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Entry version 166 (31 Jul 2019)
Sequence version 2 (01 Nov 1997)
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Protein

Mucin-2

Gene

MUC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5621480 Dectin-2 family
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-977068 Termination of O-glycan biosynthesis

SIGNOR Signaling Network Open Resource

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SIGNORi
Q02817

Protein family/group databases

MEROPS protease database

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MEROPSi
I08.951

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mucin-2
Short name:
MUC-2
Alternative name(s):
Intestinal mucin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MUC2
Synonyms:SMUC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7512 MUC2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
158370 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q02817

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4583

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31316

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01411 Pranlukast

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MUC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2506877

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001928121 – 5179Mucin-2Add BLAST5159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi? ↔ 5159By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21PhosphoserineCombined sources1
Disulfide bondi59 ↔ 67By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi423N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi670N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi770N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi894N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1215N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1230N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1787N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1820N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4339N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4351N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4362N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4373N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4422N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4438N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4502N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4616N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4627N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4752N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4787N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4881N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4888N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4955N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4970N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5019N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5038N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5069N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi5075 ↔ 5122By similarity
Disulfide bondi5089 ↔ 5136By similarity
Disulfide bondi5098 ↔ 5152By similarity
Disulfide bondi5102 ↔ 5154By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated.
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.By similarity
At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei4486 – 4487Cleavage; by autolysis; in vitro2

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1497

Encyclopedia of Proteome Dynamics

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EPDi
Q02817

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q02817

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q02817

PeptideAtlas

More...
PeptideAtlasi
Q02817

PRoteomics IDEntifications database

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PRIDEi
Q02817

ProteomicsDB human proteome resource

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ProteomicsDBi
58127

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1519
373

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q02817

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q02817

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q02817

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization.

Interacts with FCGBP.

Interacts with AGR2; disulfide-linked.

3 Publications

(Microbial infection)

Interacts in vitro with L.monocytogenes internalin proteins InlB, InlC and InlJ; for InlC binding is slightly better at pH 5.5, (the pH of the intestine) than at pH 7.4.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
AGR2O959942EBI-2105803,EBI-712648

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110670, 2 interactors

Database of interacting proteins

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DIPi
DIP-48824N

Protein interaction database and analysis system

More...
IntActi
Q02817, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q02817

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 240VWFD 1PROSITE-ProRule annotationAdd BLAST205
Domaini295 – 351TILAdd BLAST57
Domaini390 – 604VWFD 2PROSITE-ProRule annotationAdd BLAST215
Domaini859 – 1065VWFD 3PROSITE-ProRule annotationAdd BLAST207
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1401 – 14161Add BLAST16
Repeati1417 – 14322Add BLAST16
Repeati1433 – 14483Add BLAST16
Repeati1449 – 14644Add BLAST16
Repeati1465 – 147157
Repeati1472 – 147867
Repeati1479 – 14947AAdd BLAST16
Repeati1495 – 15177BAdd BLAST23
Repeati1518 – 15338AAdd BLAST16
Repeati1534 – 15568BAdd BLAST23
Repeati1557 – 15729AAdd BLAST16
Repeati1573 – 15969BAdd BLAST24
Repeati1597 – 161210AAdd BLAST16
Repeati1613 – 163510BAdd BLAST23
Repeati1636 – 165111AAdd BLAST16
Repeati1652 – 167511BAdd BLAST24
Repeati1676 – 1683128
Repeati1684 – 169913Add BLAST16
Repeati1700 – 171514Add BLAST16
Repeati1716 – 173115Add BLAST16
Repeati1732 – 174716Add BLAST16
Domaini4480 – 4690VWFD 4PROSITE-ProRule annotationAdd BLAST211
Domaini4815 – 4886VWFC 1PROSITE-ProRule annotationAdd BLAST72
Domaini4924 – 4991VWFC 2PROSITE-ProRule annotationAdd BLAST68
Domaini5075 – 5160CTCKPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1401 – 1747Approximate repeatsAdd BLAST347

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1216 Eukaryota
ENOG410YA0C LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000168234

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q02817

Database of Orthologous Groups

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OrthoDBi
129373at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006207 Cys_knot_C
IPR028580 MUC2
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR025155 WxxW_domain

