UniProtKB - Q02738 (CXB4_MOUSE)
Protein
Gap junction beta-4 protein
Gene
Gjb4
Organism
Mus musculus (Mouse)
Status
Functioni
Structural component of gap junctions (PubMed:15692151). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:15692151).By similarity1 Publication
GO - Molecular functioni
- gap junction channel activity Source: UniProtKB
GO - Biological processi
- cell-cell signaling Source: UniProtKB
- gap junction-mediated intercellular transport Source: UniProtKB
- olfactory behavior Source: MGI
- sensory perception of smell Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-190861, Gap junction assembly |
Names & Taxonomyi
Protein namesi | Recommended name: Gap junction beta-4 proteinAlternative name(s): Connexin-30.31 Publication Short name: Cx30.3 |
Gene namesi | Name:Gjb4 Synonyms:Cxn-30.3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95722, Gjb4 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Curated
Other locations
- gap junction 1 Publication
Note: Colocalizes with GJB2 at gap junction plaques in the cochlea.1 Publication
Nucleus
- nucleolus Source: MGI
- nucleoplasm Source: MGI
Plasma Membrane
- connexin complex Source: UniProtKB
- integral component of plasma membrane Source: UniProtKB
Other locations
- cell junction Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Intramembranei | 2 – 13 | By similarityAdd BLAST | 12 | |
Topological domaini | 14 – 20 | CytoplasmicCurated | 7 | |
Transmembranei | 21 – 40 | HelicalBy similarityAdd BLAST | 20 | |
Topological domaini | 41 – 73 | ExtracellularCuratedAdd BLAST | 33 | |
Transmembranei | 74 – 94 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 95 – 130 | CytoplasmicCuratedAdd BLAST | 36 | |
Transmembranei | 131 – 151 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 152 – 184 | ExtracellularCuratedAdd BLAST | 33 | |
Transmembranei | 185 – 205 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 206 – 266 | CytoplasmicCuratedAdd BLAST | 61 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057866 | 1 – 266 | Gap junction beta-4 proteinAdd BLAST | 266 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 53 ↔ 175 | By similarity | ||
Disulfide bondi | 60 ↔ 169 | By similarity | ||
Disulfide bondi | 64 ↔ 164 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
MaxQBi | Q02738 |
PaxDbi | Q02738 |
PRIDEi | Q02738 |
PTM databases
PhosphoSitePlusi | Q02738 |
Expressioni
Tissue specificityi
Detected in cochlea (at protein level) (PubMed:15692151). Detected in cochlea (PubMed:15692151). Expressed in skin (PubMed:1512260).2 Publications
Developmental stagei
Detected in cochlea after 15 dpc. Detected in the spiral limbus in neoneates at 2, 8 and 10 days after birth, before the onset of hearing.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000046623, Expressed in lip and 56 other tissues |
Genevisiblei | Q02738, MM |
Interactioni
Subunit structurei
A hemichannel or connexon is composed of a hexamer of connexins. A functional gap junction is formed by the apposition of two hemichannels (By similarity). Forms heteromeric channels with GJB2 (PubMed:15692151).
By similarity1 PublicationProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000101696 |
Miscellaneous databases
RNActi | Q02738, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R3YE, Eukaryota |
GeneTreei | ENSGT00990000203557 |
HOGENOMi | CLU_037388_4_1_1 |
InParanoidi | Q02738 |
OMAi | IFHRLYQ |
OrthoDBi | 955506at2759 |
PhylomeDBi | Q02738 |
TreeFami | TF329606 |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002270, Connexin311 IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit PTHR11984:SF30, PTHR11984:SF30, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01142, CONNEXINB5 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q02738-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNWGFLQGIL SGVNKYSTAL GRIWLSVVFI FRVLVYVVAA EEVWDDDQKD
60 70 80 90 100
FICNTKQPGC PNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYREE
110 120 130 140 150
RERKHRLKHG PNAPALYSNL SKKRGGLWWT YLLSLIFKAA VDSGFLYIFH
160 170 180 190 200
CIYKDYDMPR VVACSVTPCP HTVDCYIARP TEKKVFTYFM VVTAAICILL
210 220 230 240 250
NLSEVVYLVG KRCMEVFRPR RRKASRRHQL PDTCPPYVIS KGGHPQDESV
260
ILTKAGMATV DAGVYP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M91443 Genomic DNA Translation: AAA37428.1 BC064060 mRNA Translation: AAH64060.1 |
CCDSi | CCDS18669.1 |
PIRi | A43433 |
RefSeqi | NP_032153.1, NM_008127.4 |
Genome annotation databases
Ensembli | ENSMUST00000060419; ENSMUSP00000053307; ENSMUSG00000046623 ENSMUST00000106090; ENSMUSP00000101696; ENSMUSG00000046623 |
GeneIDi | 14621 |
KEGGi | mmu:14621 |
UCSCi | uc008uuu.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M91443 Genomic DNA Translation: AAA37428.1 BC064060 mRNA Translation: AAH64060.1 |
CCDSi | CCDS18669.1 |
PIRi | A43433 |
RefSeqi | NP_032153.1, NM_008127.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000101696 |
PTM databases
PhosphoSitePlusi | Q02738 |
Proteomic databases
MaxQBi | Q02738 |
PaxDbi | Q02738 |
PRIDEi | Q02738 |
Protocols and materials databases
Antibodypediai | 17219, 167 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000060419; ENSMUSP00000053307; ENSMUSG00000046623 ENSMUST00000106090; ENSMUSP00000101696; ENSMUSG00000046623 |
GeneIDi | 14621 |
KEGGi | mmu:14621 |
UCSCi | uc008uuu.1, mouse |
Organism-specific databases
CTDi | 127534 |
MGIi | MGI:95722, Gjb4 |
Phylogenomic databases
eggNOGi | ENOG502R3YE, Eukaryota |
GeneTreei | ENSGT00990000203557 |
HOGENOMi | CLU_037388_4_1_1 |
InParanoidi | Q02738 |
OMAi | IFHRLYQ |
OrthoDBi | 955506at2759 |
PhylomeDBi | Q02738 |
TreeFami | TF329606 |
Enzyme and pathway databases
Reactomei | R-MMU-190861, Gap junction assembly |
Miscellaneous databases
BioGRID-ORCSi | 14621, 0 hits in 17 CRISPR screens |
ChiTaRSi | Gjb4, mouse |
PROi | PR:Q02738 |
RNActi | Q02738, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000046623, Expressed in lip and 56 other tissues |
Genevisiblei | Q02738, MM |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002270, Connexin311 IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit PTHR11984:SF30, PTHR11984:SF30, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01142, CONNEXINB5 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXB4_MOUSE | |
Accessioni | Q02738Primary (citable) accession number: Q02738 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families