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UniProtKB - Q02883 (FMP30_YEAST)
Protein
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, mitochondrial
Gene
FMP30
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs).
1 PublicationMiscellaneous
Present with 178 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H+EC:3.1.4.54
Cofactori
Zn2+By similarityNote: Binds 1 or 2 zinc ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 265 | Zinc 1Sequence analysis | 1 | |
Metal bindingi | 267 | Zinc 1Sequence analysis | 1 | |
Metal bindingi | 269 | Zinc 2Sequence analysis | 1 | |
Metal bindingi | 270 | Zinc 2Sequence analysis | 1 | |
Metal bindingi | 332 | Zinc 1Sequence analysis | 1 | |
Metal bindingi | 425 | Zinc 2Sequence analysis | 1 |
GO - Molecular functioni
- N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity Source: UniProtKB-EC
- N-acylphosphatidylethanolamine-specific phospholipase D activity Source: SGD
- zinc ion binding Source: InterPro
GO - Biological processi
- N-acylethanolamine metabolic process Source: SGD
- N-acylphosphatidylethanolamine metabolic process Source: SGD
- phospholipid catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism, Phospholipid degradation, Phospholipid metabolism |
Ligand | Metal-binding, Zinc |
Chemistry databases
SwissLipidsi | SLP:000000081 |
Names & Taxonomyi
Protein namesi | Recommended name: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, mitochondrial (EC:3.1.4.54)Short name: NAPE-PLD Short name: NAPE-hydrolyzing phospholipase D Alternative name(s): Found in mitochondrial proteome protein 30 |
Gene namesi | Name:FMP30 Ordered Locus Names:YPL103C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000006024, FMP30 |
VEuPathDBi | FungiDB:YPL103C |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane Curated; Single-pass membrane protein Curated
Mitochondrion
- integral component of mitochondrial inner membrane Source: SGD
- mitochondrion Source: SGD
Other locations
- cytoplasm Source: GO_Central
- membrane-bounded organelle Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 54 – 76 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Membrane, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 39 | MitochondrionSequence analysisAdd BLAST | 39 | |
ChainiPRO_0000238633 | 40 – 468 | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, mitochondrialAdd BLAST | 429 |
Proteomic databases
MaxQBi | Q02883 |
PaxDbi | Q02883 |
PRIDEi | Q02883 |
Expressioni
Inductioni
Expressed periodically during the glycolytic and respiratory oscillations cycles.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 36078, 141 interactors |
STRINGi | 4932.YPL103C |
Miscellaneous databases
RNActi | Q02883, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the NAPE-PLD family.Curated
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3798, Eukaryota |
GeneTreei | ENSGT00940000173847 |
HOGENOMi | CLU_020884_2_1_1 |
InParanoidi | Q02883 |
OMAi | CTPAMHW |
Family and domain databases
Gene3Di | 3.60.15.10, 1 hit |
InterProi | View protein in InterPro IPR001279, Metallo-B-lactamas IPR024884, NAPE-PLD IPR036866, RibonucZ/Hydroxyglut_hydro |
Pfami | View protein in Pfam PF12706, Lactamase_B_2, 1 hit |
PIRSFi | PIRSF038896, NAPE-PLD, 1 hit |
SUPFAMi | SSF56281, SSF56281, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q02883-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNFVTCHVQM RLLLQRRLVR LRESELFRPQ TSLSTFKRHA SQKTRPIQKC
60 70 80 90 100
SRKYARILLL SVLVPYTGYA FYVSLATVKQ IDLRNEMCQR LEENNNEVTY
110 120 130 140 150
KGSLLKYSPL EVLGRFENPF EEYRIQTVFE FFANRVFELF ERNRGGIPRD
160 170 180 190 200
VHQMNKLMPV HKPTWGPNLV DVDPAEETAL PLECKVLDEL HIPTAVEENE
210 220 230 240 250
GSKCPVYNTW LGQSCNYTVY NGLRILTDPL FSDFLIHKTL GPKRITQMPS
260 270 280 290 300
QITEVPKPDI ILVSHNHPDH LDLESLEYWS GKDSPLWIVP KGMKSYMTSN
310 320 330 340 350
GCDNVLELSW WETLQVKKNN EIYHISATPA MHWSGRSLLD TNKSLWCSFL
360 370 380 390 400
LTHHGNPILF HAGDTGYVKD LFVRIKERFG KGCKLALLPC GQYCPEWHQK
410 420 430 440 450
PRHINPQEVL KIMKDLEARN VLGVHWGTFV LSGEYFLEPK EKLEMLAEWG
460
GFKDRCYCPE LGKTECFD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U43281 Genomic DNA Translation: AAB68197.1 BK006949 Genomic DNA Translation: DAA11330.1 |
PIRi | S61964 |
RefSeqi | NP_015222.1, NM_001183917.1 |
Genome annotation databases
EnsemblFungii | YPL103C_mRNA; YPL103C; YPL103C |
GeneIDi | 856001 |
KEGGi | sce:YPL103C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U43281 Genomic DNA Translation: AAB68197.1 BK006949 Genomic DNA Translation: DAA11330.1 |
PIRi | S61964 |
RefSeqi | NP_015222.1, NM_001183917.1 |
3D structure databases
SMRi | Q02883 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36078, 141 interactors |
STRINGi | 4932.YPL103C |
Chemistry databases
SwissLipidsi | SLP:000000081 |
Proteomic databases
MaxQBi | Q02883 |
PaxDbi | Q02883 |
PRIDEi | Q02883 |
Protocols and materials databases
DNASUi | 856001 |
Genome annotation databases
EnsemblFungii | YPL103C_mRNA; YPL103C; YPL103C |
GeneIDi | 856001 |
KEGGi | sce:YPL103C |
Organism-specific databases
SGDi | S000006024, FMP30 |
VEuPathDBi | FungiDB:YPL103C |
Phylogenomic databases
eggNOGi | KOG3798, Eukaryota |
GeneTreei | ENSGT00940000173847 |
HOGENOMi | CLU_020884_2_1_1 |
InParanoidi | Q02883 |
OMAi | CTPAMHW |
Miscellaneous databases
PROi | PR:Q02883 |
RNActi | Q02883, protein |
Family and domain databases
Gene3Di | 3.60.15.10, 1 hit |
InterProi | View protein in InterPro IPR001279, Metallo-B-lactamas IPR024884, NAPE-PLD IPR036866, RibonucZ/Hydroxyglut_hydro |
Pfami | View protein in Pfam PF12706, Lactamase_B_2, 1 hit |
PIRSFi | PIRSF038896, NAPE-PLD, 1 hit |
SUPFAMi | SSF56281, SSF56281, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FMP30_YEAST | |
Accessioni | Q02883Primary (citable) accession number: Q02883 Secondary accession number(s): D6W3R4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - SIMILARITY comments
Index of protein domains and families