UniProtKB - Q02817 (MUC2_HUMAN)
Mucin-2
MUC2
Functioni
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
1 PublicationGO - Biological processi
- maintenance of gastrointestinal epithelium Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q02817 |
Reactomei | R-HSA-5083625, Defective GALNT3 causes HFTC R-HSA-5083632, Defective C1GALT1C1 causes TNPS R-HSA-5083636, Defective GALNT12 causes CRCS1 R-HSA-5621480, Dectin-2 family R-HSA-913709, O-linked glycosylation of mucins R-HSA-977068, Termination of O-glycan biosynthesis |
SignaLinki | Q02817 |
SIGNORi | Q02817 |
Protein family/group databases
MEROPSi | I08.951 |
Names & Taxonomyi
Protein namesi | Recommended name: Mucin-2Short name: MUC-2 Alternative name(s): Intestinal mucin-2 |
Gene namesi | Name:MUC2 Synonyms:SMUC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7512, MUC2 |
MIMi | 158370, gene |
neXtProti | NX_Q02817 |
Subcellular locationi
Extracellular region or secreted
Note: In the intestine, secreted into the inner and outer mucus layers.By similarity
Extracellular region or secreted
- extracellular space Source: GO_Central
- inner mucus layer Source: UniProtKB
- outer mucus layer Source: UniProtKB
Golgi apparatus
- Golgi lumen Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular matrix Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
PharmGKBi | PA31316 |
Miscellaneous databases
Pharosi | Q02817, Tdark |
Chemistry databases
DrugBanki | DB01411, Pranlukast |
Genetic variation databases
BioMutai | MUC2 |
DMDMi | 2506877 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000019281 | 21 – 5179 | Mucin-2Add BLAST | 5159 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | ? ↔ 5159 | By similarity | ||
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Disulfide bondi | 37 ↔ 169 | PROSITE-ProRule annotation | ||
Disulfide bondi | 59 ↔ 206 | PROSITE-ProRule annotation | ||
Glycosylationi | 163 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 391 ↔ 528 | PROSITE-ProRule annotation | ||
Disulfide bondi | 413 ↔ 563 | PROSITE-ProRule annotation | ||
Glycosylationi | 423 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 435 ↔ 443 | PROSITE-ProRule annotation | ||
Glycosylationi | 670 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 770 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 860 ↔ 992 | PROSITE-ProRule annotation | ||
Disulfide bondi | 882 ↔ 1027 | PROSITE-ProRule annotation | ||
Disulfide bondi | 891 ↔ 989 | PROSITE-ProRule annotation | ||
Glycosylationi | 894 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 909 ↔ 916 | PROSITE-ProRule annotation | ||
Glycosylationi | 1139 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1154 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1215 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1230 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1246 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1787 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1820 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 4339 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 4351 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 4362 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 4373 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 4422 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 4438 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 4481 ↔ 4622 | PROSITE-ProRule annotation | ||
Glycosylationi | 4502 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 4503 ↔ 4661 | PROSITE-ProRule annotation | ||
Disulfide bondi | 4527 ↔ 4535 | PROSITE-ProRule annotation | ||
Glycosylationi | 4616 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 4627 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 4752 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 4787 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 4881 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 4888 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 4955 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 4970 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 5019 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 5038 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 5069 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 5075 ↔ 5122 | By similarity | ||
Disulfide bondi | 5089 ↔ 5136 | By similarity | ||
Disulfide bondi | 5098 ↔ 5152 | By similarity | ||
Disulfide bondi | 5102 ↔ 5154 | By similarity |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 4486 – 4487 | Cleavage; by autolysis; in vitro | 2 |
Keywords - PTMi
Autocatalytic cleavage, Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
CPTACi | CPTAC-1497 |
EPDi | Q02817 |
jPOSTi | Q02817 |
MassIVEi | Q02817 |
PaxDbi | Q02817 |
PeptideAtlasi | Q02817 |
PRIDEi | Q02817 |
ProteomicsDBi | 58127 |
PTM databases
GlyConnecti | 1519, 2 N-Linked glycans (3 sites), 27 O-Linked glycans 373, 8 O-Linked glycans |
GlyGeni | Q02817, 32 sites, 2 N-linked glycans (3 sites), 51 O-linked glycans (1 site) |
iPTMneti | Q02817 |
PhosphoSitePlusi | Q02817 |
SwissPalmi | Q02817 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization.
