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Protein

Dual specificity mitogen-activated protein kinase kinase 1

Gene

MAP2K1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

Ras proteins such as HRAS mediate the activation of RAF proteins such as RAF1 or BRAF which in turn activate extracellular signal-regulated kinases (ERK) through MAPK (mitogen-activated protein kinases) and ERK kinases MAP2K1/MEK1 and MAP2K2/MEK2. Activation occurs through phosphorylation of Ser-218 and Ser-222. MAP2K1/MEK1 is also the target of negative feed-back regulation by its substrate kinases, such as MAPK1/ERK2. These phosphorylate MAP2K1/MEK1 on Thr-292, thereby facilitating dephosphorylation of the activating residues Ser-218 and Ser-222. Inhibited by serine/threonine phosphatase 2A (By similarity). Many inhibitors have been identified including pyrrole derivatives, TAK-733 (one of a series of 8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione derivatives), CH4987655 and RDEA119/BAY 869766.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei77Inhibitor; via carbonyl oxygen8 Publications1
Binding sitei78Inhibitor; via amide nitrogen and carbonyl oxygen8 Publications1
Binding sitei97ATPPROSITE-ProRule annotation6 Publications1
Binding sitei97Inhibitor8 Publications1
Active sitei190Proton acceptorPROSITE-ProRule annotation1
Binding sitei190Inhibitor8 Publications1
Binding sitei194Inhibitor; via carbonyl oxygen8 Publications1
Binding sitei208ATPPROSITE-ProRule annotation6 Publications1
Binding sitei208Inhibitor8 Publications1
Binding sitei212Inhibitor; via amide nitrogen8 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 82ATPPROSITE-ProRule annotation6 Publications9
Nucleotide bindingi143 – 146ATPPROSITE-ProRule annotation6 Publications4
Nucleotide bindingi150 – 153ATPPROSITE-ProRule annotation6 Publications4
Nucleotide bindingi192 – 195ATPPROSITE-ProRule annotation6 Publications4

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase kinase activity Source: UniProtKB
  • protein C-terminus binding Source: MGI
  • protein kinase activity Source: ProtInc
  • protein N-terminus binding Source: MGI
  • protein serine/threonine/tyrosine kinase activity Source: UniProtKB
  • protein serine/threonine kinase activator activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB
  • protein tyrosine kinase activity Source: UniProtKB-KW
  • scaffold protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.12.2 2681
ReactomeiR-HSA-110056 MAPK3 (ERK1) activation
R-HSA-445144 Signal transduction by L1
R-HSA-5210891 Uptake and function of anthrax toxins
R-HSA-5673000 RAF activation
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5674499 Negative feedback regulation of MAPK pathway
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
SignaLinkiQ02750
SIGNORiQ02750

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)
Short name:
MAP kinase kinase 1
Short name:
MAPKK 1
Short name:
MKK1
Alternative name(s):
ERK activator kinase 1
MAPK/ERK kinase 1
Short name:
MEK 1
Gene namesi
Name:MAP2K1
Synonyms:MEK1, PRKMK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000169032.9
HGNCiHGNC:6840 MAP2K1
MIMi176872 gene
neXtProtiNX_Q02750

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Cardiofaciocutaneous syndrome 3 (CFC3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of cardiofaciocutaneous syndrome, a multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. Distinctive features of CFC3 include macrostomia and horizontal shape of palpebral fissures.
See also OMIM:615279
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03509353F → S in CFC3. 1 PublicationCorresponds to variant dbSNP:rs121908594EnsemblClinVar.1
Natural variantiVAR_069780128G → V in CFC3. 1 PublicationCorresponds to variant dbSNP:rs730880508EnsemblClinVar.1
Natural variantiVAR_035094130Y → C in CFC3. 1 PublicationCorresponds to variant dbSNP:rs121908595EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi97K → R: Inactivation. 1 Publication1
Mutagenesisi150S → A: No loss of activity. 1 Publication1
Mutagenesisi212S → A: No loss of activity. 1 Publication1
Mutagenesisi218S → A: Inactivation. 1 Publication1
Mutagenesisi222S → A: Inactivation. 1 Publication1

