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UniProtKB - Q02846 (GUC2D_HUMAN)

Entry version 219 (07 Apr 2021)
Sequence version 2 (01 Feb 1996)
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Protein

Retinal guanylyl cyclase 1

Gene

GUCY2D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:21928830, PubMed:30319355, PubMed:26100624, PubMed:9600905, PubMed:15123990). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity).By similarity5 Publications

Miscellaneous

The gene names for receptor guanylyl cyclases are inconsistent between mouse and human. The ortholog of the mouse Gucy2d gene is a pseudogene in humans.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by GUCA1A when free calcium ions concentration is low, and inhibited by GUCA1A when free calcium ions concentration is high (By similarity). Negatively regulated by RD3; inhibits the basal and GUCA1A-stimulated guanylate cyclase activity (PubMed:21928830).By similarity1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.31 mM for GTP (in absence of RD3)1 Publication
  2. KM=1.57 mM for GTP (in presence of 30 nM of RD3)1 Publication
  3. KM=0.94 mM for GTP (in presence of 60 nM of RD3)1 Publication
  1. Vmax=3.5 nmol/min/mg enzyme (in absence of RD3)1 Publication
  2. Vmax=1.4 nmol/min/mg enzyme (in presence of 30 nM of RD3)1 Publication
  3. Vmax=0.7 nmol/min/mg enzyme (in presence of 60 nM of RD3)1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processcGMP biosynthesis, Sensory transduction, Vision
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		4.6.1.2, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q02846

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2514859, Inactivation, recovery and regulation of the phototransduction cascade

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.85.1.3, the guanylate cyclase (gc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retinal guanylyl cyclase 1 (EC:4.6.1.26 Publications)
Short name:
RETGC-1
Alternative name(s):
CG-E1 Publication
Guanylate cyclase 2D, retinal
Rod outer segment membrane guanylate cyclase
Short name:
ROS-GC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GUCY2D
Synonyms:CORD6, GUC1A4, GUC2D1 Publication, RETGC, RETGC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4689, GUCY2D

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600179, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q02846

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000132518.6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini52 – 462ExtracellularSequence analysisAdd BLAST411
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei463 – 487HelicalSequence analysisAdd BLAST25
Topological domaini488 – 1103CytoplasmicSequence analysisAdd BLAST616