Interacts with FCGBP.
Interacts with AGR2; disulfide-linked.
3 Publications(Microbial infection) Interacts in vitro with L.monocytogenes internalin proteins InlB, InlC and InlJ; for InlC binding is slightly better at pH 5.5, (the pH of the intestine) than at pH 7.4.
1 PublicationBinary interactionsi
Q02817
With | #Exp. | IntAct |
---|---|---|
AGR2 [O95994] | 2 | EBI-2105803,EBI-712648 |
Protein-protein interaction databases
BioGRIDi | 110670, 3 interactors |
DIPi | DIP-48824N |
IntActi | Q02817, 4 interactors |
Miscellaneous databases
RNActi | Q02817, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q02817 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 207 | VWFD 1PROSITE-ProRule annotationAdd BLAST | 173 | |
Domaini | 295 – 351 | TILAdd BLAST | 57 | |
Domaini | 389 – 564 | VWFD 2PROSITE-ProRule annotationAdd BLAST | 176 | |
Domaini | 858 – 1028 | VWFD 3PROSITE-ProRule annotationAdd BLAST | 171 | |
Repeati | 1401 – 1416 | 1Add BLAST | 16 | |
Repeati | 1417 – 1432 | 2Add BLAST | 16 | |
Repeati | 1433 – 1448 | 3Add BLAST | 16 | |
Repeati | 1449 – 1464 | 4Add BLAST | 16 | |
Repeati | 1465 – 1471 | 5 | 7 | |
Repeati | 1472 – 1478 | 6 | 7 | |
Repeati | 1479 – 1494 | 7AAdd BLAST | 16 | |
Repeati | 1495 – 1517 | 7BAdd BLAST | 23 | |
Repeati | 1518 – 1533 | 8AAdd BLAST | 16 | |
Repeati | 1534 – 1556 | 8BAdd BLAST | 23 | |
Repeati | 1557 – 1572 | 9AAdd BLAST | 16 | |
Repeati | 1573 – 1596 | 9BAdd BLAST | 24 | |
Repeati | 1597 – 1612 | 10AAdd BLAST | 16 | |
Repeati | 1613 – 1635 | 10BAdd BLAST | 23 | |
Repeati | 1636 – 1651 | 11AAdd BLAST | 16 | |
Repeati | 1652 – 1675 | 11BAdd BLAST | 24 | |
Repeati | 1676 – 1683 | 12 | 8 | |
Repeati | 1684 – 1699 | 13Add BLAST | 16 | |
Repeati | 1700 – 1715 | 14Add BLAST | 16 | |
Repeati | 1716 – 1731 | 15Add BLAST | 16 | |
Repeati | 1732 – 1747 | 16Add BLAST | 16 | |
Domaini | 4479 – 4662 | VWFD 4PROSITE-ProRule annotationAdd BLAST | 184 | |
Domaini | 4815 – 4886 | VWFC 1PROSITE-ProRule annotationAdd BLAST | 72 | |
Domaini | 4924 – 4991 | VWFC 2PROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 5075 – 5160 | CTCKPROSITE-ProRule annotationAdd BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1399 – 1773 | DisorderedSequence analysisAdd BLAST | 375 | |
Regioni | 1401 – 1747 | Approximate repeatsAdd BLAST | 347 | |
Regioni | 1885 – 4320 | DisorderedSequence analysisAdd BLAST | 2436 | |
Regioni | 4382 – 4414 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 4660 – 4685 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1401 – 1698 | Pro residuesSequence analysisAdd BLAST | 298 | |
Compositional biasi | 1699 – 1717 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1718 – 1744 | Pro residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1745 – 1759 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1885 – 4271 | Polar residuesSequence analysisAdd BLAST | 2387 | |
Compositional biasi | 4279 – 4320 | Polar residuesSequence analysisAdd BLAST | 42 | |
