UniProtKB - Q02788 (CO6A2_MOUSE)
Protein
Collagen alpha-2(VI) chain
Gene
Col6a2
Organism
Mus musculus (Mouse)
Status
Functioni
Collagen VI acts as a cell-binding protein.
GO - Molecular functioni
- collagen binding Source: MGI
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- response to glucose Source: Ensembl
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
Reactomei | R-MMU-1442490, Collagen degradation R-MMU-1650814, Collagen biosynthesis and modifying enzymes R-MMU-186797, Signaling by PDGF R-MMU-2022090, Assembly of collagen fibrils and other multimeric structures R-MMU-216083, Integrin cell surface interactions R-MMU-3000178, ECM proteoglycans R-MMU-419037, NCAM1 interactions R-MMU-8948216, Collagen chain trimerization |
Names & Taxonomyi
Protein namesi | Recommended name: Collagen alpha-2(VI) chain |
Gene namesi | Name:Col6a2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88460, Col6a2 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
Note: Recruited on membranes by CSPG4.By similarity
Extracellular region or secreted
- collagen-containing extracellular matrix Source: UniProtKB
- extracellular matrix Source: MGI
- extracellular region Source: MGI
- extracellular space Source: BHF-UCL
Plasma Membrane
- sarcolemma Source: MGI
Other locations
- collagen trimer Source: UniProtKB-KW
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Extracellular matrix, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000005833 | 26 – 1034 | Collagen alpha-2(VI) chainAdd BLAST | 1009 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 155 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 342 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 645 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 716 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 720 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 800 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 912 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Keywords - PTMi
Glycoprotein, Hydroxylation, PhosphoproteinProteomic databases
EPDi | Q02788 |
jPOSTi | Q02788 |
MaxQBi | Q02788 |
PaxDbi | Q02788 |
PeptideAtlasi | Q02788 |
PRIDEi | Q02788 |
2D gel databases
REPRODUCTION-2DPAGEi | Q02788 |
PTM databases
GlyConnecti | 2221, 1 N-Linked glycan (1 site) |
GlyGeni | Q02788, 5 sites |
iPTMneti | Q02788 |
PhosphoSitePlusi | Q02788 |
Expressioni
Tissue specificityi
Highly expressed in adipose tissue, lung, adrenal glands and ovary. Lower levels in testis, tongue, skin, kidney, heart, intestine and spleen. No expression in skeletal muscle or liver.
Gene expression databases
Bgeei | ENSMUSG00000020241, Expressed in male reproductive system and 261 other tissues |
Genevisiblei | Q02788, MM |
Interactioni
Subunit structurei
Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha-6(VI).
Interacts with CSPG4 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 198824, 5 interactors |
ComplexPortali | CPX-2965, Collagen type VI trimer |
IntActi | Q02788, 4 interactors |
MINTi | Q02788 |
STRINGi | 10090.ENSMUSP00000001181 |
Miscellaneous databases
RNActi | Q02788, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 249 | VWFA 1PROSITE-ProRule annotationAdd BLAST | 189 | |
Domaini | 630 – 820 | VWFA 2PROSITE-ProRule annotationAdd BLAST | 191 | |
Domaini | 848 – 1029 | VWFA 3PROSITE-ProRule annotationAdd BLAST | 182 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 26 – 270 | Nonhelical regionAdd BLAST | 245 | |
Regioni | 271 – 605 | Triple-helical regionAdd BLAST | 335 | |
Regioni | 606 – 1034 | Nonhelical regionAdd BLAST | 429 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 381 – 383 | Cell attachment siteSequence analysis | 3 | |
