UniProtKB - Q02858 (TIE2_MOUSE)
Angiopoietin-1 receptor
Tek
Functioni
Catalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation1 PublicationEC:2.7.10.1PROSITE-ProRule annotation1 Publication
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 853 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 962 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 828 – 836 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- growth factor binding Source: MGI
- identical protein binding Source: MGI
- protein tyrosine kinase activity Source: UniProtKB
- signaling receptor activity Source: MGI
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- angiogenesis Source: UniProtKB
- branching involved in blood vessel morphogenesis Source: DFLAT
- cell-cell adhesion Source: MGI
- cell-matrix adhesion Source: MGI
- endothelial cell proliferation Source: UniProtKB
- glomerulus vasculature development Source: MGI
- heart development Source: UniProtKB
- heart trabecula formation Source: UniProtKB
- hemopoiesis Source: MGI
- multicellular organism development Source: GO_Central
- negative regulation of angiogenesis Source: UniProtKB
- negative regulation of apoptotic process Source: MGI
- negative regulation of endothelial cell apoptotic process Source: UniProtKB
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of actin cytoskeleton reorganization Source: MGI
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of cell adhesion Source: MGI
- positive regulation of cytokine production involved in immune response Source: MGI
- positive regulation of endothelial cell migration Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of focal adhesion assembly Source: UniProtKB
- positive regulation of intracellular signal transduction Source: UniProtKB
- positive regulation of kinase activity Source: GO_Central
- positive regulation of MAPK cascade Source: GO_Central
- positive regulation of peptidyl-serine phosphorylation Source: MGI
- positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of protein import into nucleus Source: MGI
- positive regulation of protein kinase B signaling Source: UniProtKB
- positive regulation of protein phosphorylation Source: MGI
- positive regulation of vascular endothelial growth factor receptor signaling pathway Source: DFLAT
- protein autophosphorylation Source: UniProtKB
- regulation of angiogenesis Source: MGI
- regulation of cell migration Source: MGI
- regulation of endothelial cell proliferation Source: DFLAT
- regulation of establishment or maintenance of cell polarity Source: UniProtKB
- regulation of NIK/NF-kappaB signaling Source: MGI
- response to estrogen Source: MGI
- response to hypoxia Source: MGI
- response to retinoic acid Source: BHF-UCL
- sprouting angiogenesis Source: UniProtKB
- substrate adhesion-dependent cell spreading Source: UniProtKB
- Tie signaling pathway Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
- vasculogenesis Source: UniProtKB
Keywordsi
Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 3474 |
Reactomei | R-MMU-210993, Tie2 Signaling R-MMU-5673001, RAF/MAP kinase cascade |
Names & Taxonomyi
Protein namesi | Recommended name: Angiopoietin-1 receptor (EC:2.7.10.1)Alternative name(s): Endothelial tyrosine kinase HYK STK1 Tunica interna endothelial cell kinase Tyrosine kinase with Ig and EGF homology domains-2 Tyrosine-protein kinase receptor TEK Tyrosine-protein kinase receptor TIE-2 Short name: mTIE2 p140 TEK CD_antigen: CD202b |
Gene namesi | Name:Tek Synonyms:Hyk, Tie-2, Tie2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98664, Tek |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Plasma membrane
Extracellular region or secreted
- Secreted By similarity
Other locations
- Cell junction By similarity
- focal adhesion By similarity
Note: Recruited to cell-cell contacts in quiescent endothelial cells. Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted (By similarity).By similarity
Cytoskeleton
- centriolar satellite Source: MGI