The PANTHER Classification System

More...
PANTHERi
PTHR11339:SF261 PTHR11339:SF261, 3 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF08742 C8, 4 hits
PF13330 Mucin2_WxxW, 2 hits
PF01826 TIL, 1 hit
PF00094 VWD, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832 C8, 4 hits
SM00041 CT, 1 hit
SM00214 VWC, 3 hits
SM00215 VWC_out, 2 hits
SM00216 VWD, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57567 SSF57567, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS01208 VWFC_1, 2 hits
PS50184 VWFC_2, 2 hits
PS51233 VWFD, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q02817-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLPLARLAA VCLALSLAGG SELQTEGRTR YHGRNVCSTW GNFHYKTFDG
60 70 80 90 100
DVFRFPGLCD YNFASDCRGS YKEFAVHLKR GPGQAEAPAG VESILLTIKD
110 120 130 140 150
DTIYLTRHLA VLNGAVVSTP HYSPGLLIEK SDAYTKVYSR AGLTLMWNRE
160 170 180 190 200
DALMLELDTK FRNHTCGLCG DYNGLQSYSE FLSDGVLFSP LEFGNMQKIN
210 220 230 240 250
QPDVVCEDPE EEVAPASCSE HRAECERLLT AEAFADCQDL VPLEPYLRAC
260 270 280 290 300
QQDRCRCPGG DTCVCSTVAE FSRQCSHAGG RPGNWRTATL CPKTCPGNLV
310 320 330 340 350
YLESGSPCMD TCSHLEVSSL CEEHRMDGCF CPEGTVYDDI GDSGCVPVSQ
360 370 380 390 400
CHCRLHGHLY TPGQEITNDC EQCVCNAGRW VCKDLPCPGT CALEGGSHIT
410 420 430 440 450
TFDGKTYTFH GDCYYVLAKG DHNDSYALLG ELAPCGSTDK QTCLKTVVLL
460 470 480 490 500
ADKKKNAVVF KSDGSVLLNQ LQVNLPHVTA SFSVFRPSSY HIMVSMAIGV
510 520 530 540 550
RLQVQLAPVM QLFVTLDQAS QGQVQGLCGN FNGLEGDDFK TASGLVEATG
560 570 580 590 600
AGFANTWKAQ STCHDKLDWL DDPCSLNIES ANYAEHWCSL LKKTETPFGR
610 620 630 640 650
CHSAVDPAEY YKRCKYDTCN CQNNEDCLCA ALSSYARACT AKGVMLWGWR
660 670 680 690 700
EHVCNKDVGS CPNSQVFLYN LTTCQQTCRS LSEADSHCLE GFAPVDGCGC
710 720 730 740 750
PDHTFLDEKG RCVPLAKCSC YHRGLYLEAG DVVVRQEERC VCRDGRLHCR
760 770 780 790 800
QIRLIGQSCT APKIHMDCSN LTALATSKPR ALSCQTLAAG YYHTECVSGC
810 820 830 840 850
VCPDGLMDDG RGGCVVEKEC PCVHNNDLYS SGAKIKVDCN TCTCKRGRWV
860 870 880 890 900
CTQAVCHGTC SIYGSGHYIT FDGKYYDFDG HCSYVAVQDY CGQNSSLGSF
910 920 930 940 950
SIITENVPCG TTGVTCSKAI KIFMGRTELK LEDKHRVVIQ RDEGHHVAYT
960 970 980 990 1000
TREVGQYLVV ESSTGIIVIW DKRTTVFIKL APSYKGTVCG LCGNFDHRSN
1010 1020 1030 1040 1050
NDFTTRDHMV VSSELDFGNS WKEAPTCPDV STNPEPCSLN PHRRSWAEKQ
1060 1070 1080 1090 1100
CSILKSSVFS ICHSKVDPKP FYEACVHDSC SCDTGGDCEC FCSAVASYAQ
1110 1120 1130 1140 1150
ECTKEGACVF WRTPDLCPIF CDYYNPPHEC EWHYEPCGNR SFETCRTING
1160 1170 1180 1190 1200
IHSNISVSYL EGCYPRCPKD RPIYEEDLKK CVTADKCGCY VEDTHYPPGA
1210 1220 1230 1240 1250
SVPTEETCKS CVCTNSSQVV CRPEEGKILN QTQDGAFCYW EICGPNGTVE
1260 1270 1280 1290 1300
KHFNICSITT RPSTLTTFTT ITLPTTPTSF TTTTTTTTPT SSTVLSTTPK
1310 1320 1330 1340 1350
LCCLWSDWIN EDHPSSGSDD GDREPFDGVC GAPEDIECRS VKDPHLSLEQ
1360 1370 1380 1390 1400
HGQKVQCDVS VGFICKNEDQ FGNGPFGLCY DYKIRVNCCW PMDKCITTPS
1410 1420 1430 1440 1450
PPTTTPSPPP TTTTTLPPTT TPSPPTTTTT TPPPTTTPSP PITTTTTPLP
1460 1470 1480 1490 1500
TTTPSPPIST TTTPPPTTTP SPPTTTPSPP TTTPSPPTTT TTTPPPTTTP
1510 1520 1530 1540 1550
SPPMTTPITP PASTTTLPPT TTPSPPTTTT TTPPPTTTPS PPTTTPITPP
1560 1570 1580 1590 1600
TSTTTLPPTT TPSPPPTTTT TPPPTTTPSP PTTTTPSPPT ITTTTPPPTT
1610 1620 1630 1640 1650
TPSPPTTTTT TPPPTTTPSP PTTTPITPPT STTTLPPTTT PSPPPTTTTT
1660 1670 1680 1690 1700
PPPTTTPSPP TTTTPSPPIT TTTTPPPTTT PSSPITTTPS PPTTTMTTPS
1710 1720 1730 1740 1750
PTTTPSSPIT TTTTPSSTTT PSPPPTTMTT PSPTTTPSPP TTTMTTLPPT
1760 1770 1780 1790 1800
TTSSPLTTTP LPPSITPPTF SPFSTTTPTT PCVPLCNWTG WLDSGKPNFH
1810 1820 1830 1840 1850
KPGGDTELIG DVCGPGWAAN ISCRATMYPD VPIGQLGQTV VCDVSVGLIC
1860 1870 1880 1890 1900
KNEDQKPGGV IPMAFCLNYE INVQCCECVT QPTTMTTTTT ENPTPPTTTP
1910 1920 1930 1940 1950
ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT
1960 1970 1980 1990 2000
TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT
2010 2020 2030 2040 2050
PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT
2060 2070 2080 2090 2100
PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT
2110 2120 2130 2140 2150
QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT
2160 2170 2180 2190 2200
TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI
2210 2220 2230 2240 2250
TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT
2260 2270 2280 2290 2300
TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP
2310 2320 2330 2340 2350
TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP
2360 2370 2380 2390 2400
TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ
2410 2420 2430 2440 2450
TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT
2460 2470 2480 2490 2500
TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT
2510 2520 2530 2540 2550
TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT
2560 2570 2580 2590 2600
VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT
2610 2620 2630 2640 2650
PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT
2660 2670 2680 2690 2700
GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT
2710 2720 2730 2740 2750
PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT
2760 2770 2780 2790 2800
PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT
2810 2820 2830 2840 2850
TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV
2860 2870 2880 2890 2900
TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP
2910 2920 2930 2940 2950
TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG
2960 2970 2980 2990 3000
TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP
3010 3020 3030 3040 3050
TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP
3060 3070 3080 3090 3100
ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT
3110 3120 3130 3140 3150
TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT
3160 3170 3180 3190 3200
PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT
3210 3220 3230 3240 3250
PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT
3260 3270 3280 3290 3300
QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT
3310 3320 3330 3340 3350
TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI
3360 3370 3380 3390 3400
TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT
3410 3420 3430 3440 3450
TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP
3460 3470 3480 3490 3500
TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP
3510 3520 3530 3540 3550
TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ
3560 3570 3580 3590 3600
TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT
3610 3620 3630 3640 3650
TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT
3660 3670 3680 3690 3700
TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT
3710 3720 3730 3740 3750
VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT
3760 3770 3780 3790 3800
PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT
3810 3820 3830 3840 3850
GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT
3860 3870 3880 3890 3900
PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT
3910 3920 3930 3940 3950
PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT
3960 3970 3980 3990 4000
TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV
4010 4020 4030 4040 4050
TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP
4060 4070 4080 4090 4100
TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG
4110 4120 4130 4140 4150
TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP
4160 4170 4180 4190 4200
TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTGPPTH
4210 4220 4230 4240 4250
TSTAPIAELT TSNPPPESST PQTSRSTSSP LTESTTLLST LPPAIEMTST
4260 4270 4280 4290 4300
APPSTPTAPT TTSGGHTLSP PPSTTTSPPG TPTRGTTTGS SSAPTPSTVQ
4310 4320 4330 4340 4350
TTTTSAWTPT PTPLSTPSII RTTGLRPYPS SVLICCVLND TYYAPGEEVY
4360 4370 4380 4390 4400
NGTYGDTCYF VNCSLSCTLE FYNWSCPSTP SPTPTPSKST PTPSKPSSTP
4410 4420 4430 4440 4450
SKPTPGTKPP ECPDFDPPRQ ENETWWLCDC FMATCKYNNT VEIVKVECEP
4460 4470 4480 4490 4500
PPMPTCSNGL QPVRVEDPDG CCWHWECDCY CTGWGDPHYV TFDGLYYSYQ
4510 4520 4530 4540 4550
GNCTYVLVEE ISPSVDNFGV YIDNYHCDPN DKVSCPRTLI VRHETQEVLI
4560 4570 4580 4590 4600
KTVHMMPMQV QVQVNRQAVA LPYKKYGLEV YQSGINYVVD IPELGVLVSY
4610 4620 4630 4640 4650
NGLSFSVRLP YHRFGNNTKG QCGTCTNTTS DDCILPSGEI VSNCEAAADQ
4660 4670 4680 4690 4700
WLVNDPSKPH CPHSSSTTKR PAVTVPGGGK TTPHKDCTPS PLCQLIKDSL
4710 4720 4730 4740 4750
FAQCHALVPP QHYYDACVFD SCFMPGSSLE CASLQAYAAL CAQQNICLDW
4760 4770 4780 4790 4800
RNHTHGACLV ECPSHREYQA CGPAEEPTCK SSSSQQNNTV LVEGCFCPEG
4810 4820 4830 4840 4850
TMNYAPGFDV CVKTCGCVGP DNVPREFGEH FEFDCKNCVC LEGGSGIICQ
4860 4870 4880 4890 4900
PKRCSQKPVT HCVEDGTYLA TEVNPADTCC NITVCKCNTS LCKEKPSVCP
4910 4920 4930 4940 4950
LGFEVKSKMV PGRCCPFYWC ESKGVCVHGN AEYQPGSPVY SSKCQDCVCT
4960 4970 4980 4990 5000
DKVDNNTLLN VIACTHVPCN TSCSPGFELM EAPGECCKKC EQTHCIIKRP
5010 5020 5030 5040 5050
DNQHVILKPG DFKSDPKNNC TFFSCVKIHN QLISSVSNIT CPNFDASICI
5060 5070 5080 5090 5100
PGSITFMPNG CCKTCTPRNE TRVPCSTVPV TTEVSYAGCT KTVLMNHCSG
5110 5120 5130 5140 5150
SCGTFVMYSA KAQALDHSCS CCKEEKTSQR EVVLSCPNGG SLTHTYTHIE
5160 5170
SCQCQDTVCG LPTGTSRRAR RSPRHLGSG
Length:5,179
Mass (Da):540,300
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i85CD7571FB9A5663
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JR65A0A0G2JR65_HUMAN
Mucin-2
MUC2
2,817Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JM87A0A0G2JM87_HUMAN
Mucin-2
MUC2
1,779Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9UMI9Q9UMI9_HUMAN
Mucin-2
MUC2 MLP
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1351H → L in AAA59875 (PubMed:1885763).Curated1
Sequence conflicti1412T → S in AAA59875 (PubMed:1885763).Curated1
Sequence conflicti1449L → P in AAA59875 (PubMed:1885763).Curated1
Sequence conflicti1504M → T in AAA59875 (PubMed:1885763).Curated1
Sequence conflicti4076 – 4083TGTQTPTT → NGLQAPTP (PubMed:2703501).Curated8
Sequence conflicti4087T → S (PubMed:2703501).Curated1
Sequence conflicti4130 – 4131TP → VL (PubMed:2703501).Curated2
Sequence conflicti4138V → M (PubMed:2703501).Curated1
Sequence conflicti4146 – 4152GTQTPTT → STKSTTV (PubMed:2703501).Curated7
Sequence conflicti4163P → A (PubMed:2703501).Curated1
Sequence conflicti4175 – 4176TT → MI (PubMed:2703501).Curated2
Sequence conflicti4179T → S (PubMed:2703501).Curated1
Sequence conflicti4192 – 4194GTQ → TGS (PubMed:2703501).Curated3

