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Entry version 150 (13 Feb 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Alkaline ceramidase YDC1

Gene

YDC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conversion of dihydroceramide and also phytoceramide to dihydrosphingosine or phytosphingosine. Prefers dihydroceramide. Very low reverse hydrolysis activity, catalyzing synthesis of dihydroceramide from fatty acid and dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide. May play a role in heat stress response.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • dihydroceramidase activity Source: SGD
  • phytoceramidase activity Source: GO_Central

GO - Biological processi

  • ceramide biosynthetic process Source: SGD
  • ceramide catabolic process Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:YPL087W-MONOMER
YEAST:YPL087W-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-1660661 Sphingolipid de novo biosynthesis

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000929

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alkaline ceramidase YDC1 (EC:3.5.1.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YDC1
Ordered Locus Names:YPL087W
ORF Names:LPG21W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YPL087W

Saccharomyces Genome Database

More...
SGDi
S000006008 YDC1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 42LumenalSequence analysisAdd BLAST42
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei43 – 60HelicalSequence analysisAdd BLAST18
Topological domaini61 – 66CytoplasmicSequence analysis6
Transmembranei67 – 89HelicalSequence analysisAdd BLAST23
Topological domaini90 – 98LumenalSequence analysis9
Transmembranei99 – 121HelicalSequence analysisAdd BLAST23
Topological domaini122 – 133CytoplasmicSequence analysisAdd BLAST12
Transmembranei134 – 156HelicalSequence analysisAdd BLAST23
Topological domaini157 – 159LumenalSequence analysis3
Transmembranei160 – 182HelicalSequence analysisAdd BLAST23
Topological domaini183 – 202CytoplasmicSequence analysisAdd BLAST20
Transmembranei203 – 225HelicalSequence analysisAdd BLAST23
Topological domaini226 – 239LumenalSequence analysisAdd BLAST14
Transmembranei240 – 262HelicalSequence analysisAdd BLAST23
Topological domaini263 – 317CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002124651 – 317Alkaline ceramidase YDC1Add BLAST317

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q02896

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q02896

PRoteomics IDEntifications database

More...
PRIDEi
Q02896

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
36094, 70 interactors

Database of interacting proteins

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DIPi
DIP-7600N

Protein interaction database and analysis system

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IntActi
Q02896, 10 interactors

Molecular INTeraction database

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MINTi
Q02896

STRING: functional protein association networks

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STRINGi
4932.YPL087W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q02896

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alkaline ceramidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00730000110920

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000192011

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q02896

KEGG Orthology (KO)

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KOi
K04711

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHETAYG

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008901 Ceramidase

The PANTHER Classification System

More...
PANTHERi
PTHR12956 PTHR12956, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05875 Ceramidase, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q02896-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFSWPYPEA PIEGYWGKPT SLIDWCEENY VVSPYIAEWS NTITNSIFLM
60 70 80 90 100
TAFYSTYSAW RNKLETRYIL IGMGFSLVGI GSWLFHMTLQ YRYQLLDELP
110 120 130 140 150
MLYATIIPSW SIFAETQEIL IKDEKKRKES SFRIQMVISF IMCGIVTILT
160 170 180 190 200
WIYVVVQKPA IFQVLYGILT LLVVVLSGWL TYYHVHDSFA KKNLFITMVM
210 220 230 240 250
GMIPFVIGFI CWQLDIHLCS FWIYIRRTYL ALPLGVLLEL HAWWHLLTGT
260 270 280 290 300
GVYIFVVYLQ YLRILTHGNP NDFLFIWRWG FFPELVRKGL PIGTSYSLEY
310
LGPIVNTQVD DETKKNN
Length:317
Mass (Da):37,231
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57872056DEBE4B69
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF214455 Genomic DNA Translation: AAG22594.1
U43281 Genomic DNA Translation: AAB68212.1
AY693224 Genomic DNA Translation: AAT93243.1
BK006949 Genomic DNA Translation: DAA11346.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S61979

NCBI Reference Sequences

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RefSeqi
NP_015238.1, NM_001183901.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPL087W_mRNA; YPL087W_mRNA; YPL087W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856018

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPL087W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214455 Genomic DNA Translation: AAG22594.1
U43281 Genomic DNA Translation: AAB68212.1
AY693224 Genomic DNA Translation: AAT93243.1
BK006949 Genomic DNA Translation: DAA11346.1
PIRiS61979
RefSeqiNP_015238.1, NM_001183901.1

3D structure databases

ProteinModelPortaliQ02896
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36094, 70 interactors
DIPiDIP-7600N
IntActiQ02896, 10 interactors
MINTiQ02896
STRINGi4932.YPL087W

Chemistry databases

SwissLipidsiSLP:000000929

Proteomic databases

MaxQBiQ02896
PaxDbiQ02896
PRIDEiQ02896

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
856018
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL087W_mRNA; YPL087W_mRNA; YPL087W
GeneIDi856018
KEGGisce:YPL087W

Organism-specific databases

EuPathDBiFungiDB:YPL087W
SGDiS000006008 YDC1

Phylogenomic databases

GeneTreeiENSGT00730000110920
HOGENOMiHOG000192011
InParanoidiQ02896
KOiK04711
OMAiFHETAYG

Enzyme and pathway databases

BioCyciMetaCyc:YPL087W-MONOMER
YEAST:YPL087W-MONOMER
ReactomeiR-SCE-1660661 Sphingolipid de novo biosynthesis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q02896

Family and domain databases

InterProiView protein in InterPro
IPR008901 Ceramidase
PANTHERiPTHR12956 PTHR12956, 1 hit
PfamiView protein in Pfam
PF05875 Ceramidase, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYDC1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02896
Secondary accession number(s): D6W3T0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1996
Last modified: February 13, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
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