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- apical plasma membrane Source: MGI
- basal plasma membrane Source: MGI
- basolateral plasma membrane Source: MGI
- integral component of plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- cell surface Source: MGI
- cell-cell junction Source: MGI
- focal adhesion Source: UniProtKB-SubCell
- integral component of membrane Source: MGI
- membrane raft Source: MGI
- microvillus Source: MGI
- perinuclear region of cytoplasm Source: MGI
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 746 | ExtracellularSequence analysisAdd BLAST | 724 | |
Transmembranei | 747 – 767 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 768 – 1122 | CytoplasmicSequence analysisAdd BLAST | 355 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, SecretedPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 853 | K → A: Loss of kinase activity. 2 Publications | 1 | |
Mutagenesisi | 1100 | Y → F: Reduced levels of autophosphorylation. Abolishes interaction with GRB2 and GRB7. Abolishes phosphorylation of GRB7 and PIK3R1. 3 Publications | 1 | |
Mutagenesisi | 1106 | Y → F: Reduced levels of autophosphorylation. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL5199 |
DrugCentrali | Q02858 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | By similarityAdd BLAST | 22 | |
ChainiPRO_0000024475 | 23 – 1122 | Angiopoietin-1 receptorAdd BLAST | 1100 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 102 | By similarity | ||
Glycosylationi | 140 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 158 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 211 ↔ 220 | By similarity | ||
Disulfide bondi | 224 ↔ 233 | By similarity | ||
Disulfide bondi | 227 ↔ 240 | By similarity | ||
Disulfide bondi | 242 ↔ 251 | By similarity | ||
Disulfide bondi | 255 ↔ 264 | By similarity | ||
Disulfide bondi | 268 ↔ 274 | By similarity | ||
Disulfide bondi | 280 ↔ 287 | By similarity | ||
Disulfide bondi | 289 ↔ 298 | By similarity | ||
Disulfide bondi | 302 ↔ 311 | By similarity | ||
Disulfide bondi | 315 ↔ 323 | By similarity | ||
Disulfide bondi | 317 ↔ 329 | By similarity | ||
Disulfide bondi | 331 ↔ 340 | By similarity | ||
Disulfide bondi | 370 ↔ 424 | By similarity | ||
Glycosylationi | 399 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 438 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 464 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 558 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 595 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 648 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 690 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 858 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 990 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1100 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 1106 | Phosphotyrosine; by autocatalysis1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | non-CPTAC-3433 |
jPOSTi | Q02858 |
MaxQBi | Q02858 |
PaxDbi | Q02858 |
PRIDEi | Q02858 |
PTM databases
GlyConnecti | 2128, 1 N-Linked glycan (1 site) |
GlyGeni | Q02858, 9 sites |
iPTMneti | Q02858 |
PhosphoSitePlusi | Q02858 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000006386, Expressed in brain blood vessel and 297 other tissues |
ExpressionAtlasi | Q02858, baseline and differential |
Genevisiblei | Q02858, MM |
Interactioni
Subunit structurei
Homodimer. Heterodimer with TIE1.
Interacts with ANGPT1, ANGPT2 and ANGPT4. At cell-cell contacts in quiescent cells, forms a signaling complex composed of ANGPT1 plus TEK molecules from two adjoining cells. In the absence of endothelial cell-cell contacts, interaction with ANGPT1 mediates contacts with the extracellular matrix.
Interacts (tyrosine phosphorylated) with TNIP2.
Interacts (tyrosine phosphorylated) with SHC1 (via SH2 domain) (By similarity).
Interacts with PTPRB; this promotes endothelial cell-cell adhesion.
Interacts with DOK2, GRB2, GRB7, GRB14, PIK3R1 and PTPN11/SHP2. Colocalizes with DOK2 at contacts with the extracellular matrix in migrating cells.