Compositional biasi | 4382 – 4413 | Pro residuesSequence analysisAdd BLAST | 32 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
InParanoidi | Q02817 |
OrthoDBi | 12226at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR006207, Cys_knot_C IPR028580, MUC2 IPR036084, Ser_inhib-like_sf IPR002919, TIL_dom IPR014853, Unchr_dom_Cys-rich IPR001007, VWF_dom IPR001846, VWF_type-D IPR025155, WxxW_domain |
PANTHERi | PTHR11339:SF261, PTHR11339:SF261, 5 hits |
Pfami | View protein in Pfam PF08742, C8, 4 hits PF13330, Mucin2_WxxW, 2 hits PF01826, TIL, 1 hit PF00094, VWD, 4 hits |
SMARTi | View protein in SMART SM00832, C8, 4 hits SM00041, CT, 1 hit SM00214, VWC, 3 hits SM00215, VWC_out, 2 hits SM00216, VWD, 4 hits |
SUPFAMi | SSF57567, SSF57567, 4 hits |
PROSITEi | View protein in PROSITE PS01185, CTCK_1, 1 hit PS01225, CTCK_2, 1 hit PS01208, VWFC_1, 2 hits PS50184, VWFC_2, 2 hits PS51233, VWFD, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGLPLARLAA VCLALSLAGG SELQTEGRTR YHGRNVCSTW GNFHYKTFDG
60 70 80 90 100
DVFRFPGLCD YNFASDCRGS YKEFAVHLKR GPGQAEAPAG VESILLTIKD
110 120 130 140 150
DTIYLTRHLA VLNGAVVSTP HYSPGLLIEK SDAYTKVYSR AGLTLMWNRE
160 170 180 190 200
DALMLELDTK FRNHTCGLCG DYNGLQSYSE FLSDGVLFSP LEFGNMQKIN
210 220 230 240 250
QPDVVCEDPE EEVAPASCSE HRAECERLLT AEAFADCQDL VPLEPYLRAC
260 270 280 290 300
QQDRCRCPGG DTCVCSTVAE FSRQCSHAGG RPGNWRTATL CPKTCPGNLV
310 320 330 340 350
YLESGSPCMD TCSHLEVSSL CEEHRMDGCF CPEGTVYDDI GDSGCVPVSQ
360 370 380 390 400
CHCRLHGHLY TPGQEITNDC EQCVCNAGRW VCKDLPCPGT CALEGGSHIT
410 420 430 440 450
TFDGKTYTFH GDCYYVLAKG DHNDSYALLG ELAPCGSTDK QTCLKTVVLL
460 470 480 490 500
ADKKKNAVVF KSDGSVLLNQ LQVNLPHVTA SFSVFRPSSY HIMVSMAIGV
510 520 530 540 550
RLQVQLAPVM QLFVTLDQAS QGQVQGLCGN FNGLEGDDFK TASGLVEATG
560 570 580 590 600
AGFANTWKAQ STCHDKLDWL DDPCSLNIES ANYAEHWCSL LKKTETPFGR
610 620 630 640 650
CHSAVDPAEY YKRCKYDTCN CQNNEDCLCA ALSSYARACT AKGVMLWGWR
660 670 680 690 700
EHVCNKDVGS CPNSQVFLYN LTTCQQTCRS LSEADSHCLE GFAPVDGCGC
710 720 730 740 750
PDHTFLDEKG RCVPLAKCSC YHRGLYLEAG DVVVRQEERC VCRDGRLHCR
760 770 780 790 800
QIRLIGQSCT APKIHMDCSN LTALATSKPR ALSCQTLAAG YYHTECVSGC
810 820 830 840 850
VCPDGLMDDG RGGCVVEKEC PCVHNNDLYS SGAKIKVDCN TCTCKRGRWV
860 870 880 890 900
CTQAVCHGTC SIYGSGHYIT FDGKYYDFDG HCSYVAVQDY CGQNSSLGSF
910 920 930 940 950
SIITENVPCG TTGVTCSKAI KIFMGRTELK LEDKHRVVIQ RDEGHHVAYT
960 970 980 990 1000
TREVGQYLVV ESSTGIIVIW DKRTTVFIKL APSYKGTVCG LCGNFDHRSN
1010 1020 1030 1040 1050
NDFTTRDHMV VSSELDFGNS WKEAPTCPDV STNPEPCSLN PHRRSWAEKQ
1060 1070 1080 1090 1100
CSILKSSVFS ICHSKVDPKP FYEACVHDSC SCDTGGDCEC FCSAVASYAQ
1110 1120 1130 1140 1150
ECTKEGACVF WRTPDLCPIF CDYYNPPHEC EWHYEPCGNR SFETCRTING
1160 1170 1180 1190 1200
IHSNISVSYL EGCYPRCPKD RPIYEEDLKK CVTADKCGCY VEDTHYPPGA
1210 1220 1230 1240 1250
SVPTEETCKS CVCTNSSQVV CRPEEGKILN QTQDGAFCYW EICGPNGTVE
1260 1270 1280 1290 1300
KHFNICSITT RPSTLTTFTT ITLPTTPTSF TTTTTTTTPT SSTVLSTTPK
1310 1320 1330 1340 1350
LCCLWSDWIN EDHPSSGSDD GDREPFDGVC GAPEDIECRS VKDPHLSLEQ
1360 1370 1380 1390 1400