Keywords - Cellular componenti

Cell projection, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leber congenital amaurosis 1 (LCA1)9 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00343552A → S in LCA1; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs61749665EnsemblClinVar.1
Natural variantiVAR_06716955T → M in LCA1. 1 PublicationCorresponds to variant dbSNP:rs201414567EnsemblClinVar.1
Natural variantiVAR_067170103E → V in LCA1. 1 Publication1
Natural variantiVAR_023770105C → Y in LCA1; does not affect basal guanylate cyclase activity; reduces GUCA1A-induced guanylate cyclase activity. 2 PublicationsCorresponds to variant dbSNP:rs61749669EnsemblClinVar.1
Natural variantiVAR_067171312T → M in LCA1. 1 PublicationCorresponds to variant dbSNP:rs61749673EnsemblClinVar.1
Natural variantiVAR_023771325L → P in LCA1; does not affect basal guanylate cyclase activity; reduces GUCA1A-induced guanylate cyclase activity. 2 PublicationsCorresponds to variant dbSNP:rs61749675EnsemblClinVar.1
Natural variantiVAR_009129362A → S in LCA1. Corresponds to variant dbSNP:rs61749677EnsemblClinVar.1
Natural variantiVAR_067173405 – 406LD → PN in LCA1. 2
Natural variantiVAR_067174438R → C in LCA1. 1 PublicationCorresponds to variant dbSNP:rs565948960Ensembl.1
Natural variantiVAR_009131565F → S in LCA1; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs61749755EnsemblClinVar.1
Natural variantiVAR_009130573I → V in LCA1. Corresponds to variant dbSNP:rs61749756EnsemblClinVar.1
Natural variantiVAR_067175640W → L in LCA1. 1 Publication1
Natural variantiVAR_067176660R → Q in LCA1. 1 PublicationCorresponds to variant dbSNP:rs61750162EnsemblClinVar.1
Natural variantiVAR_082624710A → V in LCA1; loss of basal and GUCA1A-induced guanylate cyclase activity; does not affect endoplasmic reticulum membrane localization. 2 PublicationsCorresponds to variant dbSNP:rs781725943EnsemblClinVar.1
Natural variantiVAR_067177728D → H in LCA1. 1 Publication1
Natural variantiVAR_067178734I → A in LCA1; requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_067179768R → W in LCA1 and CSNB1I. 3 PublicationsCorresponds to variant dbSNP:rs61750168EnsemblClinVar.1
Natural variantiVAR_067180784M → R in LCA1. 1 PublicationCorresponds to variant dbSNP:rs375010731Ensembl.1
Natural variantiVAR_067181795R → Q in LCA1. 1 PublicationCorresponds to variant dbSNP:rs61750171EnsemblClinVar.1
Natural variantiVAR_009134858P → S in LCA1; severely impairs basal and GUCA1A-induced guanylate cyclase activity. 2 PublicationsCorresponds to variant dbSNP:rs61750176EnsemblClinVar.1
Natural variantiVAR_082628902V → L in LCA1; increases basal and GUCA1A-induced guanylate cyclase activity; inhibition by RD3 is less effective; does not affect endoplasmic reticulum membrane localization. 1 Publication1
Natural variantiVAR_009135954L → P in LCA1; severely impairs basal and GUCA1A induced guanylate cyclase. 2 PublicationsCorresponds to variant dbSNP:rs61750182EnsemblClinVar.1
Natural variantiVAR_0671821007S → L in LCA1. 1 Publication1
Natural variantiVAR_0671831027I → IGI in LCA1. 1
Cone-rod dystrophy 6 (CORD6)14 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_003438837 – 839ERT → DCM in CORD6. 1 Publication3
Natural variantiVAR_003436837E → D in CORD6. 1 PublicationCorresponds to variant dbSNP:rs28933695EnsemblClinVar.1
Natural variantiVAR_003437838R → C in CORD6. 4 PublicationsCorresponds to variant dbSNP:rs61750172EnsemblClinVar.1
Natural variantiVAR_071605838R → G in CORD6. 1 Publication1
Natural variantiVAR_015373838R → H in CORD6. 4 PublicationsCorresponds to variant dbSNP:rs61750173EnsemblClinVar.1
Natural variantiVAR_071606838R → P in CORD6. 1 Publication1
Natural variantiVAR_082625841E → K in CORD6; decreases basal and GUCA1A-induced guanylate cyclase activity; inhibition by RD3 is less effective; does not affect endoplasmic reticulum membrane localization. 2 Publications1
Natural variantiVAR_082626846K → N in CORD6; decreases basal and GUCA1A-induced guanylate cyclase activity; inhibition by RD3 is less effective; does not affect endoplasmic reticulum membrane localization. 2 Publications1
Natural variantiVAR_071607849T → A in CORD6. 1 Publication1
Natural variantiVAR_082627873P → R in CORD6; loss basal and GUCA1A-induced guanylate cyclase activity; does not affect endoplasmic reticulum membrane localization. 1 PublicationCorresponds to variant dbSNP:rs1567961680EnsemblClinVar.1
Natural variantiVAR_071608949I → T in CORD6. 1 PublicationCorresponds to variant dbSNP:rs267606857EnsemblClinVar.1
Choroidal dystrophy, central areolar, 1 (CACD1)1 Publication
The disease may be caused by variants affecting the gene represented in this entry.
Disease descriptionA form of central areolar choroidal dystrophy, a retinal disease that affects the macula and results in a well-demarcated circumscribed area of atrophy of the pigment epithelium and choriocapillaris. CACD1 inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080484933V → A in CACD1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1567961904EnsemblClinVar.1
Night blindness, congenital stationary, 1I (CSNB1I)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of congenital stationary night blindness, a non-progressive retinal disorder characterized by impaired night vision or in dim light, with good vision only on bright days. CSNB1I patients present with night blindness from infancy or early childhood. Visual acuity is preserved, but some patients have color vision and/or visual field defects. Progression to mild retinitis pigmentosa may occur. CSNB1I inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067179768R → W in LCA1 and CSNB1I. 3 PublicationsCorresponds to variant dbSNP:rs61750168EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi822R → P: Fails to become activated by GUCA1A and by GUCA1B. Does not affect the binding to RP3. 1 Publication1
Mutagenesisi823M → R: Fails to become activated by GUCA1A and by GUCA1B. Does not affect the binding to RP3. 1 Publication1
Mutagenesisi925E → K: Changes the substrate specificity from GTP to ATP. 1 Publication1
Mutagenesisi997C → D: Changes the substrate specificity from GTP to ATP. 1 Publication1

