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Protein

Collagen alpha-2(VI) chain

Gene

Col6a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Collagen VI acts as a cell-binding protein.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-186797 Signaling by PDGF
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-419037 NCAM1 interactions
R-MMU-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-2(VI) chain
Gene namesi
Name:Col6a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:88460 Col6a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000583326 – 1034Collagen alpha-2(VI) chainAdd BLAST1009

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi645N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei716PhosphothreonineBy similarity1
Modified residuei720PhosphoserineBy similarity1
Glycosylationi800N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi912N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

MaxQBiQ02788
PaxDbiQ02788
PeptideAtlasiQ02788
PRIDEiQ02788

2D gel databases

REPRODUCTION-2DPAGEiQ02788

PTM databases

iPTMnetiQ02788
PhosphoSitePlusiQ02788

Expressioni

Tissue specificityi

Highly expressed in adipose tissue, lung, adrenal glands and ovary. Lower levels in testis, tongue, skin, kidney, heart, intestine and spleen. No expression in skeletal muscle or liver.

Gene expression databases

BgeeiENSMUSG00000020241 Expressed in 241 organ(s), highest expression level in male reproductive system
CleanExiMM_COL6A2
ExpressionAtlasiQ02788 baseline and differential
GenevisibleiQ02788 MM

Interactioni

Subunit structurei

Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha-6(VI). Interacts with CSPG4 (By similarity).By similarity

Protein-protein interaction databases

ComplexPortaliCPX-2965 Collagen type VI trimer
IntActiQ02788, 4 interactors
MINTiQ02788
STRINGi10090.ENSMUSP00000001181

Structurei

3D structure databases

ProteinModelPortaliQ02788
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 249VWFA 1PROSITE-ProRule annotationAdd BLAST189
Domaini630 – 820VWFA 2PROSITE-ProRule annotationAdd BLAST191
Domaini848 – 1029VWFA 3PROSITE-ProRule annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 270Nonhelical regionAdd BLAST245
Regioni271 – 605Triple-helical regionAdd BLAST335
Regioni606 – 1034Nonhelical regionAdd BLAST429

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi381 – 383Cell attachment siteSequence analysis3
Motifi441 – 443Cell attachment siteSequence analysis3
Motifi504 – 506Cell attachment siteSequence analysis3
Motifi513 – 515Cell attachment siteSequence analysis3
Motifi554 – 556Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the type VI collagen family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IS7F Eukaryota
ENOG410XT53 LUCA
GeneTreeiENSGT00820000126981
HOGENOMiHOG000111863
HOVERGENiHBG051051
InParanoidiQ02788
KOiK06238
OrthoDBiEOG091G020V
PhylomeDBiQ02788
TreeFamiTF331207

Family and domain databases

Gene3Di3.40.50.410, 3 hits
InterProiView protein in InterPro
IPR008160 Collagen
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 5 hits
PF00092 VWA, 3 hits
SMARTiView protein in SMART
SM00327 VWA, 3 hits
SUPFAMiSSF53300 SSF53300, 3 hits
PROSITEiView protein in PROSITE
PS50234 VWFA, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q02788-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTIKMLQGP LSVLLIGGLL GVLHAQQQEA ISPQEQEAVS PDISTTERNN
60 70 80 90 100
NCPEKADCPV NVYFVLDTSE SVAMQSPTDS LLYHMQQFVP QFISQLQNEF
110 120 130 140 150
YLDQVALSWR YGGLHFSDQV EVFSPPGSDR ASFTKSLQGI RSFRRGTFTD
160 170 180 190 200
CALANMTQQI RQHVGKGVVN FAVVITDGHV TGSPCGGIKM QAERAREEGI
210 220 230 240 250
RLFAVAPNRN LNEQGLRDIA NSPHELYRNN YATMRPDSTE IDQDTINRII
260 270 280 290 300
KVMKHEAYGE CYKVSCLEIP GPHGPKGYRG QKGAKGNMGE PGEPGQKGRQ
310 320 330 340 350
GDPGIEGPIG FPGPKGVPGF KGEKGEFGSD GRKGAPGLAG KNGTDGQKGK
360 370 380 390 400
LGRIGPPGCK GDPGSRGPDG YPGEAGSPGE RGDQGAKGDS GRPGRRGPPG
410 420 430 440 450
DPGDKGSKGY QGNNGAPGSP GVKGGKGGPG PRGPKGEPGR RGDPGTKGGP
460 470 480 490 500
GSDGPKGEKG DPGPEGPRGL AGEVGSKGAK GDRGLPGPRG PQGALGEPGK
510 520 530 540 550
QGSRGDPGDA GPRGDSGQPG PKGDPGRPGF SYPGPRGTPG EKGEPGPPGP
560 570 580 590 600
EGGRGDFGLK GTPGRKGDKG EPADPGPPGE PGPRGPRGIP GPEGEPGPPG
610 620 630 640 650
DPGLTECDVM TYVRETCGCC DCEKRCGALD VVFVIDSSES IGYTNFTLEK
660 670 680 690 700
NFVINVVNRL GAIAKDPKSE TGTRVGVVQY SHEGTFEAIR LDDERVNSLS
710 720 730 740 750
SFKEAVKNLE WIAGGTWTPS ALKFAYNQLI KESRRQKTRV FAVVITDGRH
760 770 780 790 800
DPRDDDLNLR ALCDRDVTVT AIGIGDMFHE THESENLYSI ACDKPQQVRN
810 820 830 840 850
MTLFSDLVAE KFIDDMEDVL CPDPQIVCPE LPCQTELYVA QCTQRPVDIV
860 870 880 890 900
FLLDGSERLG EQNFHKVRRF VEDVSRRLTL ARRDDDPLNA RMALLQYGSQ
910 920 930 940 950
NQQQVAFPLT YNVTTIHEAL ERATYLNSFS HVGTGIVHAI NNVVRGARGG
960 970 980 990 1000
ARRHAELSFV FLTDGVTGND SLEESVHSMR KQNVVPTVVA VGGDVDMDVL
1010 1020 1030
TKISLGDRAA IFREKDFDSL AQPSFFDRFI RWIC
Length:1,034
Mass (Da):110,334
Last modified:February 6, 2007 - v3
Checksum:iDC56F4CC552E9997
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7D5D3Z7D5_MOUSE
Collagen alpha-2(VI) chain
Col6a2
933Annotation score:

