Gjb4

Functionⁱ

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processⁱ

cell communication Source: InterPro
olfactory behavior
Source: MGI
Inferred from mutant phenotypeⁱ
- 17728008
sensory perception of smell
Source: MGI
Inferred from mutant phenotypeⁱ
- 17728008

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-190861 Gap junction assembly

Reactomeⁱ

R-MMU-190861 Gap junction assembly

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Gap junction beta-4 protein Alternative name(s): Connexin-30.3 Short name: Cx30.3
Gene namesⁱ	Name:Gjb4 Synonyms:Cxn-30.3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:95722 Gjb4

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 20	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	21 – 40	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	41 – 75	ExtracellularSequence analysisAdd BLAST	35
Transmembraneⁱ	76 – 98	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	99 – 126	CytoplasmicSequence analysisAdd BLAST	28
Transmembraneⁱ	127 – 149	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	150 – 187	ExtracellularSequence analysisAdd BLAST	38
Transmembraneⁱ	188 – 210	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	211 – 266	CytoplasmicSequence analysisAdd BLAST	56

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000057866	1 – 266	Gap junction beta-4 proteinAdd BLAST		266

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q02738
PaxDbⁱ	Q02738
PRIDEⁱ	Q02738

PTM databases

PhosphoSitePlusⁱ	Q02738

PhosphoSitePlusⁱ

Q02738

Expressionⁱ

Tissue specificityⁱ

Expressed in skin.

Gene expression databases

Bgeeⁱ	ENSMUSG00000046623 Expressed in 41 organ(s), highest expression level in zone of skin
CleanExⁱ	MM_GJB4
Genevisibleⁱ	Q02738 MM

Interactionⁱ

Subunit structureⁱ

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000053307

STRINGⁱ

10090.ENSMUSP00000053307

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q02738
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the connexin family. Beta-type (group I) subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IE21 Eukaryota ENOG410Y9C2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144026
HOGENOMⁱ	HOG000231127
HOVERGENⁱ	HBG009576
InParanoidⁱ	Q02738
KEGG Orthology (KO) More...KOⁱ	K07623
OMAⁱ	HTVDCYI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FKH
PhylomeDBⁱ	Q02738
TreeFamⁱ	TF329606

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR002270 Connexin311 IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit PTHR11984:SF30 PTHR11984:SF30, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN PR01142 CONNEXINB5
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q02738-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNWGFLQGIL SGVNKYSTAL GRIWLSVVFI FRVLVYVVAA EEVWDDDQKD 
        60         70         80         90        100
FICNTKQPGC PNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYREE 
       110        120        130        140        150
RERKHRLKHG PNAPALYSNL SKKRGGLWWT YLLSLIFKAA VDSGFLYIFH 
       160        170        180        190        200
CIYKDYDMPR VVACSVTPCP HTVDCYIARP TEKKVFTYFM VVTAAICILL 
       210        220        230        240        250
NLSEVVYLVG KRCMEVFRPR RRKASRRHQL PDTCPPYVIS KGGHPQDESV 
       260 
ILTKAGMATV DAGVYP

Length:266

Mass (Da):30,389

Last modified:February 1, 1994 - v1

Checksum:ⁱ0772D708C004EFC1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M91443 Genomic DNA Translation: AAA37428.1 BC064060 mRNA Translation: AAH64060.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18669.1
PIRⁱ	A43433
NCBI Reference Sequences More...RefSeqⁱ	NP_032153.1, NM_008127.4
UniGeneⁱ	Mm.56906

Genome annotation databases

Ensemblⁱ	ENSMUST00000060419; ENSMUSP00000053307; ENSMUSG00000046623 ENSMUST00000106090; ENSMUSP00000101696; ENSMUSG00000046623
GeneIDⁱ	14621
KEGGⁱ	mmu:14621
UCSC genome browser More...UCSCⁱ	uc008uuu.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q02738	Gap junction beta-4 protein		RAT		265	UniRef90_Q02738
Gap junction protein		MOUSE		266
Gap junction protein		CRIGR		265
UPI000A30DA8A		MUSPA		313
UPI000B4F7F73		MERUN		266
+7

Protein	Similar proteins		Species	Score	Length	Source
Q02738	Gap junction beta-4 protein		RAT		265	UniRef50_Q02738
Gap junction protein		MOUSE		266
Gap junction protein		CRIGR		265
Gap junction protein		BAMTH		286
Gap junction protein		LEPOC		266
+44

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M91443 Genomic DNA Translation: AAA37428.1 BC064060 mRNA Translation: AAH64060.1
CCDSⁱ	CCDS18669.1
PIRⁱ	A43433
RefSeqⁱ	NP_032153.1, NM_008127.4
UniGeneⁱ	Mm.56906

3D structure databases

ProteinModelPortalⁱ	Q02738
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000053307

STRINGⁱ

10090.ENSMUSP00000053307

PTM databases

PhosphoSitePlusⁱ	Q02738

PhosphoSitePlusⁱ

Q02738

Proteomic databases

MaxQBⁱ	Q02738
PaxDbⁱ	Q02738
PRIDEⁱ	Q02738

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000060419; ENSMUSP00000053307; ENSMUSG00000046623 ENSMUST00000106090; ENSMUSP00000101696; ENSMUSG00000046623
GeneIDⁱ	14621
KEGGⁱ	mmu:14621
UCSCⁱ	uc008uuu.1 mouse

Organism-specific databases

CTDⁱ	127534
MGIⁱ	MGI:95722 Gjb4

Phylogenomic databases

eggNOGⁱ	ENOG410IE21 Eukaryota ENOG410Y9C2 LUCA
GeneTreeⁱ	ENSGT00910000144026
HOGENOMⁱ	HOG000231127
HOVERGENⁱ	HBG009576
InParanoidⁱ	Q02738
KOⁱ	K07623
OMAⁱ	HTVDCYI
OrthoDBⁱ	EOG091G0FKH
PhylomeDBⁱ	Q02738
TreeFamⁱ	TF329606

Enzyme and pathway databases

Reactomeⁱ	R-MMU-190861 Gap junction assembly

Reactomeⁱ

R-MMU-190861 Gap junction assembly

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q02738
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000046623 Expressed in 41 organ(s), highest expression level in zone of skin
CleanExⁱ	MM_GJB4
Genevisibleⁱ	Q02738 MM

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR002270 Connexin311 IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit PTHR11984:SF30 PTHR11984:SF30, 1 hit
Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN PR01142 CONNEXINB5
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXB4_MOUSE
Accessionⁱ	Q02738Primary (citable) accession number: Q02738
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	February 1, 1994
	Last modified:	November 7, 2018
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q02738 (CXB4_MOUSE)

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Gap junction beta-4 protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Nucleus

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