HGQKVQCDVS VGFICKNEDQ FGNGPFGLCY DYKIRVNCCW PMDKCITTPS
1410 1420 1430 1440 1450
PPTTTPSPPP TTTTTLPPTT TPSPPTTTTT TPPPTTTPSP PITTTTTPLP
1460 1470 1480 1490 1500
TTTPSPPIST TTTPPPTTTP SPPTTTPSPP TTTPSPPTTT TTTPPPTTTP
1510 1520 1530 1540 1550
SPPMTTPITP PASTTTLPPT TTPSPPTTTT TTPPPTTTPS PPTTTPITPP
1560 1570 1580 1590 1600
TSTTTLPPTT TPSPPPTTTT TPPPTTTPSP PTTTTPSPPT ITTTTPPPTT
1610 1620 1630 1640 1650
TPSPPTTTTT TPPPTTTPSP PTTTPITPPT STTTLPPTTT PSPPPTTTTT
1660 1670 1680 1690 1700
PPPTTTPSPP TTTTPSPPIT TTTTPPPTTT PSSPITTTPS PPTTTMTTPS
1710 1720 1730 1740 1750
PTTTPSSPIT TTTTPSSTTT PSPPPTTMTT PSPTTTPSPP TTTMTTLPPT
1760 1770 1780 1790 1800
TTSSPLTTTP LPPSITPPTF SPFSTTTPTT PCVPLCNWTG WLDSGKPNFH
1810 1820 1830 1840 1850
KPGGDTELIG DVCGPGWAAN ISCRATMYPD VPIGQLGQTV VCDVSVGLIC
1860 1870 1880 1890 1900
KNEDQKPGGV IPMAFCLNYE INVQCCECVT QPTTMTTTTT ENPTPPTTTP
1910 1920 1930 1940 1950
ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT
1960 1970 1980 1990 2000
TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT
2010 2020 2030 2040 2050
PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT
2060 2070 2080 2090 2100
PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT
2110 2120 2130 2140 2150
QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT
2160 2170 2180 2190 2200
TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI
2210 2220 2230 2240 2250
TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT
2260 2270 2280 2290 2300
TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP
2310 2320 2330 2340 2350
TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP
2360 2370 2380 2390 2400
TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ
2410 2420 2430 2440 2450
TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT
2460 2470 2480 2490 2500
TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT
2510 2520 2530 2540 2550
TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT
2560 2570 2580 2590 2600
VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT
2610 2620 2630 2640 2650
PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT
2660 2670 2680 2690 2700
GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT
2710 2720 2730 2740 2750
PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT
2760 2770 2780 2790 2800
PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT
2810 2820 2830 2840 2850
TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV
2860 2870 2880 2890 2900
TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP
2910 2920 2930 2940 2950
TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG
2960 2970 2980 2990 3000
TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP
3010 3020 3030 3040 3050
TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP
3060 3070 3080 3090 3100
ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT
3110 3120 3130 3140 3150
TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT
3160 3170 3180 3190 3200
PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT
3210 3220 3230 3240 3250
PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT
3260 3270 3280 3290 3300
QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT
3310 3320 3330 3340 3350
TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI
3360 3370 3380 3390 3400
TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT
3410 3420 3430 3440 3450
TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP
3460 3470 3480 3490 3500
TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP
3510 3520 3530 3540 3550
TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ
3560 3570 3580 3590 3600
TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT
3610 3620 3630 3640 3650
TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT
3660 3670 3680 3690 3700
TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT
3710 3720 3730 3740 3750
VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT
3760 3770 3780 3790 3800
PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT
3810 3820 3830 3840 3850
GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT
3860 3870 3880 3890 3900
PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT
3910 3920 3930 3940 3950
PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT
3960 3970 3980 3990 4000
TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV
4010 4020 4030 4040 4050
TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP
4060 4070 4080 4090 4100
TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG
4110 4120 4130 4140 4150
TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP
4160 4170 4180 4190 4200
TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTGPPTH
4210 4220 4230 4240 4250
TSTAPIAELT TSNPPPESST PQTSRSTSSP LTESTTLLST LPPAIEMTST
4260 4270 4280 4290 4300
APPSTPTAPT TTSGGHTLSP PPSTTTSPPG TPTRGTTTGS SSAPTPSTVQ
4310 4320 4330 4340 4350
TTTTSAWTPT PTPLSTPSII RTTGLRPYPS SVLICCVLND TYYAPGEEVY
4360 4370 4380 4390 4400
NGTYGDTCYF VNCSLSCTLE FYNWSCPSTP SPTPTPSKST PTPSKPSSTP
4410 4420 4430 4440 4450
SKPTPGTKPP ECPDFDPPRQ ENETWWLCDC FMATCKYNNT VEIVKVECEP
4460 4470 4480 4490 4500
PPMPTCSNGL QPVRVEDPDG CCWHWECDCY CTGWGDPHYV TFDGLYYSYQ
4510 4520 4530 4540 4550
GNCTYVLVEE ISPSVDNFGV YIDNYHCDPN DKVSCPRTLI VRHETQEVLI
4560 4570 4580 4590 4600
KTVHMMPMQV QVQVNRQAVA LPYKKYGLEV YQSGINYVVD IPELGVLVSY
4610 4620 4630 4640 4650
NGLSFSVRLP YHRFGNNTKG QCGTCTNTTS DDCILPSGEI VSNCEAAADQ
4660 4670 4680 4690 4700
WLVNDPSKPH CPHSSSTTKR PAVTVPGGGK TTPHKDCTPS PLCQLIKDSL
4710 4720 4730 4740 4750
FAQCHALVPP QHYYDACVFD SCFMPGSSLE CASLQAYAAL CAQQNICLDW
4760 4770 4780 4790 4800
RNHTHGACLV ECPSHREYQA CGPAEEPTCK SSSSQQNNTV LVEGCFCPEG
4810 4820 4830 4840 4850
TMNYAPGFDV CVKTCGCVGP DNVPREFGEH FEFDCKNCVC LEGGSGIICQ
4860 4870 4880 4890 4900
PKRCSQKPVT HCVEDGTYLA TEVNPADTCC NITVCKCNTS LCKEKPSVCP
4910 4920 4930 4940 4950
LGFEVKSKMV PGRCCPFYWC ESKGVCVHGN AEYQPGSPVY SSKCQDCVCT
4960 4970 4980 4990 5000
DKVDNNTLLN VIACTHVPCN TSCSPGFELM EAPGECCKKC EQTHCIIKRP
5010 5020 5030 5040 5050
DNQHVILKPG DFKSDPKNNC TFFSCVKIHN QLISSVSNIT CPNFDASICI
5060 5070 5080 5090 5100