Sequence cautioni

The sequence BAC31374 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA46541 differs from that shown. Reason: Frameshift at position 4.Curated
The sequence CAA46541 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12S → P in CAA46541 (Ref. 1) Curated1
Sequence conflicti205V → L in CAA46541 (Ref. 1) Curated1
Sequence conflicti273H → S in AAA37441 (PubMed:1709252).Curated1
Sequence conflicti809A → S in CAA79153 (PubMed:8489506).Curated1
Sequence conflicti853L → Q in CAA46541 (Ref. 1) Curated1
Sequence conflicti853L → Q in CAA44206 (PubMed:8380980).Curated1
Sequence conflicti967 – 971TGNDS → GNDSL in CAA46541 (Ref. 1) Curated5
Sequence conflicti967 – 971TGNDS → GNDSL in CAA44206 (PubMed:8380980).Curated5
Sequence conflicti981 – 982KQ → TR in CAA46541 (Ref. 1) Curated2
Sequence conflicti981 – 982KQ → TR in CAA44206 (PubMed:8380980).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65582 mRNA Translation: CAA46541.1 Sequence problems.
BC034414 mRNA Translation: AAH34414.1
AK042826 mRNA Translation: BAC31374.2 Different initiation.
X62332 mRNA Translation: CAA44206.1
L06343 mRNA Translation: AAA37441.1
Z18272 mRNA Translation: CAA79153.1
CCDSiCCDS23951.1
PIRiS21369
S32604
RefSeqiNP_001334136.1, NM_001347207.1
NP_666119.1, NM_146007.2
UniGeneiMm.1949

Genome annotation databases

EnsembliENSMUST00000001181; ENSMUSP00000001181; ENSMUSG00000020241
GeneIDi12834
KEGGimmu:12834
UCSCiuc007fuu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65582 mRNA Translation: CAA46541.1 Sequence problems.
BC034414 mRNA Translation: AAH34414.1
AK042826 mRNA Translation: BAC31374.2 Different initiation.
X62332 mRNA Translation: CAA44206.1
L06343 mRNA Translation: AAA37441.1
Z18272 mRNA Translation: CAA79153.1
CCDSiCCDS23951.1
PIRiS21369
S32604
RefSeqiNP_001334136.1, NM_001347207.1
NP_666119.1, NM_146007.2
UniGeneiMm.1949

3D structure databases

ProteinModelPortaliQ02788
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2965 Collagen type VI trimer
IntActiQ02788, 4 interactors
MINTiQ02788
STRINGi10090.ENSMUSP00000001181

PTM databases

iPTMnetiQ02788
PhosphoSitePlusiQ02788

2D gel databases

REPRODUCTION-2DPAGEiQ02788

Proteomic databases

MaxQBiQ02788
PaxDbiQ02788
PeptideAtlasiQ02788
PRIDEiQ02788

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001181; ENSMUSP00000001181; ENSMUSG00000020241
GeneIDi12834
KEGGimmu:12834
UCSCiuc007fuu.2 mouse

Organism-specific databases

CTDi1292
MGIiMGI:88460 Col6a2

Phylogenomic databases

eggNOGiENOG410IS7F Eukaryota
ENOG410XT53 LUCA
GeneTreeiENSGT00820000126981
HOGENOMiHOG000111863
HOVERGENiHBG051051
InParanoidiQ02788
KOiK06238
OrthoDBiEOG091G020V
PhylomeDBiQ02788
TreeFamiTF331207

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-186797 Signaling by PDGF
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-419037 NCAM1 interactions
R-MMU-8948216 Collagen chain trimerization

Miscellaneous databases

ChiTaRSiCol6a2 mouse
PROiPR:Q02788
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020241 Expressed in 241 organ(s), highest expression level in male reproductive system
CleanExiMM_COL6A2
ExpressionAtlasiQ02788 baseline and differential
GenevisibleiQ02788 MM

Family and domain databases

Gene3Di3.40.50.410, 3 hits
InterProiView protein in InterPro
IPR008160 Collagen
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 5 hits
PF00092 VWA, 3 hits
SMARTiView protein in SMART
SM00327 VWA, 3 hits
SUPFAMiSSF53300 SSF53300, 3 hits
PROSITEiView protein in PROSITE
PS50234 VWFA, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCO6A2_MOUSE
AccessioniPrimary (citable) accession number: Q02788
Secondary accession number(s): Q05505, Q8C972, Q8K229
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 6, 2007
Last modified: November 7, 2018
This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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