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Protein

Calphotin

Gene

Cpn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays important roles in both rhabdomere development and in photoreceptor cell survival. Might function as a calcium-sequestering "sponge" to regulate the amount of free cytoplasmic calcium. It binds 0.3 mole of Ca2+ per mole of protein.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: FlyBase

GO - Biological processi

  • response to stimulus Source: UniProtKB-KW
  • rhabdomere development Source: FlyBase
  • sequestering of calcium ion Source: FlyBase
  • visual perception Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSensory transduction, Vision
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calphotin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cpn
Synonyms:cap
ORF Names:CG4795
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261714 Cpn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000792901 – 864CalphotinAdd BLAST864

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q02910

PRoteomics IDEntifications database

More...
PRIDEi
Q02910

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Soma and axons of photoreceptor cells of compound eyes and ocelli.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed early in photoreceptor cell development.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261714 Expressed in 13 organ(s), highest expression level in head

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q02910 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
66588, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q02910, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0082021

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni816 – 858Leucine-zipperAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3 – 618Ala/Pro/Val-richAdd BLAST616

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q02910

Identification of Orthologs from Complete Genome Data

More...
OMAi
NAQPYDP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0PBL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q02910

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform B (identifier: Q02910-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPGTIPSPV SAPVAAPVTP SAVAAPVQVV SPAAVAPAPA APIAVTPVAP
60 70 80 90 100
PPTLASVQPA TVTIPAPAPI AAASVAPVAS VAPPVVAAPT PPAASPVSTP
110 120 130 140 150
PVAVAQIPVA VSAPVAPPVA ATPTPVAPIP VAAPVIATPP VAASAPTPAA
160 170 180 190 200
VTPVVSPVIA TPPVVPANTT VPVAAPVAAV PAAVPVVAPV LAPAVAPAVA
210 220 230 240 250
PVVAETPAPP PVAEIPVATI PECVAPLIPE VSVVATKPLA AAEPVVVAPP
260 270 280 290 300
ATETPVVAPA AASPHVSVAP AVETAVVAPV SASTEPPVAA ATLTTAPETP
310 320 330 340 350
ALAPVVAESQ VAANTVVATP PTPAPEPETI APPVVAETPE VASVAVAETT
360 370 380 390 400
PPVVPPVAAE SIPAPVVATT PVPATLAVTD PDVTASAVPE LPPVIAPSPV
410 420 430 440 450
PSAVAETPVD LAPPVLPPVA AEPVPAVVAE ETPETPAPAS APVTIAALDI
460 470 480 490 500
PEVAPVIAAP SDAPAEAPSA AAPIVSTPPT TASVPETTAP PAAVPTEPID
510 520 530 540 550
VSVLSEAAIE TPVAPPVEVT TEVAVADVAP PEAAADLIIE PVEPPAPIPD
560 570 580 590 600
LLEQTTSVPA VEAAESTSSP IPETSLPPPN EAVASPEVAV APITAPEPIP
610 620 630 640 650
EPEPSLATPT EPIPVEAPVV IQEAVDAVEV PVTETSTSIP ETTVEYPVAE
660 670 680 690 700
KVLDPAITEA PVTTQEPDVA NINDGAPATE ITTPAVEIVT AAAEVSDTAI
710 720 730 740 750
PLIDPPVPQE IAVAEIPETE TKPAEVIVEQ STIPIEAPVP EVSKYAEPVI
760 770 780 790 800
SEAPAAEVPI TAGDNPDNTS VGISEVVPTI AEKAVEEVPT SEIPEQSSSP
810 820 830 840 850
SDSVPVAKIT PLLRDLQTTD VSLLAIAATL DAIGEKLKDQ KARNQQVMDR
860
LCEIEKILGP PKSN
Length:864
Mass (Da):84,596
Last modified:May 24, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B3635A283E5C658
GO
Isoform A (identifier: Q02910-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     644-665: Missing.