By similarity7 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- growth factor binding Source: MGI
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204107, 5 interactors |
IntActi | Q02858, 7 interactors |
MINTi | Q02858 |
STRINGi | 10090.ENSMUSP00000099862 |
Chemistry databases
BindingDBi | Q02858 |
Miscellaneous databases
RNActi | Q02858, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 123 | Ig-like C2-type 1Add BLAST | 80 | |
Domaini | 210 – 252 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 254 – 299 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 301 – 341 | EGF-like 3PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 350 – 440 | Ig-like C2-type 2Add BLAST | 91 | |
Domaini | 444 – 539 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 543 – 635 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 640 – 733 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 822 – 1094 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 273 |
Domaini
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000158840 |
InParanoidi | Q02858 |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 6 hits |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR018941, Tyr_kin_Tie2_Ig-like_dom-1_N IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF10430, Ig_Tie2_1, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00060, FN3, 3 hits SM00220, S_TKc, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 3 hits PS01186, EGF_2, 3 hits PS50026, EGF_3, 1 hit PS50853, FN3, 3 hits PS50835, IG_LIKE, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MDSLAGLVLC GVSLLLYGVV EGAMDLILIN SLPLVSDAET SLTCIASGWH
60 70 80 90 100
PHEPITIGRD FEALMNQHQD PLEVTQDVTR EWAKKVVWKR EKASKINGAY
110 120 130 140 150
FCEGRVRGQA IRIRTMKMRQ QASFLPATLT MTVDRGDNVN ISFKKVLIKE
160 170 180 190 200
EDAVIYKNGS FIHSVPRHEV PDILEVHLPH AQPQDAGVYS ARYIGGNLFT
210 220 230 240 250
SAFTRLIVRR CEAQKWGPDC SRPCTTCKNN GVCHEDTGEC ICPPGFMGRT
260 270 280 290 300
CEKACEPHTF GRTCKERCSG PEGCKSYVFC LPDPYGCSCA TGWRGLQCNE
310 320 330 340 350
ACPSGYYGPD CKLRCHCTNE EICDRFQGCL CSQGWQGLQC EKEGRPRMTP
360 370 380 390 400
QIEDLPDHIE VNSGKFNPIC KASGWPLPTS EEMTLVKPDG TVLQPNDFNY
410 420 430 440 450
TDRFSVAIFT VNRVLPPDSG VWVCSVNTVA GMVEKPFNIS VKVLPEPLHA
460 470 480 490 500
PNVIDTGHNF AIINISSEPY FGDGPIKSKK LFYKPVNQAW KYIEVTNEIF
510 520 530 540 550
TLNYLEPRTD YELCVQLARP GEGGEGHPGP VRRFTTASIG LPPPRGLSLL
560 570 580 590 600
PKSQTALNLT WQPIFTNSED EFYVEVERRS LQTTSDQQNI KVPGNLTSVL
610 620 630 640 650
LSNLVPREQY TVRARVNTKA QGEWSEELRA WTLSDILPPQ PENIKISNIT
660 670 680 690 700
DSTAMVSWTI VDGYSISSII IRYKVQGKNE DQHIDVKIKN ATVTQYQLKG
710 720 730 740 750
LEPETTYHVD IFAENNIGSS NPAFSHELRT LPHSPASADL GGGKMLLIAI
760 770 780 790 800
LGSAGMTCIT VLLAFLIMLQ LKRANVQRRM AQAFQNREEP AVQFNSGTLA
810 820 830 840 850
LNRKAKNNPD PTIYPVLDWN DIKFQDVIGE GNFGQVLKAR IKKDGLRMDA
860 870 880 890 900
AIKRMKEYAS KDDHRDFAGE LEVLCKLGHH PNIINLLGAC EHRGYLYLAI
910 920 930 940 950
EYAPHGNLLD FLRKSRVLET DPAFAIANST ASTLSSQQLL HFAADVARGM
960 970 980 990 1000
DYLSQKQFIH RDLAARNILV GENYIAKIAD FGLSRGQEVY VKKTMGRLPV
1010 1020 1030 1040 1050
RWMAIESLNY SVYTTNSDVW SYGVLLWEIV SLGGTPYCGM TCAELYEKLP
1060 1070 1080 1090 1100
QGYRLEKPLN CDDEVYDLMR QCWREKPYER PSFAQILVSL NRMLEERKTY
1110 1120
VNTTLYEKFT YAGIDCSAEE AA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1AWS8 | B1AWS8_MOUSE | Receptor protein-tyrosine kinase | Tek | 1,123 | Annotation score: | ||
Q80YS4 | Q80YS4_MOUSE | Receptor protein-tyrosine kinase | Tek | 1,072 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 161 – 171 | FIHSVPRHEVP → LHPLSAPGMKYL in BAA02883 (PubMed:1282811).CuratedAdd BLAST | 11 | |