Keywords - Diseasei

Cone-rod dystrophy, Congenital stationary night blindness, Disease variant, Leber congenital amaurosis

Organism-specific databases

DisGeNET

More...DisGeNETi		3000

MalaCards human disease database

More...MalaCardsi		GUCY2D
MIMi204000, phenotype
215500, phenotype
300071, phenotype
601777, phenotype
618555, phenotype

Open Targets

More...OpenTargetsi		ENSG00000132518

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		75377, Central areolar choroidal dystrophy
1872, Cone rod dystrophy
65, Leber congenital amaurosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA187

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q02846, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GUCY2D

Domain mapping of disease mutations (DMDM)

More...DMDMi		1345920

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 51By similarityAdd BLAST51
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001238152 – 1103Retinal guanylyl cyclase 1Add BLAST1052

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi449InterchainCurated
Disulfide bondi457InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q02846

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q02846

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q02846

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q02846

PeptideAtlas

More...PeptideAtlasi		Q02846

PRoteomics IDEntifications database

More...PRIDEi		Q02846

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58131

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q02846, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q02846

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q02846

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Retina.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132518, Expressed in esophagus and 83 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q02846, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000132518, Group enriched (blood, retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; requires homodimerization for guanylyl cyclase activity (By similarity).

Interacts with RD3; promotes the exit of GUCY2D from the endoplasmic reticulum and its trafficking to the photoreceptor outer segments (PubMed:21928830, PubMed:21078983). Interaction with RD3 negatively regulates guanylate cyclase activity (PubMed:21928830).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109255, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q02846, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000254854

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q02846, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini525 – 808Protein kinasePROSITE-ProRule annotationAdd BLAST284
Domaini880 – 1010Guanylate cyclasePROSITE-ProRule annotationAdd BLAST131

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1023, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161326

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001072_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q02846

Identification of Orthologs from Complete Genome Data

More...OMAi		VSEHCTR

Database of Orthologous Groups

More...OrthoDBi		229634at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q02846

