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Protein

Cytochrome P450 4A11

Gene

CYP4A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).3 Publications

Catalytic activityi

A long-chain fatty acid + [reduced NADPH--hemoprotein reductase] + O2 = an omega-hydroxy-long-chain fatty acid + [oxidized NADPH--hemoprotein reductase] + H2O.2 Publications

Cofactori

heme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei321Heme (covalent; via 1 link)1 Publication1
Metal bindingi457Iron (heme axial ligand)1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-211935 Fatty acids
R-HSA-211958 Miscellaneous substrates
R-HSA-211979 Eicosanoids
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
SABIO-RKiQ02928

Chemistry databases

SwissLipidsiSLP:000000398

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4A11
Alternative name(s):
20-hydroxyeicosatetraenoic acid synthase
Short name:
20-HETE synthase
CYP4AII
CYPIVA11
Cytochrome P-450HK-omega
Cytochrome P450HL-omega
Fatty acid omega-hydroxylase
Lauric acid omega-hydroxylase
Long-chain fatty acid omega-monooxygenase (EC:1.14.14.802 Publications)
Gene namesi
Name:CYP4A11
Synonyms:CYP4A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000187048.12
HGNCiHGNC:2642 CYP4A11
MIMi601310 gene
neXtProtiNX_Q02928

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi130G → S: Loss of activity. 1 Publication1
Mutagenesisi321E → A: Loss of covalent heme binding. 1 Publication1

Organism-specific databases

DisGeNETi1579
OpenTargetsiENSG00000187048
PharmGKBiPA27118

Chemistry databases

ChEMBLiCHEMBL3978
DrugBankiDB00515 Cisplatin
DB00636 Clofibrate
DB01234 Dexamethasone
DB00655 Estrone
DB00898 Ethanol
DB00448 Lansoprazole
DB00157 NADH
DB00082 Pegvisomant
DB00738 Pentamidine
DB01174 Phenobarbital
DB04977 Plitidepsin
DB01045 Rifampicin
DB00755 Tretinoin

Polymorphism and mutation databases

BioMutaiCYP4A11
DMDMi2493371

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000035791 – 42 Publications4
ChainiPRO_00000035805 – 519Cytochrome P450 4A11Add BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei440PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ02928
PeptideAtlasiQ02928
PRIDEiQ02928
ProteomicsDBi58135
58136 [Q02928-2]

PTM databases

iPTMnetiQ02928
PhosphoSitePlusiQ02928

Expressioni

Tissue specificityi

Kidney and liver.1 Publication

Gene expression databases

BgeeiENSG00000187048 Expressed in 78 organ(s), highest expression level in right lobe of liver
CleanExiHS_CYP4A11
ExpressionAtlasiQ02928 baseline and differential
GenevisibleiQ02928 HS

Interactioni

Protein-protein interaction databases

BioGridi107951, 4 interactors
IntActiQ02928, 1 interactor
STRINGi9606.ENSP00000311095

Structurei

3D structure databases

ProteinModelPortaliQ02928
SMRiQ02928
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 31Poly-Leu8
Compositional biasi131 – 134Poly-Leu4

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140829
HOVERGENiHBG000182
InParanoidiQ02928
KOiK07425
PhylomeDBiQ02928
TreeFamiTF105088

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q02928-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVSVLSPSR LLGDVSGILQ AASLLILLLL LIKAVQLYLH RQWLLKALQQ
60 70 80 90 100
FPCPPSHWLF GHIQELQQDQ ELQRIQKWVE TFPSACPHWL WGGKVRVQLY
110 120 130 140 150
DPDYMKVILG RSDPKSHGSY RFLAPWIGYG LLLLNGQTWF QHRRMLTPAF
160 170 180 190 200
HYDILKPYVG LMADSVRVML DKWEELLGQD SPLEVFQHVS LMTLDTIMKC
210 220 230 240 250
AFSHQGSIQV DRNSQSYIQA ISDLNNLVFS RVRNAFHQND TIYSLTSAGR
260 270 280 290 300
WTHRACQLAH QHTDQVIQLR KAQLQKEGEL EKIKRKRHLD FLDILLLAKM
310 320 330 340 350
ENGSILSDKD LRAEVDTFMF EGHDTTASGI SWILYALATH PKHQERCREE
360 370 380 390 400
IHSLLGDGAS ITWNHLDQMP YTTMCIKEAL RLYPPVPGIG RELSTPVTFP
410 420 430 440 450
DGRSLPKGIM VLLSIYGLHH NPKVWPNPEV FDPFRFAPGS AQHSHAFLPF
460 470 480 490 500
SGGSRNCIGK QFAMNELKVA TALTLLRFEL LPDPTRIPIP IARLVLKSKN
510
GIHLRLRRLP NPCEDKDQL
Length:519
Mass (Da):59,348
Last modified:November 1, 1997 - v1
Checksum:iA8D3073EEFF48AE9
GO
Isoform 2 (identifier: Q02928-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-519: Missing.

