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Entry version 209 (16 Oct 2019)
Sequence version 3 (23 Jan 2007)
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Protein

60S ribosomal protein L6

Gene

RPL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the large ribosomal subunit.1 Publication3 Publications
(Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L6
Alternative name(s):
Large ribosomal subunit protein eL61 Publication
Neoplasm-related protein C140
Tax-responsive enhancer element-binding protein 107
Short name:
TaxREB107
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPL6
Synonyms:TXREB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10362 RPL6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603703 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q02878

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6128

Open Targets

More...
OpenTargetsi
ENSG00000089009

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34758

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q02878

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPL6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001710092 – 28860S ribosomal protein L6Add BLAST287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei94N6-succinyllysineBy similarity1
Modified residuei127PhosphoserineCombined sources1
Modified residuei207N6-succinyllysineBy similarity1
Modified residuei239N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q02878

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q02878

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q02878

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q02878

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q02878

PeptideAtlas

More...
PeptideAtlasi
Q02878

PRoteomics IDEntifications database

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PRIDEi
Q02878

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58132

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q02878

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
Q02878

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q02878

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q02878

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q02878

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000089009 Expressed in 93 organ(s), highest expression level in pituitary gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q02878 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q02878 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA060903
HPA068418

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). May bind IPO9 with low affinity (By similarity).

By similarity1 Publication3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112048, 322 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q02878

Database of interacting proteins

More...
DIPi
DIP-27547N

Protein interaction database and analysis system

More...
IntActi
Q02878, 108 interactors

Molecular INTeraction database

More...
MINTi
Q02878

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000403172

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1694 Eukaryota
COG2163 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003682

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q02878

KEGG Orthology (KO)

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KOi
K02934

Identification of Orthologs from Complete Genome Data

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OMAi
KKHGSRN

Database of Orthologous Groups

More...
OrthoDBi
1227453at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q02878

TreeFam database of animal gene trees

More...
TreeFami
TF300115

Family and domain databases

Conserved Domains Database

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CDDi
cd13156 KOW_RPL6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.30.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000915 60S_ribosomal_L6E
IPR041997 KOW_RPL6
IPR014722 Rib_L2_dom2
IPR005568 Ribosomal_L6_N
IPR008991 Translation_prot_SH3-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10715 PTHR10715, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01159 Ribosomal_L6e, 1 hit
PF03868 Ribosomal_L6e_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50104 SSF50104, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01170 RIBOSOMAL_L6E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q02878-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGEKVEKPD TKEKKPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL
60 70 80 90 100
VRGIGRYSRS AMYSRKAMYK RKYSAAKSKV EKKKKEKVLA TVTKPVGGDK
110 120 130 140 150
NGGTRVVKLR KMPRYYPTED VPRKLLSHGK KPFSQHVRKL RASITPGTIL
160 170 180 190 200
IILTGRHRGK RVVFLKQLAS GLLLVTGPLV LNRVPLRRTH QKFVIATSTK
210 220 230 240 250
IDISNVKIPK HLTDAYFKKK KLRKPRHQEG EIFDTEKEKY EITEQRKIDQ
260 270 280
KAVDSQILPK IKAIPQLQGY LRSVFALTNG IYPHKLVF
Length:288
Mass (Da):32,728
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD24A6168C7D0ECBF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43 – 63HCSRN…RSAMY → PLQPQPCPSQRNWQVFPICH V in CAA49188 (PubMed:8479925).CuratedAdd BLAST21
Sequence conflicti177 – 183GPLVLNR → DLWSSIE in CAA49188 (PubMed:8479925).Curated7
Sequence conflicti181 – 205LNRVP…IDISN → SIEFLYEEHTRNLSLPLQPK SISAI in AAB30819 (PubMed:8185817).CuratedAdd BLAST25
Sequence conflicti252 – 268AVDSQ…IPQLQ → LWTHKFYQKSKLFLSSS in CAA49188 (PubMed:8479925).CuratedAdd BLAST17

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036437100K → Q in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_025313227H → R1 PublicationCorresponds to variant dbSNP:rs17851813Ensembl.1
Natural variantiVAR_051810237K → E. Corresponds to variant dbSNP:rs16942044Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X69391 mRNA Translation: CAA49188.1
D17554 mRNA Translation: BAA04491.1
AB042820 Genomic DNA Translation: BAB17292.1
BC004138 mRNA Translation: AAH04138.1
BC020679 mRNA Translation: AAH20679.1
BC032299 mRNA Translation: AAH32299.1
BC071912 mRNA Translation: AAH71912.1
BC104824 mRNA Translation: AAI04825.1
BC104826 mRNA Translation: AAI04827.1
S71022 mRNA Translation: AAB30819.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9162.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I51803
S33714