PGSITFMPNG CCKTCTPRNE TRVPCSTVPV TTEVSYAGCT KTVLMNHCSG
5110 5120 5130 5140 5150
SCGTFVMYSA KAQALDHSCS CCKEEKTSQR EVVLSCPNGG SLTHTYTHIE
5160 5170
SCQCQDTVCG LPTGTSRRAR RSPRHLGSG
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JR65 | A0A0G2JR65_HUMAN | Mucin-2 | MUC2 | 2,817 | Annotation score: | ||
A0A6Q8PFN2 | A0A6Q8PFN2_HUMAN | Mucin-2 | MUC2 | 985 | Annotation score: | ||
A0A0G2JM87 | A0A0G2JM87_HUMAN | Mucin-2 | MUC2 | 1,779 | Annotation score: | ||
A0A6Q8PGX3 | A0A6Q8PGX3_HUMAN | Mucin-2 | MUC2 | 1,394 | Annotation score: | ||
Q9UMI9 | Q9UMI9_HUMAN | Mucin-2 | MUC2 MLP | 131 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1351 | H → L in AAA59875 (PubMed:1885763).Curated | 1 | |
Sequence conflicti | 1412 | T → S in AAA59875 (PubMed:1885763).Curated | 1 | |
Sequence conflicti | 1449 | L → P in AAA59875 (PubMed:1885763).Curated | 1 | |
Sequence conflicti | 1504 | M → T in AAA59875 (PubMed:1885763).Curated | 1 | |
Sequence conflicti | 4076 – 4083 | TGTQTPTT → NGLQAPTP (PubMed:2703501).Curated | 8 | |
Sequence conflicti | 4087 | T → S (PubMed:2703501).Curated | 1 | |
Sequence conflicti | 4130 – 4131 | TP → VL (PubMed:2703501).Curated | 2 | |
Sequence conflicti | 4138 | V → M (PubMed:2703501).Curated | 1 | |
Sequence conflicti | 4146 – 4152 | GTQTPTT → STKSTTV (PubMed:2703501).Curated | 7 | |
Sequence conflicti | 4163 | P → A (PubMed:2703501).Curated | 1 | |
Sequence conflicti | 4175 – 4176 | TT → MI (PubMed:2703501).Curated | 2 | |
Sequence conflicti | 4179 | T → S (PubMed:2703501).Curated | 1 | |
Sequence conflicti | 4192 – 4194 | GTQ → TGS (PubMed:2703501).Curated | 3 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056582 | 58 | L → P. Corresponds to variant dbSNP:rs2856111Ensembl. | 1 | |
Natural variantiVAR_056583 | 116 | V → M. Corresponds to variant dbSNP:rs11825977Ensembl. | 1 | |
Natural variantiVAR_056584 | 832 | G → S. Corresponds to variant dbSNP:rs11245936Ensembl. | 1 | |
Natural variantiVAR_059531 | 1619 | S → R. Corresponds to variant dbSNP:rs11245947Ensembl. | 1 | |
Natural variantiVAR_059532 | 1689 | P → L. Corresponds to variant dbSNP:rs11245949Ensembl. | 1 | |
Natural variantiVAR_061487 | 1768 | P → H. Corresponds to variant dbSNP:rs34493663Ensembl. | 1 | |
Natural variantiVAR_059533 | 2154 | I → T. Corresponds to variant dbSNP:rs6421972Ensembl. | 1 | |
Natural variantiVAR_059534 | 2524 | T → P. Corresponds to variant dbSNP:rs7480563Ensembl. | 1 | |
Natural variantiVAR_059535 | 2524 | T → S. Corresponds to variant dbSNP:rs7480563Ensembl. | 1 | |
Natural variantiVAR_059536 | 2653 | Q → L. Corresponds to variant dbSNP:rs7126405Ensembl. | 1 | |
Natural variantiVAR_059537 | 2653 | Q → P. Corresponds to variant dbSNP:rs7126405Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L21998 mRNA Translation: AAB95295.1 M74027 Genomic DNA Translation: AAA59875.1 M94131 mRNA Translation: AAA59163.1 M94132 mRNA Translation: AAA59164.1 |