TreeFam database of animal gene trees

More...TreeFami		TF106338

Family and domain databases

Conserved Domains Database

More...CDDi		cd07302, CHD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.1230, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001054, A/G_cyclase
IPR018297, A/G_cyclase_CS
IPR001828, ANF_lig-bd_rcpt
IPR011645, HNOB_dom_associated
IPR011009, Kinase-like_dom_sf
IPR029787, Nucleotide_cyclase
IPR028082, Peripla_BP_I
IPR000719, Prot_kinase_dom
IPR001245, Ser-Thr/Tyr_kinase_cat_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01094, ANF_receptor, 1 hit
PF00211, Guanylate_cyc, 1 hit
PF07701, HNOBA, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00044, CYCc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53822, SSF53822, 1 hit
SSF55073, SSF55073, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00452, GUANYLATE_CYCLASE_1, 1 hit
PS50125, GUANYLATE_CYCLASE_2, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q02846-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTACARRAGG LPDPGLCGPA WWAPSLPRLP RALPRLPLLL LLLLLQPPAL 
        60         70         80         90        100
SAVFTVGVLG PWACDPIFSR ARPDLAARLA AARLNRDPGL AGGPRFEVAL 
       110        120        130        140        150
LPEPCRTPGS LGAVSSALAR VSGLVGPVNP AACRPAELLA EEAGIALVPW 
       160        170        180        190        200
GCPWTQAEGT TAPAVTPAAD ALYALLRAFG WARVALVTAP QDLWVEAGRS 
       210        220        230        240        250
LSTALRARGL PVASVTSMEP LDLSGAREAL RKVRDGPRVT AVIMVMHSVL 
       260        270        280        290        300
LGGEEQRYLL EAAEELGLTD GSLVFLPFDT IHYALSPGPE ALAALANSSQ 
       310        320        330        340        350
LRRAHDAVLT LTRHCPSEGS VLDSLRRAQE RRELPSDLNL QQVSPLFGTI 
       360        370        380        390        400
YDAVFLLARG VAEARAAAGG RWVSGAAVAR HIRDAQVPGF CGDLGGDEEP 
       410        420        430        440        450
PFVLLDTDAA GDRLFATYML DPARGSFLSA GTRMHFPRGG SAPGPDPSCW 
       460        470        480        490        500
FDPNNICGGG LEPGLVFLGF LLVVGMGLAG AFLAHYVRHR LLHMQMVSGP 
       510        520        530        540        550
NKIILTVDDI TFLHPHGGTS RKVAQGSRSS LGARSMSDIR SGPSQHLDSP 
       560        570        580        590        600
NIGVYEGDRV WLKKFPGDQH IAIRPATKTA FSKLQELRHE NVALYLGLFL 
       610        620        630        640        650
ARGAEGPAAL WEGNLAVVSE HCTRGSLQDL LAQREIKLDW MFKSSLLLDL 
       660        670        680        690        700
IKGIRYLHHR GVAHGRLKSR NCIVDGRFVL KITDHGHGRL LEAQKVLPEP 
       710        720        730        740        750
PRAEDQLWTA PELLRDPALE RRGTLAGDVF SLAIIMQEVV CRSAPYAMLE 
       760        770        780        790        800
LTPEEVVQRV RSPPPLCRPL VSMDQAPVEC ILLMKQCWAE QPELRPSMDH 
       810        820        830        840        850
TFDLFKNINK GRKTNIIDSM LRMLEQYSSN LEDLIRERTE ELELEKQKTD 
       860        870        880        890        900
RLLTQMLPPS VAEALKTGTP VEPEYFEQVT LYFSDIVGFT TISAMSEPIE 
       910        920        930        940        950
VVDLLNDLYT LFDAIIGSHD VYKVETIGDA YMVASGLPQR NGQRHAAEIA 
       960        970        980        990       1000
NMSLDILSAV GTFRMRHMPE VPVRIRIGLH SGPCVAGVVG LTMPRYCLFG 
      1010       1020       1030       1040       1050
DTVNTASRME STGLPYRIHV NLSTVGILRA LDSGYQVELR GRTELKGKGA 
      1060       1070       1080       1090       1100
EDTFWLVGRR GFNKPIPKPP DLQPGSSNHG ISLQEIPPER RRKLEKARPG 