NCBI Reference Sequences

More...
RefSeqi
NP_000961.2, NM_000970.4
NP_001019833.1, NM_001024662.2
NP_001307066.1, NM_001320137.1
NP_001307067.1, NM_001320138.1
NP_001307068.1, NM_001320139.1
NP_001307069.1, NM_001320140.1
NP_001307070.1, NM_001320141.1
XP_016875270.1, XM_017019781.1
XP_016875271.1, XM_017019782.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6128

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6128

UCSC genome browser

More...
UCSCi
uc001ttu.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69391 mRNA Translation: CAA49188.1
D17554 mRNA Translation: BAA04491.1
AB042820 Genomic DNA Translation: BAB17292.1
BC004138 mRNA Translation: AAH04138.1
BC020679 mRNA Translation: AAH20679.1
BC032299 mRNA Translation: AAH32299.1
BC071912 mRNA Translation: AAH71912.1
BC104824 mRNA Translation: AAI04825.1
BC104826 mRNA Translation: AAI04827.1
S71022 mRNA Translation: AAB30819.1
CCDSiCCDS9162.1
PIRiI51803
S33714
RefSeqiNP_000961.2, NM_000970.4
NP_001019833.1, NM_001024662.2
NP_001307066.1, NM_001320137.1
NP_001307067.1, NM_001320138.1
NP_001307068.1, NM_001320139.1
NP_001307069.1, NM_001320140.1
NP_001307070.1, NM_001320141.1
XP_016875270.1, XM_017019781.1
XP_016875271.1, XM_017019782.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LE1-288[»]
4V6Xelectron microscopy5.00CE1-288[»]
5AJ0electron microscopy3.50AE1-288[»]
5LKSelectron microscopy3.60LE1-288[»]
5T2Celectron microscopy3.60H1-288[»]
6EK0electron microscopy2.90LE1-288[»]
6IP5electron microscopy3.901H1-288[»]
6IP6electron microscopy4.501H1-288[»]
6IP8electron microscopy3.901H1-288[»]
6OLEelectron microscopy3.10G42-288[»]
6OLFelectron microscopy3.90G42-288[»]
6OLGelectron microscopy3.40AE95-288[»]
6OLIelectron microscopy3.50G42-288[»]
6OLZelectron microscopy3.90AE42-288[»]
6OM0electron microscopy3.10G42-288[»]
6OM7electron microscopy3.70G42-288[»]
6QZPelectron microscopy2.90LE42-288[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112048, 322 interactors
CORUMiQ02878
DIPiDIP-27547N
IntActiQ02878, 108 interactors
MINTiQ02878
STRINGi9606.ENSP00000403172

PTM databases

iPTMnetiQ02878
PhosphoSitePlusiQ02878
SwissPalmiQ02878

Polymorphism and mutation databases

BioMutaiRPL6

2D gel databases

SWISS-2DPAGEiQ02878

Proteomic databases

EPDiQ02878
jPOSTiQ02878
MassIVEiQ02878
MaxQBiQ02878
PaxDbiQ02878
PeptideAtlasiQ02878
PRIDEiQ02878
ProteomicsDBi58132
TopDownProteomicsiQ02878

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6128

Genome annotation databases

GeneIDi6128
KEGGihsa:6128
UCSCiuc001ttu.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6128
DisGeNETi6128

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RPL6
HGNCiHGNC:10362 RPL6
HPAiHPA060903
HPA068418
MIMi603703 gene
neXtProtiNX_Q02878
OpenTargetsiENSG00000089009
PharmGKBiPA34758

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1694 Eukaryota
COG2163 LUCA
GeneTreeiENSGT00390000003682
InParanoidiQ02878
KOiK02934
OMAiKKHGSRN
OrthoDBi1227453at2759
PhylomeDBiQ02878
TreeFamiTF300115

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPL6 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RPL6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6128
PharosiQ02878

Protein Ontology

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PROi
PR:Q02878

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000089009 Expressed in 93 organ(s), highest expression level in pituitary gland
ExpressionAtlasiQ02878 baseline and differential
GenevisibleiQ02878 HS

Family and domain databases

CDDicd13156 KOW_RPL6, 1 hit
Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR000915 60S_ribosomal_L6E
IPR041997 KOW_RPL6
IPR014722 Rib_L2_dom2
IPR005568 Ribosomal_L6_N
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR10715 PTHR10715, 1 hit
PfamiView protein in Pfam
PF01159 Ribosomal_L6e, 1 hit
PF03868 Ribosomal_L6e_N, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
PROSITEiView protein in PROSITE
PS01170 RIBOSOMAL_L6E, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02878
Secondary accession number(s): Q2M3Q3, Q8WW97
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 209 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Ribosomal proteins
    Ribosomal proteins families and list of entries
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