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The number of repeats is highly polymorphic and varies among different alleles.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05658258L → P. Corresponds to variant dbSNP:rs2856111Ensembl.1
Natural variantiVAR_056583116V → M. Corresponds to variant dbSNP:rs11825977Ensembl.1
Natural variantiVAR_056584832G → S. Corresponds to variant dbSNP:rs11245936Ensembl.1
Natural variantiVAR_0595311619S → R. Corresponds to variant dbSNP:rs11245947Ensembl.1
Natural variantiVAR_0595321689P → L. Corresponds to variant dbSNP:rs11245949Ensembl.1
Natural variantiVAR_0614871768P → H. Corresponds to variant dbSNP:rs34493663Ensembl.1
Natural variantiVAR_0595332154I → T. Corresponds to variant dbSNP:rs6421972Ensembl.1
Natural variantiVAR_0595342524T → P. Corresponds to variant dbSNP:rs7480563Ensembl.1
Natural variantiVAR_0595352524T → S. Corresponds to variant dbSNP:rs7480563Ensembl.1
Natural variantiVAR_0595362653Q → L. Corresponds to variant dbSNP:rs7126405Ensembl.1
Natural variantiVAR_0595372653Q → P. Corresponds to variant dbSNP:rs7126405Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L21998 mRNA Translation: AAB95295.1
M74027 Genomic DNA Translation: AAA59875.1
M94131 mRNA Translation: AAA59163.1
M94132 mRNA Translation: AAA59164.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A49963 A43932