Keywords - Diseasei

Cardiomyopathy, Disease mutation, Ectodermal dysplasia, Mental retardation

Organism-specific databases

DisGeNETi5604
GeneReviewsiMAP2K1
MalaCardsiMAP2K1
MIMi615279 phenotype
OpenTargetsiENSG00000169032
Orphaneti1340 Cardiofaciocutaneous syndrome
PharmGKBiPA30584

Chemistry databases

ChEMBLiCHEMBL3587
DrugBankiDB06616 Bosutinib
DB05239 Cobimetinib
DB02152 K-252a
DB08911 Trametinib
GuidetoPHARMACOLOGYi2062

Polymorphism and mutation databases

BioMutaiMAP2K1
DMDMi400274

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863651 – 393Dual specificity mitogen-activated protein kinase kinase 1Add BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei218Phosphoserine; by RAF2 Publications1
Modified residuei222Phosphoserine; by RAF1 Publication1
Modified residuei286PhosphothreonineCombined sources1
Modified residuei292Phosphothreonine; by MAPK1By similarity1
Modified residuei298Phosphoserine; by PAK1 Publication1

Post-translational modificationi

Phosphorylation at Ser-218 and Ser-222 by MAP kinase kinase kinases (RAF or MEKK1) positively regulates kinase activity. Also phosphorylated at Thr-292 by MAPK1/ERK2 and at Ser-298 by PAK. MAPK1/ERK2 phosphorylation of Thr-292 occurs in response to cellular adhesion and leads to inhibition of Ser-298 phosphorylation by PAK.2 Publications
Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei8 – 9Cleavage; by anthrax lethal factor2

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ02750
MaxQBiQ02750
PaxDbiQ02750
PeptideAtlasiQ02750
PRIDEiQ02750
ProteomicsDBi58119
58120 [Q02750-2]

PTM databases

CarbonylDBiQ02750
iPTMnetiQ02750
PhosphoSitePlusiQ02750

Miscellaneous databases

PMAP-CutDBiQ02750

Expressioni

Tissue specificityi

Widely expressed, with extremely low levels in brain.1 Publication

Gene expression databases

BgeeiENSG00000169032 Expressed in 235 organ(s), highest expression level in secondary oocyte
CleanExiHS_MAP2K1
ExpressionAtlasiQ02750 baseline and differential
GenevisibleiQ02750 HS

Organism-specific databases

HPAiCAB003834
HPA026430

Interactioni

Subunit structurei

Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3/ERK1 and RGS14. Forms a heterodimer with MAP2K2/MEK2. Forms heterodimers with KSR2 which further dimerize to form tetramers. Interacts with ARBB2, LAMTOR3, MAPK1/ERK2, MORG1 and RAF1 (By similarity). Interacts with PPARG and with isoform 1 of VRK2 (PubMed:20679487, PubMed:17101779). Interacts with Yersinia yopJ (PubMed:16728640). Interacts with SGK1 (PubMed:19447520). Interacts with BIRC6/bruce (PubMed:18329369). Interacts with KSR1 (PubMed:10409742). Interacts with KAT7; the interaction promotes KAT7 phosphorylation (By similarity).By similarity6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111590, 81 interactors
CORUMiQ02750
DIPiDIP-201N
ELMiQ02750
IntActiQ02750, 69 interactors
MINTiQ02750
STRINGi9606.ENSP00000302486

Chemistry databases

BindingDBiQ02750

Structurei

Secondary structure

1393
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ02750
SMRiQ02750
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02750

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 361Protein kinasePROSITE-ProRule annotationAdd BLAST294

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni77 – 78Inhibitor binding2
Regioni144 – 146Inhibitor binding3
Regioni208 – 212Inhibitor binding5
Regioni270 – 307RAF1-bindingBy similarityAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi262 – 307Pro-richAdd BLAST46

