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Protein

Cyclic AMP-responsive element-binding protein 5

Gene

CREB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the cAMP response element and activates transcription.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri16 – 40C2H2-typePROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription by RNA polymerase II Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q02930

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 5
Short name:
CREB-5
Short name:
cAMP-responsive element-binding protein 5
Alternative name(s):
CRE-BPa
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CREB5
Synonyms:CREBPA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000146592.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16844 CREB5

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q02930

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9586

Open Targets

More...
OpenTargetsi
ENSG00000146592

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134930491

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CREB5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
334302918

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000766041 – 508Cyclic AMP-responsive element-binding protein 5Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei59PhosphothreonineCombined sources1
Modified residuei61PhosphothreonineCombined sources1
Modified residuei137PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q02930

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q02930

PeptideAtlas

More...
PeptideAtlasi
Q02930

PRoteomics IDEntifications database

More...
PRIDEi
Q02930

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58137
58138 [Q02930-2]
58139 [Q02930-3]
58140 [Q02930-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q02930

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q02930

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146592 Expressed in 201 organ(s), highest expression level in tendon

CleanEx database of gene expression profiles

More...
CleanExi
HS_CREB5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q02930 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q02930 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050020
HPA061622

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114954, 54 interactors

Protein interaction database and analysis system

More...
IntActi
Q02930, 129 interactors

Molecular INTeraction database

More...
MINTi
Q02930

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000350359

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q02930

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q02930

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini375 – 438bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni377 – 397Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni403 – 431Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 40C2H2-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1414 Eukaryota
ENOG4111CH5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156420

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220894

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG098787

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q02930

KEGG Orthology (KO)

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KOi
K09047

Identification of Orthologs from Complete Genome Data

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OMAi
MSMNSNI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0AO8

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q02930

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004827 bZIP
IPR016378 TF_CRE-BP1-typ
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00170 bZIP_1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF003153 ATF2_CRE-BP1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00338 BRLZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q02930-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIYEESKMNL EQERPFVCSA PGCSQRFPTE DHLMIHRHKH EMTLKFPSIK
60 70 80 90 100
TDNMLSDQTP TPTRFLKNCE EVGLFSELDC SLEHEFRKAQ EEESSKRNIS
110 120 130 140 150
MHNAVGGAMT GPGTHQLSSA RLPNHDTNVV IQQAMPSPQS SSVITQAPST
160 170 180 190 200
NRQIGPVPGS LSSLLHLHNR QRQPMPASMP GTLPNPTMPG SSAVLMPMER
210 220 230 240 250
QMSVNSSIMG MQGPNLSNPC ASPQVQPMHS EAKMRLKAAL THHPAAMSNG
260 270 280 290 300
NMNTMGHMME MMGSRQDQTP HHHMHSHPHQ HQTLPPHHPY PHQHQHPAHH
310 320 330 340 350
PHPQPHHQQN HPHHHSHSHL HAHPAHHQTS PHPPLHTGNQ AQVSPATQQM
360 370 380 390 400
QPTQTIQPPQ PTGGRRRRVV DEDPDERRRK FLERNRAAAT RCRQKRKVWV
410 420 430 440 450
MSLEKKAEEL TQTNMQLQNE VSMLKNEVAQ LKQLLLTHKD CPITAMQKES
460 470 480 490 500
QGYLSPESSP PASPVPACSQ QQVIQHNTIT TSSSVSEVVG SSTLSQLTTH

RTDLNPIL
Length:508
Mass (Da):56,918
Last modified:May 31, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF96F33AE562F1AD
GO
Isoform 2 (identifier: Q02930-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Show »
Length:501
Mass (Da):56,037
Checksum:i9D67856759DB9957
GO
Isoform 3 (identifier: Q02930-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Show »
Length:475
Mass (Da):53,063
Checksum:iBD75DF80FE7145E9
GO
Isoform 4 (identifier: Q02930-4) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MIYEESKMNLEQERPF → MFCTSGGNSASVMSMR
     17-155: Missing.

Show »
Length:369
Mass (Da):41,161
Checksum:i7DC1C71C6A74DEB5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KVC5H9KVC5_HUMAN
Cyclic AMP-responsive element-bindi...
CREB5
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JN33C9JN33_HUMAN
Cyclic AMP-responsive element-bindi...
CREB5
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFV2H0YFV2_HUMAN
Cyclic AMP-responsive element-bindi...
CREB5
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16F → S in AAA52072 (PubMed:8440710).Curated1
Sequence conflicti16F → S in AAC37525 (PubMed:8378084).Curated1
Sequence conflicti211 – 212MQ → IE in AAA52072 (PubMed:8440710).Curated2
Sequence conflicti211 – 212MQ → IE in AAC37525 (PubMed:8378084).Curated2
Sequence conflicti211 – 212MQ → IE in AAC37526 (PubMed:8378084).Curated2
Sequence conflicti211 – 212MQ → IE in AAC37527 (PubMed:8378084).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0500111 – 33Missing in isoform 3. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_0500121 – 16MIYEE…QERPF → MFCTSGGNSASVMSMR in isoform 4. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_0500101 – 7Missing in isoform 2. 1 Publication7
Alternative sequenceiVSP_05001317 – 155Missing in isoform 4. 3 PublicationsAdd BLAST139