Motifi | 441 – 443 | Cell attachment siteSequence analysis | 3 | |
Motifi | 504 – 506 | Cell attachment siteSequence analysis | 3 | |
Motifi | 513 – 515 | Cell attachment siteSequence analysis | 3 | |
Motifi | 554 – 556 | Cell attachment siteSequence analysis | 3 |
Sequence similaritiesi
Belongs to the type VI collagen family.Curated
Keywords - Domaini
Collagen, Repeat, SignalPhylogenomic databases
eggNOGi | KOG3544, Eukaryota |
GeneTreei | ENSGT00940000155682 |
HOGENOMi | CLU_009158_2_0_1 |
InParanoidi | Q02788 |
OrthoDBi | 140989at2759 |
PhylomeDBi | Q02788 |
TreeFami | TF331207 |
Family and domain databases
Gene3Di | 3.40.50.410, 3 hits |
InterProi | View protein in InterPro IPR008160, Collagen IPR002035, VWF_A IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF01391, Collagen, 5 hits PF00092, VWA, 3 hits |
SMARTi | View protein in SMART SM00327, VWA, 3 hits |
SUPFAMi | SSF53300, SSF53300, 3 hits |
PROSITEi | View protein in PROSITE PS50234, VWFA, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q02788-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTIKMLQGP LSVLLIGGLL GVLHAQQQEA ISPQEQEAVS PDISTTERNN
60 70 80 90 100
NCPEKADCPV NVYFVLDTSE SVAMQSPTDS LLYHMQQFVP QFISQLQNEF
110 120 130 140 150
YLDQVALSWR YGGLHFSDQV EVFSPPGSDR ASFTKSLQGI RSFRRGTFTD
160 170 180 190 200
CALANMTQQI RQHVGKGVVN FAVVITDGHV TGSPCGGIKM QAERAREEGI
210 220 230 240 250
RLFAVAPNRN LNEQGLRDIA NSPHELYRNN YATMRPDSTE IDQDTINRII
260 270 280 290 300
KVMKHEAYGE CYKVSCLEIP GPHGPKGYRG QKGAKGNMGE PGEPGQKGRQ
310 320 330 340 350
GDPGIEGPIG FPGPKGVPGF KGEKGEFGSD GRKGAPGLAG KNGTDGQKGK
360 370 380 390 400
LGRIGPPGCK GDPGSRGPDG YPGEAGSPGE RGDQGAKGDS GRPGRRGPPG
410 420 430 440 450
DPGDKGSKGY QGNNGAPGSP GVKGGKGGPG PRGPKGEPGR RGDPGTKGGP
460 470 480 490 500
GSDGPKGEKG DPGPEGPRGL AGEVGSKGAK GDRGLPGPRG PQGALGEPGK
510 520 530 540 550
QGSRGDPGDA GPRGDSGQPG PKGDPGRPGF SYPGPRGTPG EKGEPGPPGP
560 570 580 590 600
EGGRGDFGLK GTPGRKGDKG EPADPGPPGE PGPRGPRGIP GPEGEPGPPG
610 620 630 640 650
DPGLTECDVM TYVRETCGCC DCEKRCGALD VVFVIDSSES IGYTNFTLEK
660 670 680 690 700
NFVINVVNRL GAIAKDPKSE TGTRVGVVQY SHEGTFEAIR LDDERVNSLS
710 720 730 740 750
SFKEAVKNLE WIAGGTWTPS ALKFAYNQLI KESRRQKTRV FAVVITDGRH
760 770 780 790 800
DPRDDDLNLR ALCDRDVTVT AIGIGDMFHE THESENLYSI ACDKPQQVRN
810 820 830 840 850
MTLFSDLVAE KFIDDMEDVL CPDPQIVCPE LPCQTELYVA QCTQRPVDIV
860 870 880 890 900
FLLDGSERLG EQNFHKVRRF VEDVSRRLTL ARRDDDPLNA RMALLQYGSQ
910 920 930 940 950
NQQQVAFPLT YNVTTIHEAL ERATYLNSFS HVGTGIVHAI NNVVRGARGG
960 970 980 990 1000
ARRHAELSFV FLTDGVTGND SLEESVHSMR KQNVVPTVVA VGGDVDMDVL
1010 1020 1030
TKISLGDRAA IFREKDFDSL AQPSFFDRFI RWIC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z7D5 | D3Z7D5_MOUSE | Collagen alpha-2(VI) chain | Col6a2 | 933 | Annotation score: |
Sequence cautioni
The sequence BAC31374 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA46541 differs from that shown. Reason: Frameshift.Curated
The sequence CAA46541 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | S → P in CAA46541 (Ref. 1) Curated | 1 | |
Sequence conflicti | 205 | V → L in CAA46541 (Ref. 1) Curated | 1 | |
Sequence conflicti | 273 | H → S in AAA37441 (PubMed:1709252).Curated | 1 | |
Sequence conflicti | 809 | A → S in CAA79153 (PubMed:8489506).Curated | 1 | |
Sequence conflicti | 853 | L → Q in CAA46541 (Ref. 1) Curated | 1 | |
Sequence conflicti | 853 | L → Q in CAA44206 (PubMed:8380980).Curated | 1 | |
Sequence conflicti | 967 – 971 | TGNDS → GNDSL in CAA46541 (Ref. 1) Curated | 5 | |
Sequence conflicti | 967 – 971 | TGNDS → GNDSL in CAA44206 (PubMed:8380980).Curated | 5 | |
Sequence conflicti | 981 – 982 | KQ → TR in CAA46541 (Ref. 1) Curated | 2 | |