Domaini

The proline-rich region localized between residues 270 and 307 is important for binding to RAF1 and activation of MAP2K1/MEK1.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0581 Eukaryota
ENOG410XQ5A LUCA
GeneTreeiENSGT00760000119199
HOGENOMiHOG000234206
HOVERGENiHBG108518
InParanoidiQ02750
KOiK04368
OMAiELMFGCP
OrthoDBiEOG091G0DEC
PhylomeDBiQ02750
TreeFamiTF105137

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q02750-1) [UniParc]FASTAAdd to basket
Also known as: MKK1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL
60 70 80 90 100
EAFLTQKQKV GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH
110 120 130 140 150
LEIKPAIRNQ IIRELQVLHE CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS
160 170 180 190 200
LDQVLKKAGR IPEQILGKVS IAVIKGLTYL REKHKIMHRD VKPSNILVNS
210 220 230 240 250
RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY SVQSDIWSMG
260 270 280 290 300
LSLVEMAVGR YPIPPPDAKE LELMFGCQVE GDAAETPPRP RTPGRPLSSY
310 320 330 340 350
GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA
360 370 380 390
DLKQLMVHAF IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA AGV
Length:393
Mass (Da):43,439
Last modified:January 23, 2007 - v2
Checksum:i0344118FFC842D51
GO
Isoform 2 (identifier: Q02750-2) [UniParc]FASTAAdd to basket
Also known as: MKK1b

The sequence of this isoform differs from the canonical sequence as follows:
     147-172: Missing.

Show »
Length:367
Mass (Da):40,764
Checksum:i9944432D8705DEFD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRW9H3BRW9_HUMAN
Dual-specificity mitogen-activated ...
MAP2K1
217Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52A → R AA sequence (PubMed:10409742).Curated1
Sequence conflicti180Missing AA sequence (PubMed:10409742).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03509353F → S in CFC3. 1 PublicationCorresponds to variant dbSNP:rs121908594EnsemblClinVar.1
Natural variantiVAR_069780128G → V in CFC3. 1 PublicationCorresponds to variant dbSNP:rs730880508EnsemblClinVar.1
Natural variantiVAR_035094130Y → C in CFC3. 1 PublicationCorresponds to variant dbSNP:rs121908595EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040500147 – 172Missing in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05624 mRNA Translation: AAA36318.1
L11284 mRNA No translation available.
CCDSiCCDS10216.1 [Q02750-1]
PIRiA45100
RefSeqiNP_002746.1, NM_002755.3 [Q02750-1]
XP_016877900.1, XM_017022411.1 [Q02750-2]
UniGeneiHs.145442
Hs.677223

Genome annotation databases

EnsembliENST00000307102; ENSP00000302486; ENSG00000169032 [Q02750-1]
GeneIDi5604
KEGGihsa:5604
UCSCiuc010bhq.4 human [Q02750-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05624 mRNA Translation: AAA36318.1
L11284 mRNA No translation available.
CCDSiCCDS10216.1 [Q02750-1]
PIRiA45100
RefSeqiNP_002746.1, NM_002755.3 [Q02750-1]
XP_016877900.1, XM_017022411.1 [Q02750-2]
UniGeneiHs.145442
Hs.677223

