UniProtKB - Q02928 (CP4AB_HUMAN)
Protein
Cytochrome P450 4A11
Gene
CYP4A11
Organism
Homo sapiens (Human)
Status
Functioni
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid (PubMed:10553002, PubMed:10660572). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:15611369). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10620324, PubMed:10660572, PubMed:15611369). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PubMed:7679927). May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PubMed:18182499). Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer (PubMed:15145985). Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids (PubMed:18065749). Has little activity toward prostaglandins A1 and E1 (PubMed:7679927).10 Publications
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]6 PublicationsEC:1.14.14.16 PublicationsThis reaction proceeds in the forward1 Publication direction.
- an ω-methyl-long-chain fatty acid + O2 + reduced [NADPH—hemoprotein reductase] = an ω-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH—hemoprotein reductase]3 PublicationsEC:1.14.14.803 PublicationsThis reaction proceeds in the forward2 Publications direction.
- dodecanoate + O2 + reduced [NADPH—hemoprotein reductase] = 12-hydroxydodecanoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]6 PublicationsThis reaction proceeds in the forward1 Publication direction.
- O2 + reduced [NADPH—hemoprotein reductase] + tetradecanoate = 14-hydroxytetradecanoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]3 PublicationsThis reaction proceeds in the forward1 Publication direction.
- hexadecanoate + O2 + reduced [NADPH—hemoprotein reductase] = 16-hydroxyhexadecanoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]3 PublicationsEC:1.14.14.803 PublicationsThis reaction proceeds in the forward2 Publications direction.
- (9Z)-octadecenoate + O2 + reduced [NADPH—hemoprotein reductase] = 18-hydroxy-(9Z)-octadecenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationEC:1.14.14.801 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]3 PublicationsThis reaction proceeds in the forward2 Publications direction.
- 22-hydroxydocosanoate + O2 + reduced [NADPH—hemoprotein reductase] = 22-oxodocosanoate + H+ + 2 H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 22-oxodocosanoate + O2 + reduced [NADPH—hemoprotein reductase] = docosanedioate + 2 H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH—hemoprotein reductase] = 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 3-hydroxyhexadecanoate + O2 + reduced [NADPH—hemoprotein reductase] = 3,16-dihydroxyhexadecanoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
heme1 Publication
Activity regulationi
Activated by cytochrome b5.2 Publications
Kineticsi
kcat is 42 min(-1) with dodecanoic acid as substrate. kcat is 50 min(-1) with tetradecanoic acid as substrate. kcat is 10 min(-1) with hexadecanoic acid as substrate. kcat is 0.4 min(-1) with (9Z)-octadecenoic acid as substrate. kcat is 0.4 min(-1) with (5Z,8Z,11Z,14Z)-eicosatetraenoic acid as substrate.1 Publication
- KM=11 µM for dodecanoic acid1 Publication
- KM=37 µM for (5Z,8Z,11Z,14Z)-eicosatetraenoic acid1 Publication
: arachidonate metabolism Pathwayi
This protein is involved in the pathway arachidonate metabolism, which is part of Lipid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway arachidonate metabolism and in Lipid metabolism.