Note: No experimental confirmation available.
Show »
Length:842
Mass (Da):82,243
Checksum:iD71E531327EF8501
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36A → AVAPAVVA in AAA28420 (PubMed:8434015).Curated1
Sequence conflicti43I → T in AAA28420 (PubMed:8434015).Curated1
Sequence conflicti64I → V in AAA28420 (PubMed:8434015).Curated1
Sequence conflicti76A → T in AAA28405 (PubMed:8094559).Curated1
Sequence conflicti101Missing in AAA28405 (PubMed:8094559).Curated1
Sequence conflicti127 – 128AP → VQ in AAA28405 (PubMed:8094559).Curated2
Sequence conflicti155V → I in AAA28405 (PubMed:8094559).Curated1
Sequence conflicti161T → S in AAA28405 (PubMed:8094559).Curated1
Sequence conflicti535A → E in AAA28420 (PubMed:8434015).Curated1
Sequence conflicti646 – 647YP → FPEA in AAA28405 (PubMed:8094559).Curated2
Sequence conflicti646 – 647YP → FPEA in AAA28420 (PubMed:8434015).Curated2
Sequence conflicti698T → I in AAA28405 (PubMed:8094559).Curated1
Sequence conflicti702L → V in AAA28405 (PubMed:8094559).Curated1
Sequence conflicti720E → D in AAA28405 (PubMed:8094559).Curated1
Sequence conflicti784A → P in AAA28405 (PubMed:8094559).Curated1
Sequence conflicti784A → P in AAA28420 (PubMed:8434015).Curated1

<p>This subsection of the ‘Sequence’ section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingi

Edited at position 402.2 Publications
Partially edited. Target of Adar.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti402S → G in RNA edited version. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013780644 – 665Missing in isoform A. CuratedAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L02111 mRNA Translation: AAA28405.1
L05080 Genomic DNA Translation: AAA28420.1
AE014297 Genomic DNA Translation: AAF54754.1
AE014297 Genomic DNA Translation: AAF54755.1
AY058315 mRNA Translation: AAL13544.1
BT046129 mRNA Translation: ACI46517.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A47282
A47283

NCBI Reference Sequences

More...
RefSeqi
NP_731673.1, NM_169454.2 [Q02910-2]
NP_731674.1, NM_169455.2 [Q02910-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dm.5234

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0082547; FBpp0082020; FBgn0261714 [Q02910-2]
FBtr0082548; FBpp0082021; FBgn0261714 [Q02910-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41474

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4795

Keywords - Coding sequence diversityi

Alternative splicing, RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02111 mRNA Translation: AAA28405.1
L05080 Genomic DNA Translation: AAA28420.1
AE014297 Genomic DNA Translation: AAF54754.1
AE014297 Genomic DNA Translation: AAF54755.1
AY058315 mRNA Translation: AAL13544.1
BT046129 mRNA Translation: ACI46517.1
PIRiA47282
A47283
RefSeqiNP_731673.1, NM_169454.2 [Q02910-2]
NP_731674.1, NM_169455.2 [Q02910-1]
UniGeneiDm.5234

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

BioGridi66588, 26 interactors
IntActiQ02910, 3 interactors
STRINGi7227.FBpp0082021

Proteomic databases

PaxDbiQ02910
PRIDEiQ02910

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082547; FBpp0082020; FBgn0261714 [Q02910-2]
FBtr0082548; FBpp0082021; FBgn0261714 [Q02910-1]
GeneIDi41474
KEGGidme:Dmel_CG4795

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41474
FlyBaseiFBgn0261714 Cpn

Phylogenomic databases

InParanoidiQ02910
OMAiNAQPYDP
OrthoDBiEOG091G0PBL
PhylomeDBiQ02910

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41474

Protein Ontology

More...
PROi
PR:Q02910

Gene expression databases

BgeeiFBgn0261714 Expressed in 13 organ(s), highest expression level in head
GenevisibleiQ02910 DM

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCPN_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02910
Secondary accession number(s): B5X510
, Q95U45, Q9VGC8, Q9VGC9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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