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Mucin database
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21998 mRNA Translation: AAB95295.1
M74027 Genomic DNA Translation: AAA59875.1
M94131 mRNA Translation: AAA59163.1
M94132 mRNA Translation: AAA59164.1
PIRiA49963 A43932

3D structure databases

SMRiQ02817
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110670, 2 interactors
DIPiDIP-48824N
IntActiQ02817, 3 interactors

Chemistry databases

DrugBankiDB01411 Pranlukast

Protein family/group databases

MEROPSiI08.951

PTM databases

GlyConnecti1519
373
iPTMnetiQ02817
PhosphoSitePlusiQ02817
UniCarbKBiQ02817

Polymorphism and mutation databases

BioMutaiMUC2
DMDMi2506877

Proteomic databases

CPTACiCPTAC-1497
EPDiQ02817
jPOSTiQ02817
PaxDbiQ02817
PeptideAtlasiQ02817
PRIDEiQ02817
ProteomicsDBi58127

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi4583

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MUC2
HGNCiHGNC:7512 MUC2
MIMi158370 gene
neXtProtiNX_Q02817
PharmGKBiPA31316

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1216 Eukaryota
ENOG410YA0C LUCA
HOGENOMiHOG000168234
InParanoidiQ02817
OrthoDBi129373at2759

Enzyme and pathway databases

ReactomeiR-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5621480 Dectin-2 family
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-977068 Termination of O-glycan biosynthesis
SIGNORiQ02817

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MUC2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MUC2

Protein Ontology

More...
PROi
PR:Q02817

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR028580 MUC2
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR025155 WxxW_domain
PANTHERiPTHR11339:SF261 PTHR11339:SF261, 3 hits
PfamiView protein in Pfam
PF08742 C8, 4 hits
PF13330 Mucin2_WxxW, 2 hits
PF01826 TIL, 1 hit
PF00094 VWD, 4 hits
SMARTiView protein in SMART
SM00832 C8, 4 hits
SM00041 CT, 1 hit
SM00214 VWC, 3 hits
SM00215 VWC_out, 2 hits
SM00216 VWD, 4 hits
SUPFAMiSSF57567 SSF57567, 4 hits
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS01208 VWFC_1, 2 hits
PS50184 VWFC_2, 2 hits
PS51233 VWFD, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q02817
Secondary accession number(s): Q14878
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: July 31, 2019
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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