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Protein

Gap junction beta-4 protein

Gene

Gjb4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  • cell communication Source: InterPro
  • olfactory behavior Source: MGI
  • sensory perception of smell Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-4 protein
Alternative name(s):
Connexin-30.3
Short name:
Cx30.3
Gene namesi
Name:Gjb4
Synonyms:Cxn-30.3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95722 Gjb4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Topological domaini41 – 75ExtracellularSequence analysisAdd BLAST35
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 126CytoplasmicSequence analysisAdd BLAST28
Transmembranei127 – 149HelicalSequence analysisAdd BLAST23
Topological domaini150 – 187ExtracellularSequence analysisAdd BLAST38
Transmembranei188 – 210HelicalSequence analysisAdd BLAST23
Topological domaini211 – 266CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578661 – 266Gap junction beta-4 proteinAdd BLAST266

Proteomic databases

MaxQBiQ02738
PaxDbiQ02738
PRIDEiQ02738

PTM databases

PhosphoSitePlusiQ02738

Expressioni

Tissue specificityi

Expressed in skin.

Gene expression databases

BgeeiENSMUSG00000046623 Expressed in 41 organ(s), highest expression level in zone of skin
CleanExiMM_GJB4
GenevisibleiQ02738 MM

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053307

Structurei

3D structure databases

ProteinModelPortaliQ02738
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE21 Eukaryota
ENOG410Y9C2 LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiQ02738
KOiK07623
OMAiHTVDCYI
OrthoDBiEOG091G0FKH
PhylomeDBiQ02738
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002270 Connexin311
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF30 PTHR11984:SF30, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01142 CONNEXINB5
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q02738-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNWGFLQGIL SGVNKYSTAL GRIWLSVVFI FRVLVYVVAA EEVWDDDQKD
60 70 80 90 100
FICNTKQPGC PNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYREE
110 120 130 140 150
RERKHRLKHG PNAPALYSNL SKKRGGLWWT YLLSLIFKAA VDSGFLYIFH
160 170 180 190 200
CIYKDYDMPR VVACSVTPCP HTVDCYIARP TEKKVFTYFM VVTAAICILL
210 220 230 240 250
NLSEVVYLVG KRCMEVFRPR RRKASRRHQL PDTCPPYVIS KGGHPQDESV
260
ILTKAGMATV DAGVYP
Length:266
Mass (Da):30,389
Last modified:February 1, 1994 - v1
Checksum:i0772D708C004EFC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91443 Genomic DNA Translation: AAA37428.1
BC064060 mRNA Translation: AAH64060.1
CCDSiCCDS18669.1
PIRiA43433
RefSeqiNP_032153.1, NM_008127.4
UniGeneiMm.56906

Genome annotation databases

EnsembliENSMUST00000060419; ENSMUSP00000053307; ENSMUSG00000046623
ENSMUST00000106090; ENSMUSP00000101696; ENSMUSG00000046623
GeneIDi14621
KEGGimmu:14621
UCSCiuc008uuu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91443 Genomic DNA Translation: AAA37428.1
BC064060 mRNA Translation: AAH64060.1
CCDSiCCDS18669.1
PIRiA43433
RefSeqiNP_032153.1, NM_008127.4
UniGeneiMm.56906

3D structure databases

ProteinModelPortaliQ02738
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053307

PTM databases

PhosphoSitePlusiQ02738

Proteomic databases

MaxQBiQ02738
PaxDbiQ02738
PRIDEiQ02738

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060419; ENSMUSP00000053307; ENSMUSG00000046623
ENSMUST00000106090; ENSMUSP00000101696; ENSMUSG00000046623
GeneIDi14621
KEGGimmu:14621
UCSCiuc008uuu.1 mouse

Organism-specific databases

CTDi127534
MGIiMGI:95722 Gjb4

Phylogenomic databases

eggNOGiENOG410IE21 Eukaryota
ENOG410Y9C2 LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiQ02738
KOiK07623
OMAiHTVDCYI
OrthoDBiEOG091G0FKH
PhylomeDBiQ02738
TreeFamiTF329606

Enzyme and pathway databases

ReactomeiR-MMU-190861 Gap junction assembly

Miscellaneous databases

PROiPR:Q02738
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046623 Expressed in 41 organ(s), highest expression level in zone of skin
CleanExiMM_GJB4
GenevisibleiQ02738 MM

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002270 Connexin311
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF30 PTHR11984:SF30, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01142 CONNEXINB5
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXB4_MOUSE
AccessioniPrimary (citable) accession number: Q02738
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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