Sequence conflicti | 981 – 982 | KQ → TR in CAA44206 (PubMed:8380980).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X65582 mRNA Translation: CAA46541.1 Sequence problems. BC034414 mRNA Translation: AAH34414.1 AK042826 mRNA Translation: BAC31374.2 Different initiation. X62332 mRNA Translation: CAA44206.1 L06343 mRNA Translation: AAA37441.1 Z18272 mRNA Translation: CAA79153.1 |
CCDSi | CCDS23951.1 |
PIRi | S21369 S32604 |
RefSeqi | NP_001334136.1, NM_001347207.1 NP_666119.1, NM_146007.2 |
Genome annotation databases
Ensembli | ENSMUST00000001181; ENSMUSP00000001181; ENSMUSG00000020241 |
GeneIDi | 12834 |
KEGGi | mmu:12834 |
UCSCi | uc007fuu.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X65582 mRNA Translation: CAA46541.1 Sequence problems. BC034414 mRNA Translation: AAH34414.1 AK042826 mRNA Translation: BAC31374.2 Different initiation. X62332 mRNA Translation: CAA44206.1 L06343 mRNA Translation: AAA37441.1 Z18272 mRNA Translation: CAA79153.1 |
CCDSi | CCDS23951.1 |
PIRi | S21369 S32604 |
RefSeqi | NP_001334136.1, NM_001347207.1 NP_666119.1, NM_146007.2 |
3D structure databases
SMRi | Q02788 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198824, 5 interactors |
ComplexPortali | CPX-2965, Collagen type VI trimer |
IntActi | Q02788, 4 interactors |
MINTi | Q02788 |
STRINGi | 10090.ENSMUSP00000001181 |
PTM databases
GlyConnecti | 2221, 1 N-Linked glycan (1 site) |
GlyGeni | Q02788, 5 sites |
iPTMneti | Q02788 |
PhosphoSitePlusi | Q02788 |
2D gel databases
REPRODUCTION-2DPAGEi | Q02788 |
Proteomic databases
EPDi | Q02788 |
jPOSTi | Q02788 |
MaxQBi | Q02788 |
PaxDbi | Q02788 |
PeptideAtlasi | Q02788 |
PRIDEi | Q02788 |
Protocols and materials databases
Antibodypediai | 1646, 228 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000001181; ENSMUSP00000001181; ENSMUSG00000020241 |
GeneIDi | 12834 |
KEGGi | mmu:12834 |
UCSCi | uc007fuu.2, mouse |
Organism-specific databases
CTDi | 1292 |
MGIi | MGI:88460, Col6a2 |
Phylogenomic databases
eggNOGi | KOG3544, Eukaryota |
GeneTreei | ENSGT00940000155682 |
HOGENOMi | CLU_009158_2_0_1 |
InParanoidi | Q02788 |
OrthoDBi | 140989at2759 |
PhylomeDBi | Q02788 |
TreeFami | TF331207 |
Enzyme and pathway databases
Reactomei | R-MMU-1442490, Collagen degradation R-MMU-1650814, Collagen biosynthesis and modifying enzymes R-MMU-186797, Signaling by PDGF R-MMU-2022090, Assembly of collagen fibrils and other multimeric structures R-MMU-216083, Integrin cell surface interactions R-MMU-3000178, ECM proteoglycans R-MMU-419037, NCAM1 interactions R-MMU-8948216, Collagen chain trimerization |
Miscellaneous databases
BioGRID-ORCSi | 12834, 0 hits in 17 CRISPR screens |
ChiTaRSi | Col6a2, mouse |
PROi | PR:Q02788 |
RNActi | Q02788, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020241, Expressed in male reproductive system and 261 other tissues |
Genevisiblei | Q02788, MM |
Family and domain databases
Gene3Di | 3.40.50.410, 3 hits |
InterProi | View protein in InterPro IPR008160, Collagen IPR002035, VWF_A IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF01391, Collagen, 5 hits PF00092, VWA, 3 hits |
SMARTi | View protein in SMART SM00327, VWA, 3 hits |
SUPFAMi | SSF53300, SSF53300, 3 hits |
PROSITEi | View protein in PROSITE PS50234, VWFA, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CO6A2_MOUSE | |
Accessioni | Q02788Primary (citable) accession number: Q02788 Secondary accession number(s): Q05505, Q8C972, Q8K229 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | February 6, 2007 | |
Last modified: | December 2, 2020 | |
This is version 178 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families