEE…QERPF → MFCTSGGNSASVMSMR in isoform 4. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_0500101 – 7Missing in isoform 2. 1 Publication7
Alternative sequenceiVSP_05001317 – 155Missing in isoform 4. 3 PublicationsAdd BLAST139

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05515 mRNA Translation: AAA52072.1
L05911 mRNA Translation: AAC37525.1
L05912 mRNA Translation: AAC37527.1
L05913 mRNA Translation: AAC37526.1
AK292916 mRNA Translation: BAF85605.1
AK300455 mRNA Translation: BAG62175.1
AK316187 mRNA Translation: BAH14558.1
AB451409 mRNA Translation: BAG70223.1
AC003074 Genomic DNA Translation: AAS00387.1
AC005105 Genomic DNA Translation: AAP22329.1
AC005013 Genomic DNA No translation available.
AC006331 Genomic DNA No translation available.
AC006367 Genomic DNA No translation available.
AC006980 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93908.1
CH471073 Genomic DNA Translation: EAW93910.1
BC059400 mRNA Translation: AAH59400.2
CCDSiCCDS43562.1 [Q02930-3]
CCDS43563.1 [Q02930-4]
CCDS5417.1 [Q02930-1]
CCDS5418.1 [Q02930-2]
PIRiA45477
I78877
RefSeqiNP_001011666.1, NM_001011666.2 [Q02930-4]
NP_004895.2, NM_004904.3 [Q02930-2]
NP_878901.2, NM_182898.3 [Q02930-1]
NP_878902.2, NM_182899.4 [Q02930-3]
XP_005249963.1, XM_005249906.1 [Q02930-2]
XP_016868295.1, XM_017012806.1 [Q02930-2]
XP_016868297.1, XM_017012808.1 [Q02930-1]
UniGeneiHs.437075
Hs.729524

Genome annotation databases

EnsembliENST00000357727; ENSP00000350359; ENSG00000146592 [Q02930-1]
ENST00000396298; ENSP00000379592; ENSG00000146592 [Q02930-4]
ENST00000396299; ENSP00000379593; ENSG00000146592 [Q02930-3]
ENST00000396300; ENSP00000379594; ENSG00000146592 [Q02930-2]
ENST00000409603; ENSP00000387197; ENSG00000146592 [Q02930-3]
GeneIDi9586
KEGGihsa:9586
UCSCiuc003szo.4 human [Q02930-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCREB5_HUMAN
AccessioniPrimary (citable) accession number: Q02930
Secondary accession number(s): A8KA51
, B4DU13, B5BUH3, C9JK47, Q05886, Q06246, Q75N02, Q86UJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 31, 2011
Last modified: July 18, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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