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UniProtKB - Q02685 (RMI1_YEAST)
Protein
RecQ-mediated genome instability protein 1
Gene
RMI1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Structure-specific DNA-binding protein with a preference for cruciform structures. Also binds single-stranded DNA (ssDNA). Functions together with SGS1 and TOP3 to maintain genome integrity. Essential for proper meiotic cell division. Required for normal S-phase progression and DNA damage response. Required for resistance to the DNA-damaging agent methyl methanesulfonate (MMS).
3 PublicationsMiscellaneous
Present with 1500 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- enzyme activator activity Source: SGD
- four-way junction DNA binding Source: SGD
- single-stranded DNA binding Source: SGD
GO - Biological processi
- cell division Source: UniProtKB-KW
- cellular response to DNA damage stimulus Source: SGD
- DNA topological change Source: SGD
- double-strand break repair via homologous recombination Source: ComplexPortal
- meiotic cell cycle Source: UniProtKB-KW
- mitotic sister chromatid cohesion Source: SGD
- positive regulation of DNA binding Source: SGD
Keywordsi
Molecular function | DNA-binding |
Biological process | Cell cycle, Cell division, DNA damage, Meiosis |
Names & Taxonomyi
Protein namesi | Recommended name: RecQ-mediated genome instability protein 1 |
Gene namesi | Ordered Locus Names:YPL024W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005945, RMI1 |
VEuPathDBi | FungiDB:YPL024W |
Subcellular locationi
Nucleus
- nuclear replication fork Source: SGD
- nucleus Source: SGD
Other locations
- cytoplasm Source: SGD
- RecQ family helicase-topoisomerase III complex Source: SGD
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000270571 | 1 – 241 | RecQ-mediated genome instability protein 1Add BLAST | 241 |
Proteomic databases
PaxDbi | Q02685 |
PRIDEi | Q02685 |
PTM databases
iPTMneti | Q02685 |
Interactioni
Subunit structurei
Forms a complex with SGS1 and TOP3.
2 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 36153, 301 interactors |
ComplexPortali | CPX-1071, RecQ helicase-Topo III complex |
DIPi | DIP-4039N |
IntActi | Q02685, 3 interactors |
MINTi | Q02685 |
STRINGi | 4932.YPL024W |
Miscellaneous databases
RNActi | Q02685, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the RMI1 family.Curated
Phylogenomic databases
eggNOGi | KOG3683, Eukaryota |
HOGENOMi | CLU_100701_0_0_1 |
InParanoidi | Q02685 |
OMAi | CEYLEAK |
Family and domain databases
Gene3Di | 2.40.50.770, 1 hit |
InterProi | View protein in InterPro IPR013894, RMI1_N IPR042470, RMI1_N_2 |
Pfami | View protein in Pfam PF08585, RMI1_N, 1 hit |
i Sequence
Sequence statusi: Complete.
Q02685-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFSSILSQD ITDDITPPAY SATLGSREQI VFRAYQNEPW LAGTASNLIL
60 70 80 90 100
DKKLVIVDRE LLFQVLMVEN ITKSKLTQID DIKTKLDPKK QKVDRLRSGA
110 120 130 140 150
QGNGAKKYEV ITQVDMEDDG NVADNNCAKE NNSNNNSSAA KNKAVFKLTL
160 170 180 190 200
QSKSGDVFFA INSTPISWSS CMLGSKIVIL PGTVFNRGVF ILKDSQVIFL
210 220 230 240
GGINRVWNEN RDQKFCDYLE SKLQRDKQLV NGGSKKRKAN D
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U36624 Genomic DNA Translation: AAB68163.1 BK006949 Genomic DNA Translation: DAA11404.1 |
PIRi | S63458 |
RefSeqi | NP_015301.1, NM_001183838.1 |
Genome annotation databases
EnsemblFungii | YPL024W_mRNA; YPL024W; YPL024W |
GeneIDi | 856083 |
KEGGi | sce:YPL024W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U36624 Genomic DNA Translation: AAB68163.1 BK006949 Genomic DNA Translation: DAA11404.1 |
PIRi | S63458 |
RefSeqi | NP_015301.1, NM_001183838.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 36153, 301 interactors |
ComplexPortali | CPX-1071, RecQ helicase-Topo III complex |
DIPi | DIP-4039N |
IntActi | Q02685, 3 interactors |
MINTi | Q02685 |
STRINGi | 4932.YPL024W |
PTM databases
iPTMneti | Q02685 |
Proteomic databases
PaxDbi | Q02685 |
PRIDEi | Q02685 |
Genome annotation databases
EnsemblFungii | YPL024W_mRNA; YPL024W; YPL024W |
GeneIDi | 856083 |
KEGGi | sce:YPL024W |
Organism-specific databases
SGDi | S000005945, RMI1 |
VEuPathDBi | FungiDB:YPL024W |
Phylogenomic databases
eggNOGi | KOG3683, Eukaryota |
HOGENOMi | CLU_100701_0_0_1 |
InParanoidi | Q02685 |
OMAi | CEYLEAK |
Miscellaneous databases
PROi | PR:Q02685 |
RNActi | Q02685, protein |
Family and domain databases
Gene3Di | 2.40.50.770, 1 hit |
InterProi | View protein in InterPro IPR013894, RMI1_N IPR042470, RMI1_N_2 |
Pfami | View protein in Pfam PF08585, RMI1_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RMI1_YEAST | |
Accessioni | Q02685Primary (citable) accession number: Q02685 Secondary accession number(s): D6W3Y8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - SIMILARITY comments
Index of protein domains and families