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Protein

Guanylin

Gene

GUCA2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.

GO - Molecular functioni

  • guanylate cyclase activator activity Source: GO_Central
  • hormone activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-8935690 Digestion
SIGNORiQ02747

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylin
Alternative name(s):
Guanylate cyclase activator 2A
Guanylate cyclase-activating protein 1
Guanylate cyclase-activating protein I
Short name:
GCAP-I
Cleaved into the following 2 chains:
Gene namesi
Name:GUCA2A
Synonyms:GUCA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197273.3
HGNCiHGNC:4682 GUCA2A
MIMi139392 gene
neXtProtiNX_Q02747

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2980
OpenTargetsiENSG00000197273
PharmGKBiPA29065

Polymorphism and mutation databases

BioMutaiGUCA2A
DMDMi290457645

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001313522 – 115HMW-guanylinAdd BLAST94
PeptideiPRO_0000013136101 – 115GuanylinAdd BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi69 ↔ 821 Publication
Disulfide bondi104 ↔ 1121 Publication
Disulfide bondi107 ↔ 1151 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ02747
PeptideAtlasiQ02747
PRIDEiQ02747
ProteomicsDBi58118

Expressioni

Tissue specificityi

Highly expressed in ileum and colon. Found in plasma.

Gene expression databases

BgeeiENSG00000197273 Expressed in 114 organ(s), highest expression level in colonic mucosa
CleanExiHS_GUCA2A
GenevisibleiQ02747 HS

Organism-specific databases

HPAiHPA018215

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SGTAO437654EBI-12244272,EBI-347996

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109235, 1 interactor
IntActiQ02747, 13 interactors
STRINGi9606.ENSP00000349493

Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ02747
SMRiQ02747
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02747

Family & Domainsi

Sequence similaritiesi

Belongs to the guanylin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J44S Eukaryota
ENOG410Z6NA LUCA
GeneTreeiENSGT00730000111358
HOGENOMiHOG000231183
HOVERGENiHBG051861
InParanoidiQ02747
OMAiSCEICAF
OrthoDBiEOG091G0WKF
PhylomeDBiQ02747
TreeFamiTF330731

Family and domain databases

Gene3Di3.90.1450.10, 1 hit
InterProiView protein in InterPro
IPR000879 Guanylin
IPR036382 Guanylin_sf
PANTHERiPTHR11318 PTHR11318, 1 hit
PfamiView protein in Pfam
PF02058 Guanylin, 1 hit
PIRSFiPIRSF001849 Guanylin, 1 hit
PRINTSiPR00774 GUANYLIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005588 Guanylin, 1 hit
SUPFAMiSSF89890 SSF89890, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02747-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAFLLSALC LLGAWAALAG GVTVQDGNFS FSLESVKKLK DLQEPQEPRV
60 70 80 90 100
GKLRNFAPIP GEPVVPILCS NPNFPEELKP LCKEPNAQEI LQRLEEIAED
110
PGTCEICAYA ACTGC
Length:115
Mass (Da):12,388
Last modified:March 2, 2010 - v2
Checksum:iC644DA910EED26FA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0626787S → F3 PublicationsCorresponds to variant dbSNP:rs2071499Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97496 mRNA Translation: AAA35915.1
M95174 mRNA Translation: AAA58625.1
X74322 Genomic DNA Translation: CAC22258.1
AC114492 Genomic DNA No translation available.
CCDSiCCDS465.1
PIRiA46279
RefSeqiNP_291031.2, NM_033553.2
UniGeneiHs.778

Genome annotation databases

EnsembliENST00000357001; ENSP00000349493; ENSG00000197273
GeneIDi2980
KEGGihsa:2980
UCSCiuc001chd.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97496 mRNA Translation: AAA35915.1
M95174 mRNA Translation: AAA58625.1
X74322 Genomic DNA Translation: CAC22258.1
AC114492 Genomic DNA No translation available.
CCDSiCCDS465.1
PIRiA46279
RefSeqiNP_291031.2, NM_033553.2
UniGeneiHs.778

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GNANMR-A103-115[»]
1GNBNMR-A103-115[»]
1O8RNMR-A22-115[»]
ProteinModelPortaliQ02747
SMRiQ02747
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109235, 1 interactor
IntActiQ02747, 13 interactors
STRINGi9606.ENSP00000349493

Polymorphism and mutation databases

BioMutaiGUCA2A
DMDMi290457645

Proteomic databases

PaxDbiQ02747
PeptideAtlasiQ02747
PRIDEiQ02747
ProteomicsDBi58118

Protocols and materials databases

DNASUi2980
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357001; ENSP00000349493; ENSG00000197273
GeneIDi2980
KEGGihsa:2980
UCSCiuc001chd.2 human

Organism-specific databases

CTDi2980
DisGeNETi2980
EuPathDBiHostDB:ENSG00000197273.3
GeneCardsiGUCA2A
H-InvDBiHIX0028941
HGNCiHGNC:4682 GUCA2A
HPAiHPA018215
MIMi139392 gene
neXtProtiNX_Q02747
OpenTargetsiENSG00000197273
PharmGKBiPA29065
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J44S Eukaryota
ENOG410Z6NA LUCA
GeneTreeiENSGT00730000111358
HOGENOMiHOG000231183
HOVERGENiHBG051861
InParanoidiQ02747
OMAiSCEICAF
OrthoDBiEOG091G0WKF
PhylomeDBiQ02747
TreeFamiTF330731

Enzyme and pathway databases

ReactomeiR-HSA-8935690 Digestion
SIGNORiQ02747

Miscellaneous databases

EvolutionaryTraceiQ02747
GenomeRNAii2980
PROiPR:Q02747
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197273 Expressed in 114 organ(s), highest expression level in colonic mucosa
CleanExiHS_GUCA2A
GenevisibleiQ02747 HS

Family and domain databases

Gene3Di3.90.1450.10, 1 hit
InterProiView protein in InterPro
IPR000879 Guanylin
IPR036382 Guanylin_sf
PANTHERiPTHR11318 PTHR11318, 1 hit
PfamiView protein in Pfam
PF02058 Guanylin, 1 hit
PIRSFiPIRSF001849 Guanylin, 1 hit
PRINTSiPR00774 GUANYLIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005588 Guanylin, 1 hit
SUPFAMiSSF89890 SSF89890, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGUC2A_HUMAN
AccessioniPrimary (citable) accession number: Q02747
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: March 2, 2010
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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