QFS
Length:1,103
Mass (Da):120,059
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28631557E7CBDFA4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06716821W → R1 PublicationCorresponds to variant dbSNP:rs9905402EnsemblClinVar.1
Natural variantiVAR_00343552A → S in LCA1; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs61749665EnsemblClinVar.1
Natural variantiVAR_06716955T → M in LCA1. 1 PublicationCorresponds to variant dbSNP:rs201414567EnsemblClinVar.1
Natural variantiVAR_067170103E → V in LCA1. 1 Publication1
Natural variantiVAR_023770105C → Y in LCA1; does not affect basal guanylate cyclase activity; reduces GUCA1A-induced guanylate cyclase activity. 2 PublicationsCorresponds to variant dbSNP:rs61749669EnsemblClinVar.1
Natural variantiVAR_067171312T → M in LCA1. 1 PublicationCorresponds to variant dbSNP:rs61749673EnsemblClinVar.1
Natural variantiVAR_023771325L → P in LCA1; does not affect basal guanylate cyclase activity; reduces GUCA1A-induced guanylate cyclase activity. 2 PublicationsCorresponds to variant dbSNP:rs61749675EnsemblClinVar.1
Natural variantiVAR_067172325L → R Found in a patient with LCA1. 1 Publication1
Natural variantiVAR_042229328A → V1 PublicationCorresponds to variant dbSNP:rs56280231Ensembl.1
Natural variantiVAR_049254331R → S. Corresponds to variant dbSNP:rs34596269Ensembl.1
Natural variantiVAR_009129362A → S in LCA1. Corresponds to variant dbSNP:rs61749677EnsemblClinVar.1
Natural variantiVAR_067173405 – 406LD → PN in LCA1. 2
Natural variantiVAR_042230431G → D in a metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1451501407Ensembl.1
Natural variantiVAR_067174438R → C in LCA1. 1 PublicationCorresponds to variant dbSNP:rs565948960Ensembl.1
Natural variantiVAR_042231507V → M1 PublicationCorresponds to variant dbSNP:rs746002871Ensembl.1
Natural variantiVAR_009131565F → S in LCA1; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs61749755EnsemblClinVar.1
Natural variantiVAR_009130573I → V in LCA1. Corresponds to variant dbSNP:rs61749756EnsemblClinVar.1
Natural variantiVAR_049255602R → W. Corresponds to variant dbSNP:rs770740012Ensembl.1
Natural variantiVAR_067175640W → L in LCA1. 1 Publication1
Natural variantiVAR_067176660R → Q in LCA1. 1 PublicationCorresponds to variant dbSNP:rs61750162EnsemblClinVar.1
Natural variantiVAR_042232693A → E1 PublicationCorresponds to variant dbSNP:rs35146471Ensembl.1
Natural variantiVAR_009132701P → S At homozygosity may be associated with Leber congenital amaurosis in some populations. 3 PublicationsCorresponds to variant dbSNP:rs34598902EnsemblClinVar.1
Natural variantiVAR_082624710A → V in LCA1; loss of basal and GUCA1A-induced guanylate cyclase activity; does not affect endoplasmic reticulum membrane localization. 2 PublicationsCorresponds to variant dbSNP:rs781725943EnsemblClinVar.1
Natural variantiVAR_049256722R → W. Corresponds to variant dbSNP:rs34331388EnsemblClinVar.1
Natural variantiVAR_067177728D → H in LCA1. 1 Publication1
Natural variantiVAR_067178734I → A in LCA1; requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_067179768R → W in LCA1 and CSNB1I. 3 PublicationsCorresponds to variant dbSNP:rs61750168EnsemblClinVar.1
Natural variantiVAR_009133782L → H1 PublicationCorresponds to variant dbSNP:rs8069344EnsemblClinVar.1
Natural variantiVAR_067180784M → R in LCA1. 1 PublicationCorresponds to variant dbSNP:rs375010731Ensembl.1
Natural variantiVAR_067181795R → Q in LCA1. 1 PublicationCorresponds to variant dbSNP:rs61750171EnsemblClinVar.1
Natural variantiVAR_003438837 – 839ERT → DCM in CORD6. 1 Publication3
Natural variantiVAR_003436837E → D in CORD6. 1 PublicationCorresponds to variant dbSNP:rs28933695EnsemblClinVar.1
Natural variantiVAR_003437838R → C in CORD6. 4 PublicationsCorresponds to variant dbSNP:rs61750172EnsemblClinVar.1
Natural variantiVAR_071605838R → G in CORD6. 1 Publication1
Natural variantiVAR_015373838R → H in CORD6. 4 PublicationsCorresponds to variant dbSNP:rs61750173EnsemblClinVar.1
Natural variantiVAR_071606838R → P in CORD6. 1 Publication1
Natural variantiVAR_082625841E → K in CORD6; decreases basal and GUCA1A-induced guanylate cyclase activity; inhibition by RD3 is less effective; does not affect endoplasmic reticulum membrane localization. 2 Publications1
Natural variantiVAR_082626846K → N in CORD6; decreases basal and GUCA1A-induced guanylate cyclase activity; inhibition by RD3 is less effective; does not affect endoplasmic reticulum membrane localization. 2 Publications1
Natural variantiVAR_071607849T → A in CORD6. 1 Publication1
Natural variantiVAR_009134858P → S in LCA1; severely impairs basal and GUCA1A-induced guanylate cyclase activity. 2 PublicationsCorresponds to variant dbSNP:rs61750176EnsemblClinVar.1
Natural variantiVAR_082627873P → R in CORD6; loss basal and GUCA1A-induced guanylate cyclase activity; does not affect endoplasmic reticulum membrane localization. 1 PublicationCorresponds to variant dbSNP:rs1567961680EnsemblClinVar.1
Natural variantiVAR_082628902V → L in LCA1; increases basal and GUCA1A-induced guanylate cyclase activity; inhibition by RD3 is less effective; does not affect endoplasmic reticulum membrane localization. 1 Publication1
Natural variantiVAR_080484933V → A in CACD1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1567961904EnsemblClinVar.1
Natural variantiVAR_071608949I → T in CORD6. 1 PublicationCorresponds to variant dbSNP:rs267606857EnsemblClinVar.1
Natural variantiVAR_009135954L → P in LCA1; severely impairs basal and GUCA1A induced guanylate cyclase. 2 PublicationsCorresponds to variant dbSNP:rs61750182EnsemblClinVar.1
Natural variantiVAR_0671821007S → L in LCA1. 1 Publication1
Natural variantiVAR_0671831027I → IGI in LCA1. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M92432 mRNA Translation: AAA60547.1
AJ222657 Genomic DNA Translation: CAA10914.1
L26921 Genomic DNA Translation: AAA60366.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11127.1

