UniProtKB - Q02796 (LGE1_YEAST)
Protein
Transcriptional regulatory protein LGE1
Gene
LGE1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required to activate transcription of PDR3, a gene involved in retrograde regulation of multidrug resistance, a phenomenon that takes place in cells that have lost their mitochondrial genome. Also required for ubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. Its precise role in H2BK123ub1 formation however is unclear and is independent of retrograde regulation of multidrug resistance function.2 Publications
Miscellaneous
Present with 2060 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- histone methylation Source: SGD
- histone ubiquitination Source: SGD
- premeiotic DNA replication Source: SGD
- protein monoubiquitination Source: SGD
- regulation of cell size Source: SGD
Keywordsi
Molecular function | Activator, Chromatin regulator |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional regulatory protein LGE1Alternative name(s): Large cells protein 1 |
Gene namesi | Name:LGE1 Ordered Locus Names:YPL055C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005976, LGE1 |
VEuPathDBi | FungiDB:YPL055C |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: SGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076234 | 1 – 332 | Transcriptional regulatory protein LGE1Add BLAST | 332 |
Proteomic databases
MaxQBi | Q02796 |
PaxDbi | Q02796 |
PRIDEi | Q02796 |
PTM databases
iPTMneti | Q02796 |
Interactioni
Subunit structurei
Probably interacts with BRE1.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 36125, 792 interactors |
DIPi | DIP-6470N |
IntActi | Q02796, 81 interactors |
MINTi | Q02796 |
STRINGi | 4932.YPL055C |
Miscellaneous databases
RNActi | Q02796, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 284 – 328 | Sequence analysisAdd BLAST | 45 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502SA4A, Eukaryota |
HOGENOMi | CLU_826809_0_0_1 |
InParanoidi | Q02796 |
OMAi | YSANSRH |
i Sequence
Sequence statusi: Complete.
Q02796-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGYTGNNYS RYSSTPPRQR GGYHHARRSR GGAGGSYYRG GNASYGARYN
60 70 80 90 100
SDYEQPPQEG DLRQTGAYYR NGYTDTRPYY SANSRHYQAQ PSPRYNNGTN
110 120 130 140 150
SYHLPQRGNS QDTNGRTTSA SQEDNDEKRV KSRYRNMQAD HPRQQPMSVG
160 170 180 190 200
STSSRNGSSG NSSTSSTSNG LPPPPSVSSI TNNRSYHSSA YPYSSSHTYN
210 220 230 240 250
NYHHRETPPP PPSNGYYAKG YPVHVPENRS NSDGSSSSVV KKKRILDMKD
260 270 280 290 300
SPFIYLTDFD KNVKKTNNTE SECEKAREVF KESDSIDSAL EELNLKINSN
310 320 330
ELELRLLNNQ CDKHALNIQL TQEKLDSLLL MQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 28 | R → Q in AAS56364 (PubMed:17322287).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39205 Genomic DNA Translation: AAB68310.1 AY558038 Genomic DNA Translation: AAS56364.1 BK006949 Genomic DNA Translation: DAA11375.1 |
PIRi | S60935 |
RefSeqi | NP_015270.1, NM_001183869.1 |
Genome annotation databases
EnsemblFungii | YPL055C_mRNA; YPL055C; YPL055C |
GeneIDi | 856052 |
KEGGi | sce:YPL055C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39205 Genomic DNA Translation: AAB68310.1 AY558038 Genomic DNA Translation: AAS56364.1 BK006949 Genomic DNA Translation: DAA11375.1 |
PIRi | S60935 |
RefSeqi | NP_015270.1, NM_001183869.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 36125, 792 interactors |
DIPi | DIP-6470N |
IntActi | Q02796, 81 interactors |
MINTi | Q02796 |
STRINGi | 4932.YPL055C |
PTM databases
iPTMneti | Q02796 |
Proteomic databases
MaxQBi | Q02796 |
PaxDbi | Q02796 |
PRIDEi | Q02796 |
Genome annotation databases
EnsemblFungii | YPL055C_mRNA; YPL055C; YPL055C |
GeneIDi | 856052 |
KEGGi | sce:YPL055C |
Organism-specific databases
SGDi | S000005976, LGE1 |
VEuPathDBi | FungiDB:YPL055C |
Phylogenomic databases
eggNOGi | ENOG502SA4A, Eukaryota |
HOGENOMi | CLU_826809_0_0_1 |
InParanoidi | Q02796 |
OMAi | YSANSRH |
Miscellaneous databases
PROi | PR:Q02796 |
RNActi | Q02796, protein |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LGE1_YEAST | |
Accessioni | Q02796Primary (citable) accession number: Q02796 Secondary accession number(s): D6W3V9, Q6Q5I8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names