Sequence conflicti | 538 | S → C in CAA47857 (PubMed:8386827).Curated | 1 | |
Sequence conflicti | 736 | A → G in CAA47857 (PubMed:8386827).Curated | 1 | |
Sequence conflicti | 736 | A → G in AAB28663 (PubMed:8217221).Curated | 1 | |
Sequence conflicti | 745 – 761 | MLLIA…TCITV → DATHSHPWVWNDFASPC in BAA02883 (PubMed:1282811).CuratedAdd BLAST | 17 | |
Sequence conflicti | 786 | N → NV in BAA02883 (PubMed:1282811).Curated | 1 | |
Sequence conflicti | 786 | N → NV no nucleotide entry (PubMed:8395828).Curated | 1 | |
Sequence conflicti | 913 | R → G in BAA02883 (PubMed:1282811).Curated | 1 | |
Sequence conflicti | 925 – 931 | AIANSTA → CHRQQYS in BAA02883 (PubMed:1282811).Curated | 7 | |
Sequence conflicti | 1117 | S → P in BAA02883 (PubMed:1282811).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71426 mRNA Translation: CAA50557.1 X67553 mRNA Translation: CAA47857.1 D13738 mRNA Translation: BAA02883.1 S67051 mRNA Translation: AAB28663.1 |
CCDSi | CCDS71421.1 |
PIRi | I54237 JH0771 JN0712 |
RefSeqi | NP_001277478.1, NM_001290549.1 |
Genome annotation databases
Ensembli | ENSMUST00000071168; ENSMUSP00000071162; ENSMUSG00000006386 |
GeneIDi | 21687 |
KEGGi | mmu:21687 |
UCSCi | uc008tsk.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71426 mRNA Translation: CAA50557.1 X67553 mRNA Translation: CAA47857.1 D13738 mRNA Translation: BAA02883.1 S67051 mRNA Translation: AAB28663.1 |
CCDSi | CCDS71421.1 |
PIRi | I54237 JH0771 JN0712 |
RefSeqi | NP_001277478.1, NM_001290549.1 |
3D structure databases
SMRi | Q02858 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204107, 5 interactors |
IntActi | Q02858, 7 interactors |
MINTi | Q02858 |
STRINGi | 10090.ENSMUSP00000099862 |
Chemistry databases
BindingDBi | Q02858 |
ChEMBLi | CHEMBL5199 |
DrugCentrali | Q02858 |
PTM databases
GlyConnecti | 2128, 1 N-Linked glycan (1 site) |
GlyGeni | Q02858, 9 sites |
iPTMneti | Q02858 |
PhosphoSitePlusi | Q02858 |
Proteomic databases
CPTACi | non-CPTAC-3433 |
jPOSTi | Q02858 |
MaxQBi | Q02858 |
PaxDbi | Q02858 |
PRIDEi | Q02858 |
Protocols and materials databases
Antibodypediai | 2050, 1359 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000071168; ENSMUSP00000071162; ENSMUSG00000006386 |
GeneIDi | 21687 |
KEGGi | mmu:21687 |
UCSCi | uc008tsk.2, mouse |
Organism-specific databases
CTDi | 7010 |
MGIi | MGI:98664, Tek |
Phylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000158840 |
InParanoidi | Q02858 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 3474 |
Reactomei | R-MMU-210993, Tie2 Signaling R-MMU-5673001, RAF/MAP kinase cascade |
Miscellaneous databases
BioGRID-ORCSi | 21687, 0 hits in 17 CRISPR screens |
PROi | PR:Q02858 |
RNActi | Q02858, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000006386, Expressed in brain blood vessel and 297 other tissues |
ExpressionAtlasi | Q02858, baseline and differential |
Genevisiblei | Q02858, MM |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 6 hits |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR018941, Tyr_kin_Tie2_Ig-like_dom-1_N IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF10430, Ig_Tie2_1, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00060, FN3, 3 hits SM00220, S_TKc, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 3 hits PS01186, EGF_2, 3 hits PS50026, EGF_3, 1 hit PS50853, FN3, 3 hits PS50835, IG_LIKE, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TIE2_MOUSE | |
Accessioni | Q02858Primary (citable) accession number: Q02858 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 199 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index