Protein sequence database of the Protein Information Resource

More...PIRi		JH0717

NCBI Reference Sequences

More...RefSeqi		NP_000171.1, NM_000180.3
XP_011522118.1, XM_011523816.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000254854; ENSP00000254854; ENSG00000132518

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3000

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3000

UCSC genome browser

More...UCSCi		uc002gjt.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Mutations of the GUCY2D gene

Retina International's Scientific Newsletter

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92432 mRNA Translation: AAA60547.1
AJ222657 Genomic DNA Translation: CAA10914.1
L26921 Genomic DNA Translation: AAA60366.1
CCDSiCCDS11127.1
PIRiJH0717
RefSeqiNP_000171.1, NM_000180.3
XP_011522118.1, XM_011523816.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AWLmodel-A/B871-1028[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109255, 2 interactors
IntActiQ02846, 3 interactors
STRINGi9606.ENSP00000254854

Protein family/group databases

TCDBi8.A.85.1.3, the guanylate cyclase (gc) family

PTM databases

GlyGeniQ02846, 1 site
iPTMnetiQ02846
PhosphoSitePlusiQ02846

Genetic variation databases

BioMutaiGUCY2D
DMDMi1345920

Proteomic databases

jPOSTiQ02846
MassIVEiQ02846
MaxQBiQ02846
PaxDbiQ02846
PeptideAtlasiQ02846
PRIDEiQ02846
ProteomicsDBi58131

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12365, 249 antibodies

The DNASU plasmid repository

More...DNASUi		3000

Genome annotation databases

EnsembliENST00000254854; ENSP00000254854; ENSG00000132518
GeneIDi3000
KEGGihsa:3000
UCSCiuc002gjt.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3000
DisGeNETi3000

GeneCards: human genes, protein and diseases

More...GeneCardsi		GUCY2D
HGNCiHGNC:4689, GUCY2D
HPAiENSG00000132518, Group enriched (blood, retina)
MalaCardsiGUCY2D
MIMi204000, phenotype
215500, phenotype
300071, phenotype
600179, gene
601777, phenotype
618555, phenotype
neXtProtiNX_Q02846
OpenTargetsiENSG00000132518
Orphaneti75377, Central areolar choroidal dystrophy
1872, Cone rod dystrophy
65, Leber congenital amaurosis
PharmGKBiPA187
VEuPathDBiHostDB:ENSG00000132518.6

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1023, Eukaryota
GeneTreeiENSGT00940000161326
HOGENOMiCLU_001072_1_0_1
InParanoidiQ02846
OMAiVSEHCTR
OrthoDBi229634at2759
PhylomeDBiQ02846
TreeFamiTF106338

Enzyme and pathway databases

BRENDAi4.6.1.2, 2681
PathwayCommonsiQ02846
ReactomeiR-HSA-2514859, Inactivation, recovery and regulation of the phototransduction cascade

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3000, 6 hits in 1014 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3000
PharosiQ02846, Tbio

Protein Ontology

More...PROi		PR:Q02846
RNActiQ02846, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000132518, Expressed in esophagus and 83 other tissues
GenevisibleiQ02846, HS

Family and domain databases

CDDicd07302, CHD, 1 hit
Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054, A/G_cyclase
IPR018297, A/G_cyclase_CS
IPR001828, ANF_lig-bd_rcpt
IPR011645, HNOB_dom_associated
IPR011009, Kinase-like_dom_sf
IPR029787, Nucleotide_cyclase
IPR028082, Peripla_BP_I
IPR000719, Prot_kinase_dom
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF01094, ANF_receptor, 1 hit
PF00211, Guanylate_cyc, 1 hit
PF07701, HNOBA, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit
SMARTiView protein in SMART
SM00044, CYCc, 1 hit
SUPFAMiSSF53822, SSF53822, 1 hit
SSF55073, SSF55073, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00452, GUANYLATE_CYCLASE_1, 1 hit
PS50125, GUANYLATE_CYCLASE_2, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGUC2D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02846
Secondary accession number(s): Q6LEA7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1996
Last modified: April 7, 2021
This is version 219 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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