Pathwayi: oxylipin biosynthesis
This protein is involved in the pathway oxylipin biosynthesis, which is part of Lipid metabolism.3 PublicationsView all proteins of this organism that are known to be involved in the pathway oxylipin biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 321 | Heme (covalent; via 1 link)1 Publication | 1 | |
Metal bindingi | 457 | Iron (heme axial ligand)1 Publication | 1 |
GO - Molecular functioni
- alkane 1-monooxygenase activity Source: BHF-UCL
- arachidonic acid epoxygenase activity Source: UniProtKB
- arachidonic acid monooxygenase activity Source: GO_Central
- aromatase activity Source: UniProtKB-EC
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- leukotriene-B4 20-monooxygenase activity Source: UniProtKB
- long-chain fatty acid omega-hydroxylase activity Source: UniProtKB-EC
GO - Biological processi
- arachidonic acid metabolic process Source: UniProtKB
- epoxygenase P450 pathway Source: UniProtKB
- fatty acid metabolic process Source: Reactome
- icosanoid biosynthetic process Source: GO_Central
- kidney development Source: GO_Central
- lauric acid metabolic process Source: GO_Central
- leukotriene metabolic process Source: UniProtKB
- linoleic acid metabolic process Source: GO_Central
- long-chain fatty acid metabolic process Source: BHF-UCL
- omega-hydroxylase P450 pathway Source: Reactome
- oxidation-reduction process Source: UniProtKB
- oxylipin biosynthetic process Source: UniProtKB-UniPathway
- positive regulation of icosanoid secretion Source: UniProtKB
- pressure natriuresis Source: UniProtKB
- regulation of lipid metabolic process Source: Reactome
- renal water homeostasis Source: UniProtKB
- sodium ion homeostasis Source: UniProtKB
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | Heme, Iron, Metal-binding, NADP |
Enzyme and pathway databases
PathwayCommonsi | Q02928 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-211935, Fatty acids R-HSA-211958, Miscellaneous substrates R-HSA-211979, Eicosanoids R-HSA-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142816, Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) |
SABIO-RKi | Q02928 |
UniPathwayi | UPA00382 UPA00383 |
Chemistry databases
SwissLipidsi | SLP:000000398 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 4A111 Publication (EC:1.14.14.16 Publications)Alternative name(s): 20-hydroxyeicosatetraenoic acid synthase2 Publications Short name: 20-HETE synthase CYP4AII CYPIVA11 Cytochrome P-450HK-omega Cytochrome P450HL-omega Fatty acid omega-hydroxylase Lauric acid omega-hydroxylase1 Publication Long-chain fatty acid omega-monooxygenase (EC:1.14.14.802 Publications) |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2642, CYP4A11 |
MIMi | 601310, gene |
neXtProti | NX_Q02928 |
VEuPathDBi | HostDB:ENSG00000187048.12 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Peripheral membrane protein Curated
- Microsome membrane 1 Publication; Peripheral membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Plasma Membrane
- apical plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: UniProtKB
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 130 | G → S: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 321 | E → A: Loss of covalent heme binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1579 |
OpenTargetsi | ENSG00000187048 |
PharmGKBi | PA27118 |
Miscellaneous databases
Pharosi | Q02928, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3978 |
DrugBanki | DB00515, Cisplatin DB00636, Clofibrate DB01234, Dexamethasone DB14649, Dexamethasone acetate DB00898, Ethanol DB13125, Lusutrombopag DB00157, NADH DB00082, Pegvisomant DB00738, Pentamidine DB04977, Plitidepsin DB11077, Polyethylene glycol 400 DB11156, Pyrantel DB14004, Tildrakizumab DB00755, Tretinoin |
Genetic variation databases
BioMutai | CYP4A11 |
DMDMi | 2493371 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000003579 | 1 – 4 | 2 Publications | 4 | |