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L05515 mRNA Translation: AAA52072.1
L05911 mRNA Translation: AAC37525.1
L05912 mRNA Translation: AAC37527.1
L05913 mRNA Translation: AAC37526.1
AK292916 mRNA Translation: BAF85605.1
AK300455 mRNA Translation: BAG62175.1
AK316187 mRNA Translation: BAH14558.1
AB451409 mRNA Translation: BAG70223.1
AC003074 Genomic DNA Translation: AAS00387.1
AC005105 Genomic DNA Translation: AAP22329.1
AC005013 Genomic DNA No translation available.
AC006331 Genomic DNA No translation available.
AC006367 Genomic DNA No translation available.
AC006980 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93908.1
CH471073 Genomic DNA Translation: EAW93910.1
BC059400 mRNA Translation: AAH59400.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43562.1 [Q02930-3]
CCDS43563.1 [Q02930-4]
CCDS5417.1 [Q02930-1]
CCDS5418.1 [Q02930-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A45477
I78877

NCBI Reference Sequences

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RefSeqi
NP_001011666.1, NM_001011666.2 [Q02930-4]
NP_004895.2, NM_004904.3 [Q02930-2]
NP_878901.2, NM_182898.3 [Q02930-1]
NP_878902.2, NM_182899.4 [Q02930-3]
XP_005249963.1, XM_005249906.1 [Q02930-2]
XP_016868295.1, XM_017012806.1 [Q02930-2]
XP_016868297.1, XM_017012808.1 [Q02930-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.437075
Hs.729524

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357727; ENSP00000350359; ENSG00000146592 [Q02930-1]
ENST00000396298; ENSP00000379592; ENSG00000146592 [Q02930-4]
ENST00000396299; ENSP00000379593; ENSG00000146592 [Q02930-3]
ENST00000396300; ENSP00000379594; ENSG00000146592 [Q02930-2]
ENST00000409603; ENSP00000387197; ENSG00000146592 [Q02930-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9586

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9586

UCSC genome browser

More...
UCSCi
uc003szo.4 human [Q02930-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05515 mRNA Translation: AAA52072.1
L05911 mRNA Translation: AAC37525.1
L05912 mRNA Translation: AAC37527.1
L05913 mRNA Translation: AAC37526.1
AK292916 mRNA Translation: BAF85605.1
AK300455 mRNA Translation: BAG62175.1
AK316187 mRNA Translation: BAH14558.1
AB451409 mRNA Translation: BAG70223.1
AC003074 Genomic DNA Translation: AAS00387.1
AC005105 Genomic DNA Translation: AAP22329.1
AC005013 Genomic DNA No translation available.
AC006331 Genomic DNA No translation available.
AC006367 Genomic DNA No translation available.
AC006980 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW93908.1
CH471073 Genomic DNA Translation: EAW93910.1
BC059400 mRNA Translation: AAH59400.2
CCDSiCCDS43562.1 [Q02930-3]
CCDS43563.1 [Q02930-4]
CCDS5417.1 [Q02930-1]
CCDS5418.1 [Q02930-2]
PIRiA45477
I78877
RefSeqiNP_001011666.1, NM_001011666.2 [Q02930-4]
NP_004895.2, NM_004904.3 [Q02930-2]
NP_878901.2, NM_182898.3 [Q02930-1]
NP_878902.2, NM_182899.4 [Q02930-3]
XP_005249963.1, XM_005249906.1 [Q02930-2]
XP_016868295.1, XM_017012806.1 [Q02930-2]
XP_016868297.1, XM_017012808.1 [Q02930-1]
UniGeneiHs.437075
Hs.729524

3D structure databases

ProteinModelPortaliQ02930
SMRiQ02930
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114954, 54 interactors
IntActiQ02930, 129 interactors
MINTiQ02930
STRINGi9606.ENSP00000350359

PTM databases

iPTMnetiQ02930
PhosphoSitePlusiQ02930

Polymorphism and mutation databases

BioMutaiCREB5
DMDMi334302918

Proteomic databases

MaxQBiQ02930
PaxDbiQ02930
PeptideAtlasiQ02930
PRIDEiQ02930
ProteomicsDBi58137
58138 [Q02930-2]
58139 [Q02930-3]
58140 [Q02930-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357727; ENSP00000350359; ENSG00000146592 [Q02930-1]
ENST00000396298; ENSP00000379592; ENSG00000146592 [Q02930-4]
ENST00000396299; ENSP00000379593; ENSG00000146592 [Q02930-3]
ENST00000396300; ENSP00000379594; ENSG00000146592 [Q02930-2]
ENST00000409603; ENSP00000387197; ENSG00000146592 [Q02930-3]
GeneIDi9586
KEGGihsa:9586
UCSCiuc003szo.4 human [Q02930-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9586
DisGeNETi9586
EuPathDBiHostDB:ENSG00000146592.16

GeneCards: human genes, protein and diseases

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GeneCardsi
CREB5
HGNCiHGNC:16844 CREB5
HPAiHPA050020
HPA061622
neXtProtiNX_Q02930
OpenTargetsiENSG00000146592
PharmGKBiPA134930491

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00940000156420
HOGENOMiHOG000220894
HOVERGENiHBG098787
InParanoidiQ02930
KOiK09047
OMAiMSMNSNI
OrthoDBiEOG091G0AO8
PhylomeDBiQ02930

Enzyme and pathway databases

SIGNORiQ02930

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CREB5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CREB5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9586

Protein Ontology

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PROi
PR:Q02930

Gene expression databases

BgeeiENSG00000146592 Expressed in 201 organ(s), highest expression level in tendon
CleanExiHS_CREB5
ExpressionAtlasiQ02930 baseline and differential
GenevisibleiQ02930 HS

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR016378 TF_CRE-BP1-typ
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PIRSFiPIRSF003153 ATF2_CRE-BP1, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCREB5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02930
Secondary accession number(s): A8KA51
, B4DU13, B5BUH3, C9JK47, Q05886, Q06246, Q75N02, Q86UJ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 31, 2011
Last modified: December 5, 2018
This is version 169 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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