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Protein

60S ribosomal protein L6

Gene

RPL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.1 Publication3 Publications
(Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378).1 Publication

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • DNA binding Source: ProtInc
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • cytoplasmic translation Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • regulation of transcription, DNA-templated Source: ProtInc
  • ribosomal large subunit assembly Source: GO_Central
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: ProtInc
  • translational initiation Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L6
Alternative name(s):
Large ribosomal subunit protein eL61 Publication
Neoplasm-related protein C140
Tax-responsive enhancer element-binding protein 107
Short name:
TaxREB107
Gene namesi
Name:RPL6
Synonyms:TXREB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000089009.15
HGNCiHGNC:10362 RPL6
MIMi603703 gene
neXtProtiNX_Q02878

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi6128
OpenTargetsiENSG00000089009
PharmGKBiPA34758

Polymorphism and mutation databases

BioMutaiRPL6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001710092 – 28860S ribosomal protein L6Add BLAST287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei94N6-succinyllysineBy similarity1
Modified residuei127PhosphoserineCombined sources1
Modified residuei207N6-succinyllysineBy similarity1
Modified residuei239N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ02878
MaxQBiQ02878
PaxDbiQ02878
PeptideAtlasiQ02878
PRIDEiQ02878
ProteomicsDBi58132
TopDownProteomicsiQ02878

2D gel databases

SWISS-2DPAGEiQ02878

PTM databases

iPTMnetiQ02878
PhosphoSitePlusiQ02878
SwissPalmiQ02878

Expressioni

Gene expression databases

BgeeiENSG00000089009
CleanExiHS_RPL6
ExpressionAtlasiQ02878 baseline and differential
GenevisibleiQ02878 HS

Organism-specific databases

HPAiHPA060903
HPA068418

Interactioni

Subunit structurei

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). May bind IPO9 with low affinity (By similarity).By similarity1 Publication3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112048, 285 interactors
CORUMiQ02878
DIPiDIP-27547N
IntActiQ02878, 54 interactors
MINTiQ02878
STRINGi9606.ENSP00000202773

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LE1-288[»]
4V6Xelectron microscopy5.00CE1-288[»]
5AJ0electron microscopy3.50AE1-288[»]
5LKSelectron microscopy3.60LE1-288[»]
5T2Celectron microscopy3.60H1-288[»]
6EK0electron microscopy2.90LE1-288[»]
ProteinModelPortaliQ02878
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1694 Eukaryota
COG2163 LUCA
GeneTreeiENSGT00390000003682
HOVERGENiHBG002565
InParanoidiQ02878
KOiK02934
OMAiRKGDKPH
OrthoDBiEOG091G0L13
PhylomeDBiQ02878
TreeFamiTF300115

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR000915 60S_ribosomal_L6E
IPR014722 Rib_L2_dom2
IPR005568 Ribosomal_L6_N
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR10715 PTHR10715, 2 hits
PfamiView protein in Pfam
PF01159 Ribosomal_L6e, 1 hit
PF03868 Ribosomal_L6e_N, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
PROSITEiView protein in PROSITE
PS01170 RIBOSOMAL_L6E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02878-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEKVEKPD TKEKKPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL
60 70 80 90 100
VRGIGRYSRS AMYSRKAMYK RKYSAAKSKV EKKKKEKVLA TVTKPVGGDK
110 120 130 140 150
NGGTRVVKLR KMPRYYPTED VPRKLLSHGK KPFSQHVRKL RASITPGTIL
160 170 180 190 200
IILTGRHRGK RVVFLKQLAS GLLLVTGPLV LNRVPLRRTH QKFVIATSTK
210 220 230 240 250
IDISNVKIPK HLTDAYFKKK KLRKPRHQEG EIFDTEKEKY EITEQRKIDQ
260 270 280
KAVDSQILPK IKAIPQLQGY LRSVFALTNG IYPHKLVF
Length:288
Mass (Da):32,728
Last modified:January 23, 2007 - v3
Checksum:iD24A6168C7D0ECBF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43 – 63HCSRN…RSAMY → PLQPQPCPSQRNWQVFPICH V in CAA49188 (PubMed:8479925).CuratedAdd BLAST21
Sequence conflicti177 – 183GPLVLNR → DLWSSIE in CAA49188 (PubMed:8479925).Curated7
Sequence conflicti181 – 205LNRVP…IDISN → SIEFLYEEHTRNLSLPLQPK SISAI in AAB30819 (PubMed:8185817).CuratedAdd BLAST25
Sequence conflicti252 – 268AVDSQ…IPQLQ → LWTHKFYQKSKLFLSSS in CAA49188 (PubMed:8479925).CuratedAdd BLAST17

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036437100K → Q in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_025313227H → R1 PublicationCorresponds to variant dbSNP:rs17851813Ensembl.1
Natural variantiVAR_051810237K → E. Corresponds to variant dbSNP:rs16942044Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69391 mRNA Translation: CAA49188.1
D17554 mRNA Translation: BAA04491.1
AB042820 Genomic DNA Translation: BAB17292.1
BC004138 mRNA Translation: AAH04138.1
BC020679 mRNA Translation: AAH20679.1
BC032299 mRNA Translation: AAH32299.1
BC071912 mRNA Translation: AAH71912.1
BC104824 mRNA Translation: AAI04825.1
BC104826 mRNA Translation: AAI04827.1
S71022 mRNA Translation: AAB30819.1
CCDSiCCDS9162.1
PIRiI51803
S33714
RefSeqiNP_000961.2, NM_000970.4
NP_001019833.1, NM_001024662.2
NP_001307066.1, NM_001320137.1
NP_001307067.1, NM_001320138.1
NP_001307068.1, NM_001320139.1
NP_001307069.1, NM_001320140.1
NP_001307070.1, NM_001320141.1
XP_016875270.1, XM_017019781.1
XP_016875271.1, XM_017019782.1
UniGeneiHs.528668
Hs.546283
Hs.744897

Genome annotation databases

EnsembliENST00000202773; ENSP00000202773; ENSG00000089009
ENST00000424576; ENSP00000403172; ENSG00000089009
GeneIDi6128
KEGGihsa:6128
UCSCiuc001ttu.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRL6_HUMAN
AccessioniPrimary (citable) accession number: Q02878
Secondary accession number(s): Q2M3Q3, Q8WW97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 195 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

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