We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q02765 (CATS_RAT)
Protein
Cathepsin S
Gene
Ctss
Organism
Rattus norvegicus (Rat)
Status
Functioni
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
By similarityCatalytic activityi
- Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound. EC:3.4.22.27
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 137 | By similarity | 1 | |
Active sitei | 277 | By similarity | 1 | |
Active sitei | 297 | By similarity | 1 |
GO - Molecular functioni
- collagen binding Source: RGD
- cysteine-type endopeptidase activity Source: RGD
- cysteine-type peptidase activity Source: RGD
- fibronectin binding Source: RGD
- laminin binding Source: RGD
- peptidase activity Source: RGD
- proteoglycan binding Source: RGD
- serine-type endopeptidase activity Source: Reactome
GO - Biological processi
- adaptive immune response Source: RGD
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProtKB
- antigen processing and presentation of peptide antigen Source: RGD
- basement membrane disassembly Source: RGD
- bone resorption Source: RGD
- cellular response to thyroid hormone stimulus Source: RGD
- collagen catabolic process Source: RGD
- immune response Source: GO_Central
- metanephros development Source: UniProtKB
- positive regulation of cation channel activity Source: RGD
- positive regulation of inflammatory response Source: RGD
- protein processing Source: RGD
- proteolysis Source: RGD
- proteolysis involved in cellular protein catabolic process Source: RGD
- regulation of sensory perception of pain Source: RGD
- response to acidic pH Source: RGD
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Enzyme and pathway databases
BRENDAi | 3.4.22.27, 5301 |
Reactomei | R-RNO-1474228, Degradation of the extracellular matrix R-RNO-1679131, Trafficking and processing of endosomal TLR R-RNO-2022090, Assembly of collagen fibrils and other multimeric structures R-RNO-2132295, MHC class II antigen presentation R-RNO-6798695, Neutrophil degranulation |
Protein family/group databases
MEROPSi | I29.004 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Ctss |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621513, Ctss |
Subcellular locationi
Endosome
- late endosome Source: RGD
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Lysosome
- lysosome Source: RGD
Other locations
- cell surface Source: RGD
- membrane Source: RGD
- phagocytic vesicle Source: UniProtKB
Keywords - Cellular componenti
Cytoplasmic vesicle, Lysosome, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
PropeptideiPRO_0000026317 | 18 – 112 | Activation peptideAdd BLAST | 95 | |
ChainiPRO_0000026318 | 113 – 330 | Cathepsin SAdd BLAST | 218 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 100 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 110 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 124 ↔ 222 | By similarity | ||
Disulfide bondi | 134 ↔ 179 | By similarity | ||
Disulfide bondi | 168 ↔ 211 | By similarity | ||
Disulfide bondi | 271 ↔ 319 | By similarity |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenPTM databases
GlyGeni | Q02765, 2 sites |
PhosphoSitePlusi | Q02765 |
Expressioni
Tissue specificityi
Highest levels occur in the ileum followed by spleen, brain, thyroid, ovary and uterus. Low levels are found in the liver, kidney, jejunum and lung with lowest levels in the heart.
Inductioni
By thyroid-stimulating hormone.
Interactioni
Subunit structurei
Monomer.
GO - Molecular functioni
- fibronectin binding Source: RGD
- laminin binding Source: RGD
- proteoglycan binding Source: RGD
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase C1 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
InParanoidi | Q02765 |
OMAi | LSMNFMG |
OrthoDBi | 1275401at2759 |
PhylomeDBi | Q02765 |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q02765-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVLGAPGVL CDNGATAERP TLDHHWDLWK KTRMRRNTDQ NEEDVRRLIW
60 70 80 90 100
EKNLKFIMLH NLEHSMGMHS YSVGMNHMGD MTPEEVIGYM GSLRIPRPWN
110 120 130 140 150
RSGTLKSSSN QTLPDSVDWR EKGCVTNVKY QGSCGSCWAF SAEGALEGQL
160 170 180 190 200
KLKTGKLVSL SAQNLVDCST EEKYGNKGCG GGFMTEAFQY IIDTSIDSEA
210 220 230 240 250
SYPYKAMDEK CLYDPKNRAA TCSRYIELPF GDEEALKEAV ATKGPVSVGI
260 270 280 290 300
DDASHSSFFL YQSGVYDDPS CTENMNHGVL VVGYGTLDGK DYWLVKNSWG
310 320 330
LHFGDQGYIR MARNNKNHCG IASYCSYPEI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3ZZR3 | D3ZZR3_RAT | Cathepsin S | Ctss | 329 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L03201 mRNA Translation: AAA40994.1 |
PIRi | A45087 |
RefSeqi | NP_059016.1, NM_017320.1 |
Genome annotation databases
GeneIDi | 50654 |
KEGGi | rno:50654 |
UCSCi | RGD:621513, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L03201 mRNA Translation: AAA40994.1 |
PIRi | A45087 |
RefSeqi | NP_059016.1, NM_017320.1 |
3D structure databases
SMRi | Q02765 |
ModBasei | Search... |
Chemistry databases
ChEMBLi | CHEMBL1075217 |
GuidetoPHARMACOLOGYi | 2353 |
Protein family/group databases
MEROPSi | I29.004 |
PTM databases
GlyGeni | Q02765, 2 sites |
PhosphoSitePlusi | Q02765 |
Genome annotation databases
GeneIDi | 50654 |
KEGGi | rno:50654 |
UCSCi | RGD:621513, rat |
Organism-specific databases
CTDi | 1520 |
RGDi | 621513, Ctss |
Phylogenomic databases
InParanoidi | Q02765 |
OMAi | LSMNFMG |
OrthoDBi | 1275401at2759 |
PhylomeDBi | Q02765 |
Enzyme and pathway databases
BRENDAi | 3.4.22.27, 5301 |
Reactomei | R-RNO-1474228, Degradation of the extracellular matrix R-RNO-1679131, Trafficking and processing of endosomal TLR R-RNO-2022090, Assembly of collagen fibrils and other multimeric structures R-RNO-2132295, MHC class II antigen presentation R-RNO-6798695, Neutrophil degranulation |
Miscellaneous databases
PROi | PR:Q02765 |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CATS_RAT | |
Accessioni | Q02765Primary (citable) accession number: Q02765 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | September 29, 2021 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families