ChainiPRO_0000003580 | 5 – 519 | Cytochrome P450 4A11Add BLAST | 515 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 440 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q02928 |
PaxDbi | Q02928 |
PeptideAtlasi | Q02928 |
PRIDEi | Q02928 |
ProteomicsDBi | 58135 [Q02928-1] 58136 [Q02928-2] |
PTM databases
iPTMneti | Q02928 |
PhosphoSitePlusi | Q02928 |
Expressioni
Tissue specificityi
Expressed in liver (PubMed:7679927). Expressed in S2 and S3 segments of proximal tubules in cortex and outer medulla of kidney (PubMed:7679927, PubMed:10660572).2 Publications
Gene expression databases
Bgeei | ENSG00000187048, Expressed in right lobe of liver and 102 other tissues |
ExpressionAtlasi | Q02928, baseline and differential |
Genevisiblei | Q02928, HS |
Organism-specific databases
HPAi | ENSG00000187048, Group enriched (kidney, liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 107951, 4 interactors |
IntActi | Q02928, 2 interactors |
STRINGi | 9606.ENSP00000311095 |
Miscellaneous databases
RNActi | Q02928, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 24 – 31 | Poly-Leu | 8 | |
Compositional biasi | 131 – 134 | Poly-Leu | 4 |
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
GeneTreei | ENSGT00940000163504 |
InParanoidi | Q02928 |
OrthoDBi | 1247045at2759 |
PhylomeDBi | Q02928 |
TreeFami | TF105088 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q02928-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSVSVLSPSR LLGDVSGILQ AASLLILLLL LIKAVQLYLH RQWLLKALQQ
60 70 80 90 100
FPCPPSHWLF GHIQELQQDQ ELQRIQKWVE TFPSACPHWL WGGKVRVQLY
110 120 130 140 150
DPDYMKVILG RSDPKSHGSY RFLAPWIGYG LLLLNGQTWF QHRRMLTPAF
160 170 180 190 200
HYDILKPYVG LMADSVRVML DKWEELLGQD SPLEVFQHVS LMTLDTIMKC
210 220 230 240 250
AFSHQGSIQV DRNSQSYIQA ISDLNNLVFS RVRNAFHQND TIYSLTSAGR
260 270 280 290 300
WTHRACQLAH QHTDQVIQLR KAQLQKEGEL EKIKRKRHLD FLDILLLAKM
310 320 330 340 350
ENGSILSDKD LRAEVDTFMF EGHDTTASGI SWILYALATH PKHQERCREE
360 370 380 390 400
IHSLLGDGAS ITWNHLDQMP YTTMCIKEAL RLYPPVPGIG RELSTPVTFP
410 420 430 440 450
DGRSLPKGIM VLLSIYGLHH NPKVWPNPEV FDPFRFAPGS AQHSHAFLPF
460 470 480 490 500
SGGSRNCIGK QFAMNELKVA TALTLLRFEL LPDPTRIPIP IARLVLKSKN
510
GIHLRLRRLP NPCEDKDQL
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketV9GZ77 | V9GZ77_HUMAN | Cytochrome P450 4A11 | CYP4A11 | 421 | Annotation score: | ||
V9GYK4 | V9GYK4_HUMAN | Cytochrome P450 4A11 | CYP4A11 | 264 | Annotation score: | ||
V9GYQ2 | V9GYQ2_HUMAN | Cytochrome P450 4A11 | CYP4A11 | 249 | Annotation score: | ||
V9GYC6 | V9GYC6_HUMAN | Cytochrome P450 4A11 | CYP4A11 | 377 | Annotation score: | ||
E7EVL8 | E7EVL8_HUMAN | Cytochrome P450 4A11 | CYP4A11 | 520 | Annotation score: | ||
V9GY41 | V9GY41_HUMAN | Cytochrome P450 4A11 | CYP4A11 | 215 | Annotation score: | ||
A0A0C4DFV7 | A0A0C4DFV7_HUMAN | Cytochrome P450 4A11 | CYP4A11 | 455 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 | V → A AA sequence (PubMed:1739747).Curated | 1 | |
Sequence conflicti | 383 | Y → F in AAO16078 (PubMed:12464262).Curated | 1 | |
Sequence conflicti | 390 | G → S in CAA50586 (PubMed:8363569).Curated | 1 | |
Sequence conflicti | 410 – 412 | MVL → TVM in CAA50586 (PubMed:8363569).Curated | 3 |
Polymorphismi
CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to metabolize lauric acid.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048452 | 226 | N → S. Corresponds to variant dbSNP:rs12759923Ensembl. | 1 | |
Natural variantiVAR_044377 | 353 | S → G2 PublicationsCorresponds to variant dbSNP:rs3899049Ensembl. | 1 | |
Natural variantiVAR_019160 | 434 | F → S Associated with hypertension; significantly reduced arachidonic acid and lauric acid metabolizing activity. 5 PublicationsCorresponds to variant dbSNP:rs1126742Ensembl. | 1 | |
Natural variantiVAR_001257 | 500 – 519 | NGIHL…DKDQL → MESTCVSGGSLTLVKTRTSF EGLHLPSCLPDPRFCPLPVC PYPVFCLPTFPSSHLPAVPQ SACPSLSHLSPGLPTCLSTC LLPTCISCWEKS in CYP4A11V. Add BLAST | 20 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034595 | 356 – 519 | Missing in isoform 2. 1 PublicationAdd BLAST | 164 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L04751 mRNA Translation: AAA58436.1 D26481 mRNA Translation: BAA05491.1 S67580 mRNA Translation: AAB29502.1 S67581 mRNA Translation: AAB29503.1 AF525488 Genomic DNA Translation: AAO16078.1 AY369778 Genomic DNA Translation: AAQ56847.1 AL731892 Genomic DNA No translation available. BC041158 mRNA Translation: AAH41158.1 X71480 mRNA Translation: CAA50586.1 |