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S9JX-ray2.40A62-393[»]
2P55X-ray2.80A62-393[»]
3DV3X-ray2.30A62-382[»]
3DY7X-ray2.70A62-393[»]
3E8NX-ray2.50A62-393[»]
3EQBX-ray2.62A62-393[»]
3EQCX-ray1.80A35-393[»]
3EQDX-ray2.10A35-393[»]
3EQFX-ray2.70A35-393[»]
3EQGX-ray2.50A35-393[»]
3EQHX-ray2.00A35-393[»]
3EQIX-ray1.90A35-393[»]
3MBLX-ray2.60A62-382[»]
3ORNX-ray2.80A62-393[»]
3OS3X-ray2.80A62-393[»]
3PP1X-ray2.70A62-382[»]
3SLSX-ray2.30A/B45-263[»]
A/B308-383[»]
3V01X-ray2.70A62-393[»]
3V04X-ray2.70A62-393[»]
3VVHX-ray2.00A/B/C62-393[»]
3W8QX-ray2.20A39-382[»]
3WIGX-ray2.70A62-393[»]
3ZLSX-ray2.50A37-383[»]
3ZLWX-ray2.12A37-383[»]
3ZLXX-ray2.20A37-383[»]
3ZLYX-ray2.11A37-383[»]
3ZM4X-ray2.37A37-383[»]
4AN2X-ray2.50A61-392[»]
4AN3X-ray2.10A61-392[»]
4AN9X-ray2.80A61-392[»]
4ANBX-ray2.20A61-392[»]
4ARKX-ray2.60A62-393[»]
4LMNX-ray2.80A62-393[»]
4MNEX-ray2.85A/D/E/H62-393[»]
4U7ZX-ray2.80A62-393[»]
4U80X-ray2.80A62-393[»]
4U81X-ray2.70A62-393[»]
5BX0X-ray2.93A37-383[»]
5EYMX-ray2.70A/B35-393[»]
5HZEX-ray2.40A37-383[»]
ProteinModelPortaliQ02750
SMRiQ02750
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111590, 81 interactors
CORUMiQ02750
DIPiDIP-201N
ELMiQ02750
IntActiQ02750, 69 interactors
MINTiQ02750
STRINGi9606.ENSP00000302486

Chemistry databases

BindingDBiQ02750
ChEMBLiCHEMBL3587
DrugBankiDB06616 Bosutinib
DB05239 Cobimetinib
DB02152 K-252a
DB08911 Trametinib
GuidetoPHARMACOLOGYi2062

PTM databases

CarbonylDBiQ02750
iPTMnetiQ02750
PhosphoSitePlusiQ02750

Polymorphism and mutation databases

BioMutaiMAP2K1
DMDMi400274

Proteomic databases

EPDiQ02750
MaxQBiQ02750
PaxDbiQ02750
PeptideAtlasiQ02750
PRIDEiQ02750
ProteomicsDBi58119
58120 [Q02750-2]

Protocols and materials databases

DNASUi5604
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307102; ENSP00000302486; ENSG00000169032 [Q02750-1]
GeneIDi5604
KEGGihsa:5604
UCSCiuc010bhq.4 human [Q02750-1]

Organism-specific databases

CTDi5604
DisGeNETi5604
EuPathDBiHostDB:ENSG00000169032.9
GeneCardsiMAP2K1
GeneReviewsiMAP2K1
HGNCiHGNC:6840 MAP2K1
HPAiCAB003834
HPA026430
MalaCardsiMAP2K1
MIMi176872 gene
615279 phenotype
neXtProtiNX_Q02750
OpenTargetsiENSG00000169032
Orphaneti1340 Cardiofaciocutaneous syndrome
PharmGKBiPA30584
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0581 Eukaryota
ENOG410XQ5A LUCA
GeneTreeiENSGT00760000119199
HOGENOMiHOG000234206
HOVERGENiHBG108518
InParanoidiQ02750
KOiK04368
OMAiELMFGCP
OrthoDBiEOG091G0DEC
PhylomeDBiQ02750
TreeFamiTF105137

Enzyme and pathway databases

BRENDAi2.7.12.2 2681
ReactomeiR-HSA-110056 MAPK3 (ERK1) activation
R-HSA-445144 Signal transduction by L1
R-HSA-5210891 Uptake and function of anthrax toxins
R-HSA-5673000 RAF activation
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5674499 Negative feedback regulation of MAPK pathway
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
SignaLinkiQ02750
SIGNORiQ02750

Miscellaneous databases

ChiTaRSiMAP2K1 human
EvolutionaryTraceiQ02750
GeneWikiiMAP2K1
GenomeRNAii5604
PMAP-CutDBiQ02750
PROiPR:Q02750
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169032 Expressed in 235 organ(s), highest expression level in secondary oocyte
CleanExiHS_MAP2K1
ExpressionAtlasiQ02750 baseline and differential
GenevisibleiQ02750 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMP2K1_HUMAN
AccessioniPrimary (citable) accession number: Q02750
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 206 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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