PIRi | A49963, A43932 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Mucin database |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L21998 mRNA Translation: AAB95295.1 M74027 Genomic DNA Translation: AAA59875.1 M94131 mRNA Translation: AAA59163.1 M94132 mRNA Translation: AAA59164.1 |
PIRi | A49963, A43932 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6RBF | X-ray | 2.70 | A/B/C/D | 858-1259 | [»] | |
6TM6 | X-ray | 1.63 | A | 1301-1395 | [»] | |
7A5O | electron microscopy | 2.95 | A/B/C/D/E/F/G/H/I/J | 21-1397 | [»] | |
SMRi | Q02817 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110670, 3 interactors |
DIPi | DIP-48824N |
IntActi | Q02817, 4 interactors |
Chemistry databases
DrugBanki | DB01411, Pranlukast |
Protein family/group databases
MEROPSi | I08.951 |
PTM databases
GlyConnecti | 1519, 2 N-Linked glycans (3 sites), 27 O-Linked glycans 373, 8 O-Linked glycans |
GlyGeni | Q02817, 32 sites, 2 N-linked glycans (3 sites), 51 O-linked glycans (1 site) |
iPTMneti | Q02817 |
PhosphoSitePlusi | Q02817 |
SwissPalmi | Q02817 |
Genetic variation databases
BioMutai | MUC2 |
DMDMi | 2506877 |
Proteomic databases
CPTACi | CPTAC-1497 |
EPDi | Q02817 |
jPOSTi | Q02817 |
MassIVEi | Q02817 |
PaxDbi | Q02817 |
PeptideAtlasi | Q02817 |
PRIDEi | Q02817 |
ProteomicsDBi | 58127 |
Organism-specific databases
GeneCardsi | MUC2 |
HGNCi | HGNC:7512, MUC2 |
MIMi | 158370, gene |
neXtProti | NX_Q02817 |
PharmGKBi | PA31316 |
GenAtlasi | Search... |
Phylogenomic databases
InParanoidi | Q02817 |
OrthoDBi | 12226at2759 |
Enzyme and pathway databases
PathwayCommonsi | Q02817 |
Reactomei | R-HSA-5083625, Defective GALNT3 causes HFTC R-HSA-5083632, Defective C1GALT1C1 causes TNPS R-HSA-5083636, Defective GALNT12 causes CRCS1 R-HSA-5621480, Dectin-2 family R-HSA-913709, O-linked glycosylation of mucins R-HSA-977068, Termination of O-glycan biosynthesis |
SignaLinki | Q02817 |
SIGNORi | Q02817 |
Miscellaneous databases
ChiTaRSi | MUC2, human |
GeneWikii | MUC2 |
Pharosi | Q02817, Tdark |
PROi | PR:Q02817 |
RNActi | Q02817, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR006207, Cys_knot_C IPR028580, MUC2 IPR036084, Ser_inhib-like_sf IPR002919, TIL_dom IPR014853, Unchr_dom_Cys-rich IPR001007, VWF_dom IPR001846, VWF_type-D IPR025155, WxxW_domain |
PANTHERi | PTHR11339:SF261, PTHR11339:SF261, 5 hits |
Pfami | View protein in Pfam PF08742, C8, 4 hits PF13330, Mucin2_WxxW, 2 hits PF01826, TIL, 1 hit PF00094, VWD, 4 hits |
SMARTi | View protein in SMART SM00832, C8, 4 hits SM00041, CT, 1 hit SM00214, VWC, 3 hits SM00215, VWC_out, 2 hits SM00216, VWD, 4 hits |
SUPFAMi | SSF57567, SSF57567, 4 hits |
PROSITEi | View protein in PROSITE PS01185, CTCK_1, 1 hit PS01225, CTCK_2, 1 hit PS01208, VWFC_1, 2 hits PS50184, VWFC_2, 2 hits PS51233, VWFD, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MUC2_HUMAN | |
Accessioni | Q02817Primary (citable) accession number: Q02817 Secondary accession number(s): Q14878 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | November 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references