CCDSi | CCDS543.1 [Q02928-1] |
PIRi | A56859 I53015 I65981 JX0331 |
RefSeqi | NP_000769.2, NM_000778.3 [Q02928-1] NP_001306084.1, NM_001319155.1 |
Genome annotation databases
Ensembli | ENST00000310638; ENSP00000311095; ENSG00000187048 [Q02928-1] |
GeneIDi | 1579 |
KEGGi | hsa:1579 |
UCSCi | uc001cqp.5, human [Q02928-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Cytochrome P450 Allele Nomenclature Committee CYP4A11 alleles |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L04751 mRNA Translation: AAA58436.1 D26481 mRNA Translation: BAA05491.1 S67580 mRNA Translation: AAB29502.1 S67581 mRNA Translation: AAB29503.1 AF525488 Genomic DNA Translation: AAO16078.1 AY369778 Genomic DNA Translation: AAQ56847.1 AL731892 Genomic DNA No translation available. BC041158 mRNA Translation: AAH41158.1 X71480 mRNA Translation: CAA50586.1 |
CCDSi | CCDS543.1 [Q02928-1] |
PIRi | A56859 I53015 I65981 JX0331 |
RefSeqi | NP_000769.2, NM_000778.3 [Q02928-1] NP_001306084.1, NM_001319155.1 |
3D structure databases
SMRi | Q02928 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107951, 4 interactors |
IntActi | Q02928, 2 interactors |
STRINGi | 9606.ENSP00000311095 |
Chemistry databases
ChEMBLi | CHEMBL3978 |
DrugBanki | DB00515, Cisplatin DB00636, Clofibrate DB01234, Dexamethasone DB14649, Dexamethasone acetate DB00898, Ethanol DB13125, Lusutrombopag DB00157, NADH DB00082, Pegvisomant DB00738, Pentamidine DB04977, Plitidepsin DB11077, Polyethylene glycol 400 DB11156, Pyrantel DB14004, Tildrakizumab DB00755, Tretinoin |
SwissLipidsi | SLP:000000398 |
PTM databases
iPTMneti | Q02928 |
PhosphoSitePlusi | Q02928 |
Genetic variation databases
BioMutai | CYP4A11 |
DMDMi | 2493371 |
Proteomic databases
MassIVEi | Q02928 |
PaxDbi | Q02928 |
PeptideAtlasi | Q02928 |
PRIDEi | Q02928 |
ProteomicsDBi | 58135 [Q02928-1] 58136 [Q02928-2] |
Protocols and materials databases
Antibodypediai | 32832, 228 antibodies |
Genome annotation databases
Ensembli | ENST00000310638; ENSP00000311095; ENSG00000187048 [Q02928-1] |
GeneIDi | 1579 |
KEGGi | hsa:1579 |
UCSCi | uc001cqp.5, human [Q02928-1] |
Organism-specific databases
CTDi | 1579 |
DisGeNETi | 1579 |
GeneCardsi | CYP4A11 |
HGNCi | HGNC:2642, CYP4A11 |
HPAi | ENSG00000187048, Group enriched (kidney, liver) |
MIMi | 601310, gene |
neXtProti | NX_Q02928 |
OpenTargetsi | ENSG00000187048 |
PharmGKBi | PA27118 |
VEuPathDBi | HostDB:ENSG00000187048.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
GeneTreei | ENSGT00940000163504 |
InParanoidi | Q02928 |
OrthoDBi | 1247045at2759 |
PhylomeDBi | Q02928 |
TreeFami | TF105088 |
Enzyme and pathway databases
UniPathwayi | UPA00382 UPA00383 |
PathwayCommonsi | Q02928 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-211935, Fatty acids R-HSA-211958, Miscellaneous substrates R-HSA-211979, Eicosanoids R-HSA-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142816, Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) |
SABIO-RKi | Q02928 |
Miscellaneous databases
BioGRID-ORCSi | 1579, 2 hits in 871 CRISPR screens |
ChiTaRSi | CYP4A11, human |
GeneWikii | CYP4A11 |
GenomeRNAii | 1579 |
Pharosi | Q02928, Tbio |
PROi | PR:Q02928 |
RNActi | Q02928, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187048, Expressed in right lobe of liver and 102 other tissues |
ExpressionAtlasi | Q02928, baseline and differential |
Genevisiblei | Q02928, HS |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CP4AB_HUMAN | |
Accessioni | Q02928Primary (citable) accession number: Q02928 Secondary accession number(s): Q06766 Q8IWY5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 189 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families