Show »
Length:355
Mass (Da):41,052
Checksum:iA108E4661ACF9824
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GZ77V9GZ77_HUMAN
Cytochrome P450 4A11
CYP4A11
421Annotation score:
E7EVL8E7EVL8_HUMAN
Cytochrome P450 4A11
CYP4A11
520Annotation score:
V9GYQ2V9GYQ2_HUMAN
Cytochrome P450 4A11
CYP4A11
249Annotation score:
V9GYK4V9GYK4_HUMAN
Cytochrome P450 4A11
CYP4A11
264Annotation score:
V9GYC6V9GYC6_HUMAN
Cytochrome P450 4A11
CYP4A11
377Annotation score:
A0A0C4DFV7A0A0C4DFV7_HUMAN
Cytochrome P450 4A11
CYP4A11
455Annotation score:
V9GY41V9GY41_HUMAN
Cytochrome P450 4A11
CYP4A11
215Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5V → A AA sequence (PubMed:1739747).Curated1
Sequence conflicti383Y → F in AAO16078 (PubMed:12464262).Curated1
Sequence conflicti390G → S in CAA50586 (PubMed:8363569).Curated1
Sequence conflicti410 – 412MVL → TVM in CAA50586 (PubMed:8363569).Curated3

Polymorphismi

CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to metabolize lauric acid.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048452226N → S. Corresponds to variant dbSNP:rs12759923Ensembl.1
Natural variantiVAR_044377353S → G2 PublicationsCorresponds to variant dbSNP:rs3899049Ensembl.1
Natural variantiVAR_019160434F → S Associated with hypertension; significantly reduced arachidonic acid and lauric acid metabolizing activity. 5 PublicationsCorresponds to variant dbSNP:rs1126742Ensembl.1
Natural variantiVAR_001257500 – 519NGIHL…DKDQL → MESTCVSGGSLTLVKTRTSF EGLHLPSCLPDPRFCPLPVC PYPVFCLPTFPSSHLPAVPQ SACPSLSHLSPGLPTCLSTC LLPTCISCWEKS in CYP4A11V. Add BLAST20

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034595356 – 519Missing in isoform 2. 1 PublicationAdd BLAST164

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04751 mRNA Translation: AAA58436.1
D26481 mRNA Translation: BAA05491.1
S67580 mRNA Translation: AAB29502.1
S67581 mRNA Translation: AAB29503.1
AF525488 Genomic DNA Translation: AAO16078.1
AY369778 Genomic DNA Translation: AAQ56847.1
AL731892 Genomic DNA No translation available.
BC041158 mRNA Translation: AAH41158.1
X71480 mRNA Translation: CAA50586.1
CCDSiCCDS543.1 [Q02928-1]
PIRiA56859
I53015
I65981
JX0331
RefSeqiNP_000769.2, NM_000778.3 [Q02928-1]
NP_001306084.1, NM_001319155.1
UniGeneiHs.1645
Hs.726474

Genome annotation databases

EnsembliENST00000310638; ENSP00000311095; ENSG00000187048 [Q02928-1]
GeneIDi1579
KEGGihsa:1579
UCSCiuc001cqp.5 human [Q02928-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP4A11 alleles

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04751 mRNA Translation: AAA58436.1
D26481 mRNA Translation: BAA05491.1
S67580 mRNA Translation: AAB29502.1
S67581 mRNA Translation: AAB29503.1
AF525488 Genomic DNA Translation: AAO16078.1
AY369778 Genomic DNA Translation: AAQ56847.1
AL731892 Genomic DNA No translation available.
BC041158 mRNA Translation: AAH41158.1
X71480 mRNA Translation: CAA50586.1
CCDSiCCDS543.1 [Q02928-1]
PIRiA56859
I53015
I65981
JX0331
RefSeqiNP_000769.2, NM_000778.3 [Q02928-1]
NP_001306084.1, NM_001319155.1
UniGeneiHs.1645
Hs.726474

3D structure databases

ProteinModelPortaliQ02928
SMRiQ02928
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107951, 4 interactors
IntActiQ02928, 1 interactor
STRINGi9606.ENSP00000311095

Chemistry databases

ChEMBLiCHEMBL3978
DrugBankiDB00515 Cisplatin
DB00636 Clofibrate
DB01234 Dexamethasone
DB00655 Estrone
DB00898 Ethanol
DB00448 Lansoprazole
DB00157 NADH
DB00082 Pegvisomant
DB00738 Pentamidine
DB01174 Phenobarbital
DB04977 Plitidepsin
DB01045 Rifampicin
DB00755 Tretinoin
SwissLipidsiSLP:000000398

PTM databases

iPTMnetiQ02928
PhosphoSitePlusiQ02928

Polymorphism and mutation databases

BioMutaiCYP4A11
DMDMi2493371

Proteomic databases

PaxDbiQ02928
PeptideAtlasiQ02928
PRIDEiQ02928
ProteomicsDBi58135
58136 [Q02928-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310638; ENSP00000311095; ENSG00000187048 [Q02928-1]
GeneIDi1579
KEGGihsa:1579
UCSCiuc001cqp.5 human [Q02928-1]

Organism-specific databases

CTDi1579
DisGeNETi1579
EuPathDBiHostDB:ENSG00000187048.12
GeneCardsiCYP4A11
HGNCiHGNC:2642 CYP4A11
MIMi601310 gene
neXtProtiNX_Q02928
OpenTargetsiENSG00000187048
PharmGKBiPA27118
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140829
HOVERGENiHBG000182
InParanoidiQ02928
KOiK07425
PhylomeDBiQ02928
TreeFamiTF105088

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-211935 Fatty acids
R-HSA-211958 Miscellaneous substrates
R-HSA-211979 Eicosanoids
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
SABIO-RKiQ02928

Miscellaneous databases

ChiTaRSiCYP4A11 human
GeneWikiiCYP4A11
GenomeRNAii1579
PROiPR:Q02928
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187048 Expressed in 78 organ(s), highest expression level in right lobe of liver
CleanExiHS_CYP4A11
ExpressionAtlasiQ02928 baseline and differential
GenevisibleiQ02928 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP4AB_HUMAN
AccessioniPrimary (citable) accession number: Q02928
Secondary accession number(s): Q06766
, Q16865, Q16866, Q5VSP8, Q86